Intracellular targets in heme protein-induced renal injury

Kidney International

Volumn 53, Issue 1, 1998, Pages 100-111

  Nath, Karl A ^a   Grande, Joseph P ^b   Croatt, Anthony J ^b   Likely, Scott ^b   Hebbel, Robert P ^b   Enright, Helen ^b  

^a MAYO CLINIC   (United States)

^b NONE

Author keywords

Acute renal failure; Heme protein; Mitochondrial injury; Nuclear damage; Renal injury

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; DEOXYGUANOSINE; DNA; GLUTAMIC ACID; GLYCEROL; HEMOPROTEIN; MALIC ACID; ROTENONE; SUCCINIC ACID;

ACUTE KIDNEY FAILURE; ANIMAL MODEL; ARTICLE; AUTOPHAGY; CONTROLLED STUDY; DNA DAMAGE; DNA DETERMINATION; KIDNEY DISTAL TUBULE; KIDNEY INJURY; KIDNEY PROXIMAL TUBULE; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RAT;

EID: 0031888839     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.1998.00731.x     Document Type: Article

References (51)

1. ZAGER RA: Rhabdomyolysis and myohemoglobinuric acute renal failure. Kidney Int 49:314-316, 1996
2. DUBROW A, FLAMENBAUM W: Acute renal failure associated with myoglobinuria and hemoglobinuria (chapt 10), in Acute Renal Failure (2nd ed), edited by BRENNER BM, LAZARUS JM, New York, Churchill Livingstone, 1988, pp 279-294
3. SHAH SV, WALKER PD: Evidence suggesting a role for hydroxyl radical in glycerol-induced acute renal failure. Am J Physiol 255:F438-F443, 1988
4. PALLER MS: Hemoglobin- and myoglobin-induced acute renal failure in rats: Role of iron in nephrotoxicity. Am J Physiol 255:F539-F544, 1988
5. BALIGA R, ZHANG Z, BALIGA M, SHAH SV: Evidence for cytochrome P-450 as a source of catalytic iron in myoglobinuric acute renal failure. Kidney Int 49:362-369, 1996
6. WEINBERG JM, HARDING PG, HUMES HD: Mitochondrial bioenergetics during the initiation of mercuric chloride-induced renal injury. I. Direct effects of in vitro mercuric chloride on renal cortical mitochondrial function. J Biol Chem 257:60-67, 1982
7. WEINBERG JM: The cellular basis of nephrotoxicity (chapt 39), in Diseases of the Kidney (5th ed, vol 11), editited by SCHRIER RW, GOTTSCHALK CW, Boston, Little, Brown and Company, Publishers, 1993, pp 1031-1098
8. ZAGER RA: Mitochondrial free radical production induces lipid peroxidation during myohemoglobinuria. Kidney Int 49:741-751, 1996
9. KROEMER G, PETIT P, ZAMZAMI N, VAYSSIÈRE J-L, MIGNOTTE B: The biochemistry of programmed cell death. FASEB J 9:1277-1287, 1995
10. UEDA N, SHAH SV: Endonuclease-induced DNA damage and cell death in oxidant injury to renal tubular epithelial cells. J Clin Invest 90:2593-2597, 1992
11. 1 cells. Kidney Int 49:355-361, 1996
12. UEDA N, WALKER PD, HSU S-M, SHAH SV: Activation of a 15-kDa endonuclease in hypoxia/reoxygenation injury without morphologic features of apoptosis. Proc Natl Acad Sci USA 92:7202-7206, 1995
13. NATH KA, BALLA G, BALLA J, JACOB HS, VERCELLOTTI GM, LEVITT M, ROSENBERG ME: Induction of heme oxygenase is a rapid protective response in rhabdomyolysis in the rat. J Clin Invest 90:267-270, 1992
14. LEMMI CAE, PELIKAN PCD, SIKKA SC, HIRSCHBERG R, GEESAMAN B, MILLER RL, PARK KS, LIU SC, KOYLE M, RAJFER J: Cyclosporine augments renal mitochondrial function in vivo and reduces renal blood flow. Am J Physiol 257:F837-F841, 1989
