Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection

Cell

Volumn 86, Issue 3, 1996, Pages 367-377

  Liu, Rong ^a   Paxton, William A ^a   Choe, Sunny ^a   Ceradini, Daniel ^a   Martin, Scott R ^a   Horuk, Richard ^b   MacDonald, Marcy E ^c   Stuhlmann, Heidi ^d   Koup, Richard A ^a   Landau, Nathaniel R ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b BAYER AG   (Germany)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN;

ALLELE; ARTICLE; BASE PAIRING; CELL SURFACE; DELETION MUTANT; DISEASE COURSE; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SEXUAL TRANSMISSION; SIGNAL TRANSDUCTION; T LYMPHOCYTE SUBPOPULATION; VIRUS TRANSMISSION;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 15844388931     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)80110-5     Document Type: Article

References (45)

1. Alkhatib, G., Combadiere, C., Broder, C.C., Feng, Y., Kennedy, P.E., Murphy, P.M., and Berger, E.A. (1996). CC CKR5: a Rantes, MIP-1α, MIP-1β receptor as a fusion cofactor for macrophage-tropic HIV-1. Science 272, 1955-1958.
2. Baggiolini, M., Loetscher, P., Moser, B., Combadiere, C., Ahuja, S.K., and Murphy, P.M. (1995). Interleukin-8 and the chemokine family: cloning, chromosomal localization, and RNA expression of a human beta chemokine receptor-like gene. Int. J. Immunopharmacol. 17, 103-108.
3. Cao, Y., Qin, L., Zhang, L., Safrit, J., and Ho, D.D. (1995). Virologic and immunologic characterization of long-term survivors of human immunodeficiency virus type 1 infection. N. Engl. J. Med. 332, 201-208.
4. Choe, H., Farzan, M., Sun, Y., Sullivan, N., Rollins, B., Ponath, P.D., Wu, L., Mackay, C.R., LaRosa, G., Newman, W., Gerard, N., Gerard, C., and Sodroski, J. (1996). The β-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. Cell 85, 1135-1148.
5. Clerici, M., Giorgi, J.V., Chou, C.C., Gudeman, V.K., Zack, J.A., Gupta, P., Ho, H.N., Nishanian, P.G., Berzofsky, J.A., and Shearer, G.M. (1992). Cell-mediated immune response to human immunodeficiency virus (HIV) type 1 in seronegative homosexual men with recent sexual exposure to HIV-1. J. Infect. Dis. 165, 1012-1019.
6. + T cells. Science 720, 1811-1815.
7. Combadiere, C., Ahuja, S.K., and Murphy, P.M. (1995). Cloning, chromosomal localization, and RNA expression of a human beta chemokine receptor-like gene. DNA Cell. Biol. 14, 673-680.
8. Connor, R.I., and Ho, D.D. (1994). Human immunodeficiency virus type 1 variants with increased replicative capacity develop during the asymptomatic stage before disease progression. J. Virol. 68, 4400-4408.
9. Connor, R.I., Chen, B.K., Choe, S., and Landau, N.R. (1995). Vpr is required for efficient replication of human immunodeficiency virus type-1 in mononuclear phagocytes. Virology 206, 936-944.
10. Deng, D., Liu, R., Ellmeier, W., Choe, S., Unutmaz, D., Burkhart, M., DiMarzio, P., Marmon, S., Sutton, R.E., Hill, C.M., et al. (1996). Identification of a major co-receptor for primary isolates of HIV-1. Nature 381, 661-666.
11. Doranz, B.J., Rucker, J., Yi, Y., Smyth, R.J., Samson, M., Peiper, S.C., Parmentier, M., Collman, R.G., and Doms, R.W. (1996). A dualtropic primary HIV-1 isolate that uses Fusin and the β-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors. Cell 85, 1149-1158.
12. + cells is mediated by the chemokine receptor CC-CKR-5. Nature 381, 667-673.
13. Feng, Y., Broder, C.C., Kennedy, P.E., and Berger, E.A. (1996). HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane G protein-coupled receptor. Science 272, 872-877.
