Tetraploidy/aneuploidy and stem cells in cancer promotion: The role of chromosome passenger proteins

Journal of Cellular Physiology

Volumn 208, Issue 1, 2006, Pages 12-22

  Nguyen, Hao G ^a   Ravid, Katya ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AURORA A KINASE; AURORA B KINASE; BOREALIN; CHROMOSOME PASSENGER PROTEIN; CHROMOSOME PROTEIN; INNER CENTROMERIC PROTEIN; REGULATOR PROTEIN; SURVIVIN; UNCLASSIFIED DRUG;

ANEUPLOIDY; CANCER; CARCINOGENESIS; CELL TRANSFORMATION; GENE EXPRESSION REGULATION; GENE MUTATION; GENOMIC INSTABILITY; HETEROZYGOSITY LOSS; HUMAN; MITOSIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REVIEW; SIGNAL TRANSDUCTION; STEM CELL; TETRAPLOIDY;

ANEUPLOIDY; CELL CYCLE PROTEINS; CELL TRANSFORMATION, NEOPLASTIC; CHROMOSOMAL PROTEINS, NON-HISTONE; DNA, NEOPLASM; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; GENOMIC INSTABILITY; HUMANS; LOSS OF HETEROZYGOSITY; MICROTUBULE-ASSOCIATED PROTEINS; MITOSIS; MUTATION; NEOPLASM PROTEINS; NEOPLASMS; POLYPLOIDY; PROTEIN-SERINE-THREONINE KINASES; STEM CELLS;

EID: 33744917817     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.20565     Document Type: Review

References (179)

1. Adam P, Regan C, Hautmann M, Owens G. 2000. Positive- and negative-acting Kruppel-like transcription factors bind a transforming growth factor b control element required for expression of the smooth muscle cell differentiation marker SM22a in vivo. J Biol Chem 275:37798-37806.
2. Adams RR, Eckley DM, Vagnarelli P, Wheatley SP, Gerloff DL, Mackay AM, Svingen PA, Kaufmann SH, Earnshaw WC. 2001a. Human INCENP colocalizes with the Aurora-B/AIRK2 kinase on chromosomes and is overexpressed in tumour cells. Chromosoma 110:65-74.
3. Adams RR, Maiato H, Earnshaw WC, Carmena M. 2001b. Essential roles of Drosophila inner centromere protein (INCENP) and aurora B in histone H3 phosphorylation, metaphase chromosome alignment, kinetochore disjunction, and chromosome segregation. J Cell Biol 153:865-880.
4. Adams RR, Carmena M, Earnshaw WC. 2001c. Chromosomal passengers and the (aurora) ABCs of mitosis. Trends Cell Biol 11:49-54.
5. Ainsztein AM, Kandels-Lewis SE, Mackay AM, Earnshaw WC. 1998. INCENP centromere and spindle targeting: Identification of essential conserved motifs and involvement of heterochromatin protein HP1. J Cell Biol 143:1763-1774.
6. Al-Hajj M, Wicha MS, Benito-Hernandez A, Morrison SJ, Clarke MF. 2003. Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci USA 100:3983-3988.
7. Altieri DC. 2003. Survivin in apoptosis control and cell cycle regulation in cancer. Prog Cell Cycle Res 5:447-452.
8. Ambrosini G, Adida C, Altieri DC. 1997. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat Med 3:917-921.
9. Andrews PD, Knatko E, Moore WJ, Swedlow JR. 2003. Mitotic mechanics: The auroras come into view. Curr Opin Cell Biol 15:672-683.
10. Andrews PD, Ovechkina Y, Morrice N, Wagenbach M, Duncan K, Wordeman L, Swedlow JR. 2004. Aurora B regulates MCAK at the mitotic centromere. Dev Cell 6:253-268.
11. Araki K, Nozaki K, Ueba T, Tatsuka M, Hashimoto N. 2004. High expression of Aurora-B/Aurora and Ipl1-like midbody-associated protein (AIM-1) in astrocytomas. J Neurooncol 67:53-64.
12. Baccini V, Roy L, Vitrat N, Chagraoui H, Sabri S, Le Couedic JP, Debili N, Wendling F, Vainchenker W. 2001. Role of p21(Cip1/Waf1) in cell-cycle exit of endomitotic megakaryocytes. Blood 98:3274-3282.
13. Barr FA, Sillje HH, Nigg EA. 2004. Polo-like kinases and the orchestration of cell division. Nat Rev Mol Cell Biol 5:429-440.
14. Bielas JH, Loeb LA. 2005. Mutator phenotype in cancer: Timing and perspectives. Environ Mol Mutagen 45:206-213.
15. Biggins S, Severin FF, Bhalla N, Sassoon I, Hyman AA, Murray AW. 1999. The conserved protein kinase Ipl1 regulates microtubule binding to kinetochores in budding yeast. Genes Dev 13:532-544.
16. Bischoff JR, Plowman GD. 1999. The Aurora/Ipl1p kinase family: Regulators of chromosome segregation and cytokinesis. Trends Cell Biol 9:454-459.
