Human INCENP colocalizes with the Aurora-B/AIRK2 kinase on chromosomes and is overexpressed in tumour cells

Chromosoma

Volumn 110, Issue 2, 2001, Pages 65-74

  Adams, Richard R ^a   Eckley, D Mark ^b   Vagnarelli, Paola ^a   Wheatley, Sally P ^a   Gerloff, Dietlind L ^a   Mackay, Alastair M ^b,d   Svingen, Phyllis A ^c   Kaufmann, Scott H ^c   Earnshaw, William C ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MAYO CLINIC   (United States)

^d OSIRIS THERAPEUTICS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; AURORA B AURORA IPL1 RELATED KINASE 2 KINASE; CHROMOSOME PROTEIN; DNA; INNER CENTROMERE PROTEIN; PROTEIN KINASE; UNCLASSIFIED DRUG;

ANAPHASE; ARTICLE; CANCER; CANCER CELL CULTURE; CELL LEVEL; CELL PROLIFERATION; CHROMOSOME 11Q; COLON; COLORECTAL CANCER; CONTROLLED STUDY; EGG; EXON; GENE EXPRESSION; GENE LIBRARY; GENE OVEREXPRESSION; GENETIC SCREENING; GENOME; HELA CELL; HUMAN; HUMAN CELL; METAPHASE; MITOSIS SPINDLE; NUCLEOTIDE SEQUENCE; PROSTATE; PROTEIN LOCALIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TESTIS; TUMOR CELL; XENOPUS;

AMINO ACID SEQUENCE; ANIMALS; BLOTTING, SOUTHERN; CELLS, CULTURED; CENTROMERE; CHROMOSOMAL PROTEINS, NON-HISTONE; CHROMOSOMES, HUMAN; CLONING, MOLECULAR; COLONIC NEOPLASMS; FIBROBLASTS; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; METAPHASE; MICE; MOLECULAR SEQUENCE DATA; PROTEIN-SERINE-THREONINE KINASES; RNA, MESSENGER; SEQUENCE HOMOLOGY, AMINO ACID; XENOPUS LAEVIS;

EID: 0034993667     PISSN: 00095915     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004120100130     Document Type: Article

References (27)

1. INCENP binds the Aurora-related kinase AIRK2 and is required to target it to chromosomes, the central spindle and the cleavage furrow
2. Chromosomal passengers and the (Aurora) ABCs of mitosis
3. INCENP centromere and spindle targeting: Identification of essential conserved motifs and involvement of heterochromatin protein HP1
4. Telophase disk: A new mammalian mitotic organelle that bisects telophase cells with a possible function in cytokinesis
5. Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain
6. The Aurora/Ip11p kinase family: Regulators of chromosome segregation and cytokinesis
7. The INCENP antigens: Movement from the inner centromere to the midbody during mitosis
8. Defective chromosome segregation, microtubule bundling and nuclear bridging in inner centromere protein gene (Incenp)-disrupted mice
9. Mitotic histone H3 phosphorylation by the NIMA kinase in Aspergillus nidulans
10. Chromosomal passengers: Towards an integrated view of mitosis
11. The role of non-histone proteins in the chromosomal events of mitosis
12. Three human chromosomal autoantigens are recognized by sera from patients with anti-centromere antibodies
13. Chromosomal proteins and cytokinesis: Patterns of cleavage furrow formation and inner-centromere protein positioning in mitotic heterokaryons and mid-anaphase cells
14. Aurora/Ip11p-related kinases, a new oncogenic family of mitotic serine-threonine kinases
15. Mitotic phosphorylation of histone H3 is governed by Ip11/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes
16. Antibodies to defined histone epitopes reveal variations in chromatin conformation and underacetylation of centric heterochromatin in human metaphase chromosomes
17. Sli15 associates with the ip11 protein kinase to promote proper chromosome segregation in Saccharomyces cerevisiae
18. An analysis of 5′-noncoding sequences from 699 vertebrate messenger RNAs
19. Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins
20. Molecular analysis of the INCENPs (Inner Centromere Proteins): Separate domains are required for association with microtubules during interphase and with the central spindle during anaphase
21. A dominant mutant of inner centromere protein (INCENP), a chromosomal protein, disrupts prometaphase congression and cytokinesis
22. Colocalization of TD-60 and INCENP throughout G2 and mitosis: Evidence for their possible interaction in signaling cytokinesis
23. AIR-2: An Aurora/Ip11-related protein kinase associated with chromosomes and midbody microtubules is required for polar body extrusion and cytokinesis in Caenorhabditis elegans embryos
24. Organization of actin in the leading edge of cultured cells: Influence of osmium tetroxide and dehydration on the ultrastructure of actin networks
25. The survivin-like C. elegans BIR-1 protein acts with the Aurora-like kinase AIR-2 to affect chromosomes and the spindle midzone
26. Multinuclearity and increased ploidy caused by overexpression of the aurora- and Ip11-like midbody-associated protein mitotic kinase in human cancer cells