Hepatocyte growth factor signalling stimulates hypoxia inducible factor-1 (HIF-1) activity in HepG2 hepatoma cells

Carcinogenesis

Volumn 22, Issue 9, 2001, Pages 1363-1371

  Tacchini, L ^a   Dansi, P ^a   Matteucci, E ^a   Desiderio, M A ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; ACETYLCYSTEINE; CYTOKINE; DITHIOTHREITOL; HEME OXYGENASE; HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; NUCLEAR PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEASOME; PROTEIN KINASE; PROTEIN P42; PROTEIN P44; REACTIVE OXYGEN METABOLITE; REDUCING AGENT; SCATTER FACTOR; SCATTER FACTOR RECEPTOR; SCAVENGER; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; UROKINASE; UROKINASE RECEPTOR;

ARTICLE; CELL PROLIFERATION; CELL STRAIN HEPG2; COMPLEX FORMATION; CONTROLLED STUDY; CYTOSOL; DNA BINDING; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; MESENCHYME; MOLECULAR BIOLOGY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; STEADY STATE; TIME;

EID: 0034816327     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/22.9.1363     Document Type: Article

References (60)

1. The many faces of hepatocyte growth factor: From hepatopoiesis to hematopoiesis
2. Hepatocyte growth factor-scatter factor: Mitogen, motogen, and met
3. Control of invasive growth by the HGF receptor family
4. Interactions between scatter factors and their receptors: Hints for therapeutic applications
5. Hepatocyte growth factor modulates mobility and invasiveness of ovarian carcinomas via Ras-mediated pathway
6. Scatter factor induces blood vessel formation in vivo
7. Hepatocyte growth factor-induced scatter of Madin-Darby canine kidney cells requires phosphatidylinositol 3-kinase
8. Hepatocyte growth factor/scatter factor stimulates the Ras-guanine nucleotide exchanger
9. Hepatocyte growth factor is an invasion/migration factor of rat urothelial carcinoma cells in vitro
10. Hepatocyte growth factor (HGF) receptor expression is inducible and is part of the delayed-early response to HGF
11. Enhanced tumorigenicity and invasion-metastasis by hepatocyte growth factor/scatter factor-met signalling in human cells concomitant with induction of the urokinase proteolysis network
12. Activation mechanisms and urokinase-type plasminogen activator promoter by hepatocyte growth factor/scatter factor
13. Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas
14. Activated ras and ret oncogenes induce over-expression of c-met (hepatocyte growth factor receptor) in human thyroid epithelial cells
15. Overexpression and amplification of the met/HGF receptor gene during the progression of colorectal cancer
16. C-met activation is necessary but not sufficient for liver colonization by B16 murine melanoma cells
17. Hepatocyte growth factor signal coupling to various transcription factors depends on triggering of Met receptor and protein kinase transducers in human hepatoma cells HepG2
18. Hepatocyte growth factor-induced expression of ornithine decarboxylase, c-met, and c-myc is differently affected by protein kinase inhibitors in human hepatoma cells HepG2
19. Hepatocyte growth factor induces pro-apoptotic genes in HepG2 hepatoma but not in B16-F1 melanoma cells
20. Oncogenic alterations of metabolism
21. Expression of hypoxia-inducible factor 1: Mechanisms and consequences
22. Interleukin-1β and tumour necrosis factor-α stimulate DNA binding of hypoxia-inducible factor-1
23. Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1α/ARNT
24. Angiogenesis: How a tumor adapts to hypoxia
25. Hypoxia stimulates urokinase receptor expression through a heme protein-dependent pathway
26. Cloning and expression of the receptor for human urokinase plasminogen activator, a central molecule in cell surface, plasmin dependent proteolysis
27. Regulation by p38 mitogen-activated protein kinase of adenylate- and uridylate-rich element-mediated urokinase-type plasminogen activator (uPA) messenger RNA stability and uPA-dependent in vitro cell invasion
28. Transferrin receptor induction by hypoxia. HIF-1-mediated transcriptional activation and cell-specific post-transcriptional regulation
29. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
30. Purification and characterization of hypoxia-inducible factor 1
31. p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1α (HIF-1α) and enhance the transcriptional activity of HIF-1
32. Overexpression of Mos, Ras, Src, and Fos inhibits mouse mammary epithelial cell differentiation
33. Reciprocal positive regulation of hypoxia-inducible factor 1α and insulin-like growth factor 2
34. Fas activates NF-κB and induces apoptosis in T-cell lines by signaling pathways distinct from those induced by TNF-α
35. Phosphatidylinositol 3-kinase contributes to Erk1/Erk2 MAP kinase activation associated with hepatocyte growth factor-induced cell scattering
36. Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia
37. Proteasome inhibitors: Valuable new tools for cell biologists
38. Regulation of the hypoxia-inducible transcription factor 1α by the ubiquitin-proteasome pathway
39. The transcription factors ATF-1 and CREB-1 bind constitutively to the hypoxia-inducible factor-1 (HIF-1) DNA recognition site
40. Activation of hypoxia-inducible factor 1; definition of regulatory domains within the α subunit
41. HIF-1 and human disease: One highly involved factor
42. Involvement of oxidative stress in tumor cytotoxic activity of hepatocyte growth factor/scatter factor
43. Thiol reducing reagents inhibit the heat shock response. Involvement of a redox mechanism in the heat shock signal transduction pathway
44. ERK activation upon hypoxia: Involvement in HIF-1 activation
45. Mitogen-activated protein kinases: Specific messages from ubiquitous messengers
46. Proteasome inhibitors activate stress kinases and induce Hsp72. Diverse effects on apoptosis
47. Delayed and sustained activation of p42/p44 mitogen-activated protein kinase induced by proteasome inhibitors through p21(ras) in PC12 cells
48. Differential signaling by alternative HGF isoforms through c-Met: Activation of both MAP kinase and PI 3-kinase pathways is insufficient for mitogenesis
49. Integrin signaling
50. Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor
51. Epidermal growth factor- and hepatocyte growth factor-receptor activity in serum-free cultures of human hepatocytes
52. Stromal expression of c-Ets1 transcription factor correlates with tumor invasion
53. Heme oxygenase: Protective gene or Trojan horse
54. Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1α during hypoxia
55. Oxygen radicals and signaling
56. Redox regulation of cellular signalling
57. Antioxidant/pro-oxidant equilibrium regulates HIF-1α and NF-κB redox sensitivity. Evidence for inhibition by glutathione oxidation in alveolar epithelial cells
58. Redox signaling and the control of cell growth and death
59. Interleukin 1 induces hypoxia-inducible factor 1 in human gingival and synovial fibroblasts
60. Hypoxia-inducible factor 1α (HIF-1α) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes