Differential regulation of HIV-1 fusion cofactor expression by CD28 costimulation of CD4+ T cells

Science

Volumn 276, Issue 5310, 1997, Pages 273-276

  Carroll, Richard G ^a   Riley, James L ^b   Levine, Bruce L ^c   Feng, Yu ^d   Kaushal, Sumesh ^a   Ritchey, David W ^a   Bernstein, Wendy ^b   Weislow, Owen S ^e   Brown, Charles R ^d   Berger, Edward A ^d   June, Carl H ^a,c   St Louis, Daniel C ^a  

^a HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE   (United States)

^b WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^c NAVAL MEDICAL RESEARCH INSTITUTE   (United States)

^d NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^e SRA Technologies Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; CD4 ANTIGEN; VIRUS FUSION PROTEIN;

ARTICLE; CONTROLLED STUDY; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NORMAL HUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; VIRUS RESISTANCE;

ANTIBODIES, MONOCLONAL; ANTIGENS, CD28; ANTIGENS, CD3; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; GENE EXPRESSION REGULATION; HIV-1; HUMANS; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; MEMBRANE FUSION; MEMBRANE PROTEINS; MUROMONAB-CD3; PHYTOHEMAGGLUTININS; RECEPTORS, CCR5; RECEPTORS, CXCR4; RECEPTORS, CYTOKINE; RECEPTORS, HIV; RNA, MESSENGER; UP-REGULATION; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0031002027     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.276.5310.273     Document Type: Article

References (53)

