Carbon monoxide: Endogenous production, physiological functions, and pharmacological applications

Pharmacological Reviews

Volumn 57, Issue 4, 2005, Pages 585-630

  Wu, Lingyun ^a   Wang, Rui ^b  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

^b LAKEHEAD UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON MONOXIDE; COMPLEMENTARY DNA; GLUTATHIONE TRANSFERASE; HEME; HEME DERIVATIVE; HEME OXYGENASE; HEME OXYGENASE 1; MESSENGER RNA; N(G) NITROARGININE METHYL ESTER; RETROVIRUS VECTOR; SCAVENGER;

BLOOD VESSEL COMPLIANCE; CALCIUM BINDING; CHEMICAL REACTION; CHEMORECEPTOR; DOWN REGULATION; ENZYME ACTIVITY; ENZYME LOCALIZATION; EXPIRATORY FLOW; FETOPLACENTAL UNIT; GENE OVEREXPRESSION; GENE TRANSFER; HEARING ACUITY; HEME SYNTHESIS; LEARNING; LONG TERM POTENTIATION; MOLECULAR CLONING; NOCICEPTION; NONHUMAN; OLFACTORY DISCRIMINATION; OXIDATION KINETICS; OXYGEN AFFINITY; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW; STRUCTURAL HOMOLOGY; THERMOREGULATION; THROMBOCYTE AGGREGATION; UPREGULATION; VIRAL GENE DELIVERY SYSTEM; VISUAL ACUITY;

ANIMALS; CARBON MONOXIDE; HEME; HEME OXYGENASE (DECYCLIZING); HUMANS; ION CHANNELS; NITRIC OXIDE SYNTHASE;

EID: 29844442868     PISSN: 00316997     EISSN: 15210081     Source Type: Journal    
DOI: 10.1124/pr.57.4.3     Document Type: Review

References (546)

1. Abraham NG (2003) Therapeutic applications of human heme oxygenase gene transfer and gene therapy. Curr Pharm Des 9:2513-2524.
2. Abraham NG, Botros FT, Rezzani R, Rodella L, Bianchi R, and Goodman AI (2002) Differential effect of cobalt protoporphyrin on distributions of heme oxygenase in renal structure and on blood pressure in SHR. Cell Mol Biol 48:895-902.
3. Abraham NG, Drummond GS, Lutton JD, and Kappas A (1996) The biological significance and physiological role of heme oxygenase. Cell Physiol Biochem 6:129-168.
4. Abraham NG, Lin JH, Schwartzman ML, Levere RD, and Shibahara S (1988) The physiological significance of heme oxygenase. Int J Biochem 20:543-558.
5. Abraham NG, Scapagnini G, and Kappas A (2003) Human heme oxygenase: cell cycle-dependent expression and DNA microarray identification of multiple gene responses after transduction of endothelial cells. J Cell Biochem 90:1098-1111.
6. Acevedo CH and Ahmed A (1998) Heme oxygenase-1 inhibits human myometrial contractility via carbon monoxide and is upregulated by progesterone during pregnancy. J Clin Investig 101:949-955.
7. Agarwal A, Balla J, Alam J, Croatt AJ, and Nath KA (1995) Induction of heme oxygenase in toxic renal injury: a protective role in cisplatin nephrotoxicity in the rat. Kidney Int 48:1298-1307.
8. Aizawa T, Ishizaka N, Taguchi J, Nagai R, Mori I, Tang SS, Ingelfinger JR, and Ohno M (2000) Heme oxygenase-1 is upregulated in the kidney of angiotensin II-induced hypertensive rats: possible role in renoprotection. Hypertension 35:800-806.
9. Alam J, Cai J, and Smith A (1994) Isolation and characterization of the mouse heme oxygenase-1 gene. Distal 5′ sequences are required for induction by heme or heavy metals. J Biol Chem 269:1001-1009.
10. Alam J, Wicks C, Stewart D, Gong P, Touchard C, Otterbein S, Choi AMK, Burow ME, and Tou J-S (2000) Mechanism of heme oxygenase-1 gene activation by cadmium in MCF-7 mammary epithelial cells. Role of p38 kinase and Nrf2 transcription factor. J Biol Chem 275:27694-27702.
11. Alcaraz MJ, Fernandez P, and Guillen MI (2003) Anti-inflammatory actions of the heme oxygenase-1 pathway. Curr Pharm Des 9:2541-2551.
12. Alcaraz MJ, Habib A, Creminon C, Vicente AM, Lebret M, Levy-Toledano S, and Maclouf J (2001) Heme oxygenase-1 induction by nitric oxide in RAW 264.7 macrophages is upregulated by a cyclo-oxygenase-2 inhibitor. Biochim Biophys Acta 1526:13-16.
13. Alexanderanu IC and Lawson DM (2003) Heme oxygenase in the rat ovary: immunohistochemical localization and possible role in steroidogenesis. Exp Biol Med 228:59-63.
14. Allen ER (1977) Properties and reactions of carbon monoxide, in Carbon Monoxide (National Research Council-Subcommittee on Carbon Monoxide) pp 4-27, National Academy of Sciences.
15. Allen TA and Root WS (1957) Partition of carbon monoxide and oxygen between air and whole blood of rats, dogs and men as affected by plasma pH. J Appl Physiol Respir Environ Exerc Physiol 10:186.
16. Alm P, Ekstrom P, Henningsson R, and Lundquist I (1999) Morphological evidence for the existence of nitric oxide and carbon monoxide pathways in the rat islets of Langerhans: an immunocytochemical and confocal microscopic study. Diabetologia 42:978-986.
17. Amersi F, Buelow R, Kato H, Ke B, Coito AJ, Shen XD, Zhao D, Zaky J, Melinek J, Lassman CR, et al. (1999) Upregulation of heme oxygenase-1 protects genetically fat Zucker rat livers from ischemia/reperfusion injury. J Clin Investig 104:1631-1639.
18. Andersen ME, Clewell HJ 3rd, Mahle DA, and Gearhart JM (1994) Gas uptake studies of deuterium isotope effects on dichloromethane metabolism in female B6C3F1 mice in vivo. Toxicol Appl Pharmacol 128:158-165.
19. Andersson JA, Uddman R, Tajti J, and Cardell LO (2002) Heme oxygenase and nitric oxide synthase in human middle ear epithelium indicates local carbon monoxide and nitric oxide production. Acta Otolaryngol 122:634-637.
20. Applegate LA, Luscher P, and Tyrrell RM (1991) Induction of heme oxygenase: a general response to oxidant stress in cultured mammalian cells. Cancer Res 51:974-978.
21. Appleton SD, Marks GS, Nakatsu K, Brien JF, Smith GN, and Graham CH (2002) Heme oxygenase activity in placenta: direct dependence on oxygen availability. Am J Physiol Heart Circ Physiol 282:H2055-H2059.
22. Archakov AI, Devichensky VM, and Karjakin AV (1975) Participation of cytochrome b5 in the NADPH oxidation reaction. The evidence for two cytochromes b5 in liver microsomes. Arch Biochem Biophys 166:295-307.
23. Archakov AI, Karuzina II, Petushkova NA, Lisitsa AV, and Zgoda VG (2002) Production of carbon monoxide by cytochrome P450 during iron-dependent lipid peroxidation. Toxicol In Vitro 16:1-10.
24. Arias-Diaz J, Villa N, Hernandez J, Vara E, and Balibrea JL (1997) Carbon monoxide contributes to the cytokine-induced inhibition of surfactant synthesis by human type II pneumocytes. Arch Surg 132:1352-1360.
25. Artinian LR, Ding JM, and Gillette MU (2001) Carbon monoxide and nitric oxide: interacting messengers in muscarinic signaling to the brain's circadian clock. Exp Neurol 171:293-300.
26. + channels and non-selective cation channels to membrane potential of pulmonary arterial smooth muscle cells of the rabbit. J Physiol (Lond) 514:747-758.
27. Bak I, Szendrei L, Turoczi T, Papp G, Joo F, Das DK, de Leiris J, Der P, Juhasz B, Varga E, et al. (2003) Heme oxygenase-1-related carbon monoxide production and ventricular fibrillation in isolated ischemic/reperfused mouse myocardium. FASEB J 17:2133-2135.
28. Baker HM, Anderson BF, and Baker EN (2003) Dealing with iron: common structural principles in proteins that transport iron and heme. Proc Natl Acad Sci USA 100:3579-3583.
29. Bakken AF, Thaler MM, and Schmid R (1972) Metabolic regulation of heme catabolism and bilirubin production. Hormonal control of hepatic heme oxygenase activity. J Clin Investig 51:530-536.
30. Balazy M, Kaminski PM, Mao K, Tan J, and Wolin MS (1998) S-Nitrosoglutathione, a product of the reaction between peroxynitrite and glutathione that generates nitric oxide. J Biol Chem 273:32009-32015.
31. Balla G, Jacob HS, Balla J, Rosenberg M, Nath K, Apple F, Eaton JW, and Vercellotti GM (1992) Ferritin: a cytoprotective antioxidant stratagem of endothelium. J Biol Chem 267:18148-18153.
32. Balla G, Vercellotti GM, Muller-Eberhard U, Eaton J, and Jacob HS (1991) Exposure of endothelial cells to free heme potentiates damage mediated by granulocytes and toxic oxygen species. Lab Investig 64:648-655.
33. Balla J, Jacob HS, Balla G, Nath K, Eaton JW, and Vercellotti GM (1993) Endothelial-cell heme uptake from heme proteins: induction of sensitization and desensitization to oxidant damage. Proc Natl Acad Sci USA 90:9285-9289.
34. Balla J, Nath KA, Balla G, Juckett MB, Jacob HS, and Vercellotti GM (1995) Endothelial cell heme oxygenase and ferritin induction in rat lung by hemoglobin in vivo. Am J Physiol Lung Cell Mol Physiol 268:L321-L327.
35. Baranano DE, Rao M, Ferris CD, and Snyder SH (2002) Biliverdin reductase: a major physiologic cytoprotectant. Proc Natl Acad Sci USA 99:16093-16098.
36. Baranano DE, Wolosker H, Bae BI, Barrow RK, Snyder SH, and Ferris CD (2000) A mammalian iron ATPase induced by iron. J Biol Chem 275:15166-15173.
37. Barber A, Robson SC, and Lyall E (1999) Hemeoxygenase and nitric oxide synthase do not maintain human uterine quiescence during pregnancy. Am J Pathol 155:831-840.
38. Barber A, Robson SC, Myatt L, Bulmer JN, and Lyall F (2001) Heme oxygenase expression in human placenta and placental bed: reduced expression of placenta endothelial HO-2 in preeclampsia and fetal growth restriction. FASEB J 15:1158-1168.
39. Barkoudah E, Jaggar JH, and Leffler CW (2004) The permissive role of endothelial NO in CO-induced cerebrovascular dilation. Am J Physiol Heart Circ Physiol 287:H1459-H1465.
40. Bauer M and Bauer I (2003) Heme oxygenase-1: redox regulation and role in the hepatic response to oxidative stress. Antioxid Redox Signal 4:749-758.
41. Beckman JS, Beckman TW, Chen J, Marshall PA, and Freeman BA (1990) Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA 87:1620-1624.
42. Bergeron M, Ferriero DM, and Sharp FR (1998) Developmental expression of heme oxygenase-1 (HSP32) in rat brain: an immunocytochemical study. Brain Res Dev Brain Res 105:181-194.
43. Beri R and Chandra R (1993) Chemistry and biology of heme. Effect of metal salts, organometals, and metalloporphyrins on heme synthesis and catabolism, with special reference to clinical implications and interactions with cytochrome P-450. Drug Metab Rev 25:49-152.
44. Bernard C (1857) Lecons Sur les Effets des Substances Toxiques et Medicamenteuses. Bailliere, Paris.
45. Beschorner R, Adjodah D, Schwab JM, Mittelbronn M, Pedal I, Mattern R, Schluesener HJ, and Meyermann R (2000) Long-term expression of heme oxygenase-1 (HO-1, HSP-32) following focal cerebral infarctions and traumatic brain injury in humans. Acta Neuropathol (Berl) 100:377-384.
46. Bhuyan AK and Kumar R (2002) Kinetic barriers to the folding of horse cytochrome c in the reduced state. Biochemistry 41:12821-12834.
47. Bidmon H-J, Emde B, Oermann E, Kubitz R, Witte OW, and Zilles K (2001) Heme oxygenase-1 (HSP-32) and heme oxygenase-2 induction in neurons and glial cells of cerebral regions and its relation to iron accumulation after focal cortical photothrombosis. Exp Neurol 168:1-22.
48. Blute TA, Lee MR, and Eldred MD (2000) Direct imaging of NMDA-stimulated nitric oxide production in the retina. Vis Neurosci 17:557-566.
49. Boehning D, Moon C, Sharma S, Hurt KJ, Hester LD, Ronnett GV, Shugar D, and Snyder SH (2003) Carbon monoxide neurotransmission activated by CK2 phosphorylation of heme oxygenase-2. Neuron 40:129-137.
50. Boehning D, Sedaghat L, Sedlak TW, and Snyder SH (2004) Heme oxygenase-2 is activated by calcium-calmodulin. J Biol Chem 279:30927-30930.
51. Botros FT, Laniado-Schwartzman M, and Abraham NG (2002) Regulation of cyclooxygenase-and cytochrome p450-derived eicosanoids by heme oxygenase in the rat kidney. Hypertension 39:639-644.
52. Bouton C and Demple B (2000) Nitric oxide-inducible expression of heme oxygenase-1 in human cells. Translation-independent stabilization of the mRNA and evidence for direct action of nitric oxide. J Biol Chem 275:32688-32693.
53. Brian JE Jr, Heistad DD, and Faraci FM (1994) Effect of carbon monoxide on rabbit cerebral arteries. Stroke 25:639-643.
54. Brouard S, Berberat PO, Tobiasch E, Seldon MP, Bach FH, and Soares MP (2002) Heme oxygenase-1-derived carbon monoxide requires the activation of transcription factor NF-kappa B to protect endothelial cells from tumor necrosis factoralpha-mediated apoptosis. J Biol Chem 277:17950-17961.
55. Brouard S, Otterbein LE, Anrather J, Tobiasch E, Bach FH, Choi AM, and Soares MP (2000) Carbon monoxide generated by heme oxygenase 1 suppresses endothelial cell apoptosis. J Exp Med 192:1015-1026.
56. Brown SD and Piantadosi CA (1992) Recovery of energy metabolism in rat brain after carbon monoxide hypoxia. J Clin Investig 89:666-672.
57. Brune B, Schmidt KU, and Ullrich V (1990) Activation of soluble guanylate cyclase by carbon monoxide and inhibition by superoxide anion. Eur J Biochem 192:683-688.
58. Brune B and Ullrich V (1987) Inhibition of platelet aggregation by carbon monoxide is mediated by activation of guanylate cyclase. Mol Pharmacol 32:497-504.
59. Burmester T, Welch B, Reinhardt S, and Hankeln T (2000) A vertebrate globin expressed in the brain. Nature (Lond) 407:520-523.
60. Burnett AL, Johns DG, Kriegsfeld LJ, Klein SL, Calvin DC, Demas GE, Schramm LP, Tonegawa S, Nelson RJ, Snyder SH, and Poss KD (1998) Ejaculatory abnormalities in mice with targeted disruption of the gene for heme oxygenase-2. Nat Med 4:84-87.
61. Cagiano R, Ancona D, Cassano T, Tattoli M, Trabace L, and Cuomo V (1998) Effects of prenatal exposure to low concentrations of carbon monoxide on sexual behaviour and mesolimbic dopaminergic function in rat offspring. Br J Pharmacol 125:909-915.