17. Bischoff JR, Anderson L, Zhu Y, Mossie K, Ng L, Souza B, Schryver B, Flanagan P, Clairvoyant F, Ginther C, Chan CS, Novotny M, Slamon DJ, Plowman GD. 1998. A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers. Embo J 17:3052-3065.
18. Bishop JD, Schumacher JM. 2002. Phosphorylation of the carboxyl terminus of inner centromere protein (INCENP) by the Aurora B Kinase stimulates Aurora B kinase activity. J Biol Chem 277:27577-27580.
19. Bissell MJ, Labarge MA. 2005. Context, tissue plasticity, and cancer; Are tumor stem cells also regulated by the microenvironment? Cancer Cell 7:17-23.
20. Blanc-Brude OP, Yu J, Simosa H, Conte MS, Sessa WC, Altieri DC. 2002. Inhibitor of apoptosis protein survivin regulates vascular injury. Nat Med 8:987-994.
21. Borre M, Hoyer M, Nerstrom B, Overgaard J. 1998. DNA ploidy and survival of patients with clinically localized prostate cancer treated without intent to cure. Prostate 36:244-249.
22. Brinkley BR. 2001. Managing the centrosome numbers game: From Chaos to stability in cancer cell division. Trends Cell Biol 11:18-21.
23. Cahill DP, Lengauer C, Yu J, Riggins GJ, Willson JK, Markowitz SD, Kinzler KW, Vogelstein B. 1998. Mutations of mitotic checkpoint genes in human cancers. Nature 392:300-303.
24. Cahill DP, Kinzler KW, Vogelstein B, Lengauer C. 1999. Genetic instability and darwinian selection in tumours. Trends Cell Biol 9:M57-M60.
25. Carmena M, Earnshaw WC. 2003. The cellular geography of aurora kinases. Nat Rev Mol Cell Biol 4:842-854.
26. Carter BZ, Wang RY, Schober WD, Milella M, Chism D, Andreeff M. 2003. Targeting Survivin expression induces cell proliferation defect and subsequent cell death involving mitochondrial pathway in myeloid leukemic cells. Cell Cycle 2:488-493.
27. Carvalho A, Carmena M, Sambade C, Earnshaw WC, Wheatley SP. 2003. Survivin is required for stable checkpoint activation in taxol-treated HeLa cells. J Cell Sci 116:2987-2998.
28. Castedo M, Perfettini JL, Roumier T, Andreau K, Medema R, Kroemer G. 2004. Cell death by mitotic catastrophe: A molecular definition. Oncogene 23:2825-2837.
29. Castro A, Arlot-Bonnemains Y, Vigneron S, Labbe JC, Prigent C, Lorca T. 2002. APC/Fizzy-Related targets Aurora-A kinase for proteolysis. EMBO Rep 3:457-462.
30. Chantalat L, Skoufias DA, Kleman JP, Jung B, Dideberg O, Margolis RL. 2000. Crystal structure of human survivin reveals a bow tie-shaped dimer with two unusual alpha-helical extensions. Mol Cell 6:183-189.
31. Cheeseman IM, Anderson S, Jwa M, Green EM, Kang J, Yates JR 3rd, Chan CS, Drubin DG, Barnes G. 2002. Phospho-regulation of kinetochore-microtubule attachments by the Aurora kinase Ipl1p. Cell 111:163-172.
32. Chen J, Jin S, Tahir SK, Zhang H, Liu X, Sarthy AV, McGonigal TP, Liu Z, Rosenberg SH, Ng SC. 2003. Survivin enhances Aurora-B kinase activity and localizes Aurora-B in human cells. J Biol Chem 278:486-490.
33. Chobanian AV, Prescott MF, Haudenschild CC. 1984. Recent advances in molecular pathology. The effects of hypertension on the arterial wall. Exp Mol Pathol 41:153-169.
34. Choi N, Baumann M, Flentjie M, Kellokumpu-Lehtinen P, Senan S, Zamboglou N, Kosmidis P. 2001. Predictive factors in radiotherapy for non-small cell lung cancer: Present status. Lung Canc 31:43-56.
35. Cong XL, Han ZC. 2004. Survivin and leukemia. Int J Hematol 80:232-238.
36. Conway EM, Pollefeyt S, Cornelissen J, DeBaere I, Steiner-Mosonyi M, Ong K, Baens M, Collen D, Schuh AC. 2000. Three differentially expressed survivin cDNA variants encode proteins with distinct antiapoptotic functions. Blood 95:1435-1442.
37. Cooke CA, Heck MM, Earnshaw WC. 1987. The inner centromere protein (INCENP) antigens: Movement from inner centromere to midbody during mitosis. J Cell Biol 105:2053-2067.
38. Cutts SM, Fowler KJ, Kile BT, Hii LL, O'Dowd RA, Hudson DF, Saffery R, Kalitsis P, Earle E, Choo KH. 1999. Defective chromosome segregation, microtubule bundling and nuclear bridging in inner centromere protein gene (Incenp)-disrupted mice. Hum Mol Genet 8:1145-1155.
39. Dai W, Wang Q, Liu T, Swamy M, Fang Y, Xie S, Mahmood R, Yang YM, Xu M, Rao CV. 2004. Slippage of mitotic arrest and enhanced tumor development in mice with BubR1 haploinsufficiency. Cancer Res 64:440-445.
