Piperazine-based CCR5 antagonists as HIV-1 inhibitors. I: 2(S)-methyl piperazine as a key pharmacophore element

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 16, 2001, Pages 2143-2146

  Tagat, Jayaram R ^a   McCombie, Stuart W ^a   Steensma, Ruo W ^a   Lin, Sue Ing ^a   Nazareno, Dennis V ^a   Baroudy, Bahige ^a   Vantuno, Nicole ^a   Xu, Serena ^a   Liu, Jia ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; BENZAMIDE DERIVATIVE; CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CCR3; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CCR5 ANTAGONIST; HUMAN IMMUNODEFIENCY VIRUS 1 INHIBITOR; N [4 [[[6,7 DIHYDRO 2 (4 METHYLPHENYL) 5H BENZOCYCLOHEPTEN 8 YL]CARBONYL]AMINO]BENZYL] N,N DIMETHYL 2H TETRAHYDROPYRAN 4 AMINIUM CHLORIDE; PIPERAZINE DERIVATIVE; RANTES; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG PROTEIN BINDING; DRUG STRUCTURE; HUMAN; HUMAN CELL; PHARMACOPHORE; STEREOCHEMISTRY; VIRUS INHIBITION;

ANTI-HIV AGENTS; HIV-1; MICROBIAL SENSITIVITY TESTS; PIPERAZINES; RECEPTORS, CCR5; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035921055     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00381-X     Document Type: Article

References (22)