62. Cantrell JM and Tucker A (1995) Low dose carbon monoxide does not reduce vasoconstriction in isolated rat lungs. Exp Lung Res 22:21-32.
63. Cao L, Blute TA, and Eldred WD (2000) Localization of heme oxygenase-2 and modulation of cGMP levels by carbon monoxide and/or nitric oxide in the retina. Vis Neurosci 17:319-329.
64. Cao L and Eldred WD (2003) Inhibitors of nitric oxide synthase block carbon monoxide-induced increases in cGMP in retina. Brain Res 988:78-83.
65. Carlsson GH, Nicholls P, Svistunenko D, Berglund GI, and Hajdu J (2005) Complexes of horseradish peroxidase with formate, acetate and carbon monoxide. Biochemistry 44:635-642.
66. Carratu MR, Renna G, Giustino A, De Salvia MA, and Cuomo V (1993) Changes in peripheral nervous system activity produced in rats by prenatal exposure to carbon monoxide. Arch Toxicol 67:297-301.
67. Carraway MS, Ghio AJ, Suliman HB, Carter JD, Whorton AR, and Piantadosi CA (2002) Carbon monoxide promotes hypoxic pulmonary vascular remodeling. Am J Physiol Lung Cell Mol Physiol 282:L693-L702.
68. Cavicchi M, Gibbs L, and Whittle BJ (2000) Inhibition of inducible nitric oxide synthase in the human intestinal epithelial cell line, DLD-1, by the inducers of heme oxygenase 1, bismuth salts, heme and nitric oxide donors. Gut 47:771-778.
69. Chang EF, Wong RJ, Vreman HJ, Igarashi T, Galo E, Sharp FR, Stevenson DK, and Noble-Haeusslein LJ (2003) Heme oxygenase-2 protects against lipid peroxidationmediated cell loss and impaired motor recovery after traumatic brain injury. J Neurosci 23:3689-3696.
70. Chauveau C, Bouchet D, Roussel JC, Mathieu P, Braudeau C, Renaudin K, Tesson L, Soulillou JP, Iyer S, Buelow R, and Anegon I (2002) Gene transfer of heme oxygenase-1 and carbon monoxide delivery inhibit chronic rejection. Am J Transplant 2:581-592.
71. Chen K and Maines MD (2000) Nitric oxide induces heme oxygenase-1 via mitogenactivated protein kinases ERK and p38. Cell Mol Biol 46:609-617.
72. Christodoulides N, Durante W, Kroll MH, and Schafer AI (1995) Vascular smooth muscle cell heme oxygenase generate guanyl cyclase-stimulatory carbon monoxide. Circulation 91:2306-2309.
73. Christou H, Morita T, Hsieh C-M, Koike H, Arkonac B, Perrella MA, and Kourembanas S (2000) Prevention of hypoxia-induced pulmonary hypertension by enhancement of endogenous heme oxygenase-1 in the rat. Circ Res 86:1224-1229.
74. Ciccognani DT, Hughes MN, and Poole RK (1992) Carbon monoxide-binding properties of the cytochrome bo quinol oxidase complex in Escherichia coli are changed by copper deficiency in continuous culture. FEMS Microbiol Lett 73:1-6.
75. Clark JE, Foresti R, Sarathchandra P, Kaur H, Green CJ, and Motterlini R (2000) Heme oxygenase-1-derived bilirubin ameliorates postischemic myocardial dysfunction. Am J Physiol Heart Circ Physiol 278:H643-H651.
76. Clark JE, Naughton P, Shurey S, Green CJ, Johnson TR, Mann BE, Foresti R, and Motterlini R (2003) Cardioprotective actions by a water-soluble carbon monoxidereleasing molecule. Circ Res 93:e2-e8.
77. Coburn RF (1970a) Enhancement by phenobarbitol and diphenylhydantoin of carbon monoxide production in normal man. N Engl J Med 283:512-515.
78. Coburn RF (1970b) The carbon monoxide body stores. Ann NY Acad Sci 174:11-22.
79. Coburn RF and Forman HJ (1987) Carbon monoxide toxicity. Handbook Physiol 4:439-456.
80. Coburn RF and Mayers LB (1971) Myoglobin oxygen tension determined from measurements of carboxymyglobin in skeletal muscle. Am J Physiol 220:66-74.
81. Coburn RF, Williams WJ, and Forster RE (1965) Effect of erythrocyte destruction on carbon monoxide production in man. J Clin Investig 43:1098-1103.
82. Coburn RF, Williams WI, and Kahn SB (1966) Endogenous carbon monoxide production in patients with hemolytic anemia. J Clin Investig 45:460-468.
83. Coceani F, Breen CA, Lees JG, Falk JR, and Olley PM (1988) Further evidence implicating a cytochrome P450 mediated reaction in the contractile tension of the lamb ductus arteriosus. Circ Res 62:471-477.
84. Coceani F, Hamilton NC, Labuc J, and Olley PM (1984) Cytochrome P450-linked monooxygenase: involvement in the lamb ductus arteriosus. Am J Physiol 246: H640-H643.
85. Cuturi MC, Christoph F, Woo J, Iyer S, Brouard S, Heslan JM, Pignon P, Soulillou JP, and Buelow R (1999) RDP1258, a new rationally designed immunosuppressive peptide, prolongs allograft survival in rats: analysis of its mechanism of action. Mol Med 5:820-832.
86. Datta PK and Lianos EA (1999) Nitric oxide induces heme oxygenase-1 gene expression in mesangial cells. Kidney Int 55:1734-1739.
87. Delivoria-Papadopoulos M, Coburn RF, and Forster FE (1974) Cyclic variation of rate of carbon monoxide production in normal women. J Appl Physiol 36:49-51.
88. Dennery PA, Seidman DS, and Stevenson DK (2001) Neonatal hyperbilirubinemia. N Engl J Med 344:581-590.
89. Dennery PA, Spitz DR, Yang G, Tatarov A, Lee CS, Shegog ML, and Poss KD (1998) Oxygen toxicity and iron accumulation in the lungs of mice lacking heme oxygenase-2. J Clin Investig 101:1001-1011.
90. Deramaudt BM, Braunstein S, Remy P, and Abraham NG (1998) Gene transfer of human heme oxygenase into coronary endothelial cells potentially promotes angiogenesis. J Cell Biochem 68:121-127.
91. Deramaudt BM, Remy P, and Abraham NG (1999) Upregulation of human heme oxygenase gene expression by Ets-family proteins. J Cell Biochem 72:311-321.
92. Ding Y, McCoubrey WK, and Maines MD (1999) Interaction of heme oxgenase-2 with nitric oxide donors. Is the oxygenase an intracelluar 'sink' for NO? Eur J Biochem 264:854-861.
93. Dioum EM, Rutter J, Tuckerman JR, Gonzalez G, Gilles-Gonzalez MA, and McKnight SL (2002) NPAS2: a gas-responsive transcription factor. Science (Wash DC) 298:2385-2387.
94. Doi K, Akaike T, Fujii S, Tanaka S, Ikebe N, Beppu T, Shibahara S, Ogawa M, and Maeda H (1999) Induction of haem oxygenase-1 by nitric oxide and ischaemia in experimental solid tumours and implications for tumour growth. Br J Cancer 80:1945-1954.
95. Dore S, Takahashi M, Ferris CD, Zakhary R, Hester LD, Guastella D, and Snyder SH (1999) Bilirubin, formed by activation of heme oxygenase-2, protects neurons against oxidative stress injury. Proc Natl Acad Sci USA 96:2445-2450.
96. Dubuis E, Gautier M, Melin A, Rebocho M, Girardin C, Bonnet P, and Vandier C (2002) Chronic carbon monoxide enhanced IbTx-sensitive currents in rat resistance pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 283:L120-L129.
97. Ca channels. Cardiovasc Res 65:751-761.
98. Duckers HJ, Boehm M, True AL, Yet SF, San H, Park JL, Clinton Webb R, Lee ME, Nabel GJ, and Nabel EG (2001) Heme oxygenase-1 protects against vascular constriction and proliferation. Nat Med 7:693-698.
99. Dulak J and Józkowicz A (2002) Angiogenic gene therapy with vascular endothelial growth factor: hope or hype? Eur Surg 34:101-104.
100. Durante W (2002) Carbon monoxide and vascular smooth muscle cell growth, in Carbon Monoxide and Cardiovascular Functions (Wang R ed) pp 45-65, CRC Press, Boca Raton, FL.
101. Durante W, Christodoulides N, Cheng K, Peyton KJ, Sunahara RK, and Schafer AI (1997a) cAMP induces heme oxygenase-1 gene expression and carbon monoxide production in vascular smooth muscle. Am J Physiol 273:H317-H323.
102. Durante W, Kroll MH, Christodoulides N, Peyton KJ, and Schafer AI (1997b) Nitric oxide induces heme oxygenase-1 gene expression and carbon monoxide production in vascular smooth muscle cells. Circ Res 80:557-564.
103. Durante W, Peyton KJ, and Schafer AI (1999) Platelet-derived growth factor stimulates heme oxygenase-1 gene expression and carbon monoxide production in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 19:2666-2672.
104. Eisenstein RS, Garcia-Mayol D, Pettingell W, and Munro HN (1991) Regulation of ferritin and heme oxygenase synthesis in rat fibroblasts by different forms of iron. Proc Natl Acad Sci USA 88:688-692.
105. Elbirt KK, Whitmarsh AJ, Davis RJ, and Bonkovsky HL (1998) Mechanism of sodium arsenite-mediated induction of heme oxygenase-1 in hepatoma cells. Role of mitogen-activated protein kinases. J Biol Chem 273:8922-8931.
106. Escalante B, Sacerdoti D, Davidian MM, Laniado-Schwartzman M, and McGiff JC (1991) Chronic treatment with tin normalizes blood pressure in spontaneously hypertensive rats. Hypertension 17:776-779.
107. Estabrook RW, Franklin MR, and Hildebrandt AG (1980) Factors influencing the inhibitory reactions, in Biological Effects of Carbon Monoxide (Coburn RF ed) pp 218, Annals of the New York Academy of Sciences, New York.
108. Ewing JF, Haber SN, and Maines MD (1992) Normal and heat-induced patterns of expression of heme oxygenase-1 (HSP32) in rat brain: hyperthermia causes rapid induction of mRNA and protein. J Neurochem 58:1140-1149.
109. Ewing JF and Maines MD (1992) In situ hybridization and immunohistochemical localization of heme oxygenase-2 mRNA and protein in normal rat brain: differential distribution of isoenzyme 1 and 2. Mol Cell Neurosci 3:559-570.
110. Ewing JF and Maines MD (1995) Distribution of constitutive (HO-2) and heatinducible (HO-1) heme oxygenase isozymes in rat testes: HO-2 displays stagespecific expression in germ cells. Endocrinology 136:2294-2302.
111. Ewing JF, Raju VS, and Maines MD (1994) Induction of heart heme oxygenase-1 (HSP32) by hyperthermia: possible role in stress-mediated elevation of cyclic 3′:5′-guanosine monophosphate. J Pharmacol Exp Ther 271:408-414.
112. Fagan KA, Fouty BW, Tyler RC, Morris KG Jr, Hepler LK, Sato K, LeCras TD, Abman SH, Weinberger HD, Huang PL, et al. (1999) The pulmonary circulation of homozygous or heterozygous eNOS-null mice is hyperresponsive to mild hypoxia. J Clin Investig 103:291-299.
113. Fang J, Akaike T, and Maeda H (2004) Antiapoptotic role of heme oxygenase (HO) and the potential of HO as a target in anticancer treatment. Apoptosis 9:27-35.
114. Fang J, Sawa T, Akaike T, Akuta T, Sahoo SK, Khaled G, Hamada A, and Maeda H (2003) In vivo antitumor activity of pegylated zinc protoporphyrin: Targeted inhibition of heme oxygenase in solid tumor. Cancer Res 63:3567-3574.
115. Fenn WO and Cobb DM (1932) The burning of carbon monoxide by heart and skeletal muscle. Am J Physiol 102:393-401.
116. Fernandez M, Lambrecht RW, and Bonkovsky HL (2001) Increased heme oxygenase activity in splanchnic organs from portal hypertensive rats: role in modulating mesenteric vascular reactivity. J Hepatol 34:812-817.
117. Ferris CD, Jaffrey SR, Sawa A, Takahashi M, Brady SD, Barrow RK, Tysoe SA, Wolosker H, Baranano DE, Dore S, et al. (1999) Haem oxygenase-1 prevents cell death by regulating cellular iron. Nat Cell Biol 1:152-157.
118. Fogg S, Agarwal A, Nick HS, and Visner GA (1999) Iron regulates hyperoxiadependent human heme oxygenase 1 gene expression in pulmonary endothelial cells. Am J Respir Cell Mol Biol 20:797-804.
119. Foresti R, Hammad J, Clark JE, Johnson TR, Mann BE, Friebe A, Green CJ, and Motterlini R (2004) Vasoactive properties of CORM-3, a novel water-soluble carbon monoxide-releasing molecule. Br J Pharmacol 142:453-460.
120. Foresti R, Hoque M, Bains S, Green CJ, and Motterlini R (2003) Haem and nitric oxide: synergism in the modulation of the endothelial haem oxygenase-1 pathway. Biochem J 372:381-390.
121. Foresti R and Motterlini R (1999) The heme oxygenase pathway and its interaction with nitric oxide in the control of cellular homeostasis. Free Radic Res 31:459-475.
122. Foresti R, Sarathchandra P, Clark JE, Green CJ, and Motterlini R (1999) Peroxynitrite induces haem oxygenase-1 in vascular endothelial cells: a link to apoptosis. Biochem J 339:729-736.
123. Forster RE (1970) Carbon monoxide and the partial pressure of oxygen in tissue. Ann NY Acad Sci 174:233-241.
124. Frankel D, Mehindate K, and Schipper HM (2000) Role of heme oxygenase-1 in the regulation of manganese superoxide dismutase gene expression in oxidatively challenged astroglia. J Cell Physiol 185:80-86.
125. Friebe A and Koesling D (1998) Mechanism of YC-1-induced activation of soluble guanylyl cyclase. Mol Pharmacol 53:123-127.
126. Friebe A, Schultz G, and Koesling D (1996) Sensitizing soluble guanylyl cyclase to become a highly CO-sensitive enzyme. EMBO (Eur Mol Biol Organ) J 15:6863-6868.
127. Fujimoto H, Ohno M, Ayabe S, Kobayashi H, Ishizaka N, Kimura H, Yoshida K, and Nagai R (2004) Carbon monoxide protects against cardiac ischemia-reperfusion injury in vivo via MAPK and Akt-eNOS pathways. Arterioscler Thromb Vasc Biol 24:1848-1853.
128. Fujita T, Toda K, Karimova A, Yan SF, Naka Y, Yet SF, and Pinsky DJ (2001) Paradoxical rescue from ischemic lung injury by inhaled carbon monoxide driven by derepression of fibrinolysis. Nat Med 7:598-604.
129. Furchgott RF and Jothianandan D (1991) Endothelium-dependent and -independent vasodilation involving cyclic GMP: relaxation induced by nitric oxide, carbon monoxide and light. Blood Vessels 28:52-61.
130. Gagov H, Kadinov B, Hristov K, Boev K, Itzev D, Bolton T, and Duridanova D (2003) Role of constitutively expressed heme oxygenase-2 in the regulation of guinea pig coronary artery tone. Pflueg Arch Eur J Physiol 446:412-421.
