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Volumn 13, Issue 16, 2002, Pages 1945-1960

Adenovirus-mediated transfer and overexpression of heme oxygenase 1 cDNA in lung prevents bleomycin-induced pulmonary fibrosis via a Fas-Fas ligand-independent pathway

Author keywords

[No Author keywords available]

Indexed keywords

BLEOMYCIN; COMPLEMENTARY DNA; FAS ANTIGEN; FAS LIGAND; GAMMA INTERFERON; HEME OXYGENASE 1; DNA; FASL PROTEIN, MOUSE; HEME OXYGENASE; HMOX1 PROTEIN, MOUSE; HYDROXYPROLINE; LIGAND; MEMBRANE PROTEIN;

EID: 0036431777     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/10430340260355356     Document Type: Article
Times cited : (81)

References (61)
  • 1
    • 0035132559 scopus 로고    scopus 로고
    • Different effects of angiotensin II and catecholamine on renal cell apoptosis and proliferation in rats
    • Aizawa, T., Ishizaka, N., Kurokawa, K., Nagai, R., Nakajima, H., Taguchi, J., and Ohno, M. (2001). Different effects of angiotensin II and catecholamine on renal cell apoptosis and proliferation in rats. Kidney Int. 59, 645-653.
    • (2001) Kidney Int , vol.59 , pp. 645-653
    • Aizawa, T.1    Ishizaka, N.2    Kurokawa, K.3    Nagai, R.4    Nakajima, H.5    Taguchi, J.6    Ohno, M.7
  • 2
    • 0034133548 scopus 로고    scopus 로고
    • Idiopathic pulmonary fibrosis: Diagnosis and treatment. International consensus statement from the American Thoracic Society and the European Respiratory Society
    • American Thoracic Society. (2000). Idiopathic pulmonary fibrosis: Diagnosis and treatment. International consensus statement from the American Thoracic Society and the European Respiratory Society. Am. J. Respir. Crit. Care Med. 161, 646-664.
    • (2000) Am. J. Respir. Crit. Care Med , vol.161 , pp. 646-664
  • 3
    • 0033846131 scopus 로고    scopus 로고
    • The Fas/Fas-ligand system is not required for bleomycin-induced pulmonary fibrosis in mice
    • Aoshiba, K., Yasui, S., Tamaoki, J., and Nagai, A. (2000). The Fas/Fas-ligand system is not required for bleomycin-induced pulmonary fibrosis in mice. Am. J. Respir. Crit. Care Med. 162, 695-700.
    • (2000) Am. J. Respir. Crit. Care Med , vol.162 , pp. 695-700
    • Aoshiba, K.1    Yasui, S.2    Tamaoki, J.3    Nagai, A.4
  • 4
    • 0028559768 scopus 로고
    • An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3
    • Bett, A.J., Haddara, W., Prevec, L., and Graham, F.L. (1994). An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3. Proc. Natl. Acad. Sci. U.S.A. 91, 8802-8806.
    • (1994) Proc. Natl. Acad. Sci. U.S.A , vol.91 , pp. 8802-8806
    • Bett, A.J.1    Haddara, W.2    Prevec, L.3    Graham, F.L.4
  • 5
    • 0029064989 scopus 로고
    • Control of collagen deposition in mammalian lung
    • Bienkowski, R.S., and Gotkin, M.G. (1995). Control of collagen deposition in mammalian lung. Proc. Soc. Exp. Biol. Med. 209, 118-140.
    • (1995) Proc. Soc. Exp. Biol. Med , vol.209 , pp. 118-140
    • Bienkowski, R.S.1    Gotkin, M.G.2
  • 6
    • 0026010305 scopus 로고
    • Transforming growth factor β1 is present at sites of extracellular matrix gene expression in human pulmonary fibrosis
    • Broekelmann, T.J., Limper, A.H., Colby, T.V., and McDonald, J.A. (1991). Transforming growth factor β1 is present at sites of extracellular matrix gene expression in human pulmonary fibrosis. Proc. Natl. Acad. Sci. U.S.A. 88, 6642-6646.
    • (1991) Proc. Natl. Acad. Sci. U.S.A , vol.88 , pp. 6642-6646
    • Broekelmann, T.J.1    Limper, A.H.2    Colby, T.V.3    McDonald, J.A.4
  • 8
    • 0035027015 scopus 로고    scopus 로고
    • Attenuation of lung inflammation and fibrosis in interferon-T-deficient mice after intratracheal bleomycin
    • Chen, E.S., Greenlee, B.M., Wills-Karp, M., and Moller, D.R. (2001). Attenuation of lung inflammation and fibrosis in interferon-T-deficient mice after intratracheal bleomycin. Am. J. Respir. Cell Mol. Biol. 24, 545-555.
    • (2001) Am. J. Respir. Cell Mol. Biol , vol.24 , pp. 545-555
    • Chen, E.S.1    Greenlee, B.M.2    Wills-Karp, M.3    Moller, D.R.4
  • 9
    • 0030188587 scopus 로고    scopus 로고
    • Heme oxygenase-l: Function, regulation, and implication of a novel stress-inducible protein in oxidant-induced lung injury
