The pulmonary circulation of homozygous or heterozygous eNOS-null mice is hyperresponsive to mild hypoxia

Journal of Clinical Investigation

Volumn 103, Issue 2, 1999, Pages 291-299

  Fagan, Karen A ^a,b,d   Fouty, Brian W ^a,b   Tyler, Robert C ^a   Morris Jr , Kenneth G ^a   Hepler, Lisa K ^a   Sato, Koichi ^a   LeCras, Timothy D ^a,d   Abman, Steven H ^a,d   Weinberger, Howard D ^a   Huang, Paul L ^e   McMurtry, Ivan F ^a,b   Rodman, David M ^a,b,c  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b 4200 East Nineth Avenue   (United States)

^c Division of Cardiology ^*  (United States)

^d UNIVERSITY OF COLORADO   (United States)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; FEMALE; GENE DISRUPTION; HEART RIGHT VENTRICLE HYPERTROPHY; HEART RIGHT VENTRICLE PRESSURE; HETEROZYGOSITY; HOMOZYGOSITY; HYPOXIA; INHALATIONAL DRUG ADMINISTRATION; LUNG CIRCULATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PULMONARY ARTERY; PULMONARY HYPERTENSION; VASOCONSTRICTION;

EID: 0032896721     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI3862     Document Type: Article

References (39)

