Heme oxygenase-1 inhibits atherogenesis in Watanabe heritable hyperlipidemic rabbits

Circulation

Volumn 104, Issue 15, 2001, Pages 1831-1836

  Ishikawa, Kazunobu ^a   Sugawara, Daisuke ^a   Goto, Jun ^a   Watanabe, Yasuyuki ^a   Kawamura, Keiichi ^a   Shiomi, Masashi ^b   Itabe, Hiroyuki ^c   Maruyama, Yukio ^a  

^a FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

^b KOBE UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c TEIKYO UNIVERSITY   (Japan)

Author keywords

Atherosclerosis; Heme oxygenase; Hypercholesterolemia

Indexed keywords

HEME OXYGENASE; LIPID PEROXIDE; PROTOPORPHYRIN TIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; CONTROLLED STUDY; DESCENDING AORTA; ENZYME INHIBITION; FOAM CELL; HYPERLIPIDEMIA; LIPID COMPOSITION; LIPID OXIDATION; LIPID PEROXIDATION; MACROPHAGE; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RABBIT;

EID: 0035834084     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/hc3901.095897     Document Type: Article

References (35)

1. Smooth muscle cell-derived carbon monoxide is a regulator of vascular cGMP
2. Upregulation of heme oxygenase-1 protects genetically fat Zucker rat livers from ischemia/reperfusion injury
3. Heme oxygenase-1-derived carbon monoxide contributes to the suppression of acute hypertensive responses in vivo
4. Effect of tumor necrosis factor α and interleukin-1β on heme oxygenase-1 expression in human endothelial cells
5. Induction of heme oxygenase-1 inhibits the monocyte transmigration induced by mildly oxidized LDL
6. The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase
7. Antibody-induced transplant arteriosclerosis is prevented by graft expression of anti-oxidant and antiapoptotic genes
8. Overexpression of heme oxygenase-1 expression in human pulmonary epithelial cells results in cell growth arrest and increased resistance to hyperoxia
9. Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency
10. Atherosclerosis
11. Expression of heme oxygenase-1 in atherosclerotic lesions
12. Probucol prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbit, an animal model for familial hypercholesterolemia
13. Paradoxical enhancement of atherosclerosis by probucol treatment in apolipoprotein E-deficient mice
14. Dual control mechanism for heme oxygenase: Tin (IV)-protoporphyrin potently inhibits enzyme activity while markedly increasing content of enzyme protein in liver
15. Photophysical studies of tin (IV)-protoporphyrin: Potential phototoxicity of a chemotherapeutic agent proposed for the prevention of neonatal jaundice
16. Protoporphyrin overload in unrestrained rats: Biochemical and histopathologic characterization of a new model of protoporphyric hepatopathy
17. Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptornegative mice
18. Serial inbreeding of rabbits with hereditary hyperlipidemia (WHHL rabbit)
19. Heme oxygenase-1 inhibits atherosclerotic lesion formation in LDL receptor knockout mice
20. Inheritability of atherosclerosis and the role of lipoproteins as risk factors in the development of atherosclerosis in WHHL rabbits: Risk factors related to coronary atherosclerosis are different from those related to aortic atherosclerosis
21. Induction of mRNA for LDL receptors in heterozygous WHHL rabbits treated with pravastatin and cholestyramine
22. Granulocyte-macrophage colony-stimulating factor prevents the progression of atherosclerosis via changes in the cellular and extracellular composition of atherosclerotic lesions in Watanabe heritable hyperlipidemic rabbits
23. A monoclonal antibody against oxidized lipoprotein recognizes foam cells in atherosclerotic lesions: Complex formation of oxidized phosphatidylcholines and polypeptides
24. Protein measurement with the Folin phenol reagent
25. A simple assay for lipid hydroperoxides in serum or plasma
26. Methods to determine oxidation of low-density lipoproteins
27. A rapid method of total lipid extraction and characterization
28. Pitfalls using metalloporphyrins in carbon monoxide research
29. Soluble guanylate cyclase from bovine lung: Activation of nitric oxide and carbon monoxide and spectral characterization of the ferrous and ferric states
30. The chemical modification of KCa channels by carbon monoxide in vascular smooth muscle cells
31. Bilirubin is an antioxidant of possible physiological importance
32. Induction of heme oxygenase-1 suppresses venular leukocyte adhesion elicited by oxidative stress: Role of bilirubin generated by the enzyme
33. Ferritin: A cytoprotective antioxidant stratagem of endothelium
34. Biliverdin reductase activity in cattle, sheep, rabbits and rats
35. Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/binding proteins