Crystal structure of human survivin reveals a bow tie-shaped dimer with two unusual α-helical extensions

Molecular Cell

Volumn 6, Issue 1, 2000, Pages 183-189

  Chantalat, Laurent ^a   Skoufias, Dimitrios A ^a   Kleman, Jean Philippe ^a   Jung, Barbara ^b   Dideberg, Otto ^a   Margolis, Robert L ^a  

^a CEA GRENOBLE   (France)

^b SIDNEY KIMMEL CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIMER; SURVIVIN;

ALPHA HELIX; APOPTOSIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CRYSTAL STRUCTURE; DIMERIZATION; HUMAN; MAMMAL CELL; MITOSIS SPINDLE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PREDICTION; PROTEIN PROTEIN INTERACTION; SEQUENCE ANALYSIS; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

MAMMALIA;

EID: 0033635270     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(05)00020-1     Document Type: Article

References (32)

1. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma
2. Induction of apoptosis and inhibition of cell proliferation by survivin gene targeting
3. The protein data bank
4. Free R value: A novel statistical quantity for assessing the accuracy of crystal structures
5. Crystallography and NMR system: A new software suite for macromolecular structure determination
6. The CCP4 suite: Programs for protein crystallography
7. Crystal structure of the human protein kinase CK2 regulatory subunit reveals its zinc finger-mediated dimerization
8. Three differentially expressed survivin cDNA variants encode proteins with distinct antiapoptotic functions
9. Miscellaneous algorithms for density modification
10. IAP family proteins - Suppressors of apoptosis
11. Caenorhabditis elegans inhibitor of apoptosis protein (IAP) homologue BIR-1 plays a conserved role in cytokinesis
12. Selenomethionyl proteins produced for analysis by multiwavelength anomalous diffraction (MAD): A vehicle for direct determination of three-dimensional structure
13. Solution structure of a baculoviral inhibitor of apoptosis (IAP) repeat
14. Dali: A network tool for protein structure comparison
15. Surface, subunit interfaces and interior of oligomeric proteins
16. Improved methods for binding protein models in electron density maps and the location of errors in these models
17. Deterin, a new inhibitor of apoptosis from Drosophila melanogaster
18. Expression of a murine homologue of the inhibitor of apoptosis protein is related to cell proliferation
19. Control of apoptosis and mitotic spindle checkpoint by survivin
20. Pleiotropic cell-division defects and apoptosis induced by interference with survivin function
21. Cell division regulation by BIR1, a member of the inhibitor of apoptosis family in yeast
22. Expression of a novel antiapoptosis gene, survivin, correlated with tumor cell apoptosis and p53 accumulation in gastric carcinomas
23. Zinc fingers are sticking together
24. Solvent content of protein crystals
25. Crystal structure and mutagenic analysis of the inhibitor-of-apoptosis protein survivin
26. Processing of X-ray diffraction data collected in oscillation mode
27. Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1
28. NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP
29. IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs
30. Role for yeast inhibitor of apoptosis (IAP)-like proteins in cell division
31. Crystal structure of Apaf-1 caspase recruitment domain: An alpha-helical Greek key fold for apoptotic signaling
32. Participation of Bir1p, a member of the inhibitor of apoptosis family, in yeast chromosome segregation events