Carbon monoxide-induced relaxation and distribution of haem oxygenase isoenzymes in the pig urethra and lower oesophagogastric junction

British Journal of Pharmacology

Volumn 120, Issue 2, 1997, Pages 312-318

  Werkström, Viktoria ^a   Ny, Lars ^a   Persson, Katarina ^a   Andersson, Karl Erik ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

Carbon monoxide; Cyclic nucleotides; Haem oxygenase; Lower oesophagogastric junction; Lower urinary tract; Potassium channels; Smooth muscle relaxation

Indexed keywords

4 AMINOPYRIDINE; APAMIN; CARBON MONOXIDE; CHARYBDOTOXIN; CYCLIC AMP; CYCLIC GMP; CYCLIC NUCLEOTIDE; GLIBENCLAMIDE; GUANYLATE CYCLASE INHIBITOR; HEME OXYGENASE; IBERIOTOXIN; METHYLENE BLUE; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LOWER ESOPHAGUS SPHINCTER; NERVE FIBER; NONHUMAN; PERIKARYON; PRIORITY JOURNAL; SMOOTH MUSCLE RELAXATION; SMOOTH MUSCLE TONE; SWINE; URETHRA; VASCULAR ENDOTHELIUM;

ANIMALS; CARBON MONOXIDE; CYCLIC AMP; CYCLIC GMP; ESOPHAGOGASTRIC JUNCTION; HEME OXYGENASE (DECYCLIZING); ISOENZYMES; METHYLENE BLUE; MUSCLE RELAXATION; POTASSIUM CHANNEL BLOCKERS; SWINE; URETHRA;

EID: 0031016768     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0700893     Document Type: Article

References (34)

