SCOPUS 정보 검색 플랫폼

Volumn 44, Issue 21, 2001, Pages 3339-3342

Discovery of 4-[(Z)-(4-bromophenyl)(ethoxyimino)methyl]-1′-[(2,4-dimethyl- 3pyridinyl)carbonyl]-4′-methyl-1,4′bipiperidine N-oxide (SCH 351125): An orally bioavailable human CCR5 antagonist for the treatment of HIV infection

(8) Palani, A a Shapiro, S a Clader, J W a Greenlee, W J a Cox, K b Strizki, J c Endres, M c Baroudy, B M c

a Chemical Research (United States)

b Drug Safety and Metabolism and Antiviral Research ^* (United States)

c MERCK RESEARCH LABORATORIES (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [(4 BROMOPHENYL)(ETHOXYIMINO)METHYL] 1' [(2,4 DIMETHYL 3 PYRIDINYL)CARBONYL] 4' METHYL 1,4' BIPIPERIDINE; 4 [(4 BROMOPHENYL)(ETHOXYIMINO)METHYL] 1' [(2,4 DIMETHYL 3 PYRIDINYL)CARBONYL] 4' METHYL 1,4' BIPIPERIDINE N OXIDE; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CCR5 ANTAGONIST; N [4 [[[6,7 DIHYDRO 2 (4 METHYLPHENYL) 5H BENZOCYCLOHEPTEN 8 YL]CARBONYL]AMINO]BENZYL] N,N DIMETHYL 2H TETRAHYDROPYRAN 4 AMINIUM CHLORIDE; NANOPARTICLE; RANTES; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CLINICAL TRIAL; CYTOKINE PRODUCTION; DOG; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SAFETY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NONHUMAN; PHASE 1 CLINICAL TRIAL; RAT; STRUCTURE ACTIVITY RELATION; VIRUS INHIBITION; VIRUS ISOLATION;

ADMINISTRATION, ORAL; ANIMALS; ANTI-HIV AGENTS; BIOLOGICAL AVAILABILITY; CELL LINE; CYCLIC N-OXIDES; DOGS; DRUG EVALUATION, PRECLINICAL; HIV-1; HUMANS; LEUKOCYTES, MONONUCLEAR; MACACA FASCICULARIS; PIPERAZINES; PIPERIDINES; PYRIDINES; RATS; RECEPTORS, CCR5; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035846074 PISSN: 00222623 EISSN: None Source Type: Journal
DOI: 10.1021/jm015526o Document Type: Article

Times cited : (108)

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