Inhibition of Aurora B kinase blocks chromosome segregation, overrides the spindle checkpoint, and perturbs microtubule dynamics in mitosis

Current Biology

Volumn 12, Issue 11, 2002, Pages 900-905

  Kallio, Marko J ^a   McCleland, Mark L ^b   Todd Stukenberg, P ^b   Gorbsky, Gary J ^a  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; CHROMOSOMES; MICROTUBULES; MITOSIS; PROTEIN-SERINE-THREONINE KINASES; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; ANIMALS;

SACCHAROMYCETALES; VERTEBRATA;

AURORA KINASE; PROTEIN SERINE THREONINE KINASE;

ANIMAL; ARTICLE; CHROMOSOME; DRUG ANTAGONISM; MICROTUBULE; MITOSIS; PHYSIOLOGY;

EID: 0037018844     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(02)00887-4     Document Type: Article

References (19)

1. The Aurora/IpI1 p kinase family: Regulators of chromosome segregation and cytokinesis
2. Aurora/IpI1 p-related kinases, a new oncogenic family of mitotic serine-threonine kinases
3. The centrosome-associated Aurora/IpI-like kinase family
4. Chromosomal passengers and the (aurora) ABCs of mitosis
5. Isolation and characterization of chromosome-gain and increase-in-ploidy mutants in yeast
6. The budding yeast protein kinase IpI1/Aurora allows the absence of tension to activate the spindle checkpoint
7. Evidence that the IpI1-Sli15 (Aurora Kinase-INCENP) complex promotes chromosome bi-orientation by altering kinetochore-spindle pole connections
8. Aurora B kinase exists in a complex with survivin and incenp and its kinase activity is stimulated by survivin binding and phosphorylation
9. The mitotic spindle checkpoint
10. CENP-E is essential for reliable bioriented spindle attachment, but chromosome alignment can be achieved via redundant mechanisms in mammalian cells
11. Elevating the level of Cdc34/Ubc3 ubiquitin-conjugating enzyme in mitosis inhibits association of CENP-E with kinetochores and blocks the metaphase alignment of chromosomes
12. Cold-labile and cold-stable microtubules in the mitotic spindle of mammalian cells
13. A MAP kinase-dependent spindle assembly checkpoint in Xenopus egg extracts
14. AIR-2: An Aurora/IpI1-related protein kinase associated with chromosomes and midbody microtubules is required for polar body extrusion and cytokinesis in Caenorhabditis elegans embryos
15. The aurora-related kinase AIR-2 recruits ZEN-4/CeMKLP1 to the mitotic spindle at metaphase and is required for cytokinesis
16. The survivin-like C. elegans BIR-1 protein acts with the Aurora-like kinase AIR-2 to affect chromosomes and the spindle midzone
17. Essential roles of Drosophila inner centromere protein (INCENP) and aurora B in histone H3 phosphorylation, metaphase chromosome alignment, kinetochore disjunction, and chromosome segregation
18. Drosophila aurora B kinase is required for histone H3 phosphorylation and condensin recruitment during chromosome condensation and to organize the central spindle during cytokinesis
19. Multinuclearity and increased ploidy caused by overexpression of the aurora- and IpI1-like midbody-associated protein mitotic kinase in human cancer cells