Defective chromosome segregation, microtubule bundling and nuclear bridging in inner centromere protein gene (Incenp)-disrupted mice

Human Molecular Genetics

Volumn 8, Issue 7, 1999, Pages 1145-1155

  Cutts, Suzanne M ^a   Fowler, Kerry J ^a   Kile, Benjamin T ^a   Hii, Linda L P ^a   O'Dowd, Rachael A ^a   Hudson, Damien F ^a   Saffery, Richard ^a   Kalitsis, Paul ^a   Earle, Elizabeth ^a   Choo, K H A ^a  

^a ROYAL CHILDREN'S HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; TUBULIN;

ANAPHASE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL STRUCTURE; CENTROMERE; CHROMATIN; CHROMOSOME SEGREGATION; CONTROLLED STUDY; EMBRYO; GENE DISRUPTION; GENETIC RECOMBINATION; HETEROZYGOTE; HOMOZYGOTE; IMMUNOCYTOCHEMISTRY; LETHALITY; METAPHASE; MICRONUCLEUS; MICROTUBULE; MOUSE; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; PREIMPLANTATION EMBRYO; PRIORITY JOURNAL;

ANIMALS; CELL NUCLEUS; CHICKENS; CHROMOSOMAL PROTEINS, NON-HISTONE; CHROMOSOME SEGREGATION; CHROMOSOMES; EMBRYONIC AND FETAL DEVELOPMENT; GENE TARGETING; IMMUNOHISTOCHEMISTRY; MICE; MICE, KNOCKOUT; MICROTUBULES; MUTATION; PHENOTYPE; TUBULIN;

EID: 0032776404     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/8.7.1145     Document Type: Article

References (35)

