Dual roles of human BubR1, a mitotic checkpoint kinase, in the monitoring of chromosomal instability

Cancer Cell

Volumn 4, Issue 6, 2003, Pages 483-497

  Shin, Hyun Jin ^a   Baek, Kwan Hyuck ^a   Jeon, Ae Hwa ^b   Park, Moon Taek ^c   Lee, Su Jae ^c   Kang, Chang Mo ^c   Lee, Hyun Sook ^d   Yoo, Seong Ho ^e   Chung, Doo Hyun ^e   Sung, Young Chul ^b   McKeon, Frank ^f   Lee, Chang Woo ^a,b  

^a National Cancer Center   (South Korea)

^b Pohang University of Science and Technology (POSTECH)   (South Korea)

^c Korea Institute of Radiation and Medical Science   (South Korea)

^d Ewha Womans University   (South Korea)

^e Seoul National University College of Medicine   (South Korea)

^f HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BUB1 RELATED PROTEIN; CASPASE; UBIQUITIN;

ADENOVIRUS; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL CYCLE; CELL PROLIFERATION; CHROMOSOME ABERRATION; COLON ADENOCARCINOMA; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; MITOSIS; MITOSIS INHIBITION; MITOSIS SPINDLE; POLYPLOIDY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; STAINING;

ADENOVIRIDAE; MUS MUSCULUS;

EID: 9144242386     PISSN: 15356108     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1535-6108(03)00302-7     Document Type: Article

References (45)