40. Deng G, Lu Y, Zlotnikov G, Thor AD, Smith HS. 1996. Loss of heterozygosity in normal tissue adjacent to breast carcinomas. Science 274:2057-2059.
41. Descamps S, Prigent C. 2001. Two mammalian mitotic aurora kinases: Who's who? Sci STKE 2001:PE1.
42. Dethloff LA, de la Iglesia FA. 1998. Chemical-induced hepatocyte ploidy. Toxicol Appl Pharmacol 150:443.
43. Dewar H, Tanaka K, Nasmyth K, Tanaka TU. 2004. Tension between two kinetochores suffices for their bi-orientation on the mitotic spindle. Nature 428:93-97.
44. Ditchfield C, Johnson VL, Tighe A, Ellston R, Haworth C, Johnson T, Mortlock A, Keen N, Taylor SS. 2003. Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores. J Cell Biol 161:267-280.
45. Doggrell SA. 2004. Dawn of Aurora kinase inhibitors as anticancer drugs. Expert Opin Investig Drugs 13:1199-1201.
46. Doherty SC, McKeown SR, McKelvey-Martin V, Downes CS, Atala A, Yoo JJ, Simpson DA, Kaufmann WK. 2003. Cell cycle checkpoint function in bladder cancer. J Natl Cancer Inst 95:1859-1868.
47. Ducat D, Zheng Y. 2004. Aurora kinases in spindle assembly and chromosome segregation. Exp Cell Res 301:60-67.
48. Duesberg P, Li R. 2003. Multistep carcinogenesis: A chain reaction of aneup-loidizations. Cell Cycle 2:202-210.
49. Duesberg P, Rausch C, Rasnick D, Hehlmann R. 1998. Genetic instability of cancer cells is proportional to their degree of aneuploidy. Proc Natl Acad Sci USA 95:13692-13697.
50. Duesberg P, Stindl R, Hehlmann R. 2000. Explaining the high mutation rates of cancer cells to drug and multidrug resistance by chromosome reassortments that are catalyzed by aneuploidy. Proc Natl Acad Sci USA 97:14295-14300.
51. Edgar BA, Orr-Weaver TL. 2001. Endoreplication cell cycles: More for less. Cell 105:297-306.
52. Fabarius A, Hehlmann R, Duesberg PH. 2003. Instability of chromosome structure in cancer cells increases exponentially with degrees of aneuploidy. Cancer Genet Cytogenet 143:59-72.
53. Fearon ER, Vogelstein B. 1990. A genetic model for colorectal tumorigenesis. Cell 61:759-767.
54. Fishman GI. 1998. Timing is everything in life: Conditional transgene expression in the cardiovascular system. Circ Res 82:837-844.
55. Fortugno P, Wall NR, Giodini A, O'Connor DS, Plescia J, Padgett KM, Tognin S, Marchisio PC, Altieri DC. 2002. Survivin exists in immunochemically distinct subcellular pools and is involved in spindle microtubule function. J Cell Sci 115:575-585.
56. Fujita M, Mizuno M, Nagasaka T, Wakabayashi T, Maeda K, Ishii D, Arima T, Kawajiri A, Inagaki M, Yoshida J. 2004. Aurora-B dysfunction of multinucleated giant cells in glioma detected by site-specific phosphorylated antibodies. J Neurosurg 101:1012-1017.
57. Fujiwara T, Bandi M, Nitta M, Ivanova EV, Bronson RT, Pellman D. 2005. Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells. Nautre 437:1043-1047.
58. Fukuda S, Pelus LM. 2002. Elevation of Survivin levels by hematopoietic growth factors occurs in quiescent CD34+ hematopoietic stem and progenitor cells before cell cycle entry. Cell Cycle 1:322-326.
59. Gadea BB, Ruderman JV. 2005. Aurora kinase inhibitor ZM447439 blocks chromosome-induced spindle assembly, the completion of chromosome condensation, and the establishment of the spindle integrity checkpoint in Xenopus egg extracts. Mol Biol Cell 16:1305-1318.
60. Galipeau PC, Cowan DS, Sanchez CA, Barrett MT, Emond MJ, Levine DS, Rabinovitch PS, Reid BJ. 1996. 17p (p53) allelic losses, 4N (G2/tetraploid) populations, and progression to aneuploidy in Barrett's esophagus. Proc Natl Acad Sci USA 93:7081-7084.
61. Galitski T, Saldanha AJ, Styles CA, Lander ES, Fink GR. 1999. Ploidy regulation of gene expression. Science 285:251-254.
62. Gandillet A, Alexandre E, Royer C, Cinqualbre J, Jaeck D, Richert L. 2003. Hepatocyte ploidy in regenerating livers after partial hepatectomy, drug-induced necrosis, and cirrhosis. Eur Surg Res 35:148-160.
63. Gassmann R, Carvalho A, Henzing AJ, Ruchaud S, Hudson DF, Honda R, Nigg EA, Gerloff DL, Earnshaw WC. 2004. Borealin: A novel chromosomal passenger required for stability of the bipolar mitotic spindle. J Cell Biol 166:179-191.
