Essential roles of Drosophila inner centromere protein (INCENP) and aurora B in histone H3 phosphorylation, metaphase chromosome alignment, kinetochore disjunction, and chromosome segregation

Journal of Cell Biology

Volumn 153, Issue 4, 2001, Pages 865-879

  Adams, Richard R ^a   Maiato, Helder ^a   Earnshaw, William C ^a   Carmena, Mar ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Chromosomal passengers; Chromosomes; Cytokinesis; Mitosis; RNAi

Indexed keywords

AURORA B KINASE; CHROMOSOME PROTEIN; HISTONE H3; INNER CENTROMERE PROTEIN; KINESIN; UNCLASSIFIED DRUG;

ANAPHASE; ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CENTROMERE; CHROMOSOME SEGREGATION; CONTROLLED STUDY; CYTOKINESIS; DROSOPHILA; EMBRYO; METAPHASE; MITOSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION;

ANAPHASE; ANIMALS; CELL DIVISION; CELLS, CULTURED; CHROMOSOMAL PROTEINS, NON-HISTONE; CHROMOSOME SEGREGATION; CHROMOSOMES; DROSOPHILA; DROSOPHILA PROTEINS; HISTONES; KINETOCHORES; METAPHASE; MICROTUBULE-ASSOCIATED PROTEINS; MICROTUBULES; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; TELOPHASE;

ANIMALIA; DROSOPHILA MELANOGASTER; MELANOGASTER;

EID: 0035858865     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.153.4.865     Document Type: Article

References (37)

1. pavarotti encodes a kinesin-like protein required to orga nize the central spindle and contractile ring for cytokinesis
2. INCENP binds the aurora-related kinase AIRK2 and is required to target it to chromosomes, the central spindle and cleavage furrow
3. Chromosomal passengers and the (Aurora) ABCs of mitosis
4. INCENP centromere and spindle targeting: Identification of essential conserved motifs and involvement of heterochromatin protein HP1
5. Telophase disk: A new mammalian mitotic organelle that bisects telophase cells with a possible function in cytokinesis
6. Injection of anticentromere antibodies in interphase disrupts events required for chromosome movement in mitosis
7. Chromatid segregation at anaphase requires the barren product, a novel chromosome-associated protein that interacts with Topoisomerase II
8. The conserved protein kinase Ipl1 regulates microtubule binding to kinetochores in budding yeast
9. Isolation and characterization of chromosome-gain and increase-in-ploidy mutants in yeast
10. Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways
11. Defective chromosome segregation, microtubule bundling and nuclear bridging in inner centromere protein gene (Incenp)-disrupted mice
12. Chromosomal passengers: Towards an integrated view of mitosis
13. Chromosomal proteins and cytokinesis: Patterns of cleavage furrow formation and inner centromere protein positioning in mitotic heterokaryons and mid-anaphase cells
14. Specific destruction of kinetochore protein CENP-C and disruption of cell division by herpes simplex virus immediate-early protein Vmw110
15. Cell cycle-dependent specific positioning and clustering of centromeres and telomeres in fission yeast
16. Aurora/Ipl1p-related kinases, a new oncogenic family of mitotic serine-threonine kinases
17. Drosophila aurora B kinase is required for histone H3 phosphorylation and condensin recruitment during chromosome condensation and to organize the central spindle during cytokinesis
18. Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles
19. NDC10: A gene involved in chromosome segregation in Saccharomyces cerevisiae
20. Cell cycle progression and chromosome segregation in mammalian cells cultured in the presence of the topoisomerase II inhibitors ICRF-187 [(+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane; ADR-529] and ICRF-159 (Razoxane)
21. Heterochromatic deposition of centromeric histone H3-like proteins
22. Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes
23. Incenp and an aurora-like kinase form a complex essential for chromosome segregation and efficient completion of cytokinesis
24. Sli15 associates with the ipl1 protein kinase to promote proper chromosome segregation in Saccharomyces cerevisiae
25. Molecular analysis of the INCENPs (inner centromere proteins): Separate domains are required for association with microtubules during interphase and with the central spindle during anaphase
26. A dominant mutant of inner centromere protein (INCENP), a chromosomal protein, disrupts prometaphase congression and cytokinesis
27. Cloning, mapping, and expression of ial, a novel Drosophila member of the Ipl1/aurora mitotic control kinase family
28. AIR-2: An Aurora/Ipl1-related protein kinase associated with chromosomes and midbody microtubules is required for polar body extrusion and cytokinesis in Caenorhabditis elegans embryos
29. The aurora-related kinase AIR-2 recruits ZEN4/CeMKLP1 to the mitotic spindle at metaphase and is required for cytokinesis
30. Human survivin is a kinetochore-associated passenger protein
31. The survivin-like C. elegans BIR-1 protein acts with the aurora-like kinase AIR-2 to affect chromosomes and the spindle midzone
32. A role for Drosophila SMC4 in the resolution of sister chromatids in mitosis
33. AIM-1: A mammalian midbody-associated protein required for cytokinesis
34. Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype
35. Immunolocalization of CENP-A suggests a distinct nucleosome structure at the inner kinetochore plate of active centromeres
36. INCENP binds directly to tubulin and requires dynamic microtubules to target to the cleavage furrow
37. The A- and B-type cyclins of Drosophila are accumulated and destroyed in temporally distinct events that define separable phases of the G2-M transition