1. Abrieu A., Kahana J.A., Wood K.W., Cleveland D.W. CENP-E as an essential component of the mitotic checkpoint in vitro. Cell. 102:2000;817-826.
2. Ambrosini G., Adida C., Altieri D.C. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat. Med. 3:1997;917-921.
3. Baek K.H., Shin H.J., Yoo J.K., Cho J.H., Choi Y.H., Sung Y.C., McKeon F., Lee C.W. p53 deficiency and defective mitotic checkpoint in proliferating T lymphocytes increase chromosomal instability through aberrant exit from mitotic arrest. J. Leukoc. Biol. 73:2003;850-861.
4. Biggins S., Murray A.W. Sister chromatid cohesion in mitosis. Curr. Opin. Genet. Dev. 9:1999;230-236.
5. Brummelkamp T.R., Bernards R., Agami R. A system for stable expression of short interfering RNAs in mammalian cells. Science. 296:2002;550-553.
6. Cahill D.P., Lengauer C., Yu J., Riggins G.J., Willson J.K., Markowitz S.D., Kinzler K.W., Vogelstein B. Mutations of mitotic checkpoint genes in human cancers. Nature. 392:1998;300-303.
7. Chan G.K.T., Jablonski S.A., Sudakin V., Hittle J.C., Yen T.J. Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC. J. Cell Biol. 146:1999;941-954.
8. Chen R.H. BubR1 is essential for kinetochore localization of other spindle checkpoint proteins and its phosphorylation requires Mad1. J. Cell Biol. 158:2002;487-496.
9. Davenport J.W., Fernandes E.R., Harris L.D., Neale G.A.M., Goorha R. The mouse mitotic checkpoint gene Bub1b, a novel Bub1 family member, is expressed in a cell cycle-dependent manner. Genomics. 55:1999;113-117.
10. Dobles M., Liberal V., Scott M., Benezra R., Sorger P.K. Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2. Cell. 101:2000;635-645.
11. Fang G. Checkpoint protein BubR1 acts synergistically with Mad2 to inhibit anaphase-promoting complex. Mol. Biol. Cell. 13:2002;755-766.
12. Gorbsky G.J., Chen R.H., Murray A.W. Microinjection of antibody to Mad2 protein into mammalian cells in mitosis induces premature anaphase. J. Cell Biol. 141:1998;1193-1205.
13. Haruki N., Saito H., Harano T., Nomoto S., Takahashi T., Osada H., Fujii Y., Takahashi T. Molecular analysis of the mitotic checkpoint genes BUB1, BUBR1 and BUB3 in human lung cancers. Cancer Lett. 162:2001;201-205.
14. Hernando E., Orlow I., Liberal V., Nohales G., Benezra R., Cordon-Cardo C. Molecular analyses of the mitotic checkpoint components hsMAD2, hBUB1 and hBUB3 in human cancer. Int. J. Cancer. 95:2001;223-227.
15. Hershko A., Ciechanover A. The ubiquitin system. Annu. Rev. Biochem. 67:1998;425-479.
16. King R.W., Deshaies R.J., Peters J.M., Kirschner M.W. How proteolysis drives the cell cycle. Science. 274:1996;1652-1659.
17. Lanni J.S., Jacks T. Characterization of the p53-dependent postmitotic checkpoint following spindle disruption. Mol. Cell. Biol. 18:1998;1055-1064.
18. Lengauer C., Kinzler K.W., Vogelstein B. Genetic instabilities in human cancers. Nature. 396:1998;643-649.
19. Li F., Ambrosini G., Chu E.Y., Plescia J., Tognin S., Marchisio P.C., Altieri D.C. Control of apoptosis and mitotic spindle checkpoint by survivin. Nature. 396:1998;580-584.
20. Li W., Lan Z., Wu H., Wu S., Meadows J., Chen J., Zhu V., Dai W. BUBR1 phosphorylation is regulated during mitotic checkpoint activation. Cell Growth Differ. 10:1999;769-775.
21. Li Y., Benezra R. Identification of a human mitotic checkpoint gene. hsMAD2 Science. 274:1996;246-248.
22. Masuda A., Takahashi T. Chromosome instability in human lung cancer. possible underlying mechanisms and potential consequences in the pathogenesis Oncogene. 21:2002;6884-6897.
23. Michel L., Liberal V., Chatterjee A., Kirchwegger R., Pasche B., Gerald W., Dobles M., Sorger P.K., Murty V.V.V.S., Benezra R. MAD2 haplo-insufficiency causes premature anapahase and chromosome instability in mammalian cells. Nature. 409:2001;355-359.
24. Millband D.N., Hardwick K.G. Fission yeast Mad3p is required for Mad2p to inhibit the anaphase-promoting complex and localizes to kinetochore in a Bub1p-, Bub3p-, and Mad1p-dependent manner. Mol. Cell. Biol. 22:2002;2728-2742.
25. Minn A.J., Boise L.H., Thompson C.B. Expression of Bcl-xL and loss of p53 can cooperate to overcome a cell cycle checkpoint induced by mitotic spindle damage. Genes Dev. 10:1996;2621-2631.
26. Minshull J., Straight A., Rudner A.D., Dernburg A.F., Belmont A., Murray A.W. Protein phosphatase 2A regulates MPF activity and sister chromatid cohesion in budding yeast. Curr. Biol. 6:1996;1609-1620.
27. Nasmyth K., Peters J.M., Uhlmann F. Splitting the chromosome. cutting the ties that bind sister chromatids Science. 288:2000;1379-1385.
28. cdc2 phosphorylation of survivin. Proc. Natl. Acad. Sci. USA. 97:2000;13103-13107.
29. Pihan G.A., Doxsey S.J. Mutations and aneuploidy. co-conspirators in cancer Cancer Cell. 4:2003;89-94.
30. Saeki A., Tamura S., Ito N., Kiso S., Matsuda Y., Yabuuchi I., Kawata S., Matsuzawa Y. Frequent impairment of the spindle assembly checkpoint in hepatocellular carcinoma. Cancer. 94:2002;2047-2054.
31. Saitoh H., Tomkiel J.E., Cooke C.A., Ratrie H.R., Maurer M., Rothfield N.F., Earnshaw W.C. CENP-C, an autoantigen in scleroderma, is a component of the human inner kinetochore plate. Cell. 70:1992;115-125.
32. Shah J.V., Cleveland D.E. Waiting for anaphase; Mad2 and the spindle assembly checkpoint. Cell. 103:2000;997-1000.
33. Shi Y. Mechanisms of caspase activation and inhibition during apoptosis. Mol. Cell. 9:2002;459-470.
34. Shichiri M., Yoshinaga K., Hisatomi H., Sugihara K., Hirata Y. Genetic and epigenetic inactivation of mitotic checkpoint genes hBUB1 and hBUBR1 and their relationship to survival. Cancer Res. 62:2002;13-17.
35. Sudakin V., Chan G.K., Yen T.J. Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2. J. Cell Biol. 154:2001;925-936.
36. Takahashi T., Haruki N., Nomoto S., Masuda A., Saji S., Osada H., Takahashi T. Identification of frequent impairment of the mitotic checkpoint and molecular analysis of the mitotic checkpoint genes, hsMAD2 and p55CDC, in human lung cancers. Oncogene. 18:1999;4295-4300.
37. cdc20 by the mitotic checkpoint protein BubR1. Dev. Cell. 1:2001;227-237.
38. Taylor S.S., Mckeon F. Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage. Cell. 89:1997;727-735.
39. Taylor S.S., Ha E., Mckeon F. The human homologue of Bub3 is required for kinetochore localization of Bub1 and Mad3/Bub1-related protein kinase. J. Cell Biol. 142:1998;1-11.
40. Wang Y., Burke D.J. Cdc55p, the B type regulatory subunit of protein phosphatase 2A, has multiple functions in mitosis and is required for the kinetochore/spindle checkpoint in Saccharomyces cerevisiae. Mol. Cell. Biol. 17:1996;620-626.
41. Wassmann K., Benezra R. Mitotic checkpoints. from yeast to cancer Curr. Opin. Genet. Dev. 11:2001;83-90.
42. Waters J.C., Chen R.H., Murray A.W., Salmon E.D. Localization of Mad2 to kinetochores depends on microtubule attachment, not tension. J. Cell Biol. 141:1998;1181-1191.
43. Wu H., Lan Z., Li W., Wu S., Weinstein J., Sakamoto K.M., Dai W. p55CDC/hCDC20 is associated with BUBR1 and may be a downstream target of the spindle checkpoint kinase. Oncogene. 19:2000;4557-4562.
44. Yu H. Regulation of APC-cdc20 by the spindle checkpoint. Curr. Opin. Cell Biol. 14:2002;706-714.
45. Zachariae W., Nasmyth K. Whose end is destruction. cell division and the anaphase-promoting complex Genes Dev. 13:1999;2039-2058.