14. Field, J., Nikawa, J.I., Broek, D., MacDonald, B., Rodgers, L., Wilson, I.A., Lerner, R.A., and Wigler, M. (1988). Purification of a RAS-responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition method. Mol. Cell. Biol. 8, 2159-2165.
15. Fisher, A.G., Ensoli, B., Looney, D., Rose, A., Gallo, R.C., Saag, M.S., Shaw, G.M., Hahn, B.H., and Wong-Staal, F. (1988). Biologically diverse molecular variants within a single HIV-1 isolate. Nature 334, 444-447.
16. Gartner, S., Markovits, P., Markovitz, D.M., Kaplan, M.H., Gallo, R.C., and Popovic, M. (1986). The role of mononuclear phagocytes in HTLV-III/LAV infection. Science 233, 215-219.
17. He, J., and Landau, N.R. (1995). Use of a novel Human Immunodeficiency virus Type 1 reporter virus expressing human placental alkaline phosphatase to detect an alternative viral receptor. J. Virol. 69, 4587-4592.
18. Horuk, R. (1994). Molecular properties of the chemokine receptor family. Trends Pharmacol. Sci. 15, 159-165.
19. Horuk, R., Chitnis, C.E., Darbonne, W.C., Colby, T.J., Rybicki, A., Hadley, T.J., and Miller, L.H. (1993). A receptor for the malarial parasite Plasmodium vivax: the erythrocyte chemokine receptor. Science 267, 1182-1184.
20. Koyanagi, Y., Miles, S., Mitsuasu, R.T., Merrill, J.E., Vinters, H.V., and Chen, I.S.Y. (1987). Dual infection of the central nervous system by AIDS viruses with distinct cellular tropisms. Science 236, 819-822.
21. Landau, N.R., and Littman, D.R. (1992). A packaging system for producing murine leukemia virus vectors with variable tropism. J. Virol. 66, 5110-5113.
22. Landau, N.R., Page, K.A., and Littman, D.R. (1991). Pseudotyping with human T-cell leukemia virus type I broadens the human immunodeficiency virus host range. J. Virol. 65, 162-169.
23. Langlade-Demoyen, P., Ngo-Giang-Huong, N., Ferchal, F., and Oksenhendler, E. (1994). Human immunodeficiency virus (HIV) nef-specific cytotoxic T lymphocytes in noninfected heterosexual contact of HIV-infected patients. J. Clin. Invest. 93, 1293-1297.
24. Lenburg, M.E., and Landau, N.R. (1993). Vpu-induced degradation of CD4: requirement for specific amino acid residues in the cytoplasmic domain of CD4. J. Virol. 67, 7238-7245.
25. Locke, P.A., MacDonald, M.E., Srinidhi, J., Gilliam, T.C., Tanzi, R.E., Conneally, P., Wexler, N.S., Haines, J.L., and Gusella, J.F. (1988). A genetic map of the chromosome 4 short arm. Somat. Cell. Mol. Genet. 19, 95-101.
26. MacDonald, M.E., Lin, C., Srinidhi, L., Bates, G., Altherr, M., Whaley, W.L., Lehrach, H., Wasmuth, J., and Gusella, J.F. (1991). Complex patterns of linkage disequilibrium in the Huntington disease region. Am. J. Hum. Genet. 49, 723-734.
27. MacDonald, M.E., Novelletto, A., Lin, C.,Tagle, D., Barnes, G., Bates, G., Taylor, S., Allitto, B., Altherr, M., Myers, R., et al. (1992). The Huntington's disease candidate region exhibits many different haplotypes. Nature Genet. 1, 99-103.
28. Mallinson, G., Soo, K.S., Schall, T.J., Pisacka, M., and Anstee, D.J. (1995). Mutations in the erythrocyte chemokine receptor (Duffy) gene: the molecular basis of the Fya/Fyb antigens and identification of a deletion in the Duffy gene of an apparently healthy individual with the Fy(α-β-) phenotype. Br. J. Haematol. 90, 823-829.
29. Morgenstern, J.P., and Land, H. (1990). Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line. Nucleic Acids Res. 18, 3587-3596.
