Alterations of the vascular and the myocardial guanylate cyclase/cGMP-system induced by long-term hypertension in rats

Pharmaceutica Acta Helvetiae

Volumn 73, Issue 1, 1998, Pages 27-35

  Kojda, Georg ^a   Kottenberg, Karin ^a   Hacker, Andreas ^a   Noack, Eike ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Heart; Hypertension; Nitric oxide; Organic nitrates; Soluble guanylate cyclase; Superoxide

Indexed keywords

ACETYLCHOLINE; ARGININE; CYCLIC GMP; GLYCERYL TRINITRATE; GUANYLATE CYCLASE; N ACETYL S NITROSOPENICILLAMINE; N(G) NITROARGININE; NITRIC OXIDE; NORADRENALIN; ORGANIC NITRATE; PENTAERYTHRITYL TETRANITRATE; PHENYLEPHRINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; BLOOD VESSEL REACTIVITY; CARDIOVASCULAR FUNCTION; CONFERENCE PAPER; CONTROLLED STUDY; DESENSITIZATION; HEART MUSCLE CONTRACTILITY; HYPERTENSION; INOTROPISM; MALE; NONHUMAN; RAT; VASCULAR SMOOTH MUSCLE;

ANIMALS; AORTA, THORACIC; CYCLIC GMP; ENDOTHELIUM, VASCULAR; GUANYLATE CYCLASE; HYPERTENSION; MALE; MYOCARDIAL CONTRACTION; MYOCARDIUM; RATS; RATS, INBRED SHR; RATS, WISTAR;

EID: 0032104469     PISSN: 00316865     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0031-6865(97)00044-7     Document Type: Conference Paper

References (59)