64. Geddis AE, Kaushansky K. 2004. Megakaryocytes express functional Aurora-B kinase in endomitosis. Blood 104:1017-1024.
65. Giet R, Glover DM. 2001. Drosophila aurora B kinase is required for histone H3 phosphorylation and condensin recruitment during chromosome condensation and to organize the central spindle during cytokinesis. J Cell Biol 152:669-682.
66. Giet R, Prigent C. 1999. Aurora/Ipl1p-related kinases, a new oncogenic family of mitotic serine-threonine kinases. J Cell Sci 112(Pt 21):3591-3601.
67. Gisselsson D, Pettersson L, Hoglund M, Heidenblad M, Gorunova L, Wiegant J, Mertens F, Dal Cin P, Mitelman F, Mandahl N. 2000. Chromosomal breakage-fusion-bridge events cause genetic intratumor heterogeneity. Proc Natl Acad Sci USA 97:5357-5362.
68. Goepfert TM, Brinkley BR. 2000. The centrosome-associated Aurora/Ipl-like kinase family. Curr Top Dev Biol 49:331-342.
69. Goto H, Yasui Y, Kawajiri A, Nigg EA, Terada Y, Tatsuka M, Nagata K, Inagaki M. 2003. Aurora-B regulates the cleavage furrow-specific vimentin phosphorylation in the cytokinetic process. J Biol Chem 278:8526-8530.
70. Greaves S. 2001. A roar for INCENP. Nat Cell Biol 3:E14.
71. Grossman D, Kim PJ, Blanc-Brude OP, Brash DE, Tognin S, Marchisio PC, Altieri DC. 2001. Transgenic expression of survivin in keratinocytes counteracts UVB-induced apoptosis and cooperates with loss of p53. J Clin Invest 108:991-999.
72. Gunawan B, Bergmann F, Braun S, Hemmerlein B, Ringert RH, Jakse G, Fuzesi L. 1999. Polyploidization and losses of chromosomes 1, 2, 6, 10, 13, and 17 in three cases of chromophobe renal cell carcinomas. Cancer Genet Cytogenet 110:57-61.
73. Gupta S. 2000. Hepatic polyploidy and liver growth control. Semin Cancer Biol 10:161-171.
74. Gurbuxani S, XuY, Keerthivasan G, Wickrema A, Crispino JD. 2005. Differential requirements for survivin in hematopoietic cell development. Proc Natl Acad Sci USA 102:11480-11485.
75. Hahn WC, Weinberg RA. 2002. Rules for making human tumor cells. N Engl J Med 347:1593-1603.
76. Hanahan D, Weinberg RA. 2000. The hallmarks of cancer. Cell 100:57-70.
77. Hanks S, Coleman K, Reid S, Plaja A, Firth H, Fitzpatrick D, Kidd A, Mehes K, Nash R, Robin N, Shannon N, Tolmie J, Swansbury J, Irrthum A, Douglas J, Rahman N. 2004. Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B. Nat Genet 36:1159-1161.
78. Harrington EA, Bebbington D, Moore J, Rasmussen RK, Ajose-Adeogun AO, Nakayama T, Graham JA, Demur C, Hercend T, Diu-Hercend A, Su M, Golec JM, Miller KM. 2004. VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo. Nat Med 10:262-267.
79. Hauf S, Cole RW, LaTerra S, Zimmer C, Schnapp G, Walter R, Heckel A, van Meel J, Rieder CL, Peters JM. 2003. The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint. J Cell Biol 161:281-294.
80. Hixon ML, Obejero-Paz C, Muro-Cacho C, Wagner MW, Millie E, Nagy J, Hassold TJ, Gualberto A. 2000. Cks1 mediates vascular smooth muscle cell polyploidization. J Biol Chem 275:40434-40442.
81. Honda R, Korner R, Nigg EA. 2003. Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis. Mol Biol Cell 14:3325-3341.
82. Ivanov A, Cragg MS, Erenpreisa J, Emzinsh D, Lukman H, Illidge TM. 2003. Endopolyploid cells produced after severe genotoxic damage have the potential to repair DNA double strand breaks. J Cell Sci 116:4095-4106.
83. Jones MR, Ravid K. 2004. Vascular smooth muscle polyploidization as a biomarker for aging and its impact on differential gene expression. J Biol Chem 279:5306-5313.
84. Kajiwara Y, Yamasaki F, Hama S, Yahara K, Yoshioka H, Sugiyama K, Arita K, Kurisu K. 2003. Expression of survivin in astrocytic tumors: Correlation with malignant grade and prognosis. Cancer 97:1077-1083.
85. Kallio MJ, McCleland ML, Stukenberg PT, Gorbsky GJ. 2002. Inhibition of aurora B kinase blocks chromosome segregation, overrides the spindle checkpoint, and perturbs microtubule dynamics in mitosis. Curr Biol 12:900-905.
86. Kang J, Cheeseman IM, Kallstrom G, Velmurugan S, Barnes G, Chan CS. 2001. Functional cooperation of Dam1, Ipl1, and the inner centromere protein (INCENP)-related protein SH15 during chromosome segregation. J Cell Biol 155:763-774.
87. Kaplan SS, Rybka WB, Blom J, Shekhter-Levin S. 1998. Tetraploidy in acute myeloid leukemia secondary to large cell lymphoma. Leuk Lymphoma 31:617-623.
