Determinants for the syncytium-inducing phenotype of HIV-1 subtype F isolates are located in the V3 region

AIDS Research and Human Retroviruses

Volumn 16, Issue 9, 2000, Pages 867-870

  Holm Hansen, Carol ^a,c   Baan, Elly ^d   Åsjö, Birgitta ^b   Pascu, Flavia Rodica ^e   Goudsmit, Jaap ^d   De Jong, J Jacques ^d  

^a UNIVERSITY OF BERGEN   (Norway)

^b HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^c NORWEGIAN INSTITUTE OF PUBLIC HEALTH   (Norway)

^d ACADEMIC MEDICAL CENTER   (Netherlands)

^e UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID SEQUENCE; ARTICLE; GENE INDUCTION; GENE LOCATION; GENETIC ANALYSIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SYNCYTIUM; VIRUS ISOLATION; VIRUS REPLICATION;

AMINO ACID SEQUENCE; AMINO ACIDS; CELL LINE; CYTOPATHOGENIC EFFECT, VIRAL; ELECTROCHEMISTRY; HIV ENVELOPE PROTEIN GP120; HIV-1; HUMANS; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PHENOTYPE; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0034631402     PISSN: 08892229     EISSN: None     Source Type: Journal    
DOI: 10.1089/08892220050042800     Document Type: Article

References (15)

1. 1. Berger EA, Doms RW, Fenyö EM, Korber BTM, Littman DR, Moore JP, Sattentau QJ, Schuitemaker H, Sodroski J, and Weiss RA: A new classification for HIV-1. Nature (London) 1998;391:240.
2. 2. Feng Y, Broder CC, Kennedy PE, and Berger EA: HIV-1 entry cofactor: Functional cDNA cloning of a seven-transmembrane G protein-coupled receptor. Science 1996;272:872-877.
3. 3. Berson JF, Long D, Dorantz BJ, Rucker J, Jirik FR, and Doms RW: A seven-transmembrane domain receptor involved in fusion and entry of T-cell tropic human immunodeficiency virus type 1 strains. J Virol 1996;70:6288-6295.
4. 4. Alkhatib G, Combadiere C, Broder C, Feng Y, Kennedy PE, Murphy PM, and Berger EA: CC CKR5: A RANTES, MIP-1α, MIP-1β receptor as a fusion cofactor for macrophage-tropic HIV-1. Science 1996;272:1955-1958.
5. 5. Marzio P, Marmon S, Sutton RE, Hill CM, Davis CB, Peiper SC, Schall TJ, Littman DR, and Landau NR: Identification of a major co-receptor for primary isolates of HIV-1. Nature (London) 1996;381:661-666.
6. 6. Dragic T, Litwin V, Allaway GP, Martin SR, Huang Y, Nagashima KA, Cayanan C, Maddon PJ, Koup RA, Moore JP, and Paxton WA: HIV-1 entry into CD4+ cells is mediated by the chemokine recptor CC-CRK-5. Nature (London) 1996;381:667-673.
7. 7. Trkola A, Paxton WA, Monard SP, Hoxie JA, Siani MA, Thompson DA, Wu L, MacKay CR, Horuk R, and Moore JP: Genetic subtype-independent inhibition of human immunodeficiency virus type 1 replication by CC and CXC chemokines. J Virol 1998;72:396-404.
8. 8. Chesebro B, Wehrly K, Nishio J, and Perryman S: Macrophagetropic human immunodeficiency virus isolates from different patients exhibit unusual V3 envelope sequence homogeneity in comparison with T-cell-tropic isolates: Definition of critical amino acids involved in cell tropism. J Virol 1992;66:6547-6554.
9. 9. Fouchier RAM, Groenink M, Koostra NA, Tersmette M, Huisman HG, Miedema F, and Schuitemaker H: Phenotype-associated sequence variation in the third variable domain of the human immunodeficiency virus type 1 gp120 molecule. J Virol 1992;66: 3183-3187.
10. 10. de Jong J-J, de Ronde A, Keulen W, Tersmette M, and Goudsmit J: Minimal requirements for the human immunodeficiency virus type 1 V3 domain to support the syncytium-inducing phenotype: Analysis by single amino acid substitution. J Virol 1992; 66:6777-6780.
11. 11. Morris JF, Sternberg EJ, Gutshall L, Petteway SR, and Ivanoff LA: Effect of a single amino acid substitution in the V3 domain of the human immunodeficiency virus type 1: Generation of revertant viruses to overcome defects in infectivity in specific cell types. J Virol 1994;68:8380-8385.
12. 12. Shioda T, Oka S, Ida S, Nokihara K, Toriyoshi H, Mori S, Takebe Y, Kimura S, Shimada K, and Nagai Y: A naturally occurring single amino acid substitution in the V3 region of the human immunodeficiency virus type 1 Env protein alters the cellular host range and antigenic structure of the virus. J Virol 1994;68: 7689-7696.
13. 13. Holm-Hansen C, Grothues D, Rustad S, Røsok B, Pascu R, and Åsjö B: Characterization of HIV-1 from Romanian children: Lack of correlation between V3 loop amino acid sequence and syncytium formation in MT-2 cells. AIDS Res Hum Retroviruses 1995;11:597-603.
14. 14. de Jong J-J, Goudsmit J, Keulen W, Klaver B, Krone W, Tersmette M, and de Ronde A: Human immunodeficiency virus type 1 clones chimeric for the envelope V3 domain differ in syncytium formation and replication capacity. J Virol 1992;66:757-765.
15. 15. Holm-Hansen C, Stern B, Shao J, and Åsjö B: V3 sequence analysis, biological characterization and coreceptor usage of HIV-1 isolates from asymptomatic and symptomatic individuals. Submitted (2000).