Nitrosation and oxidation in the regulation of gene expression

FASEB Journal

Volumn 14, Issue 13, 2000, Pages 1889-1900

  Marshall, Harvey E ^a   Merchant, Kunal ^a   Stamler, Jonathan S ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Nitric oxide; Nitrosative stress; Oxidative stress; S nitrosylation; Thiols; Transcription factors

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NITRIC OXIDE; PROTEIN P53; REACTIVE OXYGEN METABOLITE; THIOL; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1;

DNA BINDING; GENE EXPRESSION REGULATION; NITROSATION; OXIDATION; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PROCESSING; REGULATORY MECHANISM; REVIEW; TRANSCRIPTION REGULATION;

EUKARYOTA;

EID: 0033815334     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.00.011rev     Document Type: Review

References (143)

1. Oxidative stress: The paradox of aerobic life
2. Generation and disposal of reactive oxygen metabolites in the lung
3. Binuclear(2Fe-2S) clusters in the Escherichia coli SoxR protein and role of the metal centers in transcription
4. Mutational analysis of the redox-sensitive transcriptional regulator OxyR: Regions important for oxidation and transcriptional activation
5. S-nitrosylation of proteins with nitric oxide: Synthesis and characterization of biologically active compounds
6. Redox signaling: Nitrosylation and related target interactions of nitric oxide
7. Nitric oxide and nitric oxide-generating agents induce a reversible inactivation of protein kinase C activity and phorbol ester binding
8. Nitric oxide-stimulated guanine nucleotide exchange on p21ras
9. Posttranslational modification of glyceraldehyde-3-phosphate dehydrogenase by S-nitrosylation and subsequent NADH attachment
10. Blood flow regulation by S-nitrosohemoglobin in the physiological oxygen gradient
11. Fas-induced caspase denitrosylation
12. Polynitrosylated proteins: Characterization, bioactivity, and functional consequences
13. An apoptotic model for nitrosative stress
14. Oxidative modifications in nitrosative stress
15. Roles of nitric oxide in inducible resistance of Escherichia coli to activated murine macrophages
16. Nitrosative stress: Metabolic pathways involving the flavohemoglobin
17. Nitrosative stress: Activation of the transcription factor OxyR
18. Redox signal transduction: Mutations shifting [2Fe-2S] centers of the SoxR sensor-regulator to the oxidized form
19. Molecular and cellular aspects of thiol-disulfide exchange
20. Activation of the OxyR transcription factor by reversible disulfide bond formation
21. NO+, NO, and NO-donation by S-nitrosothiols: Implications for regulation of physiological functions by S-nitrosylation and acceleration of disulfide formation
22. The Y-box motif mediates redox-dependent transcriptional activation in mouse cells
23. (S)NO signals: Translocation, regulation, and a consensus motif
24. Redox sensing by prokaryotic transcription factors
25. Protein-sulfenic acid stabilization and function in enzyme catalysis and gene regulation
26. NF-kappa B: A lesson in family values
27. Induction and stabilization of I-kappa B alpha by nitric oxide mediates inhibition of NF-kappa B
28. Nitric oxide attenuates vascular smooth muscle cell activation by interferon-gamma
29. Thiol modulation of TNF-alpha and IL-1 induced MnSOD gene expression and activation of NF-kappa B
30. Inhibitors of the proteasome pathway interfere with induction of nitric oxide synthase in macrophages by blocking activation of transcription factor NF-kappa B
31. Structure, regulation, and function of NF-kappa B
32. Intracellular thiols regulate activation of nuclear factor kappa B and transcription of human immunodeficiency virus
33. Modulation of transcription factor NF-kappa B binding activity by oxidation-reduction in vitro
34. Thioredoxin regulates the DNA binding activity of NF-kappaB by reduction of a disulphide bond involving cysteine 62
35. Two different cellular redox systems regulate the DNA-binding activity of the p50 subunit of NF-kappa B in vitro
36. Oxidoreductive regulation of nuclear factor kappa B. Involvement of a cellular reducing catalyst thioredoxin
37. 2 and antioxidants have opposite effects on activation of NF-kappa B and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor
38. Activation and attenuation of transcription factor NF-kappa B in mouse glomerular mesangial cells in response to tumor necrosis factor-alpha, immunoglobulin G, and adenosine 3':5'-cyclic monophosphate
39. Assessing oxygen radicals as mediators in activation of inducible eukaryotic transcription factor NF-kappa B
40. Separation of oxidant-initiated and redox-regulated steps in the NF-kappa B signal transduction pathway
41. Inhibition by N-acetyl-L-cysteine of interleukin-6 mRNA induction and activation of NF kappa B by tumor necrosis factor alpha in a mouse fibroblastic cell line. Balb/3T3
42. Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF
43. P21ras as a common signaling target of reactive free radicals and cellular redox stress
44. Oncogenic Ha-Ras-induced signaling activates NF-kappaB transcriptional activity, which is required for cellular transformation
