Inducible nitric oxide synthase and heme oxygenase-1 in rat heart: Direct effect of chronic exposure to hypoxia

Annals of Clinical and Laboratory Science

Volumn 33, Issue 2, 2003, Pages 208-215

  Grilli, Alfredo ^a   De Lutiis, Maria Anna ^a   Patruno, Antonia ^a   Speranza, Lorenza ^a   Gizzi, Federico ^a   Taccardi, Alfonso A ^a   Di Napoli, Pericle ^a   De Caterina, Raffaele ^a   Conti, Pio ^a   Felaco, Mario ^a  

^a UNIVERSITY OF CHIETI   (Italy)

Author keywords

Heme oxygenase; Hypoxia; Nitric oxide synthase; Oxidative stress; Rat heart, carbon monoxide

Indexed keywords

CARBON MONOXIDE; HEME OXYGENASE 1; MESSENGER RNA; NITRIC OXIDE SYNTHASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL TONE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INDUCTION; ENZYME REGULATION; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HYPOXIA; IMMUNOREACTIVITY; LONG TERM EXPOSURE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; ANOXIA; BLOTTING, WESTERN; DNA PRIMERS; ENZYME INDUCTION; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GENE EXPRESSION; HEME OXYGENASE (DECYCLIZING); HEME OXYGENASE-1; IMMUNOENZYME TECHNIQUES; MYOCARDIUM; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TIME FACTORS;

ANIMALIA; MAMMALIA; RATTUS NORVEGICUS;