1. Cremona, G., Wood, A.M., Hall, L.W., Bower, E.A., and Higenbottam, T. 1994. Effects of inhibition of nitric oxide release on vascular tone in isolated lungs of pig, sheep, dog, and man. J. Physiol. 481:185-195.
2. Blitzer, M.L., Loh, E., Roddy, M.A., Stamler, J.S., and Creager, M.A. 1996. Endothelium-derived nitric oxide regulates systemic and pulmonary vascular resistance during acute hypoxia in humans. J. Am. Coll. Cardiol. 28:591-596.
3. Shirai, M., et al. 1997. Endogenous nitric oxide attenuates hypoxic vasoconstriction of small pulmonary arteries and veins in anesthetized cats. Acta. Physiol. Scand. 159:263-264.
4. Hillier, S.C., et al. 1997. Hypoxic vasoconstriction in pulmonary arterioles and venules. J. Appl. Physiol. 82:1084-1090.
5. Blitzer, M.L., Lee, S.D., and Creager, M.A. 1996. Endothelium-derived nitric oxide mediates hypoxic vasodilation of resistance vessels in humans. Am. J. Physiol. 271:H1182-H1185.
6. Persson, M.G., Gustafsson, L.E., Wiklund, N.P., Moncada, S., and Hedqvist, P. 1990. Endogenous nitric oxide as a probable modulator of pulmonary circulation and hypoxic pressor response in vivo. Acta Physiol. Scand. 140:449-457.
7. Leeman, M., deBeyl, V.Z., Delcroix, M., and Naeije, R. 1994. Effects of endogenous nitric oxide on pulmonary vascular tone in intact dogs. Am. J. Physiol. 266:H2343-H2347.
8. Stamler, J.S., Loh, E., Roddy, M.A., Currie, K.E., and Creager, M.A. 1994. Nitric oxide regulates basal and systemic pulmonary vascular resistance in healthy humans. Circulation. 89:2035-2040.
9. Karamsetty, V.S., MacLean, M.R., McCulloch, K.M., Kane, K.A., and Wadsworth, R.M. 1996. Hypoxic constrictor response in the isolated pulmonary artery from chronically hypoxic rats. Respir. Physiol. 105:85-93.
10. Kantrow, S.P., et al. 1997. Hypoxia inhibits nitric oxide synthesis in isolated rabbit lung. Am. J. Physiol. 272:L1167-L1173.
11. Isaacson, T.C., Hampl, V., Weir, K.E., Nelson, D.F., and Archer, S.L. 1994. Increased endothelium-derived NO in hypertension pulmonary circulation of chronically hypoxic rats. J. Appl. Physiol. 76:933-940.
12. Tyler, R.C., et al. 1996. Variability in endothelial nitric oxide synthase gene expression in hypoxic, monocrotaline, and fawn-hooded hypertensive rat lungs. Circulation. 94:I-647. (Abstr.)
13. Resta, T.C., and Walker, B.R. 1996. Chronic hypoxia selectively augments endothelium-dependent arterial vasodilation. Am. J. Physiol. 270:H888-H896.
14. Brashers, V.L., Peach, M.J., and Rose, C.E. 1988. Augmentation of hypoxic pulmonary vasoconstriction in the isolated perfused rat lung by in vitro antagonists of endothelium-dependent relaxation. J. Clin. Invest. 82:1495-1502.
15. Barer G., Emery, C., Stewart, A., Bee, D., and Howard, P. 1993. Endothelial control of the pulmonary circulation in normal and chronically hypoxic rats. J. Physiol. 463:1-16.
16. Hampl, V., Archer, S.L., Nelson, D.D., and Weir, K.E. 1993. Chronic EDRF inhibition and hypoxia. Effects on pulmonary circulation and systemic blood pressure. J. Appl. Physiol. 75:1748-1757.
17. Huang, P.L., et al. 1995. Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature. 377:239-242.
18. Shesely, E.G., et al. 1996. Elevated blood pressures in mice lacking endothelial nitnc oxide synthase. Proc. Natl. Acad. Sci. USA. 93:13176-13181.
19. Moroi, M., et al. 1998. Interaction of genetic deficiency of endothelial nitric oxide, gender, and pregnancy in vascular response to injury in mice. J. Clin. Invest. 101:1225-1232.
20. Rudic, R.D., et al. 1998. Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodeling. J. Clin. Invest. 101:731-736.
21. Steudel, W., et al. 1997. Pulmonary vasoconstriction and hypertension in mice with targeted disruption of the endothelial nitric oxide synthase (NOS 3) gene. Circ. Res. 81:34-41.
22. Steudel, W., et al. 1998. Sustained pulmonary hypertension and right ventricular hypertrophy after chronic hypoxia in mice with congenital deficiency of nitric oxide synthase 3. J. Clin. Invest. 101:2408-2477.
23. Kramer, M.F., and Coen, D.M. 1994. The polymerase chain reaction. In Current protocols in molecular biology. F.M. Ausubel et al., editors. John Wiley & Sons. Boston, MA. 15.0.1-15.1.9.
24. LeCras, T.D., Xue, C., Rengasamy, A., and Johns, R.A. 1996. Chronic hypoxia upregulates endothelial and inducible NO synthase gene and protein expression in rat lung. Am. J. Physiol. 14:L164-L170.
25. Hara, A., et al. 1997. [3H]L-NG-nitroarginine binding after transient focal ischemia and NMDA-induced excitotoxicity in type I and III nitric oxide synthase null mice. J. Cereb. Blood Flow Metab. 17:515-526.
26. Conwell, T.L., Arnold, E., Boerth, N.J., and Lincoln, T.M. 1994. Inhibition of smooth muscle cell growth by nitric oxide and activation of cAMP-dependent protein kinase by cGMP. Am. J. Physiol. 267:C1405-C1413.
27. Hales, C.A., Kradin, R.L., Brandstetter, R.D., and Zhu, Y.J. 1983. Impairment of hypoxic pulmonary artery remodeling by heparin in mice. Am. Rev. Respir. Dis. 128:747-751.
28. Kouyoumdjian, C., et al. 1994. Continuous inhalation of nitric oxide protects against development of pulmonary hypertension in chronically hypoxic rats. J. Clin. Invest. 94:578-584.
29. Sato, K., Rodman, D.M., and McMurtry, I.F. 1998. Hypoxia inhibits nitric oxide (NO) production in chronically hypoxic hypertensive rat lungs. FASEB J. 12:A493. (Abstr.)
30. Nelin, L.D., Thomas, C.J., and Dawson, C.A. 1996. Effect of hypoxia on nitric oxide production in neonatal pig lung. Am. J. Physiol. 271:H8-H14.
31. Scarborough, J.E., et al. 1998. The role of endothelial nitric oxide expression in the development of pulmonary hypertension in chronically hypoxic infant swine. J. Thorac. Cardiovasc. Surg. 115:343-348.
32. Hislop, A.A., et al. 1997. Endothelial nitric oxide synthase in hypoxic newborn pulmonary vessels. Arch. Dis. Child Fetal Neonatal Ed. 7:F16-F22.
33. Shaul, P.W., III, et al. 1997. Pulmonary endothelial NO synthase gene expression is decreased in fetal lambs with pulmonary hypertension. Am. J. Physiol. 272:L1005-L1012.
34. Quinlan, T.R., Laubach, V., Zhou, N., and Johns, R.A. 1998. Alterations in nitric oxide synthase isoform expression in NOS knockout mice exposed to normoxia or hypoxia. Chest. 114:53S-55S.
35. Giaid, A., and Saleh, D. 1995. Reduced expression of endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension. N. Engl. J. Med. 333:214-222.
36. Xue, C., and Johns, R.A. 1995. Endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension. N. Engl. J. Med. 333:1642-1644.
37. Nakayama, M., et al. 1997. A T-786 C mutation reduces promoter activity in the endothelial nitric oxide synthase gene and is associated with coronary spasm. Circ. Supp. 96:I-315. (Abstr.)
38. Villamor, E., et al. 1997. Chronic intrauterine pulmonary hypertension impairs endothelial nitric oxide synthase in the ovine fetus. Am. J. Physiol. 272:L1013-L1020.
39. Faraci, F.M., Sigmund, C.D., Shesely, E.G., Maeda, N., and Heistad, D.D. 1998. Responses of carotid artery in mice deficient in expression of the gene for endothelial NO synthase. Am. J. Physiol. 274:H564-H570.