The kinase activity of aurora B is required for kinetochore-microtubule interactions during mitosis

Current Biology

Volumn 12, Issue 11, 2002, Pages 894-899

  Murata Hori, Maki ^a   Wang, Yu Li ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; CELL LINE; FLUORESCENT ANTIBODY TECHNIQUE; KINETOCHORES; LUMINESCENT PROTEINS; MICROINJECTIONS; MICROTUBULES; MITOSIS; PROTEIN-SERINE-THREONINE KINASES; RATS; RECOMBINANT FUSION PROTEINS; SUPPORT, U.S. GOV'T, P.H.S.; TRANSFECTION; ANIMALS; GREEN FLUORESCENT PROTEINS;

AURORA KINASE; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; PHOTOPROTEIN; PROTEIN SERINE THREONINE KINASE;

ANIMAL; ARTICLE; CELL LINE; CENTROMERE; FLUORESCENT ANTIBODY TECHNIQUE; GENETIC TRANSFECTION; METABOLISM; MICROINJECTION; MICROTUBULE; MITOSIS; PHYSIOLOGY; RAT;

EID: 0037018843     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(02)00848-5     Document Type: Article

References (37)

1. AIR-2: An Aurora/IpI1-related protein kinase associated with chromosomes and midbody microtubules is required for polar body extrusion and cytokinesis in Caenorhabditis elegans embryos
2. Incenp and an Aurora-like kinase form a complex essential for chromosome segregation and efficient completion of cytokinesis
3. The aurora-related kinase AIR-2 recruits ZEN-4/CeMKLP1 to the mitotic spindle at metaphase and is required for cytokinesis
4. Essential roles of Drosophila inner centromere protein (INCENP) and aurora B in histone H3 phosphorylation, metaphase chromosome alignment, kinetocore disjunction, and chromosome segregation
5. Drosophila Aurora B kinase is required for histone H3 phosphorylation and condensing recruitment during chromosome condensation and to organize the central spindle during cytokinesis
6. Probing the dynamics and functions of aurora B kinase in living cells during mitosis and cytokinesis
7. AIM-1: A mammalian midbody-associated protein required for cytokinesis
8. Downregulation of an AIM-1 kinase couples with megakaryocytic polyploidization of human hematopoietic cells
9. Cytoplasmic dynein plays a role in mammalian mitotic spindle formation
10. Molecular characterization of the 50-kD subunit of dynactin reveals function for the complex in chromosome alignment and spindle organization during mitosis
11. CENP-E forms a link between attachment of spindle microtubules to kinetochores and the mitotic checkpoint
12. Kinetochore dynein: Its dynamics and role in the transport of the Rough deal checkpoint protein
13. CENP-E function at kinetochores is essential for chromosome alignment
14. CENP-E is a plus end-directed kinetochore motor required for metaphase chromosome alignment
15. Cytoplasmic dynein is required for poleward chromosome movement during mitosis in Drosophila embryos
16. CENP-E is essential for reliable bioriented spindle attachment, but chromosome alignment can be achieved via redundant mechanisms in mammalian cells
17. Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC
18. CENP-E as an essential component of the mitotic checkpoint in vitro
19. Cytoplasmic dynein/dynactin drives kinetochore protein transport to the spindle poles and has a role in mitotic spindle checkpoint inactivation
20. Spindle checkpoint protein Bub1 is required of kinetochore localization of Mad1, Mad2, Bub3, and CENP-E, independently of its kinase activity
21. Cytoplasmic dynein is localized to kinetochores during mitosis
22. Localization of cytoplasmic dynein to mitotic spindles and kinetochores
23. Mammalian spindle orientation and position respond to changes in cell shape in a dynein dependent fashion
24. CENP-E, a novel human centromere-associated protein required for progression from metaphase to anaphase
25. CENP-E is a putative kinetochore motor that accumulates just before mitosis
26. Localization of CENP-E in fibrous corona and outer plate of mammalian kinetochores from prometaphase through anaphase
27. The microtubule-dependent motor centromere-associated protein E (CENP-E) is an integral component of kinetochore corona fibers that link centromeres to spindle microtubules
28. Dynein is a transient kinetochore component whose binding is regulated by microtubule attachment, not tension
29. The vertebrate cell kinetochore and its roles during mitosis
30. Dynein-out at the kinetochore
31. Oscillatory movement of monooriented chromosomes and their position relative to the spindle pole result from the ejection properties of the aster and half-spindle
32. Kinetochores moving away from their associated pole do not exert a significant pushing force on the chromosome
33. Motile kinetochores and polar ejection forces dictate chromosome position on the vertebrate mitotic spindle
34. The budding yeast protein kinase IpI1/Aurora allows the absence of tension to activate the spindle checkpoint
35. CDK1 inactivation regulates anaphase spindle dynamnics and cytokinesis in vivo
36. Inhibition of chromosomal separation provides insights into cleavage furrow stimulation in cultured epithelial cells
37. Midzone microtubule bundles are continuously required for cytokinesis in cultured epithelial cells