45. Oncogenic Ras enhances NF-kappaB transcriptional activity through Raf-dependent and Raf-independent mitogen-activated protein kinase signaling pathways
46. Regulation of NF-kappaB Re1A phosphorylation and transcriptional activity by p21 (ras) and protein in kinase Czeta in primary endothelial cells
47. Role of cysteine 62 in DNA recognition by the P50 subunit of NF-kappa B
48. Distinct roles of thioredoxin in the cytoplasm and in the nucleus - A two-step mechanism of redox regulation of transcription factor NF-kappa B
49. Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase
50. Activation of human peripheral blood mononuclear cells by nitric oxide-generating compounds
51. Nitric oxide produced by human B lymphocytes inhibits apoptosis and Epstein-Barr virus reactivation
52. Nitric oxide down-regulates hepatocyte-inducible nitric oxide synthase gene expression
53. Inhibition of NF-kappaB and HIV-1 long terminal repeat transcriptional activation by inducible nitric oxide synthase 2 activity
54. Inhibition of NF-kappa B DNA binding by nitric oxide
55. Dependence and reversal of nitric oxide production on NF-kappa B in silica and lipopolysaccharide-induced macrophages
56. Exogenous nitric oxide regulates interferon-gamma plus lipopolysaccharide-induced nitric oxide synthase expression in mouse macrophages
57. The role of Jun, Fos, and the AP-1 complex in cell-proliferation and transformation
58. Antitumor promotion by phenolic antioxidants: Inhibition of AP-1 activity through induction of Fra expression
59. Effects of dexamethasone on cytokine and phorbol ester stimulated c-Fos and c-Jun DNA binding and gene expression
60. Induction of c-Fos and c-Jun protooncogenes in target cells of the lung and pleura by carcinogenic fibers
61. The regulation of AP-1 acctivity by mitogen-activated protein kinases
62. The Mos/MAP kinase pathway stabilizes c-Fos by phosphorylation and augments its transforming activity in NIH 3T3 cells
63. c-Fos transcriptional activity stimulated by H-Ras-activated protein kinase distinct from Jnk and Erk
64. Distinct effects of thioredoxin and antioxidants on the activation of transcription factors NF-kappa B and AP-1
65. Role of oxidants and antioxidants in the induction of AP-1. NF-kappaB, and glutathione S-transferase gene expression
66. Transcriptional activation of early-response genes by hydrogen peroxide in a mouse osteoblastic cell line
67. Involvement of the transcription factor NF-kappaB in tubular morphogenesis of human microvascular endothelial cells by oxidative stress
68. Stable overexpression of manganese superoxide dismutase in mitochondria identifies hydrogen peroxide as a major oxidant in the AP-1-mediated induction of matrix-degrading metalloprotease-1
69. Apoptosis induced by transforming growth factor-beta in fetal hepatocyte primary cultures: Involvement of reactive oxygen intermediates
70. JunB forms the majority of the AP-1 complex and is a target for redox regulation by receptor tyrosine kinase and G protein-coupled receptor agonists in smooth muscle cells
71. Involvement of reactive oxygen intermediates in the induction of c-Jun gene transcription by ionizing radiation
72. Involvement of reactive oxygen species in cytokine and growth factor induction of c-Fos expression in chondrocytes
73. Induction of c-fos and c-jun proto-oncogene expression by asbestos is ameliorated by N-acetyl-L-cysteine in mesothelial cells
74. Antioxidant response element
75. An electrophile responsive element (EpRE) regulates beta-naphthoflavone induction of the human gamma-glutamylcysteine synthetase regulatory subunit gene. Constitutive expression is mediated by an adjacent AP-1 site
76. Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD-(P)H: Quinone oxidoreductase1 gene
77. Functional antioxidant responsive elements
78. Disruption of c-Fos leads to increased expression of NAD(P)H: Quinone oxidoreductase1 and glutathione S-transferase
79. Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes
80. Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene
81. Regulation of gamma-glutamylcysteine synthetase subunit gene expression by the transcription factor Nrf2
82. Redox regulation of fos and jun DNA-binding activity in vitro
83. Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme
84. AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1
85. Identification of residues in the human DNA repair enzyme HAP1 (Ref-1) that are essential for redox regulation of Jun DNA binding
86. The redox and DNA-repair activities of Ref-1 are encoded by nonoverlapping domains
87. Redox regulation of c-Jun DNA binding by reversible S-glutathiolation
88. Modulation of AP-1 activity by nitric oxide (NO) in vitro: NO-mediated modulation of AP-1
89. Inhibition of AP-1 DNA binding by nitric oxide involving conserved cysteine residues in Jun and Fos
90. Nitric oxide inhibits c-Jun DNA binding by specifically targeted S-glutathionylation
91. Constitutive expression of inducible nitric oxide synthase in human bronchial epithelial cells induces c-Fos and stimulates the cGMP pathway
92. Nitric oxide and cGMP analogs activate transcription from AP-1-responsive promoters in mammalian cells