1. Choo, K.H.A. (1997) The Centromere. Oxford University Press, Oxford, UK.
2. Palmer, D.K., O'Day, K., Wener, M.H., Andrews, B.S. and Margolis, R.L. (1987) A 17-kD centromere protein (CENP-A) copurifies with nucleosome core particles and with histones. J. Cell Biol., 104, 805-815.
3. Sullivan, K.F., Hechenberger, M. and Masri, K. (1994) Human CENP-A contains a histone H3 related histone fold domain that is required for targeting to the centromere. J. Cell Biol., 127, 581-592.
4. Earnshaw, W.C. and Rothfield, N. (1985) Identification of a family of human centromere proteins using autoimmune sera from patients with scleroderma. Chromosoma, 91, 313-321.
5. Masumoto, H., Sugimoto, K. and Okazaki, T. (1989) Alphoid satellite DNA is tightly associated with centromere antigens in human chromosomes throughout the cell cycle. Exp. Cell Res., 181, 181-196.
6. Brown, M. (1995) Sequence similarities between the yeast chromosome segregation protein Mif2 and the mammalian centromere protein CENP-C. Gene, 160, 111-116.
7. Meluh, P. and Koshland, D. (1995) Evidence that the MIF2 gene of Saccharomyces cerevisiae encodes a centromere protein with homology to the mammalian centromere protein CENP-C. Mol. Cell. Biol., 6, 793-807.
8. Tomkiel, J., Cooke, C.A., Saitoh, H., Bernat, R.L. and Earnshaw, W.C. (1994) CENP-C is required for maintaining proper kinetochore size and for a timely transition to anaphase. J. Cell Biol., 125, 531-545.
9. Earnshaw, W.C. and Mackay, A.M. (1994) Role of nonhistone proteins in the chromosomal events of mitosis. FASEB J., 8, 947-956.
10. Yen, T.J., Li, G., Schaar, B.T., Szilak, I. and Cleveland, D.W. (1992) CENP-E is a putative kinetochore motor that accumulates just before mitosis. Nature, 359, 536-539.
11. Holzbaur, E. and Vallee, R. (1994) Dyneins: molecular structure and cellular function. Annu. Rev. Cell Biol., 10, 339-372.
12. Wordeman, L. and Mitchison, T.J. (1995) Identification and partial characterization of mitotic centromere-associated kinesin, a kinesin-related protein that associates with centromeres during mitosis. J. Cell Biol., 128, 95-105.
13. Tokai, N., Fujimoto-Nishiyama, A., Toyoshima, Y., Yonemura, S., Tsukita, S., Inoue, J. and Yamamota, T. (1996) Kid, a novel kinesin-like DNA binding protein is localized to chromosomes and the mitotic spindle. EMBO J., 15, 457-467.
14. Rattner, J.B., Rao, A., Fritzler, M.J., Valencia, D.W. and Yen, T.J. (1993) CENP-F is a ca. 400 kDa kinetochore protein that exhibits a cell-cycle dependent localization. Cell Motil. Cytoskeleton, 26, 214-226.
15. Liao, H., Winkfein, R.J., Mack, G., Rattner, J.B. and Yen, T.J. (1995) Cenp-F is a protein of the nuclear matrix that assembles onto kinetochores at late G2 and is rapidly degraded after mitosis. J. Cell Biol., 130, 507-518.
16. Zhu, X., Mancini, M.A., Chang, K.H., Liu, C.Y., Chen, C.F., Shan, B., Jones, D., Yang-Feng, T.L. and Lee, W.-H. (1995) Characterisation of a novel 350-kilodalton nuclear phosphoprotein that is specifically involved in mitotic-phase progression. Mol. Cell. Biol., 15, 5017-5029.
17. Rattner, J.B., Kingwell, B. and Fritzler, M.J. (1988) Detection of distinct structural domains within the primary constriction using autoantibodies. Chromosoma, 96, 360-367.
18. Earnshaw, W.C. and Cooke, C.A. (1991) Analysis of the distribution of the INCENPs throughout mitosis reveals the existence of a pathway of structural changes in the chromosomes during metaphase and early events in cleavage furrow formation. J. Cell Sci., 98, 443-461.
19. Cooke, C. A., Heck, M.M.S. and Earnshaw, W.C. (1987) The inner centromere protein (INCENP) antigens: movement from inner centromere to midbody during mitosis. J. Cell Biol., 105, 2053-2067.
20. Mackay, A.M. and Earnshaw, W.C. (1993) The INCENPs: structural and functional analysis of a family of chromosome passenger proteins. Cold Spring Harbor Symp. Quant. Biol., 58, 697-706.
21. Mackay, A.M., Eckley, D.M., Chue, C. and Earnshaw, W.C. (1993) Molecular analysis of the INCENPs (inner centromere proteins): separate domains are required for association with microtubules during interphase and with the central spindle during anaphase. J. Cell Biol., 123, 373-385.
22. Stukenberg, P.T., Lustig, K.D., McGarry, T.J., King, R.W., Kuang, J. and Kirschner, M.W. (1997) Systematic identification of mitotic phosphoproteins. Curr. Biol., 7, 338-348.
23. Fowler, K.J., Saffery, R., Kile, B.T., Irvine, D.V., Hudson, D.F., Trowell, H.E. and Choo, K.H.A. (1998) Genetic mapping of mouse centromere protein (Incenp and cenpe) genes. Cytogenet. Cell Genet., 82, 67-70.
24. Saffery, R., Irvine D.V., Kile, B.T., Hudson, D.F., Cutts, S.M. and Choo, K.H.A. (1999) Cloning, expression and promoter structure of a mammalian inner centromere protein (INCENP). Mamm. Genome, 10, 415-418.
25. Eckley, D.M., Ainsztein, A.M., Mackay, A.M., Goldberg, I.G. and Earnshaw, W.C. (1997) Chromosomal proteins and cytokinesis: patterns of cleavage furrow formation and inner centromere protein positioning in mitotic heterokaryons and mid-anaphase cells. J. Cell Biol., 136, 1169-1183.
26. Mackay, A.M., Ainsztein, A.M., Eckley, D.M. and Earnshaw, W.C. (1998) A dominant mutant of inner centromere protein (INCENP), a chromosomal protein, disrupts prometaphase congression and cytokinesis. J. Cell Biol., 140, 991-1002.
27. Mountford, P., Zevnik, B., Duwel, A., Nichols, J., Li, M., Dani, C., Robertson, M., Chambers, I. and Smith, A. (1994) Dicistronic targeting constructs: reporters and modifiers of mammalian gene expression. Proc. Natl Acad. Sci. USA, 91, 4303-4307.
28. Kalitsis, P., Fowler, K.J., Earle, E., Hill, J. and Choo, K.H.A. (1998) Targeted disruption of mouse centromere protein C gene leads to mitotic disarray and early embryo death. Proc. Natl Acad. Sci. USA,9, 1136-1141.
29. Hudson, D.F., Fowler, K.J., Earle, E., Saffery, R., Kalitsis, P., Trowell, H., Hill, J., Wreford, N.G., de Kretser, D.M., Cancilla, M.R., Howman, E., Hii, L., Cutts, S.M., Irvine, D.V. and Choo, K.H.A. (1998) Centromere protein B null mice are mitotically and meiotically normal but have lower body and testis weights. J. Cell Biol., 141, 309-319.
30. Zhang, L., Cui, X., Schmitt, K., Hubert, R., Navidi, W. and Arnheim, N. (1992) Whole genome amplification from a single cell: implications for genetic analysis. Proc. Natl Acad. Sci. USA, 89, 5847-5851.
31. Bernat, R.L., Borisy, G.G., Rothfield, N.F. and Earnshaw, W.C. (1990) Injection of anticentromere antibodies in interphase disrupts events required for chromosome movement at mitosis. J. Cell Biol., 111, 1519-1533.
32. Mullins, J.M. and Biesele, J.J. (1977) Terminal phase of cytokinesis in D-98S cells. J. Cell Biol., 73, 672-684.
33. Li, X. and Nicklas, R.B. (1995) Mitotic forces control a cell cycle checkpoint. Nature, 373, 630-632.
34. Robertson, E.J. (1987) Embryo-derived stem cell lines. In Robertson, E.J. (ed.), Teratocarcinomas and Embryo Stem Cells: A Practical Approach. IRL Press, Oxford, UK, pp. 71-112.
35. Simerly, C. and Schatten, G. (1993) Techniques for localization of specific molecules in oocytes and embryos. Methods Enzymol., 225, 516-553.