Slippage of Mitotic Arrest and Enhanced Tumor Development in Mice with BubR1 Haploinsufficiency

Cancer Research

Volumn 64, Issue 2, 2004, Pages 440-445

  Dai, Wei ^a   Wang, Qi ^a   Liu, Tongyi ^a   Swamy, Malisetty ^d   Fang, Yuqiang ^a   Xie, Suqing ^a   Mahmood, Radma ^b   Yang, Yang Ming ^a   Xu, Ming ^c   Rao, Chinthalapally V ^d  

^a NEW YORK MEDICAL COLLEGE   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^d AMERICAN HEALTH FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BUB1 RELATED PROTEIN; CARCINOGEN; CELL CYCLE PROTEIN 20; PROTEIN; SECURIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BUBR1 GENE; CANCER INHIBITION; CARCINOGENESIS; CONTROLLED STUDY; FEMALE; FIBROBLAST; GENE; GENE MUTATION; GENETIC STABILITY; HUMAN; HUMAN CELL; INTESTINE TUMOR; LUNG ADENOCARCINOMA; MALIGNANT TRANSFORMATION; MICRONUCLEUS; MITOSIS INHIBITION; MITOSIS SPINDLE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RNA INTERFERENCE;

ADENOMA; ANIMALS; CELL CYCLE PROTEINS; CELL TRANSFORMATION, NEOPLASTIC; FEMALE; FIBROBLASTS; GENE EXPRESSION REGULATION; HELA CELLS; HUMANS; LUNG NEOPLASMS; MICE; MICE, KNOCKOUT; MITOSIS; MITOTIC SPINDLE APPARATUS; PROTEIN KINASES; RNA, SMALL INTERFERING;

EID: 9144253124     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-03-3119     Document Type: Article

References (20)

1. Li, W., Lan, Z., Wu, H., Wu, S., Meadows, J., Chen, J., Zhu, V., and Dai, W. BUBR1 phosphorylation is regulated during mitotic checkpoint activation. Cell Growth Differ., 10: 769-775, 1999.
2. Sudakin, V., Chan, G. K., and Yen, T. J. Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2. J. Cell Biol., 154: 925-936, 2001.
3. Chen, R. H. BubR1 is essential for kinetochore localization of other spindle checkpoint proteins and its phosphorylation requires Mad1. J. Cell Biol., 158: 487-496, 2002.
4. Shannon, K. B., Canman, J. C., and Salmon, E. D. Mad2 and BubR1 function in a single checkpoint pathway that responds to a loss of tension. Mol. Biol. Cell, 13: 3706-3719, 2002.
5. Hoyt, M. A. A new view of the spindle checkpoint. J. Cell Biol., 154: 909-911, 2001.
6. Mao, Y., Abrieu, A., and Cleveland, D. W. Activating and silencing the mitotic checkpoint through CENP-E-dependent activation/inactivation of BubR1. Cell, 114: 87-98, 2003.
7. Rajagopalan, H., Nowak, M. A., Vogelstein, B., and Lengauer, C. The significance of unstable chromosomes in colorectal cancer. Nat. Rev. Cancer, 3: 695-701, 2003.
8. Cahill, D. P., Lengauer, C., Yu, J., Riggins, G. J., Willson, J. K., Markowitz, S. D., Kinzler, K. W., and Vogelstein, B. Mutations of mitotic checkpoint genes in human cancers. Nature (Lond.), 392: 300-303, 1998.
9. Shichiri, M., Yoshinaga, K., Hisatomi, H., Sugihara, K., and Hirata, Y. Genetic and epigenetic inactivation of mitotic checkpoint genes hBUB1 and hBUBR1 and their relationship to survival. Cancer Res., 62: 13-17, 2002.
10. Rao, C. V., Desai, D., Simi, B., Kulkarni, N., Amin, S., and Reddy, B. S. Inhibitory effect of caffeic acid esters on azoxymethane-induced biochemical changes and aberrant crypt foci formation in rat colon. Cancer Res., 53: 4182-4188, 1993.
11. Wang, Q., Liu, T-Y., Fang, Y-Q., Xie, S-Q., Huang, X., Ramashiwamy, G., Sakamoto, K., Dayzynkiewicz, Z., Xu, M., and Dai, W. BUBR1 deficiency results in abnormal megakaryopoiesis. Blood, in press, 2004.
12. Csuka, O., Szentirmay, Z., and Sugar, J. The effect of promoters on 1,2-dimethyl-hydrazine-induced colon carcinogenesis. IARC Sci. Publ., 56: 129-136, 1984.
13. Michel, L. S., Liberal, V., Chatterjee, A., Kirchwegger, R., Pasche, B., Gerald, W., Dobles, M., Sorger, P. K., Murty, V. V., and Benezra, R. MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells. Nature (Lond.), 409: 355-359, 2001.
14. Babu, J. R., Jeganathan, K. B., Baker, D. J., Wu, X., Kang-Decker, N., and van Deursen, J. M. Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation. J. Cell Biol., 160: 341-353, 2003.
15. Chan, G. K., Jablonski, S. A., Sudakin, V., Hittle, J. C., and Yen, T. J. Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC. J. Cell Biol., 146: 941-954, 1999.
16. Musacchio, A., and Hardwick, K. G. The spindle checkpoint: structural insights into dynamic signalling. Nat. Rev. Mol. Cell Biol., 3: 731-741, 2002.
17. Jallepalli, P. V., Waizenegger, I. C., Bunz, F., Langer, S., Speicher, M. R., Peters, J. M., Kinzler, K. W., Vogelstein, B., and Lengauer, C. Securin is required for chromosomal stability in human cells. Cell, 105: 445-457, 2001.
18. Reis, R. M., Nakamura, M., Masuoka, J., Watanabe, T., Colella, S., Yonekawa, Y., Kleihues, P., and Ohgaki, H. Mutation analysis of hBUB1, hBUBR1 and hBUB3 genes in glioblastomas. Acta Neuropathol. (Berl.), 101: 297-304, 2001.
19. Kaplan, K. B., Burds, A. A., Swedlow, J. R., Bekir, S. S., Sorger, P. K., and Nathke, I. S. A role for the adenomatous polyposis coli protein in chromosome segregation. Nat. Cell Biol., 3: 429-432, 2001.
20. Meyn, M. S. Ataxia-telangiectasia and cellular responses to DNA damage. Cancer Res., 55: 5991-6001, 1995.