88. Katayama H, Brinkley WE, Sen S. 2003. The Aurora kinases: Role in cell transformation and tumorigenesis. Cancer Metastasis Rev 22:451-464.
89. Kaushansky K. 2003. Thrombopoietin: a tool for understanding thrombopoiesis. J Thromb Haemost 1:1587-1592.
90. Keen N, Taylor S. 2004. Aurora-kinase inhibitors as anticancer agents. Nat Rev Cancer 4:927-936.
91. Kimura M, Kotani S, Hattori T, Sumi N, Yoshioka T, Todokoro K, Okano Y. 1997. Cell cycle-dependent expression and spindle pole localization of a novel human protein kinase, Aik, related to Aurora of Drosophila and yeast Ipl1. J Biol Chem 272:13766-13771.
92. Knudson AG. 2001. Two genetic hits (more or less) to cancer. Nat Rev Cancer 1:157-162.
93. Kobayashi K, Hatano M, Otaki M, Ogasawara T, Tokuhisa T. 1999. Expression of a murine homologue of the inhibitor of apoptosis protein is related to cell proliferation. Proc Natl Acad Sci USA 96:1457-1462.
94. Krieg A, Mahotka C, Krieg T, Grabsch H, Muller W, Takeno S, Suschek CV, Heydthausen M, Gabbert HE, Gerharz CD. 2002. Expression of different survivin variants in gastric carcinomas: First clues to a role of survivin-2B in tumour progression. Br J Cancer 86:737-743.
95. Kusuzaki K, Takeshita H, Murata H, Gebhardt MC, Springfield DS, Mankin HJ, Ashihara T, Hirasawa Y. 2000. Polyploidization induced by acridine orange in mouse osteosarcoma cells. Anticancer Res 20:965-970.
96. Lampson MA, Renduchitala K, Khodjakov A, Kapoor TM. 2004. Correcting improper chromosome-spindle attachments during cell division. Nat Cell Biol 6:232-237.
97. Lan W, Zhang X, Kline-Smith SL, Rosasco SE, Barrett-Wilt GA, Shabanowitz J, Hunt DF, Walczak CE, Stukenberg PT. 2004. Aurora B phosphorylates centromeric MCAK and regulates its localization and microtubule depolymerization activity. Curr Biol 14:273-286.
98. Lemez P, Michalova K, Zemanova Z, Marinov I, Trpakova A, Moravcova J, Jelinek J. 1998. Three cases of near-tetraploid acute myeloid leukemias originating in pluripotent myeloid progenitors. Leuk Res 22:581-588.
99. Lengauer C. 2005. Aneuploidy and genetic instability in cancer. Semin Cancer Biol 15:1.
100. Lengauer C, Kinzler KW, Vogelstein B. 1997. Genetic instability in colorectal cancers. Nature 386:623-627.
101. Lengauer C, Kinzler KW, Vogelstein B. 1998. Genetic instabilities in human cancers. Nature 396:643-649.
102. Li F. 2005. Role of survivin and its splice variants in tumorigenesis. Br J Cancer 92:212-216.
103. Li YS, Fan YS, Armstrong RF. 1996. Endoreduplication and telomeric association in a choroid plexus carcinoma. Cancer Genet Cytogenet 87:7-10.
104. Li F, Ackermann EJ, Bennett CF, Rothermel AL, Plescia J, Tognin S, Villa A, Marchisio PC, Altieri DC. 1999. Pleiotropic cell-division defects and apoptosis induced by interference with survivin function. Nat Cell Biol 1:461-466.
105. Loeb LA. 1991. Mutator phenotype may be required for multistage carcinogenesis. Cancer Res 51:3075-3079.
106. Loeb LA. 2001. A mutator phenotype in cancer. Cancer Res 61:3230-3239.
107. Loeb LA, Loeb KR, Anderson JP. 2003. Multiple mutations and cancer. Proc Natl Acad Sci USA 100:776-781.
108. Lothschutz D, Jennewein M, Pahl S, Lausberg HF, Eichler A, Mutschler W, Hanselmann RG, Oberringer M. 2002. Polyploidization and centrosome hyperamplification in inflammatory bronchi. Inflamm Res 51:416-422.
109. Malkin D, Brown EJ, Zipursky A. 2000. The role of p53 in megakaryocyte differentiation and the megakaryocytic leukemias of Down syndrome. Cancer Genet Cytogenet 116:1-5.
110. Mantel C, Braun SE, Reid S, Henegariu O, Liu L, Hangoc G, Broxmeyer HE. 1999. p21(cip-1/waf-1) deficiency causes deformed nuclear architecture, centriole overduplication, polyploidy, and relaxed microtubule damage checkpoints in human hematopoietic cells. Blood 93:1390-1398.
111. Margolis RL, Lohez OD, Andreassen PR. 2003. G1 tetraploidy checkpoint and the suppression of tumorigenesis. J Cell Biochem 88:673-683.
112. Marusawa H, Matsuzawa S, Welsh K, Zou H, Armstrong R, Tamm I, Reed JC. 2003. HBXIP functions as a cofactor of survivin in apoptosis suppression. Embo J 22:2729-2740.