1. Q. J. Sattentau and J. P. Moore, Philos. Trans. R. Soc. London 342, 59 (1993).
2. G. Alkhatib et al., Science 272, 1955 (1996); H. Choe et al., Cell 65, 1135 (1996); H. Deng et al., Nature 381, 661 (1996); B. Doranz et al., Cell 85, 1149 (1996), T. Dragic et al., Nature 381, 667 (1996); Y. Feng, C. C. Broder, P. E. Kennedy, E. A. Berger, Science 272, 872 (1996).
3. G. Alkhatib et al., Science 272, 1955 (1996); H. Choe et al., Cell 65, 1135 (1996); H. Deng et al., Nature 381, 661 (1996); B. Doranz et al., Cell 85, 1149 (1996), T. Dragic et al., Nature 381, 667 (1996); Y. Feng, C. C. Broder, P. E. Kennedy, E. A. Berger, Science 272, 872 (1996).
4. G. Alkhatib et al., Science 272, 1955 (1996); H. Choe et al., Cell 65, 1135 (1996); H. Deng et al., Nature 381, 661 (1996); B. Doranz et al., Cell 85, 1149 (1996), T. Dragic et al., Nature 381, 667 (1996); Y. Feng, C. C. Broder, P. E. Kennedy, E. A. Berger, Science 272, 872 (1996).
5. G. Alkhatib et al., Science 272, 1955 (1996); H. Choe et al., Cell 65, 1135 (1996); H. Deng et al., Nature 381, 661 (1996); B. Doranz et al., Cell 85, 1149 (1996), T. Dragic et al., Nature 381, 667 (1996); Y. Feng, C. C. Broder, P. E. Kennedy, E. A. Berger, Science 272, 872 (1996).
6. G. Alkhatib et al., Science 272, 1955 (1996); H. Choe et al., Cell 65, 1135 (1996); H. Deng et al., Nature 381, 661 (1996); B. Doranz et al., Cell 85, 1149 (1996), T. Dragic et al., Nature 381, 667 (1996); Y. Feng, C. C. Broder, P. E. Kennedy, E. A. Berger, Science 272, 872 (1996).
7. G. Alkhatib et al., Science 272, 1955 (1996); H. Choe et al., Cell 65, 1135 (1996); H. Deng et al., Nature 381, 661 (1996); B. Doranz et al., Cell 85, 1149 (1996), T. Dragic et al., Nature 381, 667 (1996); Y. Feng, C. C. Broder, P. E. Kennedy, E. A. Berger, Science 272, 872 (1996).
8. R. H. Schwartz, J. Exp. Med. 184, 1 (1996); P. S. Linsley and J. A. Ledbetter, Annu. Rev. Immunol. 11, 191 (1993); P. Bretscher, Immunol. Today 13, 74 (1992); C. H. June, J. A. Bluestone, L. M. Nadler, C. B. Thompson, ibid. 15, 321 (1994).
9. R. H. Schwartz, J. Exp. Med. 184, 1 (1996); P. S. Linsley and J. A. Ledbetter, Annu. Rev. Immunol. 11, 191 (1993); P. Bretscher, Immunol. Today 13, 74 (1992); C. H. June, J. A. Bluestone, L. M. Nadler, C. B. Thompson, ibid. 15, 321 (1994).
10. R. H. Schwartz, J. Exp. Med. 184, 1 (1996); P. S. Linsley and J. A. Ledbetter, Annu. Rev. Immunol. 11, 191 (1993); P. Bretscher, Immunol. Today 13, 74 (1992); C. H. June, J. A. Bluestone, L. M. Nadler, C. B. Thompson, ibid. 15, 321 (1994).
11. R. H. Schwartz, J. Exp. Med. 184, 1 (1996); P. S. Linsley and J. A. Ledbetter, Annu. Rev. Immunol. 11, 191 (1993); P. Bretscher, Immunol. Today 13, 74 (1992); C. H. June, J. A. Bluestone, L. M. Nadler, C. B. Thompson, ibid. 15, 321 (1994).
12. B. L. Levine et al., Science 272, 1939 (1996).
13. J. Riley et al., J. Immunol., in press.
14. F. Cocchi et al., Science 270, 1811 (1995); W. A. Paxton et al., Nature Med. 2, 412 (1996).
15. F. Cocchi et al., Science 270, 1811 (1995); W. A. Paxton et al., Nature Med. 2, 412 (1996).
16. A. Adachi et al., J. Virol. 59, 284 (1986); S. Gartner et al., Science 233, 215 (1986); J. Mascola et al., J. Infect. Dis. 169, 48 (1994).
17. A. Adachi et al., J. Virol. 59, 284 (1986); S. Gartner et al., Science 233, 215 (1986); J. Mascola et al., J. Infect. Dis. 169, 48 (1994).
18. A. Adachi et al., J. Virol. 59, 284 (1986); S. Gartner et al., Science 233, 215 (1986); J. Mascola et al., J. Infect. Dis. 169, 48 (1994).