15. NATH KA, CROATT AJ, LIKELY S, BEHRENS TW, WARDEN D: Renal oxidant injury and oxidant response to mercury. Kidney Int 50:1032-1043, 1996
16. FLOYD RA, WATSON JJ, WONG PK, ALTMILLER DH, RICKARD RC: Hydroxyl free radical adduct of deoxyguanosine: Sensitive detection and mechanisms of formation. Free Rad Res Comms 1:163-172, 1986
17. ENRIGHT HU, MILLER WJ, HEBBEL RP: Nucleosomal histone protects DNA from iron-mediated damage. Nucl Acids Res 20:3341-3346, 1992
18. NATH KA, ENRIGHT H, NUTTER LM, FISCHEREDER MF, ZOU JN, HEBBEL RP: The effect of pyruvate on oxidant injury to isolated and cellular DNA. Kidney Int 45:166-176, 1994
19. ENRIGHT H, HEBBEL RP, NATH KA: Internucleosomal cleavage of DNA as the sole criterion for apoptosis may be artifactual. J Lab Clin Med 124:63-68, 1994
20. GAVRIELI Y, SHERMAN Y, BEN-SASSON SA: Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 119:493-501, 1992
21. ZAGER RA, FUERSTENBERG SM, BAEHR PH, MYERSON D, TOROKSTORB B: An evaluation of antioxidant effects on recovery from postischemic acute renal failure. J Am Soc Nephrol 4:1588-1597, 1994
22. BEERI R, SYMON Z, BREZIS M, BEN-SASSON SA, BAEHR PH, ROSEN S, ZAGER RA: Rapid DNA fragmentation from hypoxia along the thick ascending limb of rat kidneys. Kidney Int 47:1806-1810, 1995
23. NATH KA, BALLA J, CROATT A, VERCELLOTTI GM: Heme protein-mediated renal injury: A protective role for 21-aminosteroids in vitro and in vivo. Kidney Int 47:592-602, 1995
24. AGARWAL A, BALLA J, ALAM J, CROATT AJ, NATH KA: Induction of heme oxygenase in toxic renal injury: A protective role in cisplatin nephropathy in the rat. Kidney Int 48:1298-1307, 1995
25. MCDOWELL EM, TRUMP BF: Histologic fixatives suitable for diagnostic light and electron microscopy. Arch Pathol Lab Med 100:405-414, 1976
26. SPURR AR: A low viscosity epoxy resin embedding medium for electron microscopy. J Ultrastructural Res 26:31-43, 1969
27. PREUSS HG, TOURKANTONIS A, HSU C-H, SHIM PS, BARZYK P, TIO F, SCHREINER GE: Early events in various forms of experimental acute necrosis in rats. Lab Invest 32:286-294, 1975
28. GLAUMANN H, ERICSSON JL, MARZELLA L: Mechanism of intralysosomal degradation with special reference to autophagocytosis and heterocytosis of cell organelles. Int Rev Cytol 73:149-182, 1981
29. BRUNK UT, JONES CB, SOHAL RS: A novel hypothesis of lipofuscinogenesis and cellular aging based on interactions between oxidative stress and autophagocytosis. Mutation Res 275:395-403, 1992
30. ANDERSON WAD, MORRISON DB, WILLIAMS EF JR: Pathologic changes following injections of ferrihemate (hematin) in dogs. Arch Pathol 33:589-602, 1942
31. CORCORAN AC, PAGE IH: Renal damage from ferroheme pigments myoglobin, hemoglobin, hematin. Texas Reports Biol Med 3:528-544, 1945
32. JEELANI DHAR G, BOSSENMAIER I, CARDINAL R, PETRYKA ZJ, WATSON CJ: Transitory renal failure following rapid administration of a relatively large amount of hematin in a patient with acute intermittent porphyria in clinical remission. Acta Med Scand 203:437-443, 1978