131. Gatta A, Sacerdoti D, Bolognesi M, and Merkel C (1999) Portal hypertension: state of the art. Ital J Gastroenterol Hepatol 31:326-345.
132. Gelperin A, Flores J, Raccuia-Behling F, and Cooke IR (2000) Nitric oxide and carbon monoxide modulate oscillations of olfactory interneurons in a terrestrial mollusk. J Neurophysiol 83:116-127.
133. Gerzer R, Bohme E, Hofmann F, and Schultz G (1981) Soluble guanylate cyclase purified from bovine lung contains heme and copper. FEBS Lett 132:71-74.
134. Geuens E, Brouns I, Flamez D, Dewilde S, Timmermans JP, and Moens L (2003) A globin in the nucleus! J Biol Chem 278:30417-30420.
135. Gibson QH, Olson JS, McKinme RE, and Rohlfs RJ (1986) A kinetic description of ligand binding to sperm whale myoglobin. J Biol Chem 261:10228-10239.
136. Glaum SR and Miller RJ (1993) Zinc protoporphyrin-IX blocks the effects of metabotropic glutamate receptor activation in the rat nucleus tractus solitarii. Mol Pharmacol 43:965-969.
137. Goda N, Suzuki K, Naito M, Takeoka S, Tsuchida E, Ishimura Y, Tamatani T, and Suematsu M (1998) Distribution of heme oxygenase isoforms in rat liver. Topographic basis for carbon monoxide-mediated microvascular relaxation. J Clin Investig 101:604-612.
138. Goldberg MA and Schneider TJ (1994) Similarities between the oxygen-sensing mechanisms regulating the expression of vascular endothelial growth factor and erythropoietin. J Biol Chem 269:4355-4359.
139. Graser T, Vedernikov YP, and Li DS (1990) Study on the mechanism of carbon monoxide induced endothelium-independent relaxation in porcine coronary artery and vein. Biomed Biochim Acta 49:293-296.
140. Griffiths C and Garthwaite L (2001) The shaping of nitric oxide signals by a cellular sink. J Physiol (Lond) 536:855-862.
141. Grilli A, De Lutiis MA, Patruno A, Speranza L, Gizzi F, Taccardi AA, Di Napoli P, De Caterina R, Conti P, and Felaco M (2003) Inducible nitric oxide synthase and heme oxygenase-1 in rat heart: direct effect of chronic exposure to hypoxia. Ann Clin Lab Sci 33:208-215.
142. Grundemar L and Ny L (1997) Pitfalls using metalloporphyrins in carbon monoxide research. Trends Pharmacol Sci 18:193-195.
143. Guengerich F (1978) Destruction of heme and hemoproteins mediated by liver microsomal reduced NADP-cytochrome P450 reductase. Biochemistry 17:3633-3639.
144. Gunther L, Berberat PO, Haga M, Brouard S, Smith RN, Soares MP, Bach FH, and Tobiasch E (2002) Carbon monoxide protects pancreatic β-cells from apoptosis and improves islet function/survival after transplantation. Diabetes 51:994-999.
145. Guo Y, Stein AB, Wu WJ, Tan W, Zhu X, Li QH, Dawn B, Motterlini R, and Bolli R (2004) Administration of a CO-releasing molecule at the time of reperfusion reduces infarct size in vivo. Am J Physiol Heart Circ Physiol 286:H1649-H1653.
146. Haldane J (1895) The relation of the action of carbonic oxide to oxygen tension. J Physiol (Lond) 18:201-217.
147. Haldane J and Smith JL (1896) The oxygen tension of arterial blood. J Physiol (Lond) 20:497-520.
148. Halperin MH, McFarland RA, Niven JI, and Roughton FJW (1959) The time course of the effects of carbon monoxide on visual thresholds. J Physiol (Lond) 146:583-593.
149. Hancock WW, Buelow R, Sayegh MH, and Turka LA (1998) Antibody-induced transplant arteriosclerosis is prevented by graft expression of anti-oxidant and anti-apoptotic genes. Nat Med 4:1392-1396.
150. Hanson ES, Foot LM, and Leibold EA (1999) Hypoxia posttranslationally activates iron-regulatory protein 2. J Biol Chem 274:5047-5052.
151. Harrison PM and Arosio P (1996) The ferritins: molecular properties, iron storage function and cellular regulation. Biochim Biophys Acta 1275:161-203.
152. Hartsfield CL, Alam J, Cook JL, and Choi AM (1997) Regulation of heme oxygenase-1 gene expression in vascular smooth muscle cells by nitric oxide. Am J Physiol Lung Cell Mol Physiol 273:L980-L988.
153. Hassall CJ and Hoyle CH (1997) Heme oxygenase-2 and nitric oxide synthase in guinea-pig intracardiac neurones. Neuroreport 8:1043-1046.
154. Haugen EN, Croatt AJ, and Natu KA (2000) Angiotensin II induces renal oxidant stress in vivo and heme oxygenase-1 in vivo and in vitro. Kidney Int 58:144-152.
155. Hayashi S, Omata Y, Sakamoto H, Higashimoto Y, Hara T, Sagara Y and Noguchi M (2004) Characterization of rat heme oxygenase-3 gene. Implication of processed pseudogenes derived from heme oxygenase-2 gene. Gene 336:241-250.
156. Hayashi S, Takamiya R, Yamaguchi T, Matsumoto K, Tojo SJ, Tamatani T, Kitajima M, Makino N, Ishimura Y, and Suematsu M (1999) Induction of heme oxygenase-1 suppresses venular leukocyte adhesion elicited by oxidative stress: role of bilirubin generated by the enzyme. Circ Res 85:663-671.
157. Hedlund P, Ny L, Alm P, and Andersson KE (2000) Cholinergic nerves in human corpus cavernosum and spongiosum contain nitric oxide synthase and heme oxygenase. J Urol 164:868-875.
158. Heitbrink D, Sigurdson H, Bolwien C, Brzezinski P, and Heberle J (2002) Transient binding of CO to Cu(B) in cytochrome c oxidase is dynamically linked to structural changes around a carboxyl group: a time-resolved step-scan Fourier transform infrared investigation. Biophys J 82:1-10.
159. Henningsson R, Alm P, and Lundquist I (1997) Occurrence and putative hormone regulatory function of a constitutive heme oxygenase in rat pancreatic islets. Am J Physiol Cell Physiol 273:C703-C709.
160. Henningsson R, Alm P, Ekstrom P, and Lundquist I (1999) Heme oxygenase and carbon monoxide: regulatory roles in islet hormone release: a biochemical, immunohistochemical and confocal microscopic study. Diabetes 48:66-76.
161. Henningsson R, Alm P, and Lundquist I (2001) Evaluation of heme oxygenase-CO and nitric oxide synthase-NO pathways during acute endotoxemia. Am J Physiol Cell Physiol 280:C1242-C1254.
162. Hill-Kapturczak N, Chang SH, and Agarwal A (2002) Heme oxygenase and the kidney. DNA Cell Biol 21:307-321.
163. Hill-Kapturczak N, Sikorski E, Voakes C, Garcia J, Nick HS, and Agarwal A (2003) An internal enhancer regulates heme- and cadmium-mediated induction of human heme oxygenase-1. Am J Physiol Renal Physiol 285:F515-F523.
164. Hill-Kapturczak N, Truong L, Thamilselvan V, Visner GA, Nick HS, and Agarwal A (2000) Smad7-dependent regulation of heme oxygenase-1 by transforming growth factor-beta in human renal epithelial cells. J Biol Chem 275:40904-40909.
165. Hon T, Hach A, Lee HC, Cheng T, and Zhang L (2000) Functional analysis of heme regulatory elements of the transcriptional activator Hap1. Biochem Biophys Res Commun 273:584-591.
166. Hon T, Hach A, Tamalis D, Zhu Y, and Zhang L (1999) The yeast heme-responsive transcriptional activator Hap1 is a preexisting dimer in the absence of heme. J Biol Chem 274:22770-22774.
167. Hu S and Kincaid JR (1992) Resonance Raman studies of the carbonmonoxy form of catalase. Evidence for and effects of phenolate ligation. FEBS Lett 314:293-296.
168. Huang LE, Willmore WG, Gu J, Goldberg MA, and Bunn HF (1999) Inhibition of hypoxia-inducible factor 1 activation by carbon monoxide and nitric oxide. Implications for oxygen sensing and signaling. J Biol Chem 274:9038-9044.
169. Huang Y, Wu L, Saucier D, and Wang R (2004) Altered expression of HO and NOS in hippocampus from spontaneously hypertensive rats. Exp Clin Cardiol 9:56.
170. Hunt RC, Hunt DM, Gaur N, and Smith A (1996) Hemopexin in the human retina: protection of the retina against hememediated toxicity. J Cell Physiol 168:71-80.
171. Immenschuh S, Iwahara S, Satoh H, Nell C, Katz N, and Muller-Eberhard U (1995) Expression of the mRNA of heme-binding protein 23 is coordinated with that of heme oxygenase-1 by heme and heavy metals in primary rat hepatocytes and hepatoma cells. Biochemistry 34:13407-13411.
172. Immenschuh S, Kietzmann T, Hinke V, Wiederhold M, Katz N, and Muller-Eberhard U (1998) The rat heme oxygenase-1 gene is transcriptionally induced via the protein kinase A signaling pathway in rat hepatocyte cultures. Mol Pharmacol 53:483-491.
173. Immenschuh S, Stritzke J, Iwahara S, and Ramadori G (1999) Up-regulation of heme-binding protein 23 (HBP23) gene expression by lipopolysaccharide is mediated via a nitric oxide-dependent signaling pathway in rat Kupffer cells. Hepatology 30:118-127.
174. Ingi T, Cheng J, and Ronnett GV (1996a) Carbon monoxide: an endogenous modulator of the nitric oxide-cyclic GMP signaling system. Neuron 16:835-842.
175. Ingi T, Chiang G, and Ronnett GV (1996b) The regulation of heme turnover and carbon monoxide biosynthesis in cultured primary rat olfactory receptor neurons. J Neurosci 16:5621-5628.
176. Ingi T and Ronnett GV (1995) Direct demonstration of a physiological role for carbon monoxide in olfactory receptor neurons. J Neurosci 15:8214-8222.
177. Inguaggiato P, Gonzalez-Michaca L, Croatt AJ, Haggard JJ, Alam J, and Nath KA (2001) Cellular overexpression of heme oxygenase-1 up-regulates p21 and confers resistance to apoptosis. Kidney Int 60:2181-2191.
178. Ishikawa K (2003) Heme oxygenase-1 against vascular insufficiency: roles of atherosclerotic disorders. Curr Pharm Des 9:2489-2497.
179. Ishikawa K and Maruyama Y (2001) Heme oxygenase as an intrinsic defense system in vascular wall: implication against atherogenesis. J Atheroscler Thromb 8:63-70.
180. Ishikawa K, Sugawara D, Goto J, Watanabe Y, Kawamura K, Shiomi M, Itabe H, and Maruyama Y (2001a) Heme oxygenase-1 inhibits atherogenesis in Watanabe heritable hyperlipidemic rabbits. Circulation 104:1831-1836.
181. Ishikawa K, Sugawara D, Wang XP, Suzuki K, Itabe H, Maruyama Y, and Lusis AJ (2001b) Heme oxygenase-1 inhibits atherosclerotic lesion formation in LDLreceptor knockout mice. Circ Res 88:506-512.
182. Ishizaka N, Aizawa T, Mori I, Taguchi J, Yazaki Y, Nagai R, and Ohno M (2000) Heme oxygenase-1 is upregulated in the rat heart in response to chronic administration of angiotensin II. Am J Physiol 279:H672-H678.
183. Ishizaka N and Griendling KK (1997) Heme oxygenase-1 is regulated by angiotensin II in rat vascular smooth muscle cells. Hypertension 29:790-795.
184. Ishizaka N, Leon HD, Laursen JB, Fukui T, Wilcox JN, Keulenaer GD, Griendling KK, and Alexander RW (1997) Angiotensin II-induced hypertension increases heme oxygenase-1 expression in rat aorta. Circulation 96:1923-1929.
185. Iwahara S, Satoh H, Song DX, Webb J, Burlingame AL, Nagae Y, and Muller-Eberhard U (1995) Purification, characterization and cloning of a heme-binding protein (23 kDa) in rat liver cytosol. Biochemistry 34:13398-13406.
186. 2+ -activated K channels. Circ Res 91:610-617.
187. Jaron S and Blackburn NJ (2001) Characterization of a half-apo derivative of peptidylglycine monooxygenase. Insight into the reactivity of each active site copper. Biochemistry 40:6867-6875.
188. Jeney V, Balla J, Yachie A, Varga Z, Vercellotti GM, Eaton JW, and Balla G (2002) Pro-oxidant and cytotoxic effects of circulating heme. Blood 100:879-887.
189. Johnson FK, Durante W, Peyton KJ, and Johnson RA (2003) Heme oxygenase inhibitor restores arteriolar nitric oxide function in Dahl rats. Hypertension 41:149-155.
190. Johnson FK and Johnson RA (2003) Carbon monoxide promotes endotheliumdependent constriction of isolated gracilis muscle arterioles. Am J Physiol Regul Integr Comp Physiol 285:R536-R541.
191. Johnson RA and Johnson FK (2002) The heme-heme oxygenase-carbon monoxide system and hypertension, in Carbon Monoxide and Cardiovascular Functions (Wang R ed) pp 149-163, CPC Press, Boca Raton.
192. Johnson RA, Lavesa M, Askari B, Abraham NG, and Nasjletti A (1995) A heme oxygenase product, presumably carbon monoxide, mediates a vasodepressor function in rats. Hypertension 25:166-169.
193. Johnson RA, Lavesa M, DeSeyn K, Scholer MJ, and Nasjletti A (1996) Heme oxygenase substrates acutely lower blood pressure in hypertensive rats. Am J Physiol Heart Circ Physiol 271:H1132-H1138.
194. Juan SH, Lee TS, Tseng KW, Liou JY, Shyue SK, Wu KK, and Chau LY (2001) Adenovirus-mediated heme oxygenase-1 gene transfer inhibits the development of atherosclerosis in apolipoprotein E-deficient mice. Circulation 104:1519-1525.
195. Kaide JI, Zhang F, Wei Y, Jiang H, Yu C, Wang WH, Balazy M, Abraham NG, and Nasjletti A (2001) Carbon monoxide of vascular origin attenuates the sensitivity of renal arterial vessels to vasoconstrictors. J Clin Investig 107:1163-1171.
196. Kajimura M, Shimoyama M, Tsuyama S, Suzuki T, Kozaki S, Takenaka S, Tsubota K, Oguchi Y, and Suematsu M (2003) Visualization of gaseous monoxide reception by soluble guanylate cyclase in the rat retina. FASEB J 17:506-508.
197. Kandel ER, Schwartz JH, and Jessell TM, eds (2000) Principles of Neural Science, 4th ed, McGraw-Hill, New York.
198. Kappas A, Drummond GS, and Galbraith RA (1993) Prolonged clinical use of a heme oxygenase inhibitor: hematological evidence for an inducible but reversible irondeficiency state. Pediatrics 91:537-539.
199. Karlsson JO, Axelsson KL, and Andersson RG (1985) Effects of hydroxyl radical scavengers KCN and CO on ultraviolet light- induced activation of crude soluble guanylate cyclase. J Cyclic Nucleotide Protein Phosphor Res 10:309-315.
