Instability of chromosome structure in cancer cells increases exponentially with degrees of aneuploidy

Cancer Genetics and Cytogenetics

Volumn 143, Issue 1, 2003, Pages 59-72

  Fabarius, Alice ^a   Hehlmann, Ruediger ^a   Duesberg, Peter H ^b  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANEUPLOIDY; ANIMAL CELL; ARTICLE; CANCER CELL; CATALYSIS; CHINESE HAMSTER; CHROMOSOME ABERRATION; CHROMOSOME STRUCTURE; CONTROLLED STUDY; DIPLOIDY; DNA STRAND BREAKAGE; DNA SYNTHESIS; GENE POOL; HYPOTHESIS; METAPHASE; MITOSIS; NONHUMAN; PREDICTION; PRIORITY JOURNAL; TRIPLOIDY;

CRICETINAE; CRICETULUS GRISEUS;

EID: 0038668792     PISSN: 01654608     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-4608(03)00003-7     Document Type: Article

References (66)

1. Koller P.C. The role of chromosomes in cancer biology. 1972;Springer-Verlag, New York.
2. Sandberg A.A. The chromosomes in human cancer and leukemia. 1990;Elsevier Science Publishing, New York.
3. Heim S., Mitelman F. Cancer cytogenetics. 1995;Wiley-Liss, New York.
4. Mitelman F., Mertens F., Johansson B. A breakpoint map of recurrent chromosomal rearrangements in human neoplasia. Nat Genet. 15:1997;S417-S474. [special number].
5. ISCN. Guidelines for cancer cytogenetics: supplement to an international system for human cytogenetic nomenclature. Mitelman F, editor. Basel: S. Karger, 1991.
6. Atkin N.B. Lack of reciprocal translocations in carcinomas. Cancer Genet Cytogenet. 21:1986;275-278.
7. Lindsley D.L., Sandler L., Baker B.S., Carpenter A.T.C., Denell R.E., Hall J.C., Jacobs P.A., Gabor Miklos G.L., Davis B.K., Gethmann R.C., Hardy R.W., Hessler A., Miller S.M., Nozawa H., Parry D.M., Gould-Somero M. Segmental aneuploidy and the genetic gross structure of the Drosophila genome. Genetics. 71:1972;157-184.
8. Oshimura M., Barrett J.C. Chemically induced aneuploidy in mammalian cells. mechanisms and biological significance in cancer Environ Mutagen. 8:1986;129-159.
9. Liu P., Zhang H., McLellan A., Vogel H., Bradley A. Embryonic lethality and tumorigenesis caused by segmental aneuploidy on mouse chromosome 11. Genetics. 150:1998;1155-1168.
10. Rasnick D., Duesberg P. How aneuploidy affects metabolic control and causes cancer. Biochem J. 340:1999;621-630.
11. Duesberg P., Rasnick D. Aneuploidy, the somatic mutation that makes cancer a species of its own. Cell Motil Cytoskeleton. 47:2000;81-107.
12. Li R., Sonik A., Stindl R., Rasnick D., Duesberg P. Aneuploidy versus gene mutation hypothesis of cancer. recent study claims mutation, but is found to support aneuploidy Proc Natl Acad Sci U S A. 97:2000;3236-3241.
13. Li R, Rasnick D, Duesberg P. Correspondence re: D. Zimonjic et al., Derivation of human tumor cells in vitro without widespread genomic instability [Cancer Res 2001;61:8838-44]. Cancer Res 2002;62:6345-8; author reply 6348-9.
14. Fabarius A., Willer A., Yerganian G., Hehlmann R., Duesberg P. Specific aneusomies in Chinese hamster cells at different stages of neoplastic transformation, initiated by nitrosomethylurea. Proc Natl Acad Sci U S A. 99:2002;6778-6783.
15. Marx J. Debate surges over the origins of genomic defects in cancer. Science. 297:2002;544-546.
16. Nowell P.C. The clonal evolution of tumor cell populations. Science. 194:1976;23-28.
17. Loeb L.A. Mutator phenotype may be required for multistage carcinogenesis. Cancer Res. 51:1991;3075-3079.
18. Lengauer C. How do tumors make ends meet? Proc Natl Acad Sci U S A. 98:2001;12331-12333.
19. Abdel-Rahman W.M., Katsura K., Rens W., Gorman P.A., Sheer D., Bicknell D., Bodmer W.F., Arends M.J., Wyllie A.H., Edwards P.A. Spectral karyotyping suggests additional subsets of colorectal cancers characterized by pattern of chromosome rearrangement. Proc Natl Acad Sci U S A. 98:2001;2538-2543.
20. Gisselsson D., Jonson T., Petersen A., Strombeck B., Dal Cin P., Hoglund M., Mitelman F., Mertens F., Mandahl N. Telomere dysfunction triggers extensive DNA fragmentation and evolution of complex chromosome abnormalities in human malignant tumors. Proc Natl Acad Sci U S A. 98:2001;12683-12688.