30. Naylor, S.L., Moore, S., Garcia, D., Xiang, X., Xin, X., Mohrer, M., Reus, B., Linn, R., Stanton, V., O'Connell, P., and Leach, R.J. (1996). Mapping 638 STSs to regions of human chromosome 3. Cytogenet. Cell. Genet. 72, 90-94.
31. Neote, K., DiGregorio, D., Mak, J.Y., Horuk, R., and Schall, T.J. (1993). Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor. Cell 72, 415-425.
32. Page, K.A., Landau, N.R., and Littman, D.R. (1990). Construction and use of a human immunodeficiency virus vector for analysis of virus infectivity. J. Virol. 64, 5270-5276.
33. Pantaleo, G., Menzo, S., Vaccarezza, M., Graziosi, C., Cohen, O.J., Demarest, J.F., Montefiori, D., Orenstein, J.M., Fox, C., Schrager, L.K. et al. (1995). Studies in subjects with long-term nonprogressive human immunodeficiency virus infection. N. Engl. J. Med. 332, 209-216.
34. Paxton, W., Connor, R.I., and Landau, N.R. (1993). Incorporation of Vpr into human immunodeficiency virus type-1 virions: requirement for the p6 region of gag and mutational analysis. J. Virol. 67, 7229-7237.
35. Paxton, W.A., Martin, S.R., Tse, D., O'Brien, T.R., Skurnick, J., Van-Devanter, N.L., Padian, N., Braun, J.F., Kotler, D.P., Wolinsky, S.M., and Koup, R.A. (1996). Relative resistance to HIV-1 infection of CD4 lymphocytes from persons who remain uninfected despite multiple high-risk sexual exposure. Nat. Med. 2, 412-417.
36. Raport, C.J., Schweickart, V.L., Eddy, R.J., Shows, T.B., Gray, P.W., Bacon, K.B., Premack, B.A., Gardner, P., Schall, T.J., Gao, J.L., and Murphy, P.M. (1995). The orphan G-protein-coupled receptor-encoding gene V28 is closely related to genes for chemokine receptors and is expressed in lymphoid and neural tissues. Gene 163, 295-299.
37. Rowland-Jones, S., Sutton, J., Ariyoshi, K., Dong, T., Gotch, F., McAdam, S., Whitby, D., Sabally, S., Gallimore, A., and Corrah, T.e.a. (1995). HIV-specific cytotoxic T-cells in HIV-exposed but uninfected Gambian women. Nat. Med. 1, 59-64.
38. Samson, M., Labbe, O., Mollereau, C., Vassart, G., and Parmentier, M. (1996). Molecular cloning and functional expression of a new human CC-chemokine receptor gene. Biochemistry 35, 3362-3367.
39. Sattentau, Q.J., and Weiss, R.A. (1988). The CD4 antigen: physiological ligand and HIV receptor. Cell 52, 631-633.
40. Schall, T.J. (1991). Biology of the RANTES/SIS cytokine family. Cytokine 3, 165-183.
41. Schuitemaker, H., Koot, M., Kootstra, N.A., Dercksen, M.W., de Goede, R.E., van Steenwijk, R.P., Lange, J.M., Schattenkerk, J.K., and Miedema, F. (1992). Biological phenotype of human immunodeficiency virus type 1 clones at different stages of infection: progression of disease is associated with a shift from monocytotropic to T-cell-tropic virus population. J. Virol. 66, 1354-1360.
42. Spira, A.I., and Ho, D.D. (1995). Effect of different donor cells on human immunodeficiency virus type 1 replication and selection in vitro. J. Virol. 69, 422-429.
43. Tanzi, R.E., Haines, J.L., Watkins, P.C., Stewart, G.D., Wallace, M.R., Hallewell, R., Wong, C., Wexler, N.S., Conneally, P.M., and Gusella, J.F. (1988). Genetic linkage map of human chromosome 21. Genomics 3, 129-136.
44. Wiesenfeld, S.L. (1968). Selective advantage of the sickle-cell trait. Science 160, 437.
45. Zhu, T., Mo, H., Wang, N., Nam, D.S., Cao, Y., Koup, R.A., and Ho, D.D. (1993). Genotypic and phenotypic characterization of HIV-1 patients with primary infection. Science 261, 1179-1181.