Cardiac-specific expression of heme oxygenase-1 protects against ischemia and reperfusion injury in transgenic mice

Circulation Research

Volumn 89, Issue 2, 2001, Pages 168-173

  Yet, Shaw Fang ^a   Tian, Rong ^a   Layne, Matthew D ^a   Yuan Wang, Zhi ^a   Maemura, Koji ^a   Solovyeva, Maria ^a   Ith, Bonna ^a   Melo, Luis G ^a   Zhang, Lunan ^a   Ingwall, Joanne S ^a   Dzau, Victor J ^a   Lee, Mu En ^a   Perrella, Mark A ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Cytoprotection; Heart; Infarction; Inflammation; Langendorff preparation

Indexed keywords

BILIRUBIN; CARBON MONOXIDE; HEME; HEME OXYGENASE 1;

ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; HEART FUNCTION; HEART INFARCTION; HEART MUSCLE CONTRACTILITY; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PROTECTION; HYPOXIA; INFLAMMATORY CELL; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPERFUSION INJURY; TRANSGENIC MOUSE;

EID: 0035920256     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/hh1401.093314     Document Type: Article

References (39)

1. Oxygen-derived free radicals in postischemic tissue injury
2. The oxygen free radical system: A fundamental mechanism in the production of myocardial necrosis
3. Free radicals and myocardial injury: Pharmacologic implications
4. Stress proteins-an endogenous route to myocardial protection: Fact or fiction?
5. Heat shock proteins and the ischemic heart: An endogenous protective mechanism
6. Overexpression of the rat inducible 70-kD heat stress protein in a transgenic mouse increases the resistance of the heart to ischemic injury
7. Stress (heat shock) proteins: Molecular chaperones in cardiovascular biology and disease
8. The heme oxygenase system: A regulator of second messenger gases
9. Heme oxygenase-mediated resistance to oxygen toxicity in hamster fibroblasts
10. Antibody-induced transplant arteriosclerosis is prevented by graft expression of anti-oxidant and anti-apoptotic genes
11. Expression of heme oxygenase-1 can determine cardiac xenograft survival
12. Hypoxia induces severe right ventricular dilatation and infarction in heme oxygenase-1 null mice
13. Antioxidant activity of albumin-bound bilirubin
14. Bilirubin is an antioxidant of possible physiological importance
15. Carbon monoxide provides protection against hyperoxic lung injury
16. Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway
17. Induction of heme oxygenase-1 during endotoxemia is downregulated by transforming growth factor-β1
18. Induction of heme oxygenase-1 expression in vascular smooth muscle cells: A link to endotoxic shock
19. Coordinated expression of heme oxygenase-1 and ubiquitin in the porcine heart subjected to ischemia and reperfusion
20. Enhanced expression and localization of heme oxygenase-1 during recovery phase of porcine stunned myocardium
21. Isolation and characterization of the mouse cardiac myosin heavy chain genes
22. Long-term expression of protein kinase C in adult mouse hearts improves postischemic recovery
23. Myocardial ischemia and reperfusion: A murine model
24. Myocardial infarction and remodeling in mice: Effect of reperfusion
25. Overexpression of heat shock protein 72 in transgenic mice decreases infarct size in vivo
26. Distribution of oxidation specific lipid-protein adducts and apolipoprotein B in atherosclerotic lesions of varying severity from WHHL rabbits
27. Hypercholesterolemia exacerbates transplant arteriosclerosis via increased neointimal smooth muscle cell accumulation: Studies in apolipoprotein E knockout mice
28. Neutrophil induced oxidative injury of cardiac myocytes: A compartmented system requiring CD11b/CD18-ICAM-1 adherence
29. Postreperfusion inflammation: A model for reaction to injury in cardiovascular disease
30. Myocardial ischemia-reperfusion injury in CD18- and ICAM-1-deficient mice
31. Heme oxygenase-1-derived bilirubin ameliorates postischemic myocardial dysfunction
32. Induction of heine oxygenase-1 can act protectively against cardiac ischemia/reperfusion in vivo
33. Effects of hemin on rat liver cyclic AMP-dependent protein kinases in cell extracts and intact hepatocytes
34. δ-aminolaevulinate synthase in human HepG2 hepatoma cells: Repression by haemin and induction by chemicals
35. Activation of heat shock factor 2 during hemin-induced differentiation of human erythroleukemia cells
36. Iron protoporphyrin IX (hemin) but not tin or zinc protoporphyrin IX can stimulate gene expression in K562 cells from enhancer elements containing binding sites for NF-E2
37. Albumin-bound bilirubins protect human ventricular myocytes against oxyradical damage
38. Higher serum bilirubin is associated with decreased risk for early familial coronary artery disease
39. Enzymatic defenses of the mouse heart against reactive oxygen metabolites: Alterations produced by doxorubicin