200. Karuzina II, Zgoda VG, Kuznetsova GP, Samenkova NF, and Archakov AI (1999) Heme and apoprotein modi.cation of cytochrome P450 2B4 during its oxidative inactivation in monooxygenase reconstituted system. Free Radic Biol Med 26:620-632.
201. Katori M, Buelow R, Ke B, Ma J, Coito AJ, Iyer S, Southard D, Busuttil RW, and Kupiec-Weglinski JW (2002) Heme oxygenase-1 overexpression protects rat hearts from cold ischemia/reperfusion injury via an antiapoptotic pathway. Transplantation (Baltim) 73:287-292.
202. Kawashima A, Oda Y, Yachie A, Koizumi S, and Nakanishi I (2002) Heme oxygenase-1 deficiency: the first autopsy case. Hum Pathol 33:125-130.
203. Ke B, Buelow R, Shen XD, Melinek J, Amersi F, Gao F, Ritter T, Volk HD, Busuttil RW, and Kupiec-Weglinski JW (2002) Heme oxygenase 1 gene transfer prevents CD95/Fas ligand-mediated apoptosis and improves liver allograft survival via carbon monoxide signaling pathway. Hum Gene Ther 13:1189-1199.
204. Keilin D (1966) Chapter 11: inhibition of cell respiration by carbon monoxide, in The History of Cell Respiration and Cytochrome, pp 252-268, Cambridge Press, Cambridge.
205. Keyse SM and Tyrrell AM (1989) Heme oxygenase is the major 32 kDa stress protein induced in human skin fibroblasts of UVA radiation, hydrogen peroxide and sodium arsenite. Proc Natl Acad Sci USA 86:99-103.
206. Kharitonov VG, Sharma VS, Pilz RB, Magde D, and Koesling D (1995) Basis of guanylate cyclase activation by carbon monoxide. Proc Natl Acad Sci USA 92:2568-2571.
207. Kibbe MR, Li J, Nie S, Watkins SC, Lizonova A, Kovesdi I, Simmons RL, Billiar TR, and Tzeng E (2000) Inducible nitric oxide synthase (iNOS) expression upregulates p21 and inhibits vascular smooth muscle cell proliferation through p42/44 mitogen-activated protein kinase activation and independent of p53 and cyclic guanosine monophosphate. J Vasc Surg 31:1214-1228.
208. Kim CK and Rivier CL (2000) Nitric oxide and carbon monoxide have a stimulatory role in the hypothalamic-pituitary-adrenal response to physico-emotional stressors in rats. Endocrinology 141:2244-2253.
209. Kim SK and Kim YC (1996) Effect of a single administration of benzene, toluene or m-xylene on carboxyhaemoglobin elevation and metabolism of dichloromethane in rats. J Appl Toxicol 16:437-444.
210. Kim YC, Davies MG, Marson L, Hagen PO, and Carson CC 3rd (1994) Lack of effect of carbon monoxide inhibitor on relaxation induced by electrical field stimulation in corpus cavernosum. Urol Res 22:291-293.
211. Kitamuro T, Takahashi K, Ogawa K, Udono-Fujimori R, Takeda K, Furuyama K, Nakayama M, Sun J, Fujita H, Hida W, et al. (2003) Bach1 functions as a hypoxiainducible repressor for the heme oxygenase-1 gene in human cells. J Biol Chem 278:9125-9133.
212. Koehler RC and Traystman RJ (2002) Cerebrovascular effects of carbon monoxide. Antioxid Redox Signal 4:279-290.
213. Koglin M and Behrends S (2002) Biliverdin IX is an endogenous inhibitor of soluble guanylyl cyclase. Biochem Pharmacol 64:109-116.
214. Kohsaka A, Watanobe H, Kakizaki Y, and Suda T (1999) A comparative study of the effects on nitric oxide and carbon monoxide on the in vivo release of gonadotropin-releasing hormone and neuropeptide Y from rat hypothalamus during the estradiol-induced luteinizing hormone surge: estimation by push-pull perfusion. Neuroendocrinology 69:245-253.
215. Kojda G, Kottenberg K, Hacker A, and Noack E (1998) Alterations of the vascular and the myocardial guanylate cyclase/cGMP-system induced by longterm hypertension in rats. Pharm Acta Helv 73:27-35.
216. Kostoglou-Athanassiou I, Costa A, Navarra P, Nappi G, Forsling ML, and Grossman AB (1998) Endotoxin stimulates an endogenous pathway regulating corticotropin-releasing hormone and vasopressin release involving the generation of nitric oxide and carbon monoxide. J Neuroimmunol 86:104-109.
217. Kostoglou-Athanassiou I, Forsling ML, Navarra P, and Grossman AB (1996) Oxytocin release is inhibited by the generation of carbon monoxide from the rat hypothalamus-further evidence for carbon monoxide as a neuromodulator. Mol Brain Res 42:301-306.
218. Kozma F, Johnson RA, Zhang F, Yu C, Tong X, and Nasjletti A (1999) Contribution of endogenous carbon monoxide to regulation of diameter in resistance vessels. Am J Physiol Regul Integr Comp Physiol 276:R1087-R1094.
219. Kreiser D, Yang G, Weng Y, Dominique KK, Seidman DS, Baum M, and Dennery PA (2000) The role of heme oxygenase (HO) in the regulation of somatic growth factors in pregnancy (Abstract 243). Acta Hematologica 103 (Suppl 1):61.
220. Kubaszewski E, Peters A, McClain S, Bohr D, and Furchgott RF (1993) Light-activated release of nitric oxide from vascular smooth muscle of normotensive and hypertensive rats. Biochem Biophys Res Commun 200:213-218.
221. Kubic VL and Anders MW (1978) Metabolism of dihalomethanes to carbon monoxide -III. Studies on the mechanism of the reaction. Biochem Pharmacol 27:2349-2355.
222. Kutty RK, Kutty G, Rodriguez IR, Chader GJ, and Wiggert B (1994a) Chromosomal localization of the human heme oxygenase genes: heme oxygenase-1 (HMOX1) maps to chromosome 22q12 and heme oxygenase- 2 (HMOX2) maps to chromosome 16p13.3. Genomics 20:513-516.
223. Kutty RK and Maines MD (1989) Selective induction of heme oxygenase-1 isozyme in rat testis by human chorionic gonadotropin. Arch Biochem Biophys 268:100-107.
224. Kutty RK, Nagineni CN, Kutty G, Hooks JJ, Chader GJ, and Wiggert B (1994b) Increased expression of heme oxygenase-1 in human retinal pigment epithelial cells by transforming growth factor-beta. J Cell Physiol 159:371-378.
225. Kwon S, Chung S, Ahn D, Yeon D, and Nam T (2001) Mechanism of carbon monoxide-induced relaxation in the guinea pig ileal smooth muscle. J Vet Med Sci 63:389-393.
226. Lakkisto P, Palojoki E, Backlund T, Saraste A, Tikkanen I, Voipio-Pulkki L-M, and Pulkki K (2002) Expression of heme oxygenase-1 in response to myocardial infarction in rats. J Mol Cell Cardiol 34:1357-1365.
227. Lamar CA, Mahesh VB, and Brann DW (1996) Regulation of gonadotropin releasing hormone secretion by heme molecules: a regulatory role for carbon monoxide? Endocrinology 137:790-799.
228. Landaw SA, Callahan EW, and Schmid R (1970) Catabolism of heme in vivo: comparison of the simultaneous production of bilirubin and carbon monoxide. J Clin Investig 49:914-925.
229. Lautier D, Luscher P, and Tyrrell RM (1992) Endogenous glutathione levels modulate both constitutive and UVA radiation/hydrogen peroxide inducible expression of the human heme oxygenase gene. Carcinogenesis 13:227-232.
230. Lavrovsky Y, Schwartzman ML, Levere RD, Kappas A, and Abraham NG (1994) Identification of binding sites for transcription factors NF-κB and AP-2 in the promoter region of the human heme oxygenase 1 gene. Proc Natl Acad Sci USA 91:5987-5991.
231. Laybutt DR, Kaneto H, Hasenkamp W, Grey S, Jonas JC, Sgroi DC, Groff A, Ferran C, Bonner-Weir S, Sharma A, and Weir G (2002) Increased expression of antioxidant and antiapoptotic genes in islets that may contribute to β-cell survival during chronic hyperglycemia. Diabetes 51:413-423.
232. Lee HU, Lee HJ, Park HY, Lee SH, Jang CG, and Lee SY (2001) Effects of heme oxygenase system on the cyclooxygenase in the primary cultured hypothalamic cells. Arch Pharm Res (NY) 24:607-612.
233. Lee PJ, Alam J, Wiegand GW, and Choi AMK (1996) Overexpression of heme oygenase-1 in human pulmonary epithelial cells results in cell growth arrest and increased resistance to hyperoxia. Proc Natl Acad Sci USA 93:10393-10398.
234. Lee PJ, Jiang BH, Chin BY, Iyer NV, Alam J, Semenza GL, and Choi AM (1997) Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia. J Biol Chem 272:5375-5381.
235. Lee TS and Chau LY (2002) Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice. Nat Med 8:240-246.
236. Leffler CW, Balabanova L, Fedinec AL, Waters CW, and Parfenova H (2003) Mechanism of glutamate stimulation of CO production in cerebral microvessels. Am J Physiol Heart Circ Physiol 285:H74-H80.
237. Leffler CW, Nasjletti A, Johnson RA, and Fedinec AL (2001) Contributions of prostacyclin and nitric oxide to carbon monoxide-induced cerebrovascular dilation in piglets. Am J Physiol Heart Circ Physiol 280:H1490-H1495.
238. Leffler CW, Nasjletti A, Yu C, Johnson RA, Fedinec AL, and Walker N (1999) Carbon monoxide and cerebral microvascular tone in newborn pigs. Am J Physiol Heart Circ Physiol 276:H1641-H1646.
239. Leinders-Zufall T, Shepherd GM, and Zufall F (1995) Regulation of cyclic nucleotidegated channels and membrane excitability in olfactory receptor cells by carbon monoxide. J Neurophysiol 74:1498-1508.
240. Levere RD, Martasek P, Escalante B, Schwartzman ML, and Abraham NG (1990) Effect of heme arginate administration on blood pressure in spontaneously hypertensive rats. J Clin Investig 86:213-219.
241. Li P, Jiang H, Yang L, Quan S, Dinocca S, Rodriguez F, Abraham NG, and Nasjletti A (2004) Angiotensin II induces carbon monoxide production in the perfused kidney: relationship to protein kinase C activation. Am J Physiol Renal Physiol 287:F914-F920.
242. Li Volti G, Ientile R, Abraham NG, Vanella A, Cannavo G, Mazza F, Curro M, Raciti G, Avola R, and Campisi A (2004) Immunocytochemical localization and expression of heme oxygenase-1 in primary astroglial cell cultures during differentiation: effect of glutamate. Biochem Biophys Res Commun 315:517-524.
243. Li Volti G, Wang J, Traganos F, Kappas A, and Abraham NG (2002) Differential effect of heme oxygenase-1 in endothelial and smooth muscle cell cycle progression. Biochem Biophys Res Commun 296:1077-1082.
244. Li X and Clark JD (2000a) Chronic morphine exposure and the expression of heme oxygenase type 2. Brain Res Mol Brain Res 75:179-184.
245. Li X and Clark JD (2000b) The role of heme oxygenase in neuropathic and incisional pain. Anesth Analg 90:677-682.
246. Li X and Clark JD (2003) Heme oxygenase type 2 participates in the development of chronic inflammatory and neuropathic pain. J Pain 4:101-107.
247. Liang M, Croatt AJ, and Nath KA (2000) Mechanisms underlying induction of heme oxygenase-1 by nitric oxide in renal tubular epithelial cells. Am J Physiol Renal Physiol 279:F728-F735.
248. 2+ channels through a nitric oxidedependent mechanism. Am J Physiol Gastrointest Liver Physiol 288:G7-G14.
249. Lin H and McGrath JJ (1988) Vasodilating effects of carbon monoxide. Drug Chem Toxicol 11:371-385.
250. Linden DJ, Narasimhan K, and Gurfel D (1993) Protoporphyrins modulate voltagegated Ca current in AtT-20 pituitary cells. J Neurophysiol 70:2673-2677.
251. Liu H, Song D, and Lee SS (2001) Role of heme oxygenase-carbon monoxide pathway in pathogenesis of cirrhotic cardiomyopathy in the rat. Am J Physiol Gastrointest Liver Physiol 280:G68-G74.
252. Liu N, Wang X, McCoubrey WK, and Maines MD (2000) Developmentally regulated expression of two transcripts for heme oxygenase-2 with a first exon unique to rat testis: control by corticosterone of the oxygenase protein expression. Gene 241:175-183.
253. Liu XM, Chapman GB, Peyton KJ, Schafer AI, and Durante W (2002a) Carbon monoxide inhibits apoptosis in vascular smooth muscle cells. Cardiovasc Res 55:396-405.
254. Liu XM, Chapman GB, Wang H, and Durante W (2002b) Adenovirus-mediated heme oxygenase-1 gene expression stimulates apoptosis in vascular smooth muscle cells. Circulation 105:79-84.
255. Liu XM, Peyton KJ, Ensenat D, Wang H, Schafer AI, Alam J, and Durante W (2005) Endoplasmic reticulum stress stimulates heme oxygenase-1 gene expression in vascular smooth muscle: role in cell survival. J Biol Chem 280:872-877.
256. Liu Y, Christou H, Morita T, Laughner E, Semenza GL, and Kourembanas S (1998) Carbon monoxide and nitric oxide suppress the hypoxic induction of vascular endothelial growth factor gene via the 5′ enhancer. J Biol Chem 273:15257-15262.
257. Liu Y, Zhu B, Luo L, Li P, Paty DW, and Cynader MS (2001) Heme oxygenase-1 plays an important protective role in experimental autoimmune encephalomyelitis. Neuroreport 12:1841-1845.
258. Llesuy SF and Tomaro ML (1994) Heme oxygenase and oxidative stress. Evidence of involvement of bilirubin as physiological protector against oxidative damage. Biochim Biophys Acta 1223:9-14.
259. Loennechen JP, Beisvag V, Arbo I, Waldum HL, Sandvik AK, Knardahl S, and Ellingsen O (1999) Chronic carbon monoxide exposure in vivo induces myocardial endothelin-1 expression and hypertrophy in rat. Pharmacol Toxicol 85:192-197.
260. Loennechen JP, Nilsen OG, Arbo I, Aadahl P, Nilsen T, Waldum HL, Sandvik AK, and Ellingsen O (2002) Chronic exposure to carbon monoxide and nicotine: endothelin ET(A) receptor antagonism attenuates carbon monoxide-induced myocardial hypertrophy in rat. Toxicol Appl Pharmacol 178:8-14.
261. Longo M, Jain V, Vedernikov YP, Saade GR, Goodroom L, Facchinetti F, and Garfield RE (1999) Effect of nitric oxide and carbon monoxide on uterine contractility during human and rat pregnancy. Am J Obstet Gynecol 181:981-988.
262. Lou BS, Snyder JK, Marshall P, Wang JS, Wu G, Kulmacz RJ, Tsai AL, and Wang J (2000) Resonance Raman studies indicate a unique heme active site in prostaglandin H synthase. Biochemistry 39:12424-12434.
263. Lu TH, Lambrecht RW, Pepe J, Shan Y, Kim T, and Bonkovsky HL (1998) Molecular cloning, characterization and expression of the chicken heme oxygenase-1 gene in transfected primary cultures of chick embryo liver cells. Gene 207:177-186.
264. 2+ signals between pancreatic β-cells. Am J Physiol Endocrinol Metab 285:E1055-E1063.