19. J. B. Breitmeyer, J. F. Daley, H. B. Levine, S. F. Schlossman, J. Immunol. 139, 2899 (1987); J. A. Ledbetter et al., Eur. J. Immunol. 18, 1601 (1988); A. D. Beyers, L. L. Spruyt, A. F. Williams, Proc. Natl. Acad. Sci. U.S.A. 89, 2945 (1992); H. Schrezenmeier and B. Fleischer, J. Immunol. 141, 398 (1988); J. A. Ledbetter et al., Eur. J. Immunol. 18, 525 (1988); J. L. Ceuppens and M. L. Baroja, J. Immunol. 137, 1816 (1986); J. A. Ledbetter et al., ibid. 135, 2331 (1985); T. D. Geppert and P. E. Lipsky, J. Clin. Invest. 81, 1497 (1988); T. D. Geppert, M. C. Wacholtz, L. S. Davis, P. E. Lipsky, J. Immunol. 140, 2155 (1988).
20. J. B. Breitmeyer, J. F. Daley, H. B. Levine, S. F. Schlossman, J. Immunol. 139, 2899 (1987); J. A. Ledbetter et al., Eur. J. Immunol. 18, 1601 (1988); A. D. Beyers, L. L. Spruyt, A. F. Williams, Proc. Natl. Acad. Sci. U.S.A. 89, 2945 (1992); H. Schrezenmeier and B. Fleischer, J. Immunol. 141, 398 (1988); J. A. Ledbetter et al., Eur. J. Immunol. 18, 525 (1988); J. L. Ceuppens and M. L. Baroja, J. Immunol. 137, 1816 (1986); J. A. Ledbetter et al., ibid. 135, 2331 (1985); T. D. Geppert and P. E. Lipsky, J. Clin. Invest. 81, 1497 (1988); T. D. Geppert, M. C. Wacholtz, L. S. Davis, P. E. Lipsky, J. Immunol. 140, 2155 (1988).
21. J. B. Breitmeyer, J. F. Daley, H. B. Levine, S. F. Schlossman, J. Immunol. 139, 2899 (1987); J. A. Ledbetter et al., Eur. J. Immunol. 18, 1601 (1988); A. D. Beyers, L. L. Spruyt, A. F. Williams, Proc. Natl. Acad. Sci. U.S.A. 89, 2945 (1992); H. Schrezenmeier and B. Fleischer, J. Immunol. 141, 398 (1988); J. A. Ledbetter et al., Eur. J. Immunol. 18, 525 (1988); J. L. Ceuppens and M. L. Baroja, J. Immunol. 137, 1816 (1986); J. A. Ledbetter et al., ibid. 135, 2331 (1985); T. D. Geppert and P. E. Lipsky, J. Clin. Invest. 81, 1497 (1988); T. D. Geppert, M. C. Wacholtz, L. S. Davis, P. E. Lipsky, J. Immunol. 140, 2155 (1988).
22. J. B. Breitmeyer, J. F. Daley, H. B. Levine, S. F. Schlossman, J. Immunol. 139, 2899 (1987); J. A. Ledbetter et al., Eur. J. Immunol. 18, 1601 (1988); A. D. Beyers, L. L. Spruyt, A. F. Williams, Proc. Natl. Acad. Sci. U.S.A. 89, 2945 (1992); H. Schrezenmeier and B. Fleischer, J. Immunol. 141, 398 (1988); J. A. Ledbetter et al., Eur. J. Immunol. 18, 525 (1988); J. L. Ceuppens and M. L. Baroja, J. Immunol. 137, 1816 (1986); J. A. Ledbetter et al., ibid. 135, 2331 (1985); T. D. Geppert and P. E. Lipsky, J. Clin. Invest. 81, 1497 (1988); T. D. Geppert, M. C. Wacholtz, L. S. Davis, P. E. Lipsky, J. Immunol. 140, 2155 (1988).
23. J. B. Breitmeyer, J. F. Daley, H. B. Levine, S. F. Schlossman, J. Immunol. 139, 2899 (1987); J. A. Ledbetter et al., Eur. J. Immunol. 18, 1601 (1988); A. D. Beyers, L. L. Spruyt, A. F. Williams, Proc. Natl. Acad. Sci. U.S.A. 89, 2945 (1992); H. Schrezenmeier and B. Fleischer, J. Immunol. 141, 398 (1988); J. A. Ledbetter et al., Eur. J. Immunol. 18, 525 (1988); J. L. Ceuppens and M. L. Baroja, J. Immunol. 137, 1816 (1986); J. A. Ledbetter et al., ibid. 135, 2331 (1985); T. D. Geppert and P. E. Lipsky, J. Clin. Invest. 81, 1497 (1988); T. D. Geppert, M. C. Wacholtz, L. S. Davis, P. E. Lipsky, J. Immunol. 140, 2155 (1988).