93. Stimulation of immediate early gene expression in striatal neurons by nitric oxide
94. Stimulation of the cyclic GMP pathway by NO induces expression of the immediate early genes c-Fos and JunB in PC12 cells
95. Differential activation of mitogen-activated protein kinases by nitricoxide-related species
96. 2-terminal kinases
97. Nitric oxide and thiol redox regulation of Janus kinase activity
98. Nitric oxide modulates the c-Jun N-terminal kinase/stress-activated protein kinase activity through activating c-Jun N-terminal kinase kinase
99. Redox modulation of p53 conformation and sequence-specific DNA binding in vitro
100. Characterization of baculovirus recombinant wild-type p53: Dimerization of p53 is required for high-affinity DNA binding and cysteine oxidation inhibits p53 DNA binding
101. Role of cysteine residues in regulation of p53 function
102. Pyrrolidine dithiocarbamate prevents p53 activation and promotes p53 cysteine residue oxidation
103. Effect of p53 protein redox states on binding to supercoiled and linear DNA
104. Identification of redox/repair protein Ref-1 as a potent activator of p53
105. Ref-1 regulates the transactivation and pro-apoptotic functions of p53 in vivo
106. The DNA-binding efficiency of Sp1 is affected by redox changes
107. Characterization of the DNA-binding properties of the early growth response-1(Egr-1) transcription factor: Evidence for modulation by a redox mechanism
108. Physical and functional sensitivity of zinc finger transcription factors to redox change
109. Differences in DNA-binding efficiency of Sp1 to aldolase and pyruvate kinase promoter with altered redox states in resting and proliferating rat thymocytes
110. Redox manipulation of DNA binding activity and BuGR epitope reactivity of the glucocorticoid receptor
111. DNA binding activity of the glucocortcoid receptor is sensitive to redox changes in intact cells
112. Nitric oxide mediates intracytoplasmic and intranuclear zinc release
113. Reduction of a conserved Cys is essential for Myb DNA-binding
114. The helixloop-helix/leucine repeat transcription factor USF can be functionally regulated in a redox-dependent manner
115. Identification of a conserved oxidation-sensitive cysteine residue in the NF1 family of DNA-binding proteins
116. Subunit association and DNA binding activity of the heterotrimeric transcription factor NF-Y is regulated by cellular redox
117. Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit
118. A redox mechanism controls differential DNA binding activities of hypoxia-inducible factor (HIF) lalpha and the HIF-like factor
119. Redox regulation of the DNA binding activity in transcription factor PEBP2. The roles of two conserved cysteine residues
120. Identification of redox-sensitive cysteines in GA-binding protein-alpha that regulate DNA binding and heterodimerization
121. The DNA binding activity and the dimerization ability of the thyroid transcription factor I are redox regulated
122. Redox regulation of thyroid-transcription factors, Pax-8 and TTF-1, is involved in their increased DNA-binding activities by thyrotropin in rat thyroid FRTL-5 cells
123. Cooperative DNA binding of the human HoxB5 (Hox-2.1 protein is under redox regulation in vitro
124. Redox potential controls the structure and DNA binding activity of the paired domain
125. Molecular mechanisms of transcription activation by HLF and HIF1 alpha in response to hypoxia: Their stabilization and redox signal-induced interaction with CBP/p300
126. Thioredoxin: A redox-regulating cellular cofactor for glucocorticoid hormone action. Cross talk between endocrine control of stress response and cellular antioxidant defense system
127. Redox-dependent regulation of nuclear import of the glucocorticoid receptor
128. Nitric oxide (NO) disrupts specific DNA binding of the transcription factor c-Myb in vitro
129. Inhibition of glucocorticoid receptor binding by nitric oxide
130. Redox regulation of GA-binding protein-alpha DNA binding activity
131. Ref-1 controls Pax-8 DNA-binding activity
132. Direct association with thioredoxin allows redox regulation of glucocorticoid receptor function
133. 2: Role of thioredoxin
134. 2 and modulation by glutathione in human neuroblastoma and Alzheimer's disease cybrid cells
135. Nitric oxide induces conformational and functional modifications of wildtype p53 tumor suppressor protein
136. p53 Expression in nitric oxide-induced apoptosis
137. Nitric oxide-induced p53 accumulation and regulation of inducible nitric oxide synthase expression by wild-type p53
138. Nitric oxide reduces early growth response-1 gene expression in rat lung macrophages treated with interferon-gamma and lipopolysaccharide
139. Nitric oxide regulates shear stress-induced early growth response-1 - Expression via the extracellular signal-regulated kinase pathway in endothelial cells
140. Conformational changes induced by DNA binding of NF-kappa B
141. Alteration of NF-κB P50 DNA binding kinetics by S-nitrosylation
142. A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds
143. Mechanism of covalent modification of glyceraldehyde-3-phosphate dehydrogenase at its active site thiol by nitric oxide