EID: 0038460024     PISSN: 00917370     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Helfman T, Falanga V. Gene expression in low oxygen tension. Am J Med Sci 1993;306:37-41.
2. Semenza GL. Regulation of erythropoietin production. New insights into molecular mechanisms of oxygen homeostasis. Hematol Oncol Clin North Am 1994; 8:863-884.
3. Shweiki D, Itin A, Soffer D, Keshet E. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 1992;359:843-845.
4. Firth JD, Ebert BL, Pugh CW, Ratcliffe PJ. Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3′ enhancer. Proc Natl Acad Sci USA 1994;91:6496-6500.
5. Moncada S, Higgs EA. Molecular mechanisms and therapeutic strategies related to nitric oxide. FASEB J 1995;13:1319-1330.
6. Inagami T, Naruse M, Hoover R. Endothelium as an endocrine organ. Annu Rev Physiol 1995;57:171-189.
7. Moncada S, Palmer RM, Higgs EA. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 1991;43:109-142.
8. Forstermann U, Closs EI, Pollock JS, Nakane M, Schwarz P, Gath I, Kleinert H. Nitric oxide synthase isozymes. Characterization, purification, molecular cloning, and functions. Hypertension. 1994;23:1121-1131.
9. Seki T, Hagiwara H, Naruse K, Kadowaki M, Kashiwagi M, Demura H, Hirose S, Naruse M. In situ identification of messenger RNA of endothelial type nitric oxide synthase in rat cardiac myocytes. Biochem Biophys Res Commun. 1996;218:601-605.
10. Felaco M, Di Maio FD, De Fazio P, D'Arcangelo C, De Lutiis MA, Varvara G, Grilli A, Barbacane RC, Reale M, Conti P. Localization of the e-NOS enzyme in endothelial cells and odontoblasts of healthy human dental pulp. Life Sci 2000;68:297-306.
11. Di Napoli P, Antonio Taccardi A, Grilli A, Spina R, Felaco M, Barsotti A, De Caterina R. Simvastatin reduces reperfusion injury by modulating nitric oxide synthase expression: an ex vivo study in isolated working rat hearts. Cardiovasc Res 2001;51:283-293.
12. Tanaka K, Hassall CJ, Burnstock G. Distribution of intracardiac neurones and nerve terminals that contain a marker for nitric oxide, NADPH-diaphorase, in the guinea-pig heart. Cell Tissue Res. 1993;273:293-300.
13. Carmignani M, Volpe AR, Boscolo P, Qiao N, Di Gioacchino M, Grilli A, Felaco M. Catcholamine and nitric oxide systems as targets of chronic lead exposure in inducing selective functional impairment. Life Sci 2000; 68:401-415.
14. Zhuo M, Small SA, Kandel ER, Hawkins RD. Nitric oxide and carbon monoxide produce activity-dependent long-term synaptic enhancement in hippocampus. Science 1993;260:1946-1950
15. Zakhary R, Gaine SP, Dinerman JL, Ruat M, Flavahan NA, Snyder SH. Heme oxygenase-2: endothelial and neuronal localization and role in endothelium-dependent relaxation. Proc Natl Acad Sci U S A. 1996;93:795-798.
16. Palmer LA, Semenza GL, Stoler MH, Johns RA. Hypoxia induces type II NOS gene expression in pulmonary artery endothelial cells via HIF-1. Am J Physiol 1998;274:L212-219.
17. Choi AM, Alam J. Heme oxygenase-1: function, regulation, and implication of a novel stress-inducible protein in oxidant-induced lung injury. Am J Respir Cell Mol Biol 1996;15:9-19.
18. Felaco M, Grilli A, Gorbunov N, Di Napoli P, De Lutiis MA, Di Giulio C, Taccardi AA, Barsotti A, Barbacane RC, Reale M, Conti P. Endothelial NOS expression and ischemia-reperfusion in isolated working rat heart from hypoxic and hyperoxic conditions. Biochim Biophys Acta 2000;1524:203-211.
19. Felaco M, Grilli A, De Lutiis MA, Patruno A, Libertini N, Taccardi AA, Di Napoli P, Di Giulio C, Barbacane R, Conti P. Endothelial nitric oxide synthase (eNOS) expression and localization in healthy and diabetic rat hearts. Ann Clin Lab Sci 2001;31:179-186
20. (2+)-independent nitric oxide synthase in the myocardium. Br J Pharmacol 1992;105: 575-580.
21. Felaco M, Di Napoli P, Contegiacomo G, Di Muzio M, Taccardi A, Giuliani P, Grilli A, De Lutiis MA, Di Giulio C, Barsotti A. Evidence of a relationship between coronary endothelial nitric oxide synthase activity and oxigen supply. Intern Med 1998;6:27-32.
22. Di Giulio C, Grilli A, De Lutiis MA, Di Natale F, Sabatino G, Felaco M. Does chronic hypoxia increase rat carotid body nitric oxide? Comp Biochem Physiol A Mol Integr Physiol 1998;120:243-247.
23. McKean TA. Calcium transport mechanisms in muskrat and rat hearts. Comp Biochem Physiol A Mol Integr Physiol 2001;130:771-780.
24. Gibbs CL, Loiselle DS. Cardiac Basal Methabolism. Jpn J Physiol 2001;51:399-426.
25. Mu J, Brozinick JT Jr., Valladares O, Bucan M, Birnbaum MJ. A role of AMP-activated protein kynase in contraction and hypoxia-regulated glucose transport in skeletal muscle. Mol Cell 2001;7:1085-1094.
26. Motterlini R, Green CJ, Foresti R. Regulation of heme oxygenase-1 by redox signals involving nitric oxide. Antioxid Redox Signal 2002;4:615-624.
27. Yet SF, Tian R, Layne MD, Wang ZY, Maemura K, Solovyeva M, Ith B, Melo LG, Zhang L, Ingwall JS, Dzau VJ, Lee ME, Perrella MA. Cardiac-specific expression of heme oxygenase-1 protects against ischemia and reperfusion injury in transgenic mice. Circ Res. 2001;89:168-173.
28. Jung F, Palmer LA, Zhou N, Johns RA. Hypoxic regulation of inducible nitric oxide synthase via hypoxia inducible factor-1 in cardiac myocytes. Circul Res 2000;86:319-325.
29. Kitakaze M, Node K, Komamura K, Minamino K, Hori M & Kamada T. Evidences for nitric oxide generation in cardiomyocytes: 1st augmentation by hypoxia. J Mol Cell Cardiol 1995;27:2149-2154.
30. Hogg N, Singh RJ, Kalyanaraman B. The role of glutathione in the transport and catabolism of nitric oxide. FEBS Lett 1996;382:223-228.
31. Csonka C, Varga E, Kovacs P, Ferdinandy P, Blasig IE, Szilvassy Z, Tosaki A. Heme-oxygenase and cardiac function in ischemic/reperfused rat hearts. Free Radic Biol Med 1999;27:119-126.