113. Mayer F, Stoop H, Sen S, Bokemeyer C, Oosterhuis JW, Looijenga LH. 2003. Aneuploidy of human testicular germ cell tumors is associated with amplification of centrosomes. Oncogene 22:3859-3866.
114. Meraldi P, Honda R, Nigg EA. 2002. Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells. Embo J 21:483-492.
115. Meraldi P, Honda R, Nigg EA. 2004. Aurora kinases link chromosome segregation and cell division to cancer susceptibility. Curr Opin Genet Dev 14:29-36.
116. Muchmore SW, Chen J, Jakob C, Zakula D, Matayoshi ED, Wu W, Zhang H, Li F, Ng SC, Altieri DC. 2000. Crystal structure and mutagenic analysis of the inhibitor-of-apoptosis protein survivin. Mol Cell 6:173-182.
117. Murata-Hori M, Wang YL. 2002. The kinase activity of aurora B is required for kinetochore-microtubule interactions during mitosis. Curr Biol 12:894-899.
118. Murnion ME, Adams RR, Callister DM, Allis CD, Earnshaw WC, Swedlow JR. 2001. Chromatin-associated protein phosphatase 1 regulates aurora-B and histone H3 phosphorylation. J Biol Chem 276:26656-26665.
119. Nagata Y, Jones MR, Nguyen HG, McCrann DJ, St Hilaire C, Schreiber BM, Hashimoto A, Inagaki M, Earnshaw WC, Todokoro K, Ravid K. 2005. Vascular smooth muscle cell polyploidization involves changes in chromosome passenger proteins and an endomitotic cell cycle. Exp Cell Res 305:277-291.
120. Nakayama K, Kamihira S. 2002. Survivin an important determinant for prognosis in adult T-cell leukemia: A novel biomarker in practical hematooncology. Leuk Lymphoma 43:2249-2255.
121. Nasmyth K. 2002. Segregating sister genomes: The molecular biology of chromosome separation. Science 297:559-565.
122. Nguyen HG, Chinnappan D, Urano T, Ravid K. 2005. Mechanism of Aurora-B degradation and its dependency on intact KEN and A-boxes: Identification of an aneuploidy-promoting property. Mol Cell Biol 25:4977-4992.
123. Nigg EA. 2001. Mitotic kinases as regulators of cell division and its checkpoints. Nat Rev Mol Cell Biol 2:21-32.
124. Nigg EA. 2002. Centrosome aberrations: Cause or consequence of cancer progression? Nat Rev Cancer 2:815-825.
125. Nowak MA, Komarova NL, Sengupta A, Jallepalli PV, Shih Ie M, Vogelstein B, Lengauer C. 2002. The role of chromosomal instability in tumor initiation. Proc Natl Acad Sci USA 99:16226-16231.
126. Oberringer M, Lothschutz D, Jennewein M, Koschnick M, Mutschler W, Hanselmann RG. 1999. Centrosome multiplication accompanies a transient clustering of polyploid cells during tissue repair. Mol Cell Biol Res Commun 2:190-196.
127. Ota T, Suto S, Katayama H, Han ZB, Suzuki F, Maeda M, Tanino M, Terada Y, Tatsuka M. 2002. Increased mitotic phosphorylation of histone H3 attributable to AIM-1/Aurora-B overexpression contributes to chromosome number instability. Cancer Res 62:5168-5177.
128. Park SH, Maeda T, Mohapatra G, Waldman FM, Davis RL, Feuerstein BG. 1995. Heterogeneity, polyploidy, aneusomy, and 9p deletion in human glioblastoma multiforme. Cancer Genet Cytogenet 83:127-135.
129. Parry EM, Ulucan H, Wyllie FS, Wynford-Thomas D, Parry JM. 1998. Segregational fidelity of chromosomes in human thyroid tumour cells. Chromosoma 107:491-497.
130. Patel D, Incassati A, Wang N, McCance DJ. 2004. Human papillomavirus type 16 E6 and E7 cause polyploidy in human keratinocytes and up-regulation of G2-M-phase proteins. Cancer Res 64:1299-1306.
131. Pereira G, Schiebel E. 2003. Separase regulates INCENP-Aurora B anaphase spindle function through Cdc14. Science 302:2120-2124.
132. Pinsky BA, Tatsutani SY, Collins KA, Biggins S. 2003. An Mtw1 complex promotes kinetochore biorientation that is monitored by the Ipl1/Aurora protein kinase. Dev Cell 5:735-745.
133. Rajagopalan H, Lengauer C. 2004. Aneuploidy and cancer. Nature 432:338-341.
134. Ravid K, Lu J, Zimmet JM, Jones MR. 2002. Roads to polyploidy: The megakaryocyte example. J Cell Physiol 190:7-20.
135. Roh M, Gary B, Song C, Said-Al-Naief N, Tousson A, Kraft A, Eltoum IE, Abdulkadir SA. 2003. Overexpression of the oncogenic kinase Pim-1 leads to genomic instability. Cancer Res 63:8079-8084.