33. BALLA G, VERCELLOTTI GM, MULLER-EBERHARD U, EATON J, JACOB HS: Exposure of endothelial cells to free heme potentiates damage mediated by granulocytes and toxic oxygen species. Lab Invest 64:648-655, 1991
34. CHANCE B, SIES H, BOVERIS A: Hydroperoxide metabolism in mammalian organs. Physiol Rev 59:527-605, 1979
35. IWATA M, MYERSON D, TOROK-STORB B, ZAGER RA: An evaluation of renal tubular DNA laddering in response to oxygen deprivation and oxidant injury. J Am Soc Nephrol 5:1307-1313, 1994
36. GULLANS SR, HEBERT SC: Metabolic basis of ion transport (chapt 5), in The Kidney (5th ed), edited by BRENNER BM, Philadelphia, WB Saunders, 1997, pp 211-246
37. ANDREOLI SP, MCATEER JA: Reactive oxygen molecule-mediated injury in endothelial and renal tubular epithelial cells in vitro. Kidney Int 38:785-794, 1990
38. ANDREOLI SP, MALLETT C, MCATEER JA, WILLIAMS LV: Antioxidant defense mechanisms of endothelial cells and renal tubular epithelial cells: role of the glutathione redox cycle and catalase. Pediatr Res 32:360-365, 1992
39. EL-SHENNAWAY IE, GEE DJ, APARICIO SR: Renal tubular epithelia ultrastructure in autolysis. J Pathol 147:13-21, 1985
40. SAFIRSTEIN R: Gene expression in nephrotoxic and ischemic acute renal failure. J Am Soc Nephrol 4:1387-1395, 1994
41. MEGYESI J, DI MARI J, UDVARHELYI N, PRICE PM, SAFIRSTEIN RL: DNA synthesis is dissociated from the immediate-early gene response in the post-ischemic kidney. Kidney Int 48:1451-1458, 1995
42. OUELLETTE AJ, MALT RA, SUKHATME VP, BONVENTRE JV: Expression of two "immediate early" genes. Egr-1 and c-fos, in response to renal ischemia and during compensatory renal hypertrophy in mice. J Clin Invest 85:766-771, 1990
43. BONVENTRE JV, SUKHATME VP, BAMBERGER M, OUELLETTE AJ, BROWN D: Localization of the protein product of the immediate early growth response gene, Egr-1, in the kidney after ischemia and reperfusion. Cell Regul 2:251-260, 1991
44. SILKENSEN JR, AGARWAL A, NATH KA, MANIVEL JC, ROSENBERG ME: Temporal induction of clusterin in cisplatin nephrotoxicity. J Am Soc Nephrol 8:302-305, 1997
45. BUNN HF, ESHAM WT, BULL RW: The renal handling of hemoglobin. I. Glomerular filtration. J Exp Med 129:909-924, 1969
46. BUNN HF, JANDL JH: The renal handling of hemoglobin. II. Catabolism. J Exp Med 129:925-934, 1969
47. HEBBEL RP, EATON JW: Pathobiology of heme interaction with the erythrocyte membrane. Semin Hematol 26:136-149, 1989
48. HEBBEL RP: The sickle erythrocyte in double jeopardy: Autoxidation and iron decompartmentalization. Semin Hematol 27:51-69, 1990
49. HILL PA, DAVIES DJ, KINCAID-SMITH P, RYAN GB: Ultrastructural changes in renal tubules associated with glomerular bleeding. Kidney Int 36:992-997, 1989
50. NATH KA: Tubulo-interstitial disease as a major determinant of progressive renal injury. Am J Kidney Dis 20:1-17, 1992
51. FOGAZZI GB, IMBASCIATI E, MORONI G, SCALIA A, MIHATSCH MJ, PONTICEELI C: Reversible acute renal failure from gross haematuria due to glomerulonephritis: Not only in IgA nephropathy and not associated with intratubular obstruction. Nephrol Dial Transplant 10:624-629, 1995