265. Luo D and Vincent SR (1994) Metalloporphyrins inhibit nitric oxide-dependent cGMP formation in vivo. Eur J Pharmacol 267:263-267.
266. Luomanmaki K and Coburn RF (1969) Effects of metabolism and distribution of carbon monoxide on blood and body stores. Am J Physiol 217:354-363.
267. Lyall F, Barber A, Myatt L, Bulmer J, and Robson SC (2000) Hemeoxygenase expression in human placenta and placental bed implies a role in regulation of trophoblast invasion and placental function. FASEB J 14:208-219.
268. Magee CC, Azuma H, Knoflach A, Denton MD, Chandraker A, Iyer S, Buelow R, and Sayegh M (1999) In vitro and in vivo immunomodulatory effects of RDP1258, a novel synthetic peptide. J Am Soc Nephrol 10:1997-2005.
269. Maines MD (1988) Heme oxygenase: function, multiplicity, regulatory mechanisms and clinical applications. FASEB J 2:2557-2568.
270. Maines MD (1997) The heme oxygenase system: a regulator of second messenger gases. Annu Rev Pharmacol Toxicol 37:517-554.
271. Maines MD and Ewing JF (1996) Stress response of the rat testis: in situ hybridization and immunohistochemical analysis of heme oxygenase-1 (HSP32) induction by hyperthermia. Biol Reproduct 54:1070-1079.
272. Maines MD and Kappas A (1974) Cobalt induction of hepatic heme oxygenase: with evidence that Cyt P450 is not essential for this enzyme activity. Proc Natl Acad Sci USA 71:4293-4297.
273. Maines MD and Kutty RK (1983) Differential response of testicular and ovarian heme oxygenase activity to metal ions. Arch Biochem Biophys 226:134-144.
274. Maines MD, Mayer RD, Ewing JF, and McCoubrey WK Jr (1993) Induction of kidney heme oxygenase-1 (HSP32) mRNA and protein byischemia/reperfusion: possible role of heme as both promotor of tissue damage and regulator of HSP32. J Pharmacol Exp Ther 264:457-462.
275. Maines MD, Trakshel GM, and Kutty RK (1986) Characterization of two constitutive forms of rat liver microsomal heme oxygenase: Only one molecular species of the enzyme is inducible. J Biol Chem 261:411-419.
276. Malaguarnera L, Pilastro MR, Quan S, Ghattas MH, Yang L, Mezentsev AV, Kushida T, Abraham NG, and Kappas A (2002) Significance of heme oxygenase in prolactin-mediated cell proliferation and angiogenesis in human endothelial cells. Int J Mol Med 10:433-440.
277. Mancuso C, Kostoglou-Athanassiou I, Forsling ML, Grossman AB, Preziosi P, Navarra P, and Minotti G (1997a) Activation of heme oxygenase and consequent carbon monoxide formation inhibits the release of arginine vasopressin from rat hypothalamic explants. Molecular linkage between heme catabolism and neuroendocrine function. Mol Brain Res 50:267-276.
278. Mancuso C, Preziosi P, Grossman AB, and Navarra P (1997b) The role of carbon monoxide in the regulation of neuroendocrine function. Neuroimmunomodulation 4:225-229.
279. Mansouri A and Perry CA (1984) Inhibition of platelet ADP and serotonin release by carbon monoxide and in cigarette smokers. Experientia 40:515-517.
280. Marks GS, Brien JF, Nakatsu K, and McLaughlin BE (1991) Does carbon monoxide have a physiological function? Trends Pharmacol Sci 12:185-188.
281. Marshall HE, Merchant K, and Stamler JS (2000) Nitrosation and oxidation in the regulation of gene expression. FASEB J 14:1889-1900.
282. Marshall M and Hess H (1981) [Acute effects of low carbon monoxide concentrations on blood rheology, platelet fuction and the arterial wall in the minipig (author's transl)]. Res Exp Med (Berl) 178:201-210.
283. Matz P, Turner C, Weinstein PR, Massa SM, Panter SS, and Sharp FR (1996) Heme-oxygenase-1 induction in glia throughout rat brain following experimental subarachnoid hemorrhage. Brain Res 713:211-222.
284. Maulik N, Engelman DT, Watanabe M, Engelman RM, Rousou JA, Flack JE 3rd, Deaton DW, Gorbunov NV, Elsayed NM, Kagan VE, and Das DK (1996) Nitric oxide/carbon monoxide. A molecular switch for myocardial preservation during ischemia. Circulation 94 (9 Suppl):II398-II406.
285. Mautes AEM, Bergeron M, Sharp FR, Scott Panter S, Weinzierl M, Guenther K, and Noble LT (2000) Sustained induction of heme oxygenase-1 in the traumatized spinal cord. Exp Neurol 166:254-265.
286. McCoubrey WK Jr, Huang TJ, and Maines MD (1997a) Heme oxygenase-2 is a hemoprotein and binds heme through heme regulatory motifs that are not involved in heme catalysis. J Biol Chem 272:12568-12574.
287. McCoubrey WK Jr, Huang TJ, and Maines MD (1997b) Isolation and characterization of a cDNA from the rat brain that encodes hemoprotein heme oxygenase-3. Eur J Biochem 247:725-732.
288. McGrath JJ and Smith DL (1984) Response of rat coronary circulation to carbon monoxide and nitrogen hypoxia. Proc Soc Exp Biol Med 177:132-136.
289. McLaughlin BE, Hutchinson JM, Graham CH, Smith GN, Marks GS, and Brien JF (2000) Heme oxygenase activity in term human placenta. Placenta 21:870-873.
290. Megson IL, Holmes SA, Magid KS, Pritchard RJ, and Flitney FW (2000) Selective modifiers of glutathione biosynthesis and 'repriming' of vascular smooth muscle photorelaxation. Br J Pharmacol 130:1575-1580.
291. Meilin S, Rogatsky GG, Thom SR, Zarchin N, Gugginheimer-Furman E, and Mayevsky A (1996) Effects of carbon monoxide on the brain may be mediated by nitric oxide. J Appl Physiol 81:1078-1083.
292. Melo LG, Agrawal R, Zhang L, Rezvani M, Mangi AA, Ehsan A, Griese DP, Dell'Acqua G, Mann MJ, Oyama J, et al. (2002) Gene therapy strategy for longterm myocardial protection using adeno-associated virus-mediated delivery of heme oxygenase gene. Circulation 105:602-607.
293. Middendorff R, Kumm M, Davidoff MS, Holstein AF, and Muller D (2000) Generation of cyclic guanosine monophosphate by heme oxygenases in the human testis-a regulatory role for carbon monoxide in Sertoli cells? Biol Reprod 63:651-657.
294. Miller MA and Hales CA (1979) Role of cytochrome P-450 in alveolar hypoxic pulmonary vasoconstriction in dogs. J Clin Investig 64:666-673.
295. Milosz A and Settle W (1975) A new approach to the treatment of sickle cell anemia. Res Commun Chem Pathol Pharmacol 12:137-146.
296. Miyahara S and Takahashi H (1971) Biological CO evolution. Carbon monoxide evolution during auto- and enzymatic oxidation of phenols. J Biochem (Tokyo) 69:231-233.
297. 2. Brain Res 803:194-197.
298. Montgomery MR and Rubin RJ (1973) Oxygenation during inhibition of drug metabolism by carbon monoxide or hypoxic hypoxia. J Appl Physiol 35:505-509.
299. Monzani E, Bonafe B, Fallarini A, Redaelli C, Casella L, Minchiotti L, and Galliano M (2001) Enzymatic properties of human hemalbumin. Biochim Biophys Acta 1547:302-312.
300. Moore EG and Gibson QH (1976) Cooperativity in the dissociation of nitric oxide from hemoglobin. J Biol Chem 251:2788-2794.
301. Morita T and Kourembanas S (1995) Endothelial cell expression of vasoconstrictors and growth factors is regulated by smooth muscle cell-derived carbon monoxide. J Clin Investig 96:2676-2682.
302. Morita T, Mitsialis SA, Koike H, Liu Y, and Kourembanas S (1997) Carbon monoxide controls the proliferation of hypoxic vascular smooth muscle cells. J Biol Chem 272:32804-32809.
303. Mosley K, Wembridge DE, Cattell V, and Cook HT (1998) Heme oxygenase is induced in nephrotoxic nephritis and hemin, a stimulator of heme oxygenase synthesis, ameliorates disease. Kidney Int 53:672-678.
304. Motterlini R, Clark JE, Foresti R, Sarathchandra P, Mann BE, and Green CJ (2002a) Carbon monoxide-releasing molecules: characterization of biochemical and vascular activities. Circ Res 90:E17-E24.
305. Motterlini R, Foresti R, Bassi R, and Green CJ (2000) Curcumin, an antioxidant and anti-inflammatory agent, induces heme oxygenase-1 and protects endothelial cells against oxidative stress. Free Radic Biol Med 28:1303-1312.
306. Motterlini R, Foresti R, and Green CJ (2002b) Studies on the development of carbon monoxide-releasing molecules: potential applications for the treatment of cardiovascular dysfunction, in Carbon Monoxide and Cardiovascular Functions (Wang R ed) pp 249-271, CRC Press, Boca Raton, FL.
307. Motterlini R, Foresti R, Intaglietta M, and Winslow RM (1996) NOmediated activation of heme oxygenase: endogenous cytoprotection against oxidative stress to endothelium. Am J Physiol Heart Circ Physiol 270:H107-H114.
308. Moxness MS, Brunauer LS, and Huestis WH (1996) Hemoblogin oxidation products extract phospholipids from the membrane of human erythrocytes. Biochemistry 35:7181-7187.
309. Muller RM, Taguchi H, and Shibahara S (1987) Nucleotide sequence and organization of the rat heme oxygenase gene. J Biol Chem 262:6795-6802.
310. Muller-Eberhard U (1988) Hemopexin. Meth Enzymol 163:536-565.
311. Muraosa Y, Takahashi K, Yoshizawa M, and Shibahara S (1996) cDNA cloning of a novel protein containing two zinc-finger domains that may function as a transcription factor for the human heme-oxygenase-1 gene. Eur J Biochem 235:471-479.
312. Naik JS and Walker BR (2003) Heme oxygenase-mediated vasodilation involves vascular smooth muscle cell hyperpolarization. Am J Physiol Heart Circ Physiol 285:H220-H228.
313. Naito Y, Takagi T, and Yoshikawa T (2004) Heme oxygenase-1: a new therapeutic target for inflammatory bowel disease. Aliment Pharmacol Ther 20 (Suppl 1):177-184.
314. Nakayama M, Takahashi K, Kitamuro T, Yasumoto K, Katayose D, Shirato K, Fujii-Kuriyama Y, and Shibahara S (2000) Repression of heme oxygenase-1 by hypoxia in vascular endothelial cells. Biochem Biophys Res Commun 271:665-671.
315. Nath KA, Balla G, Vercellotti GM, Balla J, Jacob HS, Levitt MD, and Rosenberg ME (1992) Induction of heme oxygenase is a rapid, protective response in rhabdomyolysis in the rat. J Clin Investig 90:267-270.
316. Nath KA, Grande JP, Croatt AJ, Likely S, Hebbel RP, and Enright H (1998) Intracellular targets in heme protein-induced renal injury. Kidney Int 53:100-111.
317. Nath KA, Grande JP, Haggard JJ, Croatt AJ, Katusic ZS, Solovey A, and Hebbel RP (2001) Oxidative stress and induction of heme oxygenase-1 in the kidney in sickle cell disease. Am J Pathol 158:893-903.
318. Nath KA, Haggard JJ, Croatt AJ, Grande JP, Poss KD, and Alam J (2000) The indispensability of heme oxygenase-1 in protecting against acute heme proteininduced toxicity in vivo. Am J Pathol 156:1527-1535.
319. Nathanson JA, Scavone C, Scanlon C, and McKee M (1995) The cellular NaC pump as a site of action for carbon monoxide and glutamate: a mechanism for long-term modulation of cellular activity. Neuron 14:781-794.
320. Navarra P, Miceli F, Tringali G, Minici F, Pardo Garcia M, Lanzone A, Mancuso S, and Apa R (2001) Evidence for a functional link between the heme oxygenasecarbon monoxide pathway and corticotropin-releasing hormone release from primary cultures of human trophoblast cells. J Clin Endocrinol Metab 86:317-323.
321. Ndisang JF, Tabien HEN, and Wang R (2004) Carbon monoxide and hypertension. J Hypertension 22:1057-1074.
322. Ndisang JF and Wang R (2002) Mechanisms underlying selective regulation of blood pressure by heme oxygenase-1 in hypertension. Hypertension 40:315-321.
323. Ndisang JF and Wang R (2003a) Age-related alterations in soluble guanylyl cyclase and cGMP pathway in spontaneously hypertensive rats. J Hypertens 21:1117-1124.
324. Ndisang JF and Wang R (2003b) Alterations in heme oxygenase/carbon monoxide system in pulmonary artery in hypertension. Exp Biol Med (Maywood) 228:557-563.
325. Ndisang JF, Wu L, Zhao W, and Wang R (2003) Induction of heme oxygenase-1 and stimulation of cGMP production by hemin in aortic tissues from hypertensive rats. Blood 101:3893-3900.
326. Neil TK, Stoltz RA, Jiang S, Laniado-Schwartzman M, Dunn MW, Levere RD, Kappas A, and Abraham NG (1995) Modulation of corneal heme oxygenase expression by oxidative stress agents. J Ocul Pharmacol Ther 11:455-468.
327. Nimura T, Weinstein PR, Massa SM, Panter S, and Sharp FR (1996) Heme oxygenase-1 (HO-1) protein induction in rat brain following focal ischemia. Brain Res Mol Brain Res 37:201-208.
328. Nishibayashi H, Tomura T, Soto R, and Estabrook RW (1968) Structure and Function of Cytochromes, p 658, University Park Press, Baltimore, MD.
329. Nishikawa Y, Stepp DW, Merkus D, Jones D, and Chilian WM (2004) In vivo role of heme oxygenase in ischemic coronary vasodilation. Am J Physiol Heart Circ Physiol 286:H2296-H2304.
330. Norimizu S, Kudo A, Kajimura M, Ishikawa K, Taniai H, Yamaguchi T, Fujii K, Arii S, Nimura Y, and Suematsu M (2003) Carbon monoxide stimulates mrp2-dependent excretion of bilirubin-IXa into bile in the perfused rat liver. Antioxid Redox Signal 5:449-456.
331. Ny L, Alm P, Ekstrom P, Larsson B, Grundemar L, and Andersson KE (1996) Localization and activity of haem oxygenase and functional effects of carbon monoxide in the feline lower oesophageal sphincter. Br J Pharmacol 118:392-399.
332. Ny L, Andersson KE, and Grundemar L (1995) Inhibition by zinc protoporphyrin-IX of receptor-mediated relaxation of the rat aorta in a manner distinct from inhibition of haem oxygenase. Br J Pharmacol 115:186-190.
333. Odrcich MJ, Graham CH, Kimura KA, McLaughlin BE, Marks GS, Nakatsu K, and Brien JF (1998) Heme oxygenase and nitric oxide synthase in the placenta of the guinea-pig during gestation. Placenta 19:509-516.
334. Ogawa K, Sun J, Taketani S, Nakajima O, Nishitani C, Sassa S, Hayashi N, Yamamoto M, Shibahara S, Fujita H, and Igarashi K (2001) Heme mediates derepression of Maf recognition element through direct binding to transcription repressor Bach1. EMBO (Eur Mol Biol Organ) J 20:2835-2843.