1. ANDERSSON, K.-E. & PERSSON, K. (1993). The L-arginine, nitric oxide pathway and non-adrenergic, non-cholinergic relaxation of the lower urinary tract. Gen. Pharmacol., 24, 833-839.
2. BRADFORD, M.M. (1976). A rapid and sensitive method for quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analyt. Biochem., 72, 248.
3. BRIDGEWATER, M., MACNEIL, H.F. & BRADING, A.F. (1993). Regulation of tone in pig urethral smooth muscle. J. Urol., 150, 223-228.
4. DANIEL, E.E. (1992). Lower oesophagus: structure and function. In Sphincters: Normal Function-Changes in Diseases. ed. Daniel, E.E., Teammate, S., Tsuchida, S., Watanabe, M., pp. 49-66. Boca Raton, U.S.A: CRC Press.
5. EDWARDS, G. & WESTON, A.H. (1994). Effect of potassium channel modulating drugs on isolated smooth muscle. In Handbook of Experimental Pharmacology, Pharmacology of Smooth Muscle. ed. Szekeres, L. & Papp, G.J., Vol III, pp. 469-531. Heidelberg: Springer-Verlag.
6. FARRUGIA, G., IRONS, W.A., RAE, J.L., SARR, M.G. & SZURSZEWSKI, J.H (1993). Activation of whole cell currents in isolated human jejunal circular smooth muscle cells by carbon monoxide. Am. J. Physiol., 264, G1184-G1189.
7. FURCHGOTT, R.F. & JOTHIANANDAN, D. (1991). Endothelium-dependent and - independent vasodilation involving cyclic GMP: relaxation induced by nitric oxide, carbon monoxide and light. Blood Vessels, 28, 52-61.
8. KEYSE, S.M. & TYRRELL, R.M. (1989). Haem oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite. Proc. Natl. Acad. Sci. U.S.A., 86, 99-103.
9. LEFER, D.J., XIN-LIANG, M. & LEFEF, A.M. (1993). A comparison of vascular biological actions of carbon monoxide and nitric oxide. Meth. Find. Exp. Clin. Pharmacol., 15, 617-622.
10. MAINES, M.D. (1988). Heme oxygenase: function multiplicity, regulatory mechanisms, and clinical applications. FASEB J., 2, 2557-2568.
11. MAINES, M.D. (1993). Carbon monoxide: an emerging regulator of cGMP in the brain. Mol. Cell. Neurosci., 4, 389-397.
12. MEFFERT, M.K., HALEY, J.E., SCHUMAN, E.M., SCHULMAN, H. & MADISON, D.V. (1994). Inhibition of hippocampal heme oxygenase, nitric oxide synthase, and long-term potentiation by metalloporphyrins. Neuron. 13, 1225-1233.
13. MORITA, T. & KOUREMBANAS, S. (1995). Endothelial cell expression of vasoconstrictors and growth factors is regulated by smooth muscle cell-derived carbon monoxide. J. Clin. Invest., 96, 2676-2682.
14. NY, L., ALM, P., EKSTRÖM, P., LARSSON, B., GRUNDEMAR, L. & ANDERSSON, K.-H. (1996). Localization and activity of haem oxygenase and functional effects of carbon monoxide in the feline lower oesophageal sphincter. Br. J. Pharmacol., 118, 392-399.
15. NY, L., ALM, P., LARSSON, B., EKSTRÖM, P. & ANDERSSON, K.-E. (1995a). Nitric oxide pathway in cat esophagus: localization of nitric oxide synthase and functional effects. Am. J. Physiol. 268, G59-G70.
16. NY, L., ANDERSSON, K.-E. & GRUNDEMAR, L. (1995b). Inhibition by zinc protoporphyrin-IX of receptor-mediated relaxation of the rat aorta in a manner distinct from inhibition of heme oxygenase. Br. J. Pharmacol., 115, 186-190.
17. NY, L., GRUNDEMAR, L., LARSSON, B., EKSTRÖM, P. & ANDERSSON, K.-E. (1995c). Carbon monoxide as a putative messenger molecule in the feline lower oesophageal sphincter NeuroReport, 6, 1261-1265.
18. PERSSON, K., ALM, P., JOHANSSON, K., LARSSON, B. & ANDERSSON, K.-E. (1993). Nitric oxide synthase in pig lower urinary tract: immunohistochemistry, NADPH diaphorase histochemistry and functional effects. Br. J. Pharmacol., 110, 521-530.
19. PERSSON, K. & ANDERSSON, K.-E. (1994). Non-adrenergic, non-cholinergic relaxations and levels of cyclic nucleotides in the rabbit lower urinary tract. Eur. J. Pharmacol., 268, 159-167.
20. RAMOS, K.S., LIN, H. & MCGRATH, J.J. (1989). Modulation of cyclic guanosine monophosphate levels in cultured aortic smooth muscle cells by carbon monoxide. Biochem. Pharmacol., 38, 1368-1370.
21. RATTAN, S. & CHAKDER, S. (1993). Inhibitory effect of CO on internal anal sphincter: heme oxygenase inhibitor inhibits NANC relaxation. Am. J. Physiol., 265, G799-G804.
22. STONE, J.R. & MARLETTA, MA. (1994). Soluble guanylute cyclase from bovine lung: activation with nitric oxide and carbon monoxide and spectral characterization of the ferrous and ferric states. Biochemistry, 33, 5636-5640.
23. THUNEBERG, L. (1989). Interstitial cells of Cajal. In Handbook of Physiology, sect. 6, vol. 1, part. 1, The Gastrointestinal System, Motility and Circulation. ed. Schultz, S.G., Wood, J.D. Rauner, B.B., pp. 349-386. Bethesda, MD, U.S.A.: Am. Physiol. Soc.
24. TØTTRUP, A., KNUDSEN, M.A., HANBERG SØRENSEN, F. & GLAVIND, E.B. (1995). Pharmacological identification of different inhibitory mediators involved in the innervation of the internal anal sphincter. Br. J. Pharmacol., 115, 158-162.
25. VERMA, A., HIRSCH, O.J., GLATT, C.E., RONNETT, G.V. & SNYDER, S.H. (1993). Carbon monoxide: a putative neural messenger. Science, 259, 381-384.
26. VOLLERTHUN, R., HÖHLER, B. & KUMMER, W. (1995). Guinea-pig postganlionic sympathetic neurons contain haem oxygenase-2. NeuroReport, 7, 173-176.
27. WALDECK, K., PERSSON, K. & ANDERSSON K.-E. (1996). Relaxant and electrophysiological effects of some potential NANC-transmitters in the rabbit urethra. FASEB. J., 10, A658.
28. WERKSTRÖM, V., PERSSON, K., NY, L., BRIDGEWATER, M., BRADING, A.F. & ANDERSSON, K.-E. (1995). Factors involved in the relaxation of female pig urethra evoked by electrical field stimulation. Br. J. Pharmacol., 116, 1599-1604.
29. WILLIS, D., MOORE, A.R., FREDERICK, R. & WILLOUGHBY, D.A. (1996). Haem oxygense: a novel target for the modulation of the inflammatory response. Nature Medicine, 2, 87-90.
30. WOLIN, M.S., CHERRY, P.D., RODENBURG, J.M., MESSINA, E.J. & KALEY, G. (1990). Methylene blue inhibits vasodilation of skeletal muscle arterioles to acetylcholine and nitric oxide via the extracellular generation of superoxide anion. J. Pharmacol. Exp. Ther., 254, 872.
31. ZAKHARY, R., GAINE, S.P., DINERMAN, J.L., RUAT, M., FLAVAHAN, N.A. & SNYDER, S.H. (1996). Heme oxygenase-2: Endothelial and neuronal localization and role in endothelium-dependent relaxation. Proc. Natl. Acad. Sci. U.S.A., 93, 795-798.
32. ZYGMUNT, P.K.E., HÖGESTÄTT, E.D. & ANDERSSON, K.E., (1996). Effects of potassium channel inhibitors on nitrergic and adrenergic neurotransmission in the rabbit urethral lamina propria. Naunyn-Schmiedeberg's Arch. Pharmacol., 354, 336-342.
33. ZYGMUNT, P.M. & HÖGESTÄTT, E.D., (1996). Role of potassium channels in endothelim-dependent relaxation resistant to nitroarginine in the rat hepatic artery. Br. J. Pharmacol., 117, 1600-1606.
34. ZYGMUNT, P.M., HÖGESTÄTT, E.D. & GRUNDEMAR, L. (1994). Light-dependent effects of zinc protoporphyrin IX on endothelium-dependent relaxation resistant to N-nitro-L-arginine. Acta. Physiol. Scand., 152, 137-143.