Heme oxygenase-1: A new therapeutic target for inflammatory bowel disease

Alimentary Pharmacology and Therapeutics, Supplement

Volumn 20, Issue 1, 2004, Pages 177-184

  Naito, Y ^a   Takagi, T ^a   Yoshikawa, T ^a  

^a KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BILIRUBIN; BILIVERDIN; CARBON MONOXIDE; DEXTRAN SULFATE; HEME OXYGENASE; HEME OXYGENASE 1; HEME OXYGENASE 2; IRON; ISOENZYME; TRINITROBENZENESULFONIC ACID;

ANTIINFLAMMATORY ACTIVITY; CATABOLISM; CONFERENCE PAPER; ENTERITIS; ENZYME ACTIVITY; ENZYME INDUCTION; GENE EXPRESSION; HUMAN; INFLAMMATION; INTESTINE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; TISSUE INJURY; TRANSCRIPTION INITIATION;

EID: 4344579195     PISSN: 09530673     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2036.2004.01992.x     Document Type: Conference Paper

References (46)

1. Maines MD. The heme oxygenase system: a regulator of second messenger gases. Annu Rev Pharmacol Toxicol 1997; 37: 517-54.
2. Scapagnini G, D'Agata V, Calabrese V, et al. Gene expression profiles of heme oxygenase isoforms in the rat brain. Brain Res 2002; 954: 51-9.
3. Shibahara S. Regulation of heme oxygenase gene expression. Semin Hematol 1988; 25: 370-6.
4. Levine AD, Fiocchi C. Immunology of inflammatory bowel disease. Curr Opin Gastroenterol 2000; 16: 306-9.
5. Motterlini R, Green CJ, Foresti R. Regulation of heme oxygenase-1 by redox signals involving nitric oxide. Antioxid Redox Signal 2002; 4: 615-24.
6. Amersi F, Buelow R, Kato H, et al. Upregulation of heme oxygenase-1 protects genetically fat Zucker rat livers from ischemia/reperfusion injury. J Clin Invest 1999; 104: 1631-9.
7. Hangaishi M, Ishizaka N, Aizawa T, et al. Induction of heme oxygenase-1 can act protectively against cardiac ischemia/ reperfusion in vivo. Biochem Biophys Res Commun 2000; 279: 582-8.
8. Tamion F, Richard V, Bonmarchand G, Leroy J, Lebreton JP, Thuillez C. Induction of heme-oxygenase-1 prevents the systemic responses to hemorrhagic shock. Am J Respir Crit Care Med 2001; 164: 1933-8.
9. Shimizu H, Takahashi T, Suzuki T, et al. Protective effect of heme oxygenase induction in ischemic acute renal failure. Crit Care Med 2000; 28: 809-17.
10. Wagner M, Cadetg P, Ruf R, Mazzucchelli L, Ferrari P, Redaelli CA. Heme oxygenase-1 attenuates ischemia/reperfusion-induced apoptosis and improves survival in rat renal allografts. Kidney Int 2003; 63: 1564-73.
11. Masini E, Vannacci A, Marzocca C, et al. Heme oxygenase-1 and the ischemia-reperfusion injury in the rat heart. Exp Biol Med (Maywood) 2003; 228: 546-9.
12. Zhang X, Bedard EL, Potter R, et al. Mitogen-activated protein kinases regulate HO-1 gene transcription after ischemia-reperfusion lung injury. Am J Physiol Lung Cell Mol Physiol 2002; 283: L815-29.
13. Kitamura Y, Matsuoka Y, Nomura Y, Taniguchi T. Induction of inducible nitric oxide synthase and heme oxygenase-1 in rat glial cells. Life Sci 1998; 62: 1717-21.
14. Datta PK, Lianos EA. Nitric oxide induces heme oxygenase-1 gene expression in mesangial cells. Kidney Int 1999; 55: 1734-9.
15. Immenschuh S, Tan M, Ramadori G. Nitric oxide mediates the lipopolysaccharide dependent upregulation of the heme oxygenase-1 gene expression in cultured rat Kupffer cells. J Hepatol 1999; 30: 61-9.
16. Mayer RD, Wang X, Maines MD. Nitric Oxide Inhibitor L-NAME Potentiates Induction of Heme Oxygenase-1 in Kidney Ischemia/Reperfused Model; a novel mechanism for regulation of the oxygenase. J Pharmacol Exp Ther 2003; 306: 43-50.
17. Otterbein LE, Kolls JK, Mantell LL, Cook JL, Alam J, Choi AM. Exogenous administration of heme oxygenase-1 by gene transfer provides protection against hyperoxia-induced lung injury. J Clin Invest 1999; 103: 1047-54.
18. Poss KD, Tonegawa S. Reduced stress defense in heme oxygenase 1-deficient cells. Proc Natl Acad Sci USA 1997; 94: 10925-30.
19. Yachie A, Niida Y, Wada T, et al. Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency. J Clin Invest 1999; 103: 129-35.
20. Tullius SG, Nieminen-Kelha M, Buelow R, et al. Inhibition of ischemia/reperfusion injury and chronic graft deterioration by a single-donor treatment with cobalt-protoporphyrin for the induction of heme oxygenase-1. Transplantation 2002; 74: 591-8.
21. Inoue S, Suzuki M, Nagashima Y, et al. Transfer of heme oxygenase 1 cDNA by a replication-deficient adenovirus enhances interleukin 10 production from alveolar macrophages that attenuates lipopolysaccharide-induced acute lung injury in mice. Hum Gene Ther 2001; 12: 967-79.
