The conserved protein kinase Ipl1 regulates microtubule binding to kinetochores in budding yeast

Genes and Development

Volumn 13, Issue 5, 1999, Pages 532-544

  Biggins, Sue ^a   Severin, Fedor F ^b   Bhalla, Needhi ^a   Sassoon, Ingrid ^b   Hyman, Anthony A ^b   Murray, Andrew W ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

Chromosome segregation; Ipl1p aurora kinase; Kinetochores; Microtubules; Sister chromatid separation; Yeast

Indexed keywords

PROTEIN KINASE;

ARTICLE; CELL CYCLE; CENTROMERE; CHROMOSOME SEGREGATION; GENETIC CONSERVATION; GENETIC STABILITY; MICROTUBULE; MITOSIS SPINDLE; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; SISTER CHROMATID; TUMOR;

EUKARYOTA; SACCHAROMYCES CEREVISIAE; SACCHAROMYCETALES;

EID: 0033106222     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.13.5.532     Document Type: Article

References (57)

1. Axton, J.M., V. Dombradi, P.T. Cohen, and D.M. Glover. 1990. One of the protein phosphatase 1 isoenzymes in Drosophila is for mitosis. Cell 63: 33-46.
2. Biggins, S. and A. Murray. 1998. Sister chromatid cohesion in mitosis. Curr. Opin. Cell Biol. 10: 769-775.
3. Bischoff, J.R., L. Anderson, Y. Zhu, K. Mossic, L. Ng, B. Souza, B. Schryver, P. Flanagan, F. Clairvoyant, C. Ginther, C.S. Chan, M. Novotny, D.J. Slamon, and G.D. Plowman. 1998. A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers. EMBO J. 17: 3052-3065.
4. Cahill, D.P., C. Lengauer, J. Yu, G.J. Riggins, J.K. Willson, S.D. Markowitz, K.W. Kinzler, and B. Vogelstein. 1998. Mutations of mitotic checkpoint genes in human cancers. Nature 392: 300-303.
5. Chan, C.S. and D. Botstein. 1993. Isolation and characterization of chromosome-gain and ploidy mutants in yeast. Genetics 135: 677-691.
6. Charles, J., S.L. Jaspersen, R.L. Tinker-Kulberg, L. Hwang, A. Szidon, and D.O. Morgan. 1998. The Polo-related kinase Cdc5 activates and is destroyed by the mitotic cyclin destruction machinery in S. cerevisiae. Curr. Biol. 9: 497-507.
7. Cho, R., M. Campbell, E. Winzeler, L. Steinmetz, A. Conway, L. Wodicka, T. Wolfsberg, A. Gabrielian, D. Landsman, D. Lockhart, and R. Davis. 1988. A genome-wide transcriptional analysis of the mitotic cell cycle. Mol. Cell 2: 65-73.
8. Ciosk, R., W. Zachariae, C. Michaelis, A. Shevchenko, M. Mann, and K. Nasmyth. 1998. An ESP1/PDS1 complex regulates loss of sister chromatid metaphase to anaphase transition in yeast. Cell 93: 1067-1076.
9. Cohen-Fix, O. and D. Koshland. 1997. The metaphase-to-anaphase transition: Avoiding a mid-life crisis. Curr. Opin. Cell Biol. 9: 800-806.
10. Cohen-Fix, O., J.M. Peters, M.W. Kirschner, and D. Koshland. 1996. Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pdslp. Genes & Dev. 10: 3081-3093.
11. Dohmen, R.J., P. Wu, and A. Varshavsky. 1994. Heat-inducible degron: A method for constructing temperature-sensitive mutants. Science 263: 1273-1276.
12. Doonan, J.H. and N.R. Morris. 1989. The bimG gene of Aspergillus nidulans, required for completion of anaphase, encodes a homolog of mammalian phosphoprotein phosphatase 1. Cell 57: 987-996.
13. Francisco, L. and C.S. Chan. 1994. Regulation of yeast chromosome segregation by Ipl1 protein type 1 protein phosphatase. Cell Mol. Biol. Res. 40: 207-213.
14. Francisco, L., W. Wang, and C.S. Chan. 1994. Type 1 protein phosphatase acts in opposition to Ipl1 protein kinase in regulating yeast chromosome segregation. Mol. Cell. Biol. 14: 4731-4740.
15. Geiser, J.R., E.J. Schott, T.J. Kingsbury, N.B. Cole, L.J. Totis, G. Bhattacharyya, L. He, and M.A. Hoyt. 1997. Saccharomyces cerevisiae genes required in the absence of the CIN8-encoded spindle motor act in functionally diverse mitotic pathways. Mol. Biol. Cell 8: 1035-1050.
