Drosophila aurora B kinase is required for histone H3 phosphorylation and condensin recruitment during chromosome condensation and to organize the central spindle during cytokinesis

Journal of Cell Biology

Volumn 152, Issue 4, 2001, Pages 669-681

  Giet, Régis ^a   Glover, David M ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Aurora B kinase; Barren; Chromosome condensation; Cytokinesis; Phospho histone H3

Indexed keywords

AURORA B KINASE; CELL PROTEIN; CONDENSIN; DOUBLE STRANDED RNA; HISTONE H3; PROTEIN KINASE; UNCLASSIFIED DRUG;

ANAPHASE; ANIMAL CELL; ARTICLE; CHROMOSOME CONDENSATION; CONTROLLED STUDY; CYTOKINESIS; DROSOPHILA; GENE MUTATION; METAPHASE; MITOSIS SPINDLE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

ADENOSINE TRIPHOSPHATASES; ANIMALS; CAENORHABDITIS ELEGANS PROTEINS; CELL CYCLE PROTEINS; CELL DIVISION; CELLS, CULTURED; CENTROMERE; CHROMOSOME SEGREGATION; CHROMOSOMES; DNA-BINDING PROTEINS; DROSOPHILA; DROSOPHILA PROTEINS; HISTONES; KINESIN; MICROTUBULE-ASSOCIATED PROTEINS; MITOTIC SPINDLE APPARATUS; MULTIPROTEIN COMPLEXES; PHOSPHORYLATION; POLYPLOIDY; PROTEIN-SERINE-THREONINE KINASES; RNA, ANTISENSE; RNA, SMALL INTERFERING;

ANIMALIA;

EID: 0035911159     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.152.4.669     Document Type: Article

References (46)

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2. INCENP binds the aurora-related kinase AIRK2 and is required to target it to chromosomes, the central spindle and cleavage furrow
3. Chromatid segregation at anaphase requires the barren product, a novel chromosome-associated protein that interacts with Topoisomerase II
4. The conserved protein kinase Ip11 regulates microtubule binding to kinetochores in budding yeast
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7. Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways
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9. Core histone N-termini play an essential role in mitotic chromosome condensation
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13. The Xenopus laevis aurora/Ip11p-related kinase pEg2 participates in the stability of the bipolar mitotic spindle
14. The Xenopus laevis aurora-related protein kinase pEg2 associates with and phosphorylates the kinesin-related protein X1Eg5
15. Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles
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19. Condensins, chromosome condensation protein complexes containing XCAP-C, XCAP-E and a Xenopus homolog of the Drosophila barren protein
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22. Gene silencing: Shrinking the black box of RNAi
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25. ATP-dependent positive supercoiling of DNA by 13S condensin: A biochemical implication for chromosome condensation
26. Phosphorylation and activation of 13S condensin by Cdc2 in vitro
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33. Gene targeting by homologous recombination in Drosophila
34. Regulation of Saccharomyces cerevisiae kinetochores by the type 1 phosphatase G1c7p
35. A human condensin complex containing hCAP-C-hCAP-E and CNAP1, a homolog of Xenopus XCAP-D2, colocalizes with phosphorylated histone H3 during the early stage of mitotic chromosome condensation
36. AIR-2: An Aurora/Ip11-related protein kinase associated with chromosomes and midbody microtubules is required for polar body extrusion and cytokinesis in Caenorhabditis elegans embryos
37. The Aurora-related kinase AIR-2 recruits ZEN-4/CeMKLP1 to the mitotic spindle at metaphase and is required for cytokinesis
38. The survivin-like C elegans BIR-1 protein acts with the Aurora-like kinase AIR-2 to affect chromosomes and the spindle midzone
39. A kinase-anchoring protein (AKAP)95 recruits human chromosome-associated protein (hCAP)-D2/Eg7 for chromosome condensation in mitotic extract
40. Fission yeast condensin complex: Essential roles of non-SMC subunits for condensation and Cdc2 phosphorylation of Cut3/SMC4
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45. The A- and B-type cyclins of Drosophila are accumulated and destroyed in temporally distinct events that define separable phases of the G2-M transition
46. Stu-7/air-2 is a C. elegans aurora homologue essential for chromosome segregation during embryonic and postembryonic development