1. Ahlner J., Andersson R.G.G., Torfgård K., Axelsson K.L. Organic nitrate esters: Clinical use and mechanisms of actions. Pharmacol. Rev. 43:1991;351-423.
2. Allen, R.C., 1986. Phagocytic leucocyte oxigenation activities and chemiluminescence: A kinetic approach to analysis. In: DeLuca, M.A., McElroy, W.D. (Eds.), Methods Enzymology, vol. 133. Academic Press, Orlando, FL, p. 449.
3. Balligand J.L., Ungureanu-Longrois D., Simmons W.W., Pimental D., Malinski T.A., Kapturczak M., Taha Z., Lowenstein C.J., Davidoff A.J., Kelly R.A., Smith T.W., Michel T. Cytokine-inducible nitric oxide synthase (iNOS) expression in cardiac myocytes. Characterization and regulation of iNOS expression and detection of iNOS activity in single cardiac myocytes in vitro. J. Biol. Chem. 269:1994;27580-27588.
4. Balligand J.L., Kobzik L., Han X., Kaye D.M., Belhassen L., O'Hara D.S., Kelly R.A., Smith T.W., Michel T. Nitric oxide-dependent parasympathetic signalling is due to activation of constitutive endothelial (type III) nitric oxide synthase in cardiac myocytes. J. Biol. Chem. 270:1995;14582-14586.
5. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:1976;248-254.
6. Brady A.J.B., Warren J.B., Poole-Wilson P.A., Williams T.J., Harding S.E. Nitric oxide attenuates cardiac myocyte contraction. Am. J. Physiol. 265:1993;H176-H182.
7. Chung S.J., Fung H.L. Identification of the subcellular site for nitroglycerin metabolism to nitric oxide in bovine coronary smooth muscle cells. J. Pharmacol. Exp. Ther. 253:1990;614-619.
8. Crabos M., Coste P., Paccalin M., Tariosse L., Daret D., Besse P., Bonoron-Adèle S. Reduced basal NO-mediated dilation and decreased endothelial NO-synthase expression in coronary vessels of spontaneously hypertensive rats. J. Mol. Cell. Cardiol. 29:1997;55-65.
9. Diamond J., Ten Eick R.E., Trapani A.J. Are increases in cyclic GMP levels responsible for the negative inotropic effects of acetylcholine in the heart? Biochem. Biophys. Res. Commun. 79:1977;912-918.
10. Feelisch M., Kelm M. Biotransformation of organic nitrates to nitric oxide by vascular smooth muscle and endothelial cells. Biochem. Biophys. Res. Commun. 180:1991;286-293.
11. Feelisch M., Noack E. Correlation between nitric oxide formation during degradation of organic nitrates and activation of guanylate cyclase. Eur. J. Pharmacol. 139:1987;19-30.
12. Field L., Dilts R.V., Ravichandran R., Lenhert G., Carnahan G.E. An unusual stable thionitrite from N-acetyl-D,L-penicillamine; X-ray crystal and molecular structure of 2-(acetylamino)-2-carboxy-1,1-dimethyl thionitrite. J. Chem. Soc. Chem. Commun. 1157:1978;249-250.
13. Forte P., Copland M., Smith L.M., Milne E., Sutherland J., Benjamin N. Basal nitric oxide synthesis in essential hypertension. Lancet. 349:1997;837-842.
14. Furchgott R.F. Role of endothelium in response of vascular smooth muscle. Circ. Res. 53:1983;557-573.
15. x: A pulse radiolysis study. Free Radic. Biol. Med. 19:1995;505-510.
16. Grunfeld S., Hamilton C.A., Mesaros S., McClain S.W., Dominiczak A.F., Bohr D.F., Malinski T. Role of superoxide in the depressed nitric oxide production by the endothelium of genetically hypertensive rats. Hypertension. 26:1995;854-857.
17. Hood W.P., Amende I., Simon R., Lichtlen P.R. The effects of intracoronary nitroglycerin on left ventricular systolic and diastolic function in man. Circulation. 61:1980;1098-1104.
18. Ignarro L.J., Lipton H., Edwards J.C., Barricos W.H., Hyman A.L., Kadowitz P.J., Gruetter C.A. Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: Evidence for the involvement of S-nitrosothiols as active intermediates. J. Pharmacol. Exp. Ther. 218:1981;739-749.
19. Keefer L.K., Nims R.W., Davies K.M., Wink D.A. 'NONOates' (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: Convenient nitric oxide dosage forms. Methods Enzymol. 268:1996;281-293.
20. Kitakaze M., Node K., Komamura K., Minamino T., Inoue M., Hori M., Kamada T. Evidence for nitric oxide generation in the cardiomyocytes: Its augmentation by hypoxia. J. Mol. Cell. Cardiol. 27:1995;2149-2154.
21. Klabunde R.E., Ritger R.C., Helgren M.C. Cardiovascular actions of inhibitors of endothelium-derived relaxing factor (nitric oxide) formation/release in anesthetized dogs. Eur. J. Pharmacol. 199:1991;51-59.
22. G-Methyl-L-arginine decreases contractility, cGMP and cAMP in isoproterenol-stimulated rat hearts in vitro. Eur. J. Pharmacol. 223:1992;1-7.
23. Kojda G., Noack E. Nitric oxide liberating, soluble guanylate cyclase stimulating and vasorelaxing properties of SPM 3672. J. Cardiovasc. Pharmacol. 22:1993;103-111.
24. Kojda G., Klaus W., Werner G., Fricke U. The influence of 3-ester side chain variation on the cardiovascular profile of nitrendipine in procine isolated trabeculae and coronary arteries. Naunyn Schmiedebergs Arch. Pharmacol. 344:1991;488-494.
25. Kojda G., Brixius K., Kottenberg K., Nix P., Schlüter K.D., Piper H.M., Noack E. The new NO donor SPM3672 increases cGMP and improves contraction in rat cardiomyocytes and isolated heart. Eur. J. Pharmacol. 284:1995;315-319.
26. Kojda G., Kottenberg K., Nix P., Schlüter K.D., Piper H.M., Noack E. Low increase in cGMP induced by organic nitrates and nitrovasodilators improves contractile response of rat ventricular myocytes. Circ. Res. 78:1996;91-101.
27. Konishi M., Su C. Role of endothelium in dilator responses of spontaneously hypertensive rat arteries. Hypertension. 5:1983;881-886.
28. Korth M. Influence of glyceryl trinitrate on force of contraction and action potential of guinea-pig myocardium. Naunyn Schmiedebergs Arch. Pharmacol. 287:1975;329-347.