22. Yachie A, Toma T, Mizuno K, et al. Heme Oxygenase-1 Production by Peripheral Blood Monocytes During Acute Inflammatory Illnesses of Children. Exp Biol Med (Maywood) 2003; 228: 550-6.
23. Otterbein LE, Bach FH, Alam J, et al. Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway. Nat Med 2000; 6: 422-8.
24. Lee TS, Chau LY. Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice. Nat Med 2002; 8: 240-6.
25. Morisaki H, Katayama T, Kotake Y, et al. Carbon monoxide modulates endotoxin-induced microvascular leukocyte adhesion through platelet-dependent mechanisms. Anesthesiology 2002; 97: 701-9.
26. Stocker R, Yamamoto Y, McDonagh AF, Glazer AN, Ames BN. Bilirubin is an antioxidant of possible physiological importance. Science 1987; 235: 1043-6.
27. Stocker R, Glazer AN, Ames BN. Antioxidant activity of albumin-bound bilirubin. Proc Natl Acad Sci USA 1987; 84: 5918-22.
28. Llesuy SF, Tomaro ML. Heme oxygenase and oxidative stress. Evidence of involvement of bilirubin as physiological protector against oxidative damage. Biochim Biophys Acta 1994; 1223: 9-14.
29. Ossola JO, Groppa MD, Tomaro ML. Relationship between oxidative stress and heme oxygenase induction by copper sulfate. Arch Biochem Biophys 1997; 337: 332-7.
30. Ossola JO, Tomaro ML. Heme oxygenase induction by UVA radiation. A response to oxidative stress in rat liver. Int J Biochem Cell Biol 1998; 30: 285-92.
31. Otani K, Shimizu S, Chijiiwa K, et al. Administration of bacterial lipopolysaccharide to rats induces heme oxygenase-1 and formation of antioxidant bilirubin in the intestinal mucosa. Dig Dis Sci 2000; 45: 2313-9.
32. Vachharajani TJ, Work J, Issekutz AC, Granger DN. Heme oxygenase modulates selectin expression in different regional vascular beds. Am J Physiol Heart Circ Physiol 2000; 278: H1613-7.
33. Hayashi S, Takamiya R, Yamaguchi T, et al. Induction of heme oxygenase-1 suppresses venular leukocyte adhesion elicited by oxidative stress: role of bilirubin generated by the enzyme. Circ Res 1999; 85: 663-71.
34. Tamion F, Richard V, Lacoume Y, Thuillez C. Intestinal preconditioning prevents systemic inflammatory response in hemorrhagic shock. Role of HO-1. Am J Physiol Gastrointest Liver Physiol 2002; 283: G408-14.
35. Hara E, Takahashi K, Takeda K, et al. Induction of heme oxygenase-1 as a response in sensing the signals evoked by distinct nitric oxide donors. Biochem Pharmacol 1999; 58: 227-36.
36. Tamaki T, Konoeda Y, Yasuhara M, et al. Glutamine-induced heme oxygenase-1 protects intestines and hearts from warm ischemic injury. Transplant Proc 1999; 31: 1018-9.
37. Coeffier M, Le Pessot F, Leplingard A, et al. Acute enteral glutamine infusion enhances heme oxygenase-1 expression in human duodenal mucosa. J Nutr 2002; 132: 2570-3.
38. Ameho CK, Adjei AA, Harrison EK, et al. Prophylactic effect of dietary glutamine supplementation on interleukin 8 and tumour necrosis factor alpha production in trinitrobenzene sulphonic acid induced colitis. Gut 1997; 41: 487-93.
39. Leplingard A, Brung-Lefebvre M, Guedon C, et al. Increase in cyclooxygenase-2 and nitric oxide-synthase-2 mRNAs in pouchitis without modification of inducible isoenzyme heme-oxygenase-1. Am J Gastroenterol 2001; 96: 2129-36.
40. Wang WP, Guo X, Koo MW, et al. Protective role of heme oxygenase-1 on trinitrobenzene sulfonic acid-induced colitis in rats. Am J Physiol Gastrointest Liver Physiol 2001; 281: G586-94.
41. Naito Y, Takagi T, Tomatsuri N, et al. Role of heme oxygenase-1 in dextran sulfate sodium-induced intestinal inflammation in mice. Gastroenterology 2003; 124(Suppl.): A-490.
42. Niessner M, Volk BA. Altered Th1/Th2 cytokine profiles in the intestinal mucosa of patients with inflammatory bowel disease as assessed by quantitative reversed transcribed polymerase chain reaction (RT-PCR). Clin Exp Immunol 1995; 101: 428-35.
43. Regler G, Andus T. Cytokines in inflammatory bowel disease. World J Surg 1998; 22: 382-9.
44. Duchmann R, Schmitt E, Knolle P, Meyer zum Buschenfelde KH, Neurath M. Tolerance towards resident intestinal flora in mice is abrogated in experimental colitis and restored by treatment with interleukin-10 or antibodies to interleukin-12. Eur J Immunol 1996; 26: 934-8.
45. Ribbons KA, Thompson JH, Liu X, Pennline K, Clark DA, Miller MJ. Anti-inflammatory properties of interleukin-10 administration in hapten-induced colitis. Eur J Pharmacol 1997; 323: 245-54.
46. Kuhn R, Lohler J, Rennick D, Rajewsky K, Muller W. Interleukin-10- deficient mice develop chronic enterocolitis. Cell 1993; 75: 263-74.