21. Anderson G.R., Brenner B.M., Swede H., Chen N., Henry W.M., Conroy J.M., Karpenko M.J., Issa J.P., Bartos J.D., Brunelle J.K., Jahreis G.P., Kahlenberg M.S., Basik M., Sait S., Rodriguez-Bigas M.A., Nowak N.J., Petrelli N.J., Shows T.B., Stoler D.L. Intrachromosomal genomic instability in human sporadic colorectal cancer measured by genome-wide allelotyping and inter- (simple sequence repeat) PCR. Cancer Res. 61:2001;8274-8283.
22. Thiagalingam S., Laken S., Willson J.K., Markowitz S.D., Kinzler K.W., Vogelstein B., Lengauer C. Mechanisms underlying losses of heterozygosity in human colorectal cancers. Proc Natl Acad Sci U S A. 98:2001;2698-2702.
23. Atkin N.B., Baker M.C. Are human cancers ever diploid-or often trisomic? Conflicting evidence from direct preparations and cultures. Cytogenet Cell Genet. 53:1990;58-60.
24. Atkin N.B. Non-random chromosomal changes in human neoplasia. Sobti R., Obe G. Eukaryotic chromosomes. structural and functional aspects:1991;153-164 Springer Verlag; New Delhi: Narosa Publishing House, New York.
25. Lewin B. Genes VI. 1997;Oxford University Press, Oxford.
26. Das S.K., Kunkel T.A., Loeb L.A. Effects of altered nucleotide concentrations on the fidelity of DNA replication. Basic Life Sci. 31:1985;117-126.
27. Ruddon R.W. Cancer biology. 1981;Oxford University Press, New York.
28. Celeste A., Petersen S., Romanienko P.J., Fernandez-Capetillo O., Chen H.T., Sedelnikova O.A., Reina-San-Martin B., Coppola V., Meffre E., Difilippantonio M.J., Redon C., Pilch D.R., Olaru A., Eckhaus M., Camerini-Otero R.D., Tessarollo L., Livak F., Manova K., Bonner W.M., Nussenzweig M.C., Nussenzweig A. Genomic instability in mice lacking histone H2AX. Science. 296:2002;922-927.
29. Masuda A., Takahashi T. Chromosome instability in human lung cancers. possible underlying mechanisms and potential consequences in the pathogenesis Oncogene. 21:2002;6884-6897.
30. Yerganian G., Leonard M. Maintenance of normal in situ chromosomal features in long-term tissue cultures. Science. 133:1961;1600-1601.
31. Ray M., Mohandas T. Proposed banding nomenclature for the Chinese hamster chromosomes (Cricetulus griseus). Cytogenet Cell Genet. 16:1976;83-91.
32. Lavappa K.S. Chromosome banding patterns and ideogram of the Armenia hamster, Cricetulus migratorius. Cytologia (Tokyo). 42:1977;65-72.
33. Duesberg P., Stindl R., Hehlmann R. Explaining the high mutation rates of cancer cells to drug and multidrug resistance by chromosome reassortments that are catalyzed by aneuploidy. Proc Natl Acad Sci U S A. 97:2000;14295-14300.
34. Li R., Yerganian G., Duesberg P., Kraemer A., Willer A., Rausch C., Hehlmann R. Aneuploidy correlated 100% with chemical transformation of Chinese hamster cells. Proc Natl Acad Sci U S A. 94:1997;14506-14511.
35. Duesberg P., Rausch C., Rasnick D., Hehlmann R. Genetic instability of cancer cells is proportional to their degree of aneuploidy. Proc Natl Acad Sci U S A. 95:1998;13692-13697.
36. Fonatsch C., Schaadt M., Kirchner H., Diehl V. A possible correlation between the degree of karyotype aberrations and the rate of sister chromatid exchanges in lymphoma lines. Int J Cancer. 26:1980;749-756.
37. Deaven L.L., Petersen D.F. The chromosomes of CHO, an aneuploid Chinese hamster cell line. G-band, C-band, and autoradiographic analyses Chromosoma. 41:1973;129-144.
38. Cairns J. Cancer. science and society:1978;W.H. Freeman, San Francisco.
39. Cram L.S., Bartholdi M.F., Ray F.A., Travis G.L., Kraemer P.M. Spontaneous neoplastic evolution of Chinese hamster cells in culture. multistep progression of karyotype Cancer Res. 43:1983;4828-4837.
40. Kirkland D.J., Venitt S. Chemical transformation of Chinese hamster cells. II. appearance of marker chromosomes in transformed cells Br J Cancer. 34:1976;145-152.
41. Hieter P., Griffiths T. Polyploidy - more is more or less. Science. 285:1999;210-211.
42. Duesberg P., Stindl R., Hehlmann R. Origin of multidrug resistance in cells with and without multidrug resistance genes. chromosome reassortments catalyzed by aneuploidy Proc Natl Acad Sci U S A. 98:2001;11283-11288.
43. Ried T., Heselmeyer-Haddad K., Blegen H., Schrock E., Auer G. Genomic changes defining the genesis, progression, and malignancy potential in solid human tumors. a phenotype/genotype correlation Genes Chromosomes Cancer. 25:1999;195-204.