29. Kowaluk E.A., Fung H.-L. Spontaneous liberation of nitric oxide cannot account for in vitro vascular relaxation by S-nitrosothiols. J. Pharmacol. Exp. Ther. 255:1990;1256-1264.
30. Küng C.F., Lüscher T.F. Different mechanisms of endothelial dysfunction with aging and hypertension in rat aorta. Hypertension. 25:1995;194-200.
31. G-methyl-L-arginine in chronically instrumented conscious dogs. J. Appl. Physiol. 77:1994;471-475.
32. Linder L., Kiowski W., Buhler F.R., Lüscher T.F. Indirect evidence for release of endothelium-derived relaxing factor in human forearm circulation in vivo: Blunted response in essential hypertension. Circulation. 81:1990;1762-1767.
33. Lüscher T.F., Raij L., Vanhoutte P.M. Endothelium-dependent responses in normotensive and hypertensive Dahl rats. Hypertension. 9:1987;157-163.
34. Luss H., Watkins S.C., Freeswick P.D., Imro A.K., Nussler A.K., Billiar T.R., Simmons R.L., Del Nido P.J., McGowan F.X. Jr. Characterization of inducible nitric oxide synthase expression in endotoxemic rat cardiac myocytes in vivo and following cytokine exposure in vitro. J. Mol. Cell. Cardiol. 27:1995;2015-2029.
35. Malinski T., Kapturczak M., Dayharsh J., Bohr D. Nitric oxide synthase activity in genetic hypertension. Biochem. Biophys. Res. Commun. 194:1993;654-658.
36. Mayhan W.G., Faraci F.M., Heistad D.D. Impairment of endothelium-dependent responses of cerebral arterioles in chronic hypertension. Am. J. Physiol. 253:1987;H1435-H1440.
37. Mayhan W.G., Faraci F.M., Heistad D.D. Responses of cerebral arterioles to adenosine 5′-diphosphate, serotonin and the thromboxane analogue U-46619 durin chronic hypertension. Hypertension. 12:1988;556-561.
38. Mohan P., Brutsaert D.L., Paulus W.J., Sys S.U. Myocardial contractile response to nitric oxide and cGMP. Circulation. 93:1996;1223-1229.
39. Moncada S., Higgs A. Mechanisms of disease: The L-arginine-nitric oxide pathway. N. Engl. J. Med. 329:1993;2002-2012.
40. Moncada S., Higgs E.A. Molecular mechanisms and therapeutic strategies related to nitric oxide. FASEB J. 9:1995;1319-1330.
41. 5-[imino(nitroamino)methyl]-L-ornithine) impairs endothelium-dependent dilations by inhibiting cytosolic nitric oxide synthesis from L-arginine. Naunyn Schmiedebergs Arch. Pharmacol. 341:1990;143-147.
42. Mülsch A., Mordvintcev P., Bassenge E., Jung F., Clement B., Busse R. In vivo spin trapping of glyceryl trinitrate-derived nitric oxide in rabbit blood vessels and organs. Circulation. 92:1995;1876-1882.
43. Nakazono K., Watanabe N., Matsuno K., Sasaki J., Sato T., Inoue M. Does superoxide underlie the pathogenesis of hypertension. Proc. Natl. Acad. Sci. USA. 88:1991;10045-10048.
44. Nathan C., Xie Q. Nitric oxide synthases: Roles, tolls and controls. Cell. 78:1994;915-918.
45. Noack, E., Feelisch, M., 1991. Molecular mechanism of nitrovasodilator bioactivation. In: Drexler, H., Zeiher, A.M., Bassenge, E., Just, H. (Eds.), Endothelial Mechanism of Vasomotor Control. Steinkopff Verlag, Darmstadt, p. 37.
46. Ohara Y., Peterson T.E., Harrison D.G. Hypercholesterolemia increases endothelial superoxide anion production. J. Clin. Invest. 91:1993;2546-2551.
47. Palmer R.M.J., Ashton D.S., Moncada S. Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature. 333:1988;664-666.
48. Panza J.A., Quyyumi A.A., Brush J.E. Jr., Epstein S.E. Abnormal endothelium-dependent vascular relaxation in patients with essential hypertension. N. Engl. J. Med. 323:1990;22-27.
49. Panza J.A., Casino P.R., Kilcoyne C.M., Quyyumi A.A. Role of endothelium-derived nitric oxide in the abnormal endothelium-dependent vascular relaxation of patients with essential hypertension. Circulation. 87:1993;1468-1474.
50. Paulus W.J., Vantrimpont P.J., Shah A.J. Acute effects of nitric oxide on the left ventricular relaxation and diastolic distensibility in humans. Circulation. 89:1994;2070-2078.
51. Preckel B., Kojda G., Schlack W., Ebel D., Kottenberg K., Noack E., Thämer V. Inotropic effects of glyceryl trinitrate and spontaneous NO-donors in the dog heart. Circulation. 96:1997;2675-2682.
52. Raff W.K., Drechsler J., Scholtholt J., Lochner W. Herzwirkung des Nitroglycerins. Pfluegers Arch. 317:1970;336-343.
53. Salvemini D., Mollace V., Pistelli A., Anggard E., Vane J. Metabolism of glyceryl trinitrate to nitric oxide by endothelial cells and smooth muscle cells and its induction by Escherichia coli lipopolysaccharide. Proc. Natl. Acad. Sci. USA. 89:1992;982-986.
54. Schultz, G., Böhme, E., 1984. Guanylate cyclase. In: Bergmeyer, H.U. (Ed.), Methods of Enzymatic Analysis. Verlag Chemie, Weinheim, p. 379.
55. Stamler J.S., Loh E., Roddy M.-A., Currie K.E., Creager M.A. Nitric oxide regulates basal systemic and pulmonary vascular resistance in healthy humans. Circulation. 89:1994;2035-2040.
56. Stasch J.P., Kazda S., Hirth C., Morich F. Role of nisoldipine on blood pressure, cardiac hypertrophy and atrial natriuretic peptides in spontaneously hypertensive rats. Hypertension. 10:1987;303-307.
57. Strauer B.E. Evidence for a positive inotropic effect of nitroglycerol on isolated human ventricular myocardium. Pharmacol. Res. Commun. 3:1971;377-383.
58. Taddei S., Virdis A., Mattei P., Salvetti A. Vasodilation to acetylcholine in primary and secondary forms of human hypertension. Hypertension. 21:1993;929-933.
59. Tschudi M.R., Mesaros S., Lüscher T.F., Malinski T. Direct in situ measurement of nitric oxide in mesenteric resistance arteries. Increased decomposition by superoxide in hypertension. Hypertension. 27:1996;32-35.