24. J. B. Breitmeyer, J. F. Daley, H. B. Levine, S. F. Schlossman, J. Immunol. 139, 2899 (1987); J. A. Ledbetter et al., Eur. J. Immunol. 18, 1601 (1988); A. D. Beyers, L. L. Spruyt, A. F. Williams, Proc. Natl. Acad. Sci. U.S.A. 89, 2945 (1992); H. Schrezenmeier and B. Fleischer, J. Immunol. 141, 398 (1988); J. A. Ledbetter et al., Eur. J. Immunol. 18, 525 (1988); J. L. Ceuppens and M. L. Baroja, J. Immunol. 137, 1816 (1986); J. A. Ledbetter et al., ibid. 135, 2331 (1985); T. D. Geppert and P. E. Lipsky, J. Clin. Invest. 81, 1497 (1988); T. D. Geppert, M. C. Wacholtz, L. S. Davis, P. E. Lipsky, J. Immunol. 140, 2155 (1988).
25. J. B. Breitmeyer, J. F. Daley, H. B. Levine, S. F. Schlossman, J. Immunol. 139, 2899 (1987); J. A. Ledbetter et al., Eur. J. Immunol. 18, 1601 (1988); A. D. Beyers, L. L. Spruyt, A. F. Williams, Proc. Natl. Acad. Sci. U.S.A. 89, 2945 (1992); H. Schrezenmeier and B. Fleischer, J. Immunol. 141, 398 (1988); J. A. Ledbetter et al., Eur. J. Immunol. 18, 525 (1988); J. L. Ceuppens and M. L. Baroja, J. Immunol. 137, 1816 (1986); J. A. Ledbetter et al., ibid. 135, 2331 (1985); T. D. Geppert and P. E. Lipsky, J. Clin. Invest. 81, 1497 (1988); T. D. Geppert, M. C. Wacholtz, L. S. Davis, P. E. Lipsky, J. Immunol. 140, 2155 (1988).
26. J. B. Breitmeyer, J. F. Daley, H. B. Levine, S. F. Schlossman, J. Immunol. 139, 2899 (1987); J. A. Ledbetter et al., Eur. J. Immunol. 18, 1601 (1988); A. D. Beyers, L. L. Spruyt, A. F. Williams, Proc. Natl. Acad. Sci. U.S.A. 89, 2945 (1992); H. Schrezenmeier and B. Fleischer, J. Immunol. 141, 398 (1988); J. A. Ledbetter et al., Eur. J. Immunol. 18, 525 (1988); J. L. Ceuppens and M. L. Baroja, J. Immunol. 137, 1816 (1986); J. A. Ledbetter et al., ibid. 135, 2331 (1985); T. D. Geppert and P. E. Lipsky, J. Clin. Invest. 81, 1497 (1988); T. D. Geppert, M. C. Wacholtz, L. S. Davis, P. E. Lipsky, J. Immunol. 140, 2155 (1988).
27. J. B. Breitmeyer, J. F. Daley, H. B. Levine, S. F. Schlossman, J. Immunol. 139, 2899 (1987); J. A. Ledbetter et al., Eur. J. Immunol. 18, 1601 (1988); A. D. Beyers, L. L. Spruyt, A. F. Williams, Proc. Natl. Acad. Sci. U.S.A. 89, 2945 (1992); H. Schrezenmeier and B. Fleischer, J. Immunol. 141, 398 (1988); J. A. Ledbetter et al., Eur. J. Immunol. 18, 525 (1988); J. L. Ceuppens and M. L. Baroja, J. Immunol. 137, 1816 (1986); J. A. Ledbetter et al., ibid. 135, 2331 (1985); T. D. Geppert and P. E. Lipsky, J. Clin. Invest. 81, 1497 (1988); T. D. Geppert, M. C. Wacholtz, L. S. Davis, P. E. Lipsky, J. Immunol. 140, 2155 (1988).
28. 5 cells were present. The CD28-induced resistance was robust because prolonged culture to 28 days did not reveal infection, and the resistance was evident after infection of CD4 cells at high and low multiplicities of infection.
29. J. A. Zack et al., Cell 61, 213 (1990).
30. LAV envelope-expressing cells at levels ∼70-fold over background.
31. LAV envelope-expressing cells at levels ∼70-fold over background.
32. LAV envelope-expressing cells at levels ∼70-fold over background.
33. C. B. Thompson et al., Proc. Natl. Acad. Sci. U.S.A. 86, 1333 (1989).
34. P. Loetscher, P. M. Seitz, M. Baggiolini, B. Moser, J. Exp. Med. 184, 569 (1996).
35. F. Miedema et al., Immunol. Rev. 140, 35 (1994).
36. M. Dean et al., Science 273, 1856 (1996); Y. Huang et al., Nature Med. 2, 1240 (1996); R. Liu et al., Cell 86, 367 (1996); M. Samson et al., Nature 382, 722 (1996).
37. M. Dean et al., Science 273, 1856 (1996); Y. Huang et al., Nature Med. 2, 1240 (1996); R. Liu et al., Cell 86, 367 (1996); M. Samson et al., Nature 382, 722 (1996).