16. Glover, D.M., M.H. Leibowitz, D.A. McLean, and H. Parry. 1995. Mutations in aurora prevent centrosome separation leading to formation of monopolar spindles. Cell 81: 95-105.
17. Goh, P.Y. and J.V. Kilmartin. 1993. NDC10: A gene involved in chromosome segregation in Saccharomyces cerevisiae. J. Cell Biol. 121: 503-512.
18. Gopalan, G., C.S. Chan, and P.J. Donovan. 1997. A novel mammalian, mitotic spindle-associated kinase is related yeast and fly chromosome segregation regulators. J. Cell Biol. 138: 643-656.
19. Guacci, V., D. Koshland, and A. Strunnikov. 1997. A direct link between sister chromatid cohesion and chromosome condensation revealed through the analysis of MCD1 in S. cerevisiae. Cell 91: 47-57.
20. Hardwick, K. and A.W. Murray. 1995. Madlp, a phosphoprotein component of the spindle assembly checkpoint in budding yeast. J. Cell Biol. 131: 709-720.
21. Hisamoto, N., K. Sugimoto, and K. Matsumoto. 1994. The Glc7 type 1 protein phosphatase of Saccharomyces is required for cell cycle progression in G2/M. Mol. Cell. Biol. 14: 3158-3165.
22. Hoyt, M.A., L. Trotis, and B.T. Roberts. 1991. S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function. Cell 66: 507-517.
23. Hoyt, M.A., L. He, K.K. Loo, and W.S. Saunders. 1992. Two Saccharomyces cerevisiae kinesin-related gene products required for mitotic spindle assembly. J. Cell Biol. 118: 109-120.
24. Hyman, A.A. and P.K. Sorger. 1995. Structure and function of kinetochores in budding yeast. Annu. Rev. Cell. Dev. Biol. 11: 471-495.
25. Kaplan, K.B., A.A. Hyman, and P.K. Sorger. 1997. Regulating the yeast kinetochore by ubiquitin-dependent degradation and Skplp-mediated phosphorylation. Cell 91: 491-500.
26. Kellogg, D.R., A. Kikuchi, T. Fujii-Nakata, C.W. Turck, and A.W. Murray. 1995. Members of the NAP/SET family of proteins interact specifically with B-type cyclins. J. Cell Biol. 130: 661-673.
27. Kimura, M., S. Kotani, T. Hattori, N. Sumi, T. Yoshioka, K. Todokoro, and Y. Okano. 1997. Cell cycle-dependent expression and spindle pole localization of novel human protein kinase, Aik, related to Aurora of Drosophila and yeast Ipl1. J. Biol. Chem. 272: 13766-13771.
28. Lechner, J. and J. Carbon. 1991. A 240 Kd multisubunit complex, CBF3, is a major component of the budding yeast centromere. Cell 64: 717-725.
29. Li, R. and A.W. Murray. 1991. Feedback control of mitosis in budding yeast. Cell 66: 519-531.
30. Loidl, J., F. Klein, and J. Engebrech. 1998. Genetic and morphological approaches for the analysis of meiotic chromosomes in yeast. Meth. Cell Biol. 53: 257-285.
31. Marschall, L.G., R.L. Jeng, J. Mulholland, and T. Stearns. 1996. Analysis of Tub4p, a yeast gamma-tubulin-like protein: Implications for microtubule-organizing center function. J. Cell Biol. 134: 443-454.
32. Marshall, W.F., A. Straight, J.F. Marko, J. Swedlow, A. Dernburg, A. Belmont, A.W. Murray, D.A. Agard, and J.W. Sedat. 1997. Interphase chromosomes undergo constrained diffusional motion in living cells. Curr. Biol. 7: 930-939.
33. Michaelis, C., R. Ciosk, and K. Nasmyth. 1997. Cohesins: Chromosomal proteins that prevent premature separation of sister chromatids. Cell 91: 35-45.
34. Minshull, J., A. Straight, A. Rudner, A. Dernburg, A. Belmont, and A.W. Murray. 1996. Protein phosphatase 2A regulates MPF activity and sister chromatid cohesion in budding yeast. Curr. Biol. 6: 1609-1620.
35. Nicklas, R.B. 1983. Measurements of the force produced by the mitotic spindle in anaphase. J. Cell Biol. 97: 542-548.
36. + gene required for chromosome disjoining encodes one of two putative type 1 protein phosphatases. Cell 57: 997-1007.
