A duodenally absorbable CXC chemokine receptor 4 antagonist, KRH-1636, exhibits a potent and selective anti-HIV-1 activity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 7, 2003, Pages 4185-4190

  Ichiyama, Kozi ^a   Yokoyama Kumakura, Sei ^b   Tanaka, Yuetsu ^c   Tanaka, Reiko ^c   Hirose, Kunitaka ^b   Bannai, Kenji ^b   Edamatsu, Takeo ^b   Yanaka, Mikiro ^b   Niitani, Yoshiaki ^b   Miyano Kurosaki, Naoko ^d   Takaku, Hiroshi ^d   Koyanagi, Yoshio ^e   Yamamoto, Naoki ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b KUREHA CORPORATION   (Japan)

^c UNIVERSITY OF THE RYUKYUS   (Japan)

^d CHIBA INSTITUTE OF TECHNOLOGY   (Japan)

^e TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; CHEMOKINE RECEPTOR CXCR4; CHEMOKINE RECEPTOR CXCR5; KRH 1636; MONOCLONAL ANTIBODY; N [4 GUANIDINO 1 (1 NAPHTHALEN 1 YLETHYLCARBAMOYL)BUTYL] 4 [(PYRIDIN 2 YLMETHYL)AMINO]METHYLBENZAMIDE; UNCLASSIFIED DRUG; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; ARGININE; DRUG DERIVATIVE; PYRIDINE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; DRUG ABSORPTION; DRUG POTENCY; DUODENUM; FEMALE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LIQUID CHROMATOGRAPHY; LYMPHOCYTE CULTURE; MALE; MEMBRANE FUSION; MOLECULAR WEIGHT; MONONUCLEAR CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; T LYMPHOCYTE; VIRUS INHIBITION; VIRUS REPLICATION; ANIMAL; CELL CULTURE; DRUG ANTAGONISM; DRUG EFFECT; IMMUNOLOGY; INTESTINE ABSORPTION; LYMPHOCYTE; MOUSE MUTANT; WISTAR RAT;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; RNA VIRUSES;

ANIMALS; ANTI-HIV AGENTS; ARGININE; HIV-1; HUMANS; INTESTINAL ABSORPTION; LYMPHOCYTES; MICE; MICE, SCID; PYRIDINES; RATS; RATS, WISTAR; RECEPTORS, CXCR4; T-LYMPHOCYTES; TUMOR CELLS, CULTURED;

EID: 0037388121     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0630420100     Document Type: Article

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