38. M. Dean et al., Science 273, 1856 (1996); Y. Huang et al., Nature Med. 2, 1240 (1996); R. Liu et al., Cell 86, 367 (1996); M. Samson et al., Nature 382, 722 (1996).
39. M. Dean et al., Science 273, 1856 (1996); Y. Huang et al., Nature Med. 2, 1240 (1996); R. Liu et al., Cell 86, 367 (1996); M. Samson et al., Nature 382, 722 (1996).
40. C. H. June et al., Mol. Cell. Biol. 7, 4472 (1987); B. L. Levine et al., Int. Immunol. 7, 891 (1995).
41. C. H. June et al., Mol. Cell. Biol. 7, 4472 (1987); B. L. Levine et al., Int. Immunol. 7, 891 (1995).
42. J. Kimpton and M. Emerman, J. Virol. 66, 2232 (1992).
43. M. T. Vahey and M. T. Wong, in PCR Primer: A Laboratory Manual, C. W. Dieffenbach and G. S. Dveksler, Eds. (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1995), p. 17; M. T. Vahey, M. T. Wong, N. L. Michael, in ibid., p. 313.
44. M. T. Vahey and M. T. Wong, in PCR Primer: A Laboratory Manual, C. W. Dieffenbach and G. S. Dveksler, Eds. (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1995), p. 17; M. T. Vahey, M. T. Wong, N. L. Michael, in ibid., p. 313.
45. F. Lori et al., J. Virol. 66, 5067 (1992); D. Trono, ibid. 66, 4893 (1992).
46. F. Lori et al., J. Virol. 66, 5067 (1992); D. Trono, ibid. 66, 4893 (1992).
47. M. Samson et al., Biochemistry 35, 3362 (1996).
48. B. Federsppiel et al., Genomics 16, 707 (1993); H. Herzog, Y. J. Hort, J. Shine, L. A. Selbie, DNA Cell Biol. 12, 465 (1993); E. E. Jazin et al., Regul. Pept. 47, 247 (1993); P. Loetscher et al., J. Biol. Chem. 269, 232 (1994); H. Nomura, B. W. Nielsen, K. Matsushima, Int. Immunol. 5, 1239 (1993).
49. B. Federsppiel et al., Genomics 16, 707 (1993); H. Herzog, Y. J. Hort, J. Shine, L. A. Selbie, DNA Cell Biol. 12, 465 (1993); E. E. Jazin et al., Regul. Pept. 47, 247 (1993); P. Loetscher et al., J. Biol. Chem. 269, 232 (1994); H. Nomura, B. W. Nielsen, K. Matsushima, Int. Immunol. 5, 1239 (1993).
50. B. Federsppiel et al., Genomics 16, 707 (1993); H. Herzog, Y. J. Hort, J. Shine, L. A. Selbie, DNA Cell Biol. 12, 465 (1993); E. E. Jazin et al., Regul. Pept. 47, 247 (1993); P. Loetscher et al., J. Biol. Chem. 269, 232 (1994); H. Nomura, B. W. Nielsen, K. Matsushima, Int. Immunol. 5, 1239 (1993).
51. B. Federsppiel et al., Genomics 16, 707 (1993); H. Herzog, Y. J. Hort, J. Shine, L. A. Selbie, DNA Cell Biol. 12, 465 (1993); E. E. Jazin et al., Regul. Pept. 47, 247 (1993); P. Loetscher et al., J. Biol. Chem. 269, 232 (1994); H. Nomura, B. W. Nielsen, K. Matsushima, Int. Immunol. 5, 1239 (1993).
52. B. Federsppiel et al., Genomics 16, 707 (1993); H. Herzog, Y. J. Hort, J. Shine, L. A. Selbie, DNA Cell Biol. 12, 465 (1993); E. E. Jazin et al., Regul. Pept. 47, 247 (1993); P. Loetscher et al., J. Biol. Chem. 269, 232 (1994); H. Nomura, B. W. Nielsen, K. Matsushima, Int. Immunol. 5, 1239 (1993).
53. We thank J. Cotte, N. Craighead, T. Francomano, S. Perfetto, and D. Kim for assistance; N. Michael for review of the manuscript; D. Birx and D. Burke for stimulating discussions and for continued support and encouragement; and B. Chesebro for the Hela-CD4-LTR-β-Gal (MAGI) cell line. We acknowledge the National Institutes of Health AIDS Research and Reference Reagent Program for providing the cells. Supported by ARMY DAMD17-93-V-3004 and by the Navy Medical Research and Development Command. The views expressed in this article are those of the authors and do not reflect the official policy or position of the Department of the Army, Navy, Department of Defense, or the U.S. government.