335. Ohta K, Yachie A, Fujimoto K, Kaneda H, Wada T, Toma T, Seno A, Kasahara Y, Yokoyama H, Seki H, and Koizumi S (2000) Tubular injury as a cardinal pathologic feature in human heme oxygenase- 1 deficiency. Am J Kidney Dis 35:863-870.
336. Okinaga S, Takahashi K, Takeda K, Yoshizawa M, Fujita H, Sasaki H, and Shibahara S (1996) Regulation of human heme oxygenase-1 gene expression under thermal stress. Blood 87:5074-5084.
337. Okuyama H, Yonetani M, Uetani Y, and Nakamura H (2001) End-tidal carbon monoxide is predictive for neonatal non-hemolytic hyperbilirubinemia. Pediatr Int 43:329-333.
338. Ortiz de Montellano PR (1998) Heme oxygenase mechanism: evidence for an electrophilic, ferric peroxide species. Acc Chem Res 31:543-549.
339. Otterbein LE, Bach FH, Alam J, Soares M, Tao Lu H, Wysk M, Davis RJ, Flavell RA, and Choi AM (2000) Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway. Nat Med 6:422-428.
340. Otterbein LE and Choi AM (2000) Heme oxygenase: colors of defense against cellular stress. Am J Physiol Lung Cell Mol Physiol 279:L1029-L1037.
341. Otterbein LE, Kolls JK, Mantell LL, Cook JL, Alam J, and Choi AMK (1999) Exogenous administration of heme oxygenase-1 by gene transfer provides protection against hyperoxia-induced lung injury. J Clin Investig 103:1047-1054.
342. Overholt JL, Bright GR, and Prabhakar NR (1996) Carbon monoxide and carotid body chemoreception. Adv Exp Med Biol 410:341-344.
343. Ozawa N, Goda N, Makino N, Yamaguchi T, Yoshimura Y, and Suematsu M (2002) Leydig cell-derived heme oxygenase-1 regulates apoptosis of premeiotic germ cells in response to stress. J Clin Investig 109:457-467.
344. Pae H-O, Oh G-S, Choi B-M, Chae S-C, Kim Y-M, Chung K-R, and Chung H-T (2004) Carbon monoxide produced by heme oxygenase-1 suppresses T cell proliferation via inhibition of IL-2 production. J Immunol 172:4744-4751.
345. Palmer LA, Semenza GL, Stoler MH, and Johns RA (1998) Hypoxia induces type II NOS gene expression in pulmonary artery endothelial cells via HIF-1. Am J Physiol 274:L212-L219.
346. Panahian N, Yoshiura M, and Maines MD (1999) Overexpression of heme oxygenase-1 is neuroprotective in a model of permanent middle cerebral artery occlusion in transgenic mice. J Neurochem 72:1187-1203.
347. Pankow D, Matschiner F, and Weigmann HJ (1991) Influence of aromatic hydrocarbons on the metabolism of dichloromethane to carbon monoxide in rats. Toxicology 68:89-100.
348. Pannen BH and Bauer M (1998) Differential regulation of hepatic arterial and portal venous vascular resistance by nitric oxide and carbon monoxide in rats. Life Sci 62:2025-2033.
349. Pantopulos K, Mueller S, Atzberger A, Ansorge W, Stremmeli W, and Hentze MW (1997) Differences in the regulation of iron regulatory protein-1 (IRP-1) by extraand intracellular oxidative stress. J Biol Chem 272:9802-9808.
350. Papapetropoulos A, Marczin N, Mora G, Milici A, Murad F, and Catravas JD (1995) Regulation of vascular smooth muscle soluble guanylate cyclase activity, mRNA and protein levels by cAMP-elevating agents. Hypertension 26:696-704.
351. Parfenova H, Neff RA 3rd, Alonso JS, Shlopov BV, Jamal CN, Sarkisova SA, and Leffler CW (2001) Cerebral vascular endothelial heme oxygenase: expression, localization and activation by glutamate. Am J Physiol Cell Physiol 281:C1954-C1963.
352. Parkes D, Kasckow J, and Vale W (1994) Carbon monoxide modulates secretion of corticotropin-releasing factor from rat hypothalamic cell cultures. Brain Res 646:315-318.
353. Penney DG and Formolo JM (1993) Carbon monoxide-induced cardiac hypertrophy is not reduced by alpha- or beta-blockade in the rat. Toxicology 80:173-187.
354. Penney DG, Tucker A, and Bambach GA (1992) Heart and lung alterations in neonatal rats exposed to CO or high altitude. J Appl Physiol 73:1713-1719.
355. Petrache I, Otterbein LE, Alam J, Wiegand GW, and Choi AM (2000) Heme oxygenase-1 inhibits TNF-alpha-induced apoptosis in cultured fibroblasts. Am J Physiol Lung Cell Mol Physiol 278:L312-L319.
356. Peyton KJ, Reyna SV, Chapman GB, Ensenat D, Liu XM, Wang H, Schafer AI, and Durante W (2002) Heme oxygenase-1-derived carbon monoxide is an autocrine inhibitor of vascular smooth muscle cell growth. Blood 99:4443-4448.
357. Piantadosi CA (2002) Biological chemistry of carbon monoxide. Antioxid Redox Signal 4:259-270.
358. Piantadosi CA, Tatro L, and Zhang J (1995) Hydroxyl radical production in the brain after CO hypoxia in rats. Free Radic Biol Med 18:603-609.
359. Pineda J, Kogan JH, and Aghajanian GK (1996) Nitric oxide and carbon monoxide activate locus coeruleus neurons through a cGMP-dependent protein kinase: involvement of a nonselective cationic channel. J Neurosci 16:1389-1399.
360. Platt JL and Nath KA (1998) Heme oxygenase: protective gene or Trojan horse. Nat Med 4:1364-1365.
361. Pomeraniec Y, Grion N, Gadda L, Pannunzio V, Podesta EJ, and Cymeryng CB (2004) Adrenocorticotropin induces heme oxygenase-1 expression in adrenal cells. J Endocrinol 180:113-124.
362. Ponka P (1999) Cell biology of heme. Am J Med Sci 318:241-256.
363. Poss KD, Thomas MJ, Ebralidze AK, O'Dell TJ, and Tonegawa S (1995) Hippocampal long-term potentiation is normal in heme oxygenase-2 mutant mice. Neuron 15:867-873.
364. Poss KD and Tonegawa S (1997a) Heme oxygenase 1 is required for mammalian iron reutilization. Proc Natl Acad Sci USA 94:10919-10924.
365. Poss KD and Tonegawa S (1997b) Reduced stress defense in heme oxygenase 1-deficient cells. Proc Natl Acad Sci USA 94:10925-10930.
366. Pozzoli G, Mancuso C, Mirtella A, Preziosi P, Grossman AB, and Navarra P (1994) Carbon monoxide as a novel neuroendocrine modulator: inhibition of stimulated corticotropin-releasing hormone release from acute rat hypothalamic explants. Endocrinology 135:2314-2317.
367. Prabhakar NR (1999) NO and CO as second messengers in oxygen sensing in the carotid body. Respir Physiol 115:161-168.
368. Premkumar DR, Smith MA, Richey PL, Petersen RB, Castellani R, Kutty RK, Wiggert B, Perry G, and Kalaria RN (1995) Induction of heme oxygenase-1 mRNA and protein in neocortex and cerebral vessels in Alzheimer's disease. J Neurochem 65:1399-1402.
369. Quan S, Yang L, Abraham NG, and Kappas A (2001) Regulation of human heme oxygenase in endothelial cells by using sense and antisense retroviral constructs. Proc Natl Acad Sci USA 98:12203-12208.
370. Ragsdale SW (2004) Life with carbon monoxide. Crit Rev Biochem Mol Biol 39:165-195.
371. Raju VS, McCoubrey WK Jr, and Maines MD (1997) Regulation of heme oxygenase-2 by glucocorticoids in neonatal rat brain: characterization of a functional glucocorticoid response element. Biochim Biophys Acta 1351:89-104.
372. Ratney RS, Wegman DH, and Elkins HB (1974) In vivo conversion of methylene chloride to carbon monoxide. Arch Environ Health 28:223-226.
373. Rattan S and Chakder S (1993) Inhibitory effect of CO on internal anal sphincter: heme oxygenase inhibitor inhibits NANC relaxation. Am J Physiol 265:G799-G804.
374. Ribeiro MM, Klein D, Pileggi A, Molano RD, Fraker C, Ricordi C, Inverardi L, and Pastori RL (2003) Heme oxygenase-1 fused to a TAT peptide transduces and protects pancreatic beta-cells. Biochem Biophys Res Commun 305:876-881.
375. Rich A, Farrugia G, and Rae JL (1994) Carbon monoxide stimulates a potassiumselective current in rabbit corneal epithelial cells. Am J Physiol 267:C435-C442.
376. + channels of rat chemoreceptor cells by a membrane-restricted and CO-sensitive mechanism. Circ Res 89:430-436.
377. Rodgers PA, Vreman HJ, Dennery PA, and Stevenson DK (1994) Sources of carbon monoxide (CO) in biological systems and applications of CO detection technologies. Semin Perinatol 18:2-10.
378. Rodriguez F, Kemp R, Balazy M, and Nasjletti A (2003) Effects of exogenous heme on renal function: role of heme oxygenase and cyclooxygenase. Hypertension 42:680-684.
379. Roman RJ (2002) P-450 metabolites of arachidonic acid in the control of cardiovascular function. Physiol Rev 82:131-185.
380. Roughton FJW and Darling RC (1944) The effect of carbon monoxide on the oxyhemoglobin dissociation curve. Am J Physiol 141:17-31.
381. Rucker M, Schafer T, Roesken F, Spitzer WJ, Bauer M, and Menger MD (2001) Reduction of inflammatory response in composite flap transfer by local stress conditioning-induced heat-shock protein 32. Surgery 129:292-301.
382. Rutter J, Reick M, and McKnight SL (2002) Metabolism and the control of circadian rhythms. Annu Rev Biochem 71:307-331.
383. Ryter SW and Tyrrell RM (2000) The heme synthesis and degradation pathways: role in oxidant sensitivity. Free Radic Biol Med 28:289-309.
384. Sabaawy HE, Zhang F, Nguyen X, ElHosseiny A, Nasjletti A, Schwartzman M, Dennery P, Kappas A, and Abraham NG (2001) Human heme oxygenase-1 gene transfer lowers blood pressure and promotes growth in spontaneously hypertensive rats. Hypertension 38:210-215.
385. Sacerdoti D, Abraham NG, Oyekan AO, Yang L, Gatta A, and McGiff JC (2004) Role of the Heme Oxygenases in Abnormalities of the mesenteric circulation in cirrhotic rats. J Pharmacol Exp Ther 308:636-643.
386. Sacerdoti D, Escalante B, Abraham NG, McGiff JC, Levere RD, and Schwartzman ML (1989) Treatment with tin prevents the development of hypertension in spontaneously hypertensive rats. Science (Wash DC) 243:388-390.
387. Sarady JK, Otterbein SL, Liu F, Otterbein LE, and Choi AMK (2002) Carbon monoxide modulates endotoxin-induced production of granulocyte macrophage colony-stimulating factor in macrophages. Am J Respir Cell Mol Biol 27:739-745.
388. Sardana MK, Drummond GS, Sassa S, and Kappas A (1981) The potent heme oxygenase inducing action of arsenic and parasiticidal arsenicals. Pharmacology 23:247-253.
389. Sass G, Seyfried S, Parreira Soares M, Yamashita K, Kaczmarek E, Neuhuber WL, and Tiegs G (2004) Cooperative effect of biliverdin and carbon monoxide on survival of mice in immune-mediated liver injury. Hepatology 40:1128-1135.
390. Sassa S (2004) Why heme needs to be degraded to iron, biliverdin IXα and carbon monoxide? Antioxid Redox Signal 6:819-824.
391. Sato K, Balla J, Otterbein L, Smith RN, Brouard S, Lin Y, Csizmadia E, Sevigny J, Robson SC, Vercellotti G, et al. (2001) Carbon monoxide generated by heme oxygenase-1 suppresses the rejection of mouse-to-rat cardiac transplants. J Immunol 166:4185-4194.
392. Sato M, Ishizawa S, Yoshida T, and Shibahara S (1990) Interaction of upstream stimulatory factor with the human heme oxygenase gene promoter. Eur J Biochem 188:231-237.
393. Sawai H, Kawada N, Yoshizato K, Nakajima H, Aono S, and Shiro Y (2003) Characterization of the heme environmental structure of cytoglobin, a fourth globin in humans. Biochemistry 42:5133-5142.
394. Scapagnini G, D'Agata V, Calabrese V, Pascale A, Colombrita C, Alkon D, and Cavallaro S (2002a) Gene expression profiles of heme oxygenase isoforms in the rat brain. Brain Res 954:51-59.
395. Scapagnini G, Foresti R, Calabrese V, Giuffrida Stella AM, Green CJ, and Motterlini R (2002b) Caffeic acid phenethyl ester and curcumin: a novel class of heme oxygenase-1 inducers. Mol Pharmacol 61:554-561.
396. Schimmer BP (1979) Adrenocortical Y1 cells. Methods Enzymol 52:570-574.
397. Schipper HM, Chertkow H, Mehindate K, Frankel D, Melmed C, and Bergman H (2000) Evaluation of heme oxygenase-1 as a systemic biological marker of sporadic AD. Neurology 54:1297-1304.
398. Schipper HM, Liberman A, and Stopa EG (1998) Neural heme oxygenase-1 expression in idiopathic Parkinson's disease. Exp Neurol 150:60-68.
399. Schwartzman ML, Masferrer J, Dunn MW, McGiff JC, and Abraham NG (1987) Cytochrome P450, drug metabolizing enzymes and arachidonic acid metabolism in bovine ocular tissues. Curr Eye Res 6:623-630.
400. 2 entry into and exit from myoglobin. J Biol Chem 276:5177-5188.
401. Seidman DS, Hendler I, Kreiser D, Schiff E, Druzin M, Stevenson DK, and Dennery PA (2000) Pregnant woman with uterine contractions have lower end tidal carbon monoxide levels (Abstract 246). Acta Hematologica 103 (Suppl 1):62.
402. Semenza GL, Agani F, Booth G, Forsythe J, Iyer N, Jiang B, Leung S, Roe R, Weiner C, and Yu A (1997) Structural and functional analysis of hypoxia-inducible factor 1. Kidney Int 51:553-555.
403. Seshadri N, Dweik RA, Laskowski D, Pothier C, Rodriguez L, Young JB, and Migrino RQ (2003) Dysregulation of endogenous carbon monoxide and nitric oxide production in patients with advanced ischemic or nonischemic cardiomyopathy. Am J Cardiol 92:820-823.
404. Sexton DJ, Muruganandam A, McKenney DJ, and Mutus B (1994) Visible light photochemical release of nitric oxide from S-nitrosoglutathione: potential photochemotherapeutic applications. J Photochem Photobiol 59:463-467.
405. Shan Y, Lambrecht RW, Lu TH, and Bonkovsky HL (1999) Effects of phenylarsine oxide on expression of heme oxygenase-1 reporter constructs in transiently transfected cultures of chick embryo liver cells. Arch Biochem Biophys 372:224-229.
406. Sharma HS and Westman J (2003) Depletion of endogenous serotonin synthesis with p-CPA attenuates upregulation of constitutive isoform of heme oxygenase-2 expression, edema formation and cell injury following a focal trauma to the rat spinal cord. Acta Neurochir Suppl 86:389-394.