136. Roy L, Coullin P, Vitrat N, Hellio R, Debili N, Weinstein J, Bernheim A, Vainchenker W. 2001. Asymmetrical segregation of chromosomes with a normal metaphase/anaphase checkpoint in polyploid megakaryocytes. Blood 97:2238-2247.
137. Sampath SC, Ohi R, Leismann O, Salic A, Pozniakovski A, Funabiki H. 2004. The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly. Cell 118:187-202.
138. Sasaki T, Lopes MB, Hankins GR, Helm GA. 2002. Expression of survivin, an inhibitor of apoptosis protein, in tumors of the nervous system. Acta Neuropathol (Berl) 104:105-109.
139. Scrittori L, Skoufias DA, Hans F, Gerson V, Sassone-Corsi P, Dimitrov S, Margolis RL. 2005. A small C-terminal sequence of Aurora B is responsible for localization and function. Mol Biol Cell 16:292-305.
140. Sell S. 2004. Stem cell origin of cancer and differentiation therapy. Crit Rev Oncol Hematol 51:1-28.
141. Sen S, Zhou H, Zhang RD, Yoon DS, Vakar-Lopez F, Ito S, Jiang F, Johnston D, Grossman HB, Ruifrok AC, Katz RL, Brinkley W, Czerniak B. 2002. Amplification/overexpression of a mitotic kinase gene in human bladder cancer. J Natl Cancer Inst 94:1320-1329.
142. Sharpless NE, DePinho RA. 2004. Telomeres, stem cells, senescence, and cancer. J Clin Invest 113:160-168.
143. Shi Q, King RW. 2005. Chromosome nondisjunction yields tetraploid rather than aneuploid cells in human cell lines. Nature 437:1038-1042.
144. Shin HJ, Baek KH, Jeon AH, Park MT, Lee SJ, Kang CM, Lee HS, Yoo SH, Chung DH, Sung YC, McKeon F, Lee CW. 2003. Dual roles of human BubR1, a mitotic checkpoint kinase, in the monitoring of chromosomal instability. Cancer Cell 4:483-497.
145. Smith GH, Boulanger CA. 2002. Mammary stem cell repertoire: New insights in aging epithelial populations. Mech Ageing Dev 123:1505-1519.
146. Song Z, Yao X, Wu M. 2003. Direct interaction between survivin and Smac/DIABLO is essential for the anti-apoptotic activity of survivin during taxol-induced apoptosis. J Biol Chem 278:23130-23140.
147. Song Z, Liu S, He H, Hoti N, Wang Y, Feng S, Wu M. 2004. A single amino acid change (Asp 53 → Ala53) converts Survivin from anti-apoptotic to pro-apoptotic. Mol Biol Cell 15:1287-1296.
148. Sorrentino R, Libertini S, Pallante PL, Troncone G, Palombini L, Bavetsias V, Spalletti-Cernia D, Laccetti P, Linardopoulos S, Chieffi P, Fusco A, Portella G. 2005. Aurora B overexpression associates with the thyroid carcinoma undifferentiated phenotype and is required for thyroid carcinoma cell proliferation. J Clin Endocrinol Metab 90:928-935.
149. Soto AM, Sonnenschein C. 2004, The somatic mutation theory of cancer: Growing problems with the paradigm? Bioessays 26:1097-1107.
150. Stewart ZA, Leach SD, Pietenpol JA. 1999. p21(Waf1/Cip1) inhibition of cyclin E/Cdk2 activity prevents endoreduplication after mitotic spindle disruption. Mol Cell Biol 19:205-215.
151. Storchova Z, Pellman D. 2004. From polyploidy to aneuploidy, genome instability and cancer. Nat Rev Mol Cell Biol 5:45-54.
152. Sugiyama K, Sugiura K, Kara T, Sugimoto K, Shima H, Honda K, Furukawa K, Yamashita S, Urano T. 2002. Aurora-B associated protein phosphatases as negative regulators of kinase activation. Oncogene 21:3103-3111.
153. Sui L, Dong Y, Ohno M, Watanabe Y, Sugimoto K, Tokuda M. 2002. Survivin expression and its correlation with cell proliferation and prognosis in epithelial ovarian tumors. Int J Oncol 21:315-320.
154. Suzuki A, Ito T, Kawano H, Hayashida M, Hayasaki Y, Tsutomi Y, Akahane K, Nakano T, Miura M, Shiraki K. 2000a. Survivin initiates procaspase 3/p21 complex formation as a result of interaction with Cdk4 to resist Fas-mediated cell death. Oncogene 19:1346-1353.
155. Suzuki A, Hayashida M, Ito T, Kawano H, Nakano T, Miura M, Akahane K, Shiraki K. 2000b. Survivin initiates cell cycle entry by the competitive interaction with Cdk4/p16(INK4a) and Cdk2/cyclin E complex activation. Oncogene 19:3225-3234.
156. Takanishi DM, Jr., Hart J, Covarelli P, Chappell R, Michelassi F. 1996. Ploidy as a prognostic feature in colonic adenocarcinoma. Arch Surg 131:587-592.
157. Tanaka TU, Rachidi N, Janke C, Pereira G, Galova M, Schiebel E, Stark MJ, Nasmyth K. 2002. Evidence that the Ipl1-Sli15 (Aurora kinase-INCENP) complex promotes chromosome bi-orientation by altering kinetochore-spindle pole connections. Cell 108:317-329.
158. Tatsuka M, Katayama H, Ota T, Tanaka T, Odashima S, Suzuki F, Terada Y. 1998. Multinuclearity and increased ploidy caused by overexpression of the aurora- and Ipl1-like midbody-associated protein mitotic kinase in human cancer cells. Cancer Res 58:4811-4816.
159. Tatsuka M, Sato S, Kitajima S, Suto S, Kawai H, Miyauchi M, Ogawa I, Maeda M, Ota T, Takata T. 2005. Overexpression of Aurora-A potentiates HRAS-mediated oncogenic transformation and is implicated in oral carcinogenesis. Oncogene 24:1122-1127.
160. Teixeira MR, Heim S. 2005. Multiple numerical chromosome aberrations in cancer: What are their causes and what are their consequences? Semin Cancer Biol 15:3-12.
161. Terada Y. 2001. Role of chromosomal passenger complex in chromosome segregation and cytokinesis. Cell Struct Funct 26:653-657.
162. Terada Y, Tatsuka M, Suzuki F, Yasuda Y, Fujita S, Otsu M. 1998. AIM-1: A mammalian midbody-associated protein required for cytokinesis. Embo J 17:667-676.
163. Tran J, Rak J, Sheehan C, Saibil SD, LaCasse E, Korneluk RG, Kerbel RS. 1999. Marked induction of the IAP family antiapoptotic proteins survivin and XIAP by VEGF in vascular endothelial cells. Biochem Biophys Res Commun 264:781-788.
164. Uren AG, Wong L, Pakusch M, Fowler KJ, Burrows FJ, Vaux DL, Choo KH. 2000. Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype. Curr Biol 10:1319-1328.
165. Vagnarelli PB, Earnshaw WC. 2001. INCENP loss from an inactive centromere correlates with the loss of sister chromatid cohesion. Chromosoma 110:393-401.
166. Vagnarelli P, Earnshaw WC. 2004. Chromosomal passengers: The four-dimensional regulation of mitotic events. Chromosoma 113:211-222.
167. Verdecia MA, Huang H, Dutil E, Kaiser DA, Hunter T, Noel JP. 2000. Structure of the human anti-apoptotic protein survivin reveals a dimeric arrangement. Nat Struct Biol 7:602-608.
168. Verdoodt B, Decordier I, Geleyns K, Cunha M, Cundari E, Kirsch-Volders M. 1999. Induction of polyploidy and apoptosis after exposure to high concentrations of the spindle poison nocodazole. Mutagenesis 14:513-520.
169. Vigneron S, Prieto S, Bernis C, Labbe JC, Castro A, Lorca T. 2004. Kinetochore localization of spindle checkpoint proteins: Who controls whom? Mol Biol Cell 15:4584-4596.
170. Wagner M, Hampel B, Bernhard D, Hala M, Zwerschke W, Jansen-Durr P. 2001. Replicative senescence of human endothelial cells in vitro involves G1 arrest, polyploidization and senescence-associated apoptosis. Exp Gerontol 36:1327-1347.
171. Wang Z, Zhang Y, Kamen D, Lees E, Ravid K. 1995. Cyclin D3 is essential for megakaryocytopoiesis. Blood 86:3783-3788.
172. Wang Z, Zhang Y, Lu J, Sun S, Ravid K. 1999. Mpl ligand enhances the transcription of the cyclin D3 gene: A potential role for Sp1 transcription factor. Blood 93:4208-4221.
173. Wang X, Willenbring H, Akkari Y, Torimaru Y, Foster M, Al-Dhalimy M, Lagasse E, Finegold M, Olson S, Grompe M. 2003. Cell fusion is the principal source of bone-marrow-derived hepatocytes. Nature 422:897-901.
174. Wheatley SP, Carvalho A, Vagnarelli P, Earnshaw WC. 2001. INCENP is required for proper targeting of Survivin to the centromeres and the anaphase spindle during mitosis. Curr Biol 11:886-890.
175. Wheatley SP, Henzing AJ, Dodson H, Khaled W, Earnshaw WC. 2004. Aurora-B phosphorylation in vitro identifies a residue of survivin that is essential for its localization and binding to inner centromere protein (INCENP) in vivo. J Biol Chem 279:5655-5660.
176. Zhang Y, Nagata Y, Yu G, Nguyen HG, Jones MR, Toselli P, Jackson CW, Tatsuka M, Todokoro K, Ravid K. 2004. Aberrant quantity and localization of Aurora-B/AIM-1 and survivin during megakaryocyte polyploidization and the consequences of Aurora-B/AIM-1-deregulated expression. Blood 103:3717-3726.
177. Zhao J, Tenev T, Martins LM, Downward J, Lemoine NR. 2000. The
178. Zimmet J, Ravid K. 2000. Polyploidy: Occurrence in nature, mechanisms, and significance for the megakaryocyte-platelet system. Exp Hematol 28:3-16.
179. Zimmet JM, Ladd D, Jackson CW, Stenberg PE, Ravid K. 1997. A role for cyclin D3 in the endomitotic cell cycle. Mol Cell Biol 17:7248-7259.