44. Nitta M., Tsuiki H., Arima Y., Harada K., Nishizaki T., Sasaki K., Mimori T., Ushio Y., Saya H. Hyperploidy induced by drugs that inhibit formation of microtubules promotes chromosome instability. Genes Cells. 7:2002;151-162.
45. Heim S., Mandahl N., Mitelman F. Genetic convergence and divergence in tumor progression. Cancer Res. 48:1988;5911-5916.
46. Chiba S., Okuda M., Mussman J.G., Fukasawa K. Genomic convergence and suppression of centrosome hyperamplification in primary p53-/- cells in prolonged culture. Exp Cell Res. 258:2000;310-321.
47. Lengauer C., Kinzler K.W., Vogelstein B. Genetic instability in colo-rectal cancers. Nature. 386:1997;623-627.
48. Furuya T., Uchiyama T., Murakami T., Adachi A., Kawauchi S., Oga A., Hirano T., Sasaki K. Relationship between chromosomal instability and intratumoral regional DNA ploidy heterogeneity in primary gastric cancers. Clin Cancer Res. 6:2000;2815-2820.
49. Miyazaki M., Furuya T., Shiraki A., Sato T., Oga A., Sasaki K. The relationship of DNA ploidy to chromosomal instability in primary human colorectal cancers. Cancer Res. 59:1999;5283-5285.
50. Yoon D.S., Wersto R.P., Zhou W., Chrest F.J., Garrett E.S., Kwon T.K., Gabrielson E. Variable levels of chromosomal instability and mitotic spindle checkpoint defects in breast cancer. Am J Pathol. 161:2002;391-397.
51. Strauss B.S. The origin of point mutations in human tumor cells. Cancer Res. 52:1992;249-253.
52. Boland C.R., Ricciardello L. How many mutations does it take to make a tumor? Proc Natl Acad Sci U S A. 96:1999;14675-14677.
53. Rachko D., Brand K.G. Chromosomal aberrations in foreign body tumorigenesis of mice. Proc Soc Exp Biol Med. 172:1983;382-388.
54. Duesberg P., Li R., Rasnick D., Rausch C., Willer A., Kraemer A., Yerganian G., Hehlmann R. Aneuploidy precedes and segregates with chemical carcinogenesis. Cancer Genet Cytogenet. 119:2000;83-93.
55. Vanderlaan M., Steele V., Nettesheim P. Increased DNA content as an early marker of transformation in carcinogen-exposed rat tracheal cell cultures. Carcinogenesis. 4:1983;721-727.
56. Danielsen H.E., Brogger A., Reith A. Specific gain of chromosome 19 in preneoplastic mouse liver cells after diethylnitrosamine treatment. Carcinogenesis. 12:1991;1777-1780.
57. Bremner R., Balmain A. Genetic changes in skin tumor progression. correlation between presence of a mutant ras gene and loss of heterozygosity on mouse chromosome 7 Cell. 61:1990;407-417.
58. Shih I.M., Zhou W., Goodman S.N., Lengauer C., Kinzler K.W., Vogelstein B. Evidence that genetic instability occurs at an early stage of colorectal tumorigenesis. Cancer Res. 61:2001;818-822.
59. Nasiell M., Kato H., Auer G., Zetterberg A., Roger V., Karlen L. Cytomorphological grading and Feulgen DNA-analysis of metaplastic and neoplastic bronchial cells. Cancer. 41:1978;1511-1521.
60. Jin Y., Jin C., Salemark L., Wennerberg J., Persson B., Jonsson N. Clonal chromosome abnormalities in premalignant lesions of the skin. Cancer Genet Cytogenet. 136:2002;48-52.
61. Sudbo J., Kildal W., Risberg B., Koppang H.S., Danielsen H.E., Reith A. DNA content as a prognostic marker in patients with oral leukoplakia. N Engl J Med. 344:2001;1270-1278.
62. Jenkins R.B., Qian J., Lieber M.M., Bostwick D.G. Detection of c-myc oncogene amplification and chromosomal anomalies in metastatic prostatic carcinoma by fluorescence in situ hybridization. Cancer Res. 57:1997;524-531.
63. Giaretti W., Monaco R., Pujic N., Rapallo A., Nigro S., Geido E. Intratumor heterogeneity of K-ras2 mutations in colorectal adenocarcinomas. association with degree of DNA aneuploidy Am J Pathol. 149:1996;237-245.
64. Harris C.C. Chemical and physical carcinogenesis. advances and perspective for the 1990s Cancer Res. 51:1991;5023s-5044s.
65. Kraemer P.M., Deaven L.L., Crissman H.A., Steinkamp J.A., Petersen D.F. On the nature of heteroploidy. Cold Spring Harbor Symposia on Quantitative Biology. 38:1974;133-144.
66. Duesberg P., Stindl R., Li R., Hehlmann R., Rasnick D. Aneuploidy versus gene mutation as cause of cancer. Current Science. 81:2001;490-500.