407. Shemin D and Wittenberg J (1951) The mechanism of porphyrin formation: the role of the tricarboxylic acid cycle. J Biol Chem 192:315-334.
408. Shibahara S, Kitamuro T, and Takahashi K (2002) Heme degradation and human disease: diversity is the soul of life. Antioxid Redox Signal 4:593-602.
409. Shibahara S, Muller RM, and Taguchi H (1987) Transcriptional control of rat heme oxygenase by heat shock. J Biol Chem 262:12889-12892.
410. Shibahara S, Nakayama M, Kitamuro T, Udono-Fujimori R, and Takahashi K (2003) Repression of heme oxygenase-1 expression as a defense strategy in humans. Exp Biol Med 228:472-473.
411. Shih DM, Xia YR, Wang XP, Miller E, Castellani LW, Subbanagounder G, Cheroutre H, Faull KF, Berliner JA, Witztum JL, and Lusis AJ (2000) Combined serum paraoxonase knockout/apolipoprotein E knockout mice exhibit increased lipoprotein oxidation and atherosclerosis. J Biol Chem 275:17527-17535.
412. Shimizu H, Takahashi T, Suzuki T, Yamasaki A, Fujiwara T, Odaka Y, Hirakawa M, Fujita H, and Akagi R (2000) Protective effect of heme oxygenase induction in ischemic acute renal failure. Crit Care Med 28:809-817.
413. Shinoda Y, Suematsu M, Wakabayashi Y, Suzuki T, Goda N, Saito S, Yamaguchi T, and Ishimura Y (1998) Carbon monoxide as a regulator of bile canalicular contractility in cultured rat hepatocytes. Hepatology 28:286-295.
414. Shiraishi F, Curtis LM, Truong L, Poss K, Visner GA, Madsen K, Nick HS, and Agarwal A (2000) Heme oxygenase-1 gene ablation or expression modulates cisplatin-induced renal tubular apoptosis. Am J Physiol Renal Physiol 278:F726-F736.
415. Shriver DT (1981) Activation of carbon monoxide by carbon and oxygen coordination, in Catalytic Activation of Carbon Monoxide (Ford PC ed) pp 1-18, American Chemistry Society, Washington, DC.
416. Sikorski EM, Hock T, Hill-Kapturczak N, and Agarwal A (2004) The story so far: molecular regulation of the heme oxygenase-1 gene in renal injury. Am J Physiol Renal Physiol 286:F425-F441.
417. Sjöstrand T (1950) Endogenous formation of carbon monoxide. Acta Physiol Scand 22:137-141.
418. Sjöstrand T (1952) The formation of carbon monoxide by the decomposition of haemoglobin in vivo. Acta Physiol Scand 26:338.
419. Smith WL and Marnett LJ (1991) Prostaglandin endoperoxide synthase: structure and catalysis. Biochem Biophys Acta 1083:1-17.
420. Snyder SH, Jaffrey SR, and Zakhary R (1998) Nitric oxide and carbon monoxide: parallel roles as neural messengers. Brain Res Rev 26:167-175.
421. Soares MP, Lin Y, Anrather J, Csizmadia E, Takigami K, Sato K, Grey ST, Colvin RB, Choi AM, Poss KD, and Bach FH (1998) Expression of heme oxygenase-1 can determine cardiac xenograft survival. Nat Med 4:1073-1077.
422. Solari V, Piotrowska AP, and Puri P (2003) Expression of heme oxygenase-1 and endothelial nitric oxide synthase in the lung of newborns with congenital diaphragmatic hernia and persistent pulmonary hypertension. J Pediatr Surg 38:808-813.
423. Song R, Zhou Z, Kim PK, Shapiro RA, Liu F, Ferran C, Choi AM, and Otterbein LE (2004) Carbon monoxide promotes Fas/CD95-induced apoptosis in Jurkat cells. J Biol Chem 279:44327-44334.
424. Srivastava P and Pandey VC (1996) Mitochondrial heme oxygenase of Mastomys coucha. Int J Biochem Cell Biol 28:1071-1077.
425. Stevens CF and Wang Y (1993) Reversal of long-term potentiation by inhibitors of haem oxygenase. Nature (Lond) 364:147-149.
426. Stevenson DK, Vreman HJ, Oh W, Fanaroff AA, Wright LL, Lemons JA, Verter J, Shankaran S, Tyson JE, and Korones SB (1994) Bilirubin production in healthy term infants as measured by carbon monoxide in breath. Clin Chem 40:1934-1939.
427. Stewart RD (1975) The effect of carbon monoxide on humans. Annu Rev Pharmacol 17:409-423.
428. Stewart RD, Fisher TN, Hosko MJ, Peterson JE, Baretta ED, and Dodd HC (1972) Carboxyhemoglobin elevation after exposure to dichloromethane. Science (Wash DC) 176:295-296.
429. Stocker R, Yamamoto Y, McDonagh AF, Glazer AN, and Ames BN (1987) Bilirubin is an antioxidant of possible physiological importance. Science (Wash DC) 235:1043-1046.
430. Stone JR and Marletta MA (1994) Soluble guanylate cyclase from bovine lung: activation with nitric oxide and carbon monoxide and spectral characterization of the ferrous and ferric states. Biochemistry 33:5636-5640.
431. Stupfel M and Bouley G (1970) Physiological and biochemical effects on rats and mice exposed to small concentrations of carbon monoxide for long periods. Ann NY Acad Sci 174:342-368.
432. Suematsu M, Goda N, Sano T, Kashiwagi S, Egawa T, Shinoda Y, and Ishimura Y (1995) Carbon monoxide: an endogenous modulator of sinusoidal tone in the perfused rat liver. J Clin Investig 96:2431-2437.
433. Suematsu M, Kashiwagi S, Sano T, Goda N, Shinoda Y, and Ishimura Y (1994) CO as an endogenous modulator of vascular perfusion. Biochem Biophys Res Commun 205:1333-1337.
434. + channel activity and vascular tone in renal arterioles. Circ Res 83:1069-1079.
435. Sun J, Hoshino H, Takaku K, Nakajima O, Muto A, Suzuki H, Tashiro S, Takahashi S, Shibahara S, Alam J, et al. (2002) Hemoprotein Bach1 regulates enhancer availability of heme oxygenase-1 gene. EMBO (Eur Mol Biol Organ) J 21:5216-5224.
436. Suttner DM and Dennery PA (1999) Reversal of HO-1 related cytoprotection with increased expression is due to reactive iron. FASEB J 13:1800-1809.
437. Sylvester JT and McGowan C (1978) The effects of agents that bind to cytochrome P-450 on hypoxic pulmonary vasoconstriction. Circ Res 43:429-437.
438. Tacchini L, Dansi P, Matteucci E, and Desiderio MA (2001) Hepatocyte growth factor signalling stimulates hypoxia inducible factor-1 (HIF-1) activity in HepG2 hepatoma cells. Carcinogenesis 22:1363-1371.
439. Taille C, El-Benna J, Lanone S, Dang MC, Ogier-Denis E, Aubier M, and Boczkowski J (2004) Induction of heme oxygenase-1 inhibits NAD(P)H oxidase activity by down-regulating cytochrome b558 expression via the reduction of heme availability. J Biol Chem 279:28681-28688.
440. Takeda A, Perry G, Abraham NG, Dwyer BE, Kutty RK, Laitinen JT, Petersen RB, and Smith MA (2000) Overexpression of heme oxygenase in neuronal cells, the possible interaction with tau. J Biol Chem 275:5395-5399.
441. Takeda K, Ishizawa S, Sato M, Yoshida T, and Shibahara S (1994) Identification of a cis-acting element that is responsible for cadmium-mediatedinduction of the human heme oxygenase gene. J Biol Chem 269:22858-22867.
442. Takahashi K, Nakayama M, Takeda K, Fujia H, and Shibahara S (1999a) Suppression of heme oxygenase-1 mRNA expression by interferon-gamma in human glioblastoma cells. J Neurochem 72:2356-2361.
443. Takahashi M, Dore S, Ferris CD, Tomita T, Sawa A, Wolosker H, Borchelt DR, Iwatsubo T, Kim SH, Thinakaran G, et al. (2000) Amyloid precursor proteins inhibit heme oxygenase activity and augment neurotoxicity in Alzheimer's disease. Neuron 28:461-473.
444. Takahashi S, Matsuura N, Kurokawa T, Takahashi Y, and Miura T (2002) Cooperation of the transcription factor hepatocyte nuclear factor-4 with Sp1 or Sp3 leads to transcriptional activation of the human haem oxygenase-1 gene promoter in a hepatoma cell line. Biochem J 367:641-652.
445. Takahashi S, Takahashi Y, Ito K, Nagano T, Shibahara S, and Miura T (1999b) Positive and negative regulation of the human heme oxygenase-1 gene expression in cultured cells. Biochim Biophys Acta 1447:231-235.
446. Tan DX, Manchester LC, Hardeland R, Lopez-Burillo S, Mayo JC, Sainz RM, and Reiter RJ (2003) Melatonin: a hormone, a tissue factor, an autocoid, a paracoid and an antioxidant vitamin. J Pineal Res 34:75-78.
447. Tang XD, Xu R, Reynolds MF, Garcia ML, Heinemann SH, and Hoshi T (2003) Haem can bind to and inhibit mammalian calcium-dependent Slo1 BK channels. Nature (Lond) 425:531-535.
448. Tenhunen R, Marver HS, and Schmid R (1968) The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase. Proc Natl Acad Sci USA 61:748-755.
449. Tenhunen R, Marver HS, and Schmid R (1969) Microsomal heme oxygenase. Characterization of the enzyme. J Biol Chem 244:6388-6394.
450. Tenhunen R, Marver HS, and Schmid R (1970) The enzymatic catabolism of hemoglobin: stimulation of microsomal heme oxygenase by hemin. J Lab Clin Med 75:410-421.
451. Terraz S, Baechtold F, Renard D, Barsi A, Rosselet A, Gnaegi A, Liaudet L, Lazor R, Haefliger JA, Schaad N, et al. (1999) Hypoxic contraction of small pulmonary arteries from normal and endotoxemic rats: fundamental role of NO. Am J Physiol 276:H1207-H1214.
452. 2+ and phospholipase A2 in endothelial cells. Am J Physiol 276:H1493-H1501.
453. Thiemermann C (2001) Inhaled CO: deadly gas or novel therapeutic? Nat Med 7:534-535.
454. Thom SR (1990) Carbon monoxide mediated brain lipid peroxidation in the rat. J Appl Physiol 68:997-1003.
455. Thom SR, Fisher D, Xu YA, Garner S, and Ischiropoulos H (1999a) Role of nitric oxide-derived oxidants in vascular injury from carbon monoxide in the rat. Am J Physiol 276:H984-H992.
456. Thom SR, Fisher D, Xu YA, Notarfrancesco K, and Ischiropoulos H (2000) Adaptive responses and apoptosis in endothelial cells exposed to carbon monoxide. Proc Natl Acad Sci USA 97:1305-1310.
457. Thom SR, Ohnishi ST, Fisher D, Xu YA, and Ischiropoulos H (1999b) Pulmonary vascular stress from carbon monoxide. Toxicol Appl Pharmacol 154:12-19.
458. Thom SR, Xu YA, and Ischiropoulos H (1997) Vascular endothelial cells generate peroxynitrite in response to carbon monoxide exposure. Chem Res Toxicol 10:1023-1031.
459. Thorup C, Jones CL, Gross SS, Moore LC, and Goligorsky MS (1999) Carbon monoxide induces vasodilation and nitric oxide release but suppresses endothelial NOS. Am J Physiol 277:F882-F889.
460. Togane Y, Morita T, Suematsu M, Ishimura Y, Yamazaki JI, and Katayama S (2000) Protective roles of endogenous carbon monoxide in neointimal development elicited by arterial injury. Am J Physiol Heart Circ Physiol 278:H623-H632.
461. Tongers J, Fiedler B, Konig D, Kempf T, Klein G, Heineke J, Kraft T, Gambaryan S, Lohmann SM, Drexler H, and Wollert KC (2004) Heme oxygenase-1 inhibition of MAP kinases, calcineurin/NFAT signaling and hypertrophy in cardiac myocytes. Cardiovasc Res 63:545-552.
462. Trakshel GM, Kutty RK, and Maines MD (1986) Purification and characterization of the major constitutive form of testicular heme oxygenase: the non-inducible isoform. J Biol Chem 261:11131-11137.
463. Trakshel GM and Maines MD (1988) Detection of two heme oxygenase isoforms in the human testis. Biochem Biophys Res Commun 154:285-291.
464. Tschugguel W, Stonek F, Zhegu Z, Dietrich W, Schneeberger C, Stimpfl T, Waldhoer T, Vycudilik W, and Huber JC (2001) Estrogen increases endothelial carbon monoxide, heme oxygenase 2 and carbon monoxide-derived cGMP by a receptormediated system. J Clin Endocrinol Metab 86:3833-3839.
465. Tsuburai T, Suzuki M, Nagashima Y, Suzukis S, Inoue S, Hashiba T, Ueda A, Ikehara K, Matsuse T, and Ishigatsubo Y (2002) Adenovirus-mediated transfer and overexpression of heme oxygenase 1 cDNA in lung prevents bleomycininduced pulmonary fibrosis via a Fas-Fas ligand-independent pathway. Hum Gene Ther 13:1945-1960.
466. Tullius SG, Nieminen-Kelha M, Buelow R, Reutzel-Selke A, Martins PN, Pratschke J, Bachmann U, Lehmann M, Southard D, Iyer S, et al. (2002) Inhibition of ischemia/reperfusion injury and chronic graft deterioration by a single-donor treatment with cobalt-protoporphyrin for the induction of heme oxygenase-1. Transplantation 74:591-598.
467. Turcanu V, Dhouib M, Gendrault JL, and Poindron P (1998a) Carbon monoxide induces murine thymocyte apoptosis by a free radical-mediated mechanism. Cell Biol Toxicol 14:47-54.
468. Turcanu V, Dhouib M, and Poindron P (1998b) Nitric oxide synthase inhibition by haem oxygenase decreases macrophage nitric-oxide-dependent cytotoxicity: a negative feedback mechanism for the regulation of nitric oxide production. Res Immunol 149:741-744.
469. Turnbull AV, Kim CK, Lee S, and Rivier CL (1998) Influence of carbon monoxide and its interaction with nitric oxide, on the adrenocorticotropin hormone response of the normal rat to a physico- emotional stress. J Neuroendocrinol 10:793-802.
470. Tyrrell R (1999) Redox regulation and oxidant activation of heme oxygenase-1. Free Radic Res 31:335-340.
471. Tyrrell RM, Applegate LA, and Tromvoukis Y (1993) The proximal promoter region of the human heme oxygenase gene contains elements involved in stimulation of transcriptional activity by a variety of agents including oxidants. Carcinogenesis 14:761-765.
472. Tzagoloff A and Wharton DC (1965) Studies on the electron transfer system: LXII. The reaction of cytochrome oxidase with carbon monoxide. J Biol Chem 240:2628.
473. Tzeng E, Kim YM, Pitt BR, Lizonova A, Kovesdi I, and Billiar TR (1997) Adenoviral transfer of the inducible nitric oxide synthase gene blocks endothelial cell apoptosis. Surgery 122:255-263.
474. Udono-Fujimori R, Takahashi K, Takeda K, Furuyama K, Kaneko K, Takahashi S, Tamai M, and Shibahara S (2004) Expression of heme oxygenase-1 is repressed by interferon-c and induced by hypoxia in human retinal pigment epithelial cells. Eur J Biochem 271:3076-3084.