37. Osborne, M., G. Schlendstedt, T. Jinks, and P. Silver. 1994. Nuf2, a spindle pole body-associated protein required for nuclear division in yeast. J. Cell Biol. 125: 853-866.
38. 1 is important for the onset of S phase and for preventing a 'reductional' anaphase in the budding yeast Saccharomyces cerevisiae. EMBO J. 14: 3788-3799.
39. Rieder, C.L. and S.P. Alexander. 1990. Kinetochores are transported poleward along a single astral microtubule during chromosome attachment to the spindle in newt lung cells. J. Cell Biol. 110: 81-95.
40. Roghi, C., R. Giet, R. Uzbekov, N. Morin, I. Chartrain, R. Le Guellec, A. Couturier, M. Doree, M. Philippe, and C. Prigent. 1998. The Xenopus protein kinase pEg2 associates with the cell cycle-dependent manner, binds to the spindle microtubules involved in bipolar mitotic spindle assembly. J. Cell Sci. 111: 557-572.
41. Roof, D.M., P.B. Meluh, and M.D. Rose. 1992. Kinesin-related proteins required for assembly of the mitotic spindle. J. Cell Biol. 118: 95-108.
42. Rose, M., F. Winston, and P. Heiter. 1990. Methods in yeast genetics. p. 198. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
43. Rudner, A.D. and A.W. Murray. 1996. The spindle assembly checkpoint. Curr. Opin. Cell Biol. 8: 773-780.
44. Sassoon, I., F.F. Severin, P.D. Andrews, M.-R. Taba, K.B. Kaplan, A.J. Ashford, M.J.R. Stark, P.K. Sorger, and A.A. Hyman. Regulation of Saccharomyces cerevisiae kinetochores by the type I phosphatase Glc7p. Genes & Dev. (this issue).
45. Schneider, B.L., W. Seufert, B. Steiner, Q.H. Yang, and A.B. Futcher. 1995. Use of polymerase chain reaction epitope tagging for protein Saccharomyces cerevisiae. Yeast 11: 1265-1274.
46. Sen, S., H. Zhou, and R. White. 1997. A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines. Oncogene 14: 2195-2200.
47. Sherman, F., G. Fink, and C. Lawrence, eds. 1974. Methods in yeast genetics, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
48. Sikorski, R.S. and P. Hieter. 1989. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122: 19-27.
49. Skibbens, R.V., V.P. Skeen, and E.D. Salmon. 1993. Directional instability of kinetochore motility during chromosome congression and segregation in mitotic newt lung cells: A push-pull mechanism. J. Cell Biol. 122: 859-875.
50. Sorger, P.K., F.F. Severin, and A.A. Hyman. 1994. Factors required for the binding of reassembled yeast kinetochores to microtubules in vitro. J. Cell Biol. 127: 995-1008.
51. Sorger, P.K., K.F. Doheny, P. Hieter, K.M. Kopski, T.C. Huffaker, and A.A. Hyman. 1995. Two genes required for the binding of an essential cerevisiae kinetochore complex to DNA. Proc. Natl. Acad. Sci. 92: 12026-12030.
52. Stemmann, O. and J. Lechner. 1996. The Saccharomyces cerevisiae kinetochore contains a cyclin-CDK complexing homologue, as identified by in vitro reconstitution. EMBO J. 15: 3611-3620.
53. Straight, A.F., A.S. Belmont, C.C. Robinett, and A.W. Murray. 1996. GFP tagging of budding yeast chromosomes reveals that protein-protein interactions can mediate sister chromatid cohesion. Curr. Biol. 6: 1599-1608.
54. Straight, A.F., W.F. Marshall, J.W. Sedat, and A.W. Murray. 1997. Mitosis in living budding yeast: Anaphase A but no metaphase plate. Science 277: 574-578.
55. Straight, A., J. Sedat, and A. Murray. 1998. Time lapse microscopy reveals unique roles for kinesins during anaphase in budding yeast. J. Cell Biol. 143: 687-694.
56. Terada, Y., M. Tatsuka, F. Suzuki, Y. Yasuda, S. Fujita, and M. Otsu. 1998. AIM-1: a mammalian midbody-associated protein required for cytokinesis. EMBO J. 17: 667-676.
57. Waters, J.C., R.V. Skibbens, and E.D. Salmon. 1996. Oscillating mitotic newt lung cell kinetochores are, on average, under tension and rarely push. J. Cell Sci. 109: 2823-2831.