475. Usami N, Tateoka Y, Watanabe K, Yamamoto I, and Yoshimura H (1995) Formation of carbon monoxide during mouse hepatic microsomal oxidative metabolism of cannabidiol; identification and determination. Biol Pharm Bull 18:529-535.
476. Ushiyama M, Morita T, Kuramochi T, Yagi S, and Katayama S (2004) Erectile dysfunction in hypertensive rats results from impairment of the relaxation evoked by neurogenic carbon monoxide and nitric oxide. Hypertens Res 27:253-261.
477. Utz J and Ullrich V (1991) Carbon monoxide relaxes ileal smooth muscle through activation of guanylyl cyclase. Biochem Pharmacol 41:1195-1201.
478. Vedernikov YP, Graser T, and Vanin AF (1989) Similar endothelium- independent arterial relaxation by carbon monoxide and nitric oxide. Biomed Biochim Acta 48:601-603.
479. Venturini CM, Palmer RMJ, and Moncada S (1993) Vascular smooth muscle contains a depletable store of a vasodilator which is light activated and restored by donors of nitric oxide. J Pharmacol Exp Ther 266:1497-1500.
480. Verma A, Hirsch DJ, Glatt CE, Ronnett GV, and Snyder SH (1993) Carbon monoxide: a putative neural messenger. Science (Wash DC) 259:381-384.
481. Vijayasarathy C, Damle S, Lenka N, and Avadhani NG (1999) Tissue variant effects of heme inhibitors on the mouse cytochrome c oxidase gene expression and catalytic activity of the enzyme complex. Eur J Biochem 266:191-200.
482. Villamor E, Perez-Vizcaino F, Cogolludo AL, Conde-Oviedo J, Zaragoza-Arnaez F, Lopez-Lopez JG, and Tamargo J (2000) Relaxant effects of carbon monoxide compared with nitric oxide in pulmonary and systemic vessels of newborn piglets. Pediatr Res 48:546-553.
483. Vincent SH, Grady RW, Shaklai N, Snider JM, and Muller-Eberhard U (1988) The influence of heme-binding proteins in heme-catalyzed oxidations. Arch Biochem Biophys 265:539-550.
484. Vincent SR, Das S, and Maines MD (1994) Brain heme oxygenase isoenzymes and nitric oxide synthase are co-localized in select neurons. Neuroscience 63:223-231.
485. Vladimirov Y, Borisenko G, Boriskina N, Kazarinov K, and Osipov A (2000) NOhemoglobin may be a light-sensitive source of nitric oxide both in solution and in red blood cells. J Photochem Photobiol B 59:115-122.
486. Vogt BA, Shanley TP, Croatt A, Alam J, Johnson KJ, and Nath KA (1996) Glomerular inflammation induces resistance to tubular injury in the rat: a novel form of acquired, heme oxygenase-dependent resistance to renal injury. J Clin Investig 98:2139-2145.
487. von Restorff W and Hebisch S (1988) Dark adaptation of the eye during carbon monoxide exposure in smokers and nonsmokers. Aviat Space Environ Med 59:928-931.
488. Vorobioff J, Bredfeldt JE, and Groszmann RJ (1984) Increased blood flow through the portal system in cirrhotic rats. Gastroenterology 87:1120-1126.
489. Vreman HJ, Ekstrand BC, and Stevenson DK (1993) Selection of metalloporphyrin heme oxygenase inhibitors based on potency and photoreactivity. Pediatr Res 33:195-200.
490. Vreman HJ, Wong RJ, Kim EC, Nabseth DC, Marks SG, and Stevenson DK (1999) Heme oxygenase activity in human umbilical cord and rat vascular tissues. Placenta 21:337-344.
491. Vreman HJ, Wong RJ, Sanesi C, Dennery PA, and Stephenson DK (1998) Simultaneous production of carbon monoxide and thiobarbituric acid reactive substances in rat tissue preparations by an iron ascorbate system. Can J Physiol Pharmacol 76:1057-1065.
492. Wagener FA, Volk H, Willis D, Abraham NG, Soares MP, Adema GJ, and Figdor CG (2003) Different faces of the heme-heme oxygenase system in inflammation. Pharmacol Rev 55:551-571.
493. Wagner CT, Durante W, Christodoulides N, Hellums JD, and Schafer AI (1997) Hemodynamic forces induce the expression of heme oxygenase in cultured vascular smooth muscle cells. J Clin Investig 100:589-596.
494. Wang R (1996) Vasorelaxation induced by carbon monoxide and underlying mechanisms. Physiol Can 27:37-39.
495. Wang R (1998) Resurgence of carbon monoxide: an endogenous gaseous vasorelaxing factor. Can J Physiol Pharmacol 76:1-15.
496. Wang R (2002) Two's company, three's a crowd: Can H2S be the third endogenous gaseous transmitter? FASEB J 16:1792-1798.
497. 2S in Biology and Medicine (Wang R ed) pp 3-32, Humana Press, Totowa.
498. Wang R, Wang ZZ, and Wu L (1997a) Carbon monoxide-induced vasorelaxation and the underlying mechanisms. Br J Pharmacol 121:927-934.
499. Wang R, Wang ZZ, Wu L, Hanna ST, and Peterson-Wakeman R (2001a) Reduced vasorelaxant effect of carbon monoxide in diabetes and the underlying mechanisms. Diabetes 50:166-174.
500. Wang R and Wu L (1997) The chemical modification of KCa channels by carbon monoxide in vascular smooth muscle cells. J Biol Chem 272:8222-8226.
501. Ca channels with carbon monoxide. Exp Biol Med (Maywood) 228:474-480.
502. Ca channels in vascular smooth muscle cells. Pflueg Arch Eur J Physiol 434:285-291.
503. Wang Y, Kinzie E, Berger FG, Lim SK, and Baumann H (2001b) Haptoglobin, an inflammation-inducible plasma protein. Redox Rep 6:379-385.
504. Warburg O (1930) The enzyme problem and biological oxidations. Johns Hopkins Bull 46:341-358.
505. Watkins CC, Boehning D, Kaplin AI, Rao M, Ferris CD, and Snyder SH (2004) Carbon monoxide mediates vasoactive intestinal polypeptide-associated nonadrenergic/ noncholinergic neurotransmission. Proc Natl Acad Sci USA 101:2631-2635.
506. Watson CJ (1965) Reminiscences of Hans Fischer and his laboratory. Perspect Biol Med 8:419-435.
507. Weber CM, Eke BC, and Maines MD (1994) Corticosterone regulates heme oxygenase-2 and NO synthase transcription and protein expression in rat brain. J Neurochem 63:953-962.
508. Werkstrom V, Ny L, Persson K, and Andersson KE (1997) Carbon monoxide-induced relaxation and distribution of haem oxygenase isoenzymes in the pig urethra and lower oesophagogastric junction. Br J Pharmacol 120:312-318.
509. White RE and Coon MJ (1980) Oxygen activation by cytochrome P450. Annu Rev Biochem 49:315-356.
510. Wiesel P, Patel AP, Carvajal IM, Wang ZY, Pellacani A, Maemura K, DiFonzo N, Rennke HG, Layne MD, Yet S-F, et al. (2001) Exacerbation of chronic renovascular hypertension and acute renal failure in heme oxygenase-1-deficient mice. Circ Res 88:1088-1094.
511. Williams SE, Wootton P, Mason HS, Bould J, Iles DE, Riccardi D, Peers C, and Kemp PJ (2004) Hemoxygenase-2 is an oxygen sensor for a calcium-sensitive potassium channel. Science (Wash DC) 306:2093-2097.
512. Willis D, Tomlinson A, Frederick R, Paul-Clark MJ, and Willoughby DA (1995) Modulation of heme oxygenase activity in rat brain and spleen by inhibitors and donors of nitric oxide. Biochem Biophys Res Commun 214:1152-1156.
513. Wirkner K, Damme B, Poelchen W, and Pankow D (1997) Effect of long-term ethanol pretreatment on the metabolism of dichloromethane to carbon monoxide in rats. Toxicol Appl Pharmacol 143:83-88.
514. Wohlrab H and Ogunmola BG (1971) Carbon monoxide binding studies of cytochrome a,a3 hemes in intact rat liver mitochondria. Biochemistry 10:1103-1106.
515. Wolff DG and Bidlak WK (1976) The formation of carbon monoxide during peroxidation of microsomal lipids. Biochem Biophys Res Commun 73:850-852.
516. Worthington MT, Cohn SM, Miller SK, Luo RQ, and Berg CL (2001) Characterization of a human plasma membrane heme transporter in intestinal and hepatocyte cell lines. Am J Physiol Gastrointest Liver Physiol 280:G1172-G1177.
517. Wu L (2005) The pro-oxidant role of methylglyoxal in mesenteric artery smooth muscle cells. Can J Physiol Pharmacol 83:63-68.
518. Wu L, Cao K, Lu Y, and Wang R (2002) Different mechanisms underlying the stimulation of KCa channels by nitric oxide and carbon monoxide. J Clin Investig 110:691-700.
519. Xi Q, Tcheranova D, Parfenova H, Horowitz B, Leffler CW, and Jaggar JH (2004) Carbon monoxide activates KCa channels in newborn arteriole smooth muscle cells by increasing apparent Ca2 sensitivity of alpha-subunits. Am J Physiol Heart Circ Physiol 286:H610-H618.
520. Xue L, Farrugia G, Miller SM, Ferris CD, Snyder SH, and Szurszewski JH (2000) Carbon monoxide and nitric oxide as coneurotransmitters in the enteric nervous system: evidence from genomic deletion of biosynthetic enzymes. Proc Natl Acad Sci USA 97:1851-1855.
521. Yachie A, Niida Y, Wada T, Igarashi N, Kaneda H, Toma T, Ohta K, Kasahara Y, and Koizumi S (1999) Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency. J Clin Investig 103:129-135.
522. Yachie A, Toma T, Mizuno K, Okamoto H, Shimura S, Ohta K, Kasahara Y, and Koizumi S (2003) Heme oxygenase-1 production by peripheral blood monocytes during acute inflammatory illnesses of children. Exp Biol Med 228:550-556.
523. Yamada N, Yamaya M, Okinaga S, Nakayama K, Sekizawa K, Shibahara S, and Sasaki H (2000) Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with susceptibility to emphysema. Am J Hum Genet 66:187-195.
524. Yang L, Quan S, and Abraham NG (1999) Retrovirus-mediated HO gene transfer into endothelial cells protects against oxidant-induced injury. Am J Physiol 277:L127-L133.
525. Yang Z-X and Qin J (2004) Interaction between endogenous nitric oxide and carbon monoxide in the pathogenesis of recurrent febrile seizures. Biochem Biophys Res Commun 315:349-355.
526. Ye J and Laychock SG (1998) A protective role for heme oxygenase expression in pancreatic islets exposed to interleukin-1β. Endocrinology 139:4155-4163.
527. Yet SF, Perrella MA, Layne MD, Hsieh CM, Maemura K, Kobzik L, Wiesel P, Christou H, Kourembanas S, and Lee ME (1999) Hypoxia induces severe right ventricular dilatation and infarction in heme oxygenase-1 null mice. J Clin Investig 103:R23-R29.
528. Yet SF, Tian R, Layne MD, Wang ZY, Maemura K, Solovyeva M, Ith B, Melo LG, Zhang L, Ingwall JS, et al. (2001) Cardiac-specific expression of heme oxygenase-1 protects against ischemia and reperfusion injury in transgenic mice. Circ Res 89:168-173.
529. Yoo MS, Chun HS, Son JJ, DeGiorgio LA, Kim DJ, Peng C, and Son JH (2003) Oxidative stress regulated genes in nigral dopaminergic neuronal cells: correlation with the known pathology in Parkinson's disease. Brain Res Mol Brain Res 110:76-84.
530. Yoshida T, Biro P, Cohen T, Muller RM, and Shibahara S (1988) Human heme oxygenase cDNA and induction of its mRNA by hemin. Eur J Biochem 171:457-461.
531. Yoshida T, Maulik N, Ho YS, Alam J, and Das DK (2001) H(mox-1) constitutes an adaptive response to effect antioxidant cardioprotection: a study with transgenic mice heterozygous for targeted disruption of the heme oxygenase-1 gene. Circulation 103:1695-1701.
532. Yoshida T, Takahashi S, and Kikuchi G (1974) Partial purification and reconstruction of the heme oxygenase system from pig spleen microsomes. J Biochem (Tokyo) 75:1187-1191.
533. Young LJ and Caughey WS (1986) Mitochondrial oxygenation of carbon monoxide. Biochem J 239:225-227.
534. Young LJ and Caughey WS (1990) Pathobiochemistry of CO poisoning. FEBS Lett 272:1-8.
535. 2, in Biochemical and Clinical Aspects of Oxygen: Proceedings of a Symposium (September 1975, Fort Collins, CO) (Caughey WS and Caughey H eds) p 355, Academic Press, New York.
536. Yu L, Gengaro PE, Niederberger M, Burke TJ, and Schrier RW (1994) Nitric oxide: a mediator in rat tubular hypoxia/reoxygenation injury. Proc Natl Acad Sci USA 91:1691-1695.
537. Zakhary R, Gaine SP, Dinerman JL, Ruat M, Flavahan NA, and Snyder SH (1996) Heme oxygenase 2: endothelial and neuronal localization and role in endotheliumdependent relaxation. Proc Natl Acad Sci USA 93:795-798.
538. Zakhary R, Poss KD, Jaffrey SR, Ferris CD, Tonegawa S, and Snyder SH (1997) Targeted gene deletion of heme oxygenase 2 reveals neural role for carbon monoxide. Proc Natl Acad Sci USA 94:14848-14853.
539. Zhang F, Kaide J, Wei Y, Jiang H, Yu C, Balazy M, Abraham NG, Wang W, and Nasjletti A (2001) Carbon monoxide produced by isolated arterioles attenuates pressure-induced vasoconstriction. Am J Physiol Heart Circ Physiol 281:H350-H358.
540. Zhang J and Piantadosi CA (1992) Mitochondrial oxidative stress after carbon monoxide hypoxia in the rat brain. J Clin Investig 90:1193-1199.
541. Zhen G, Zhang Z, and Xu Y (2003) The role of endogenous carbon monoxide in the hypoxic vascular remodeling of rat model of hypoxic pulmonary hypertension. J Huazhong Univ Sci Technolog Med Sci 23:356-368.
542. Zhuo M, Small SA, Kandel ER, and Hawkins RD (1993) Nitric oxide and carbon monoxide produce activity-dependent long-term synaptic enhancement in hippocampus. Science (Wash DC) 260:1946-1950.
543. Zuckerbraun BS, Billiar TR, Otterbein SL, Kim PK, Liu F, Choi AM, Bach FH, and Otterbein LE (2003) Carbon monoxide protects against liver failure through nitric oxide-induced heme oxygenase 1. J Exp Med 198:1707-1716.
544. Zuckerbraun BS, Otterbein LE, Boyle P, Jaffe R, Upperman J, Zamora R, and Ford HR (2005) Carbon monoxide protects against the development of experimental necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol 289:G607-G613.
545. Zufall F and Leinders-Zufall T (1997) Identification of a long-lasting form of odor adaptation that depends on the carbon monoxide/cGMP second-messenger system. J Neurosci 17:2703-2712.
546. Zygmunt PM, Hogestatt ED, and Grundemar L (1994) Light-dependent effects of zinc protoporphyrin IX on endothelium-dependent relaxation resistant to N omega-nitro-L-arginine. Acta Physiol Scand 152:137-143.