    • Choi, A.M., and Alam, J. (1996). Heme oxygenase-l: Function, regulation, and implication of a novel stress-inducible protein in oxidant-induced lung injury. Am. J. Respir. Cell Mol. Biol. 15, 9-19.
    • (1996) Am. J. Respir. Cell Mol. Biol , vol.15 , pp. 9-19
    • Choi, A.M.1    Alam, J.2
  • 10
    • 0025289423 scopus 로고
    • Cytokine networks in the regulation of inflammation and fibrosis in lung
    • Elias, J.A., Freundlich, B., Kern, J.A., and Rosenbloom, J. (1990). Cytokine networks in the regulation of inflammation and fibrosis in lung. Chest 97, 1439-1445.
    • (1990) Chest , vol.97 , pp. 1439-1445
    • Elias, J.A.1    Freundlich, B.2    Kern, J.A.3    Rosenbloom, J.4
  • 12
    • 0027425864 scopus 로고
    • Effect of antibody to transforming growth factor β on bleomycin induced accumulation of lung collagen in mice
    • Giri, S.N., Hyde, D.M., and Hollinger, M.A. (1993). Effect of antibody to transforming growth factor β on bleomycin induced accumulation of lung collagen in mice. Thorax 48, 959-966.
    • (1993) Thorax , vol.48 , pp. 959-966
    • Giri, S.N.1    Hyde, D.M.2    Hollinger, M.A.3
  • 13
    • 0015847039 scopus 로고
    • A new technique for the assay of infectivity of human adenovirus 5 DNA
    • Graham, F.L., and Van der Eb, A.J. (1973). A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 52, 456-467.
    • (1973) Virology , vol.52 , pp. 456-467
    • Graham, F.L.1    Van der Eb, A.J.2
  • 14
    • 0029124143 scopus 로고
    • Molecular mechanisms of antifibrotic effect of interferon γ in bleomycin-mouse model of lung fibrosis: Downregulation of TGF-β and procollagen I and III gene expression
    • Gurujeyalakshmi, G., and Giri, S.N. (1995). Molecular mechanisms of antifibrotic effect of interferon γ in bleomycin-mouse model of lung fibrosis: Downregulation of TGF-β and procollagen I and HI gene expression. Exp. Lung Res. 21, 791-808.
    • (1995) Exp. Lung Res , vol.21 , pp. 791-808
    • Gurujeyalakshmi, G.1    Giri, S.N.2
  • 16
    • 0030638505 scopus 로고    scopus 로고
    • Apoptosis and expression of Fas/Fas ligand mRNA in bleomycin-induced pulmonary fibrosis in mice
    • Hagimoto, N., Kuwano, K., Nomoto, Y., Kunitake, R., and Hara, N. (1997b). Apoptosis and expression of Fas/Fas ligand mRNA in bleomycin-induced pulmonary fibrosis in mice. Am. J. Respir. Cell Mol. Biol. 16, 91-101.
    • (1997) Am. J. Respir. Cell Mol. Biol , vol.16 , pp. 91-101
    • Hagimoto, N.1    Kuwano, K.2    Nomoto, Y.3    Kunitake, R.4    Hara, N.5
  • 17
    • 0031757984 scopus 로고    scopus 로고
    • Antibody-induced transplant arteriosclerosis is prevented by graft expression of anti-oxidant and anti-apoptotic genes
    • Hancock, W.W., Buelow, R., Sayegh, M.H., and Turka, L.A. (1998). Antibody-induced transplant arteriosclerosis is prevented by graft expression of anti-oxidant and anti-apoptotic genes. Nat. Med. 4, 1392-1396.
    • (1998) Nat. Med , vol.4 , pp. 1392-1396
    • Hancock, W.W.1    Buelow, R.2    Sayegh, M.H.3    Turka, L.A.4
  • 18
    • 0034782482 scopus 로고    scopus 로고
    • Adenovirus-mediated transfer of heme oxygenase-1 cDNA attenuates severe lung injury induced by the influenza virus in mice
    • hashiba, T., suzuki, M., nagashima, Y., suzuki, S., inoue, S., tsuburai, T., matsuse, T., and ishigatsubo, Y. (2001). Adenovirus-mediated transfer of heme oxygenase-1 cDNA attenuates severe lung injury induced by the influenza virus in mice. Gene Ther. 8, 1499-1507.
    • (2001) Gene Ther , vol.8 , pp. 1499-1507
    • Hashiba, T.1    Suzuki, M.2    Nagashima, Y.3    Suzuki, S.4    Inoue, S.5    Tsuburai, T.6    Matsuse, T.7    Ishigatsubo, Y.8
  • 19
    • 0028902754 scopus 로고
    • Modulation of gene expression after replication-deficient, recombinant adenovirus-mediated gene transfer by the product of a second adenovirus vector
    • Hersh, J., Crystal, R.G., and Bewlg, B. (1995). Modulation of gene expression after replication-deficient, recombinant adenovirus-mediated gene transfer by the product of a second adenovirus vector. Gene Ther. 2, 124-131.
    • (1995) Gene Ther , vol.2 , pp. 124-131
    • Hersh, J.1    Crystal, R.G.2    Bewig, B.3
  • 20
    • 0023712356 scopus 로고
    • Alterations in pulmonary mRNA encoding procollagens, fibronectin and transforming growth factor-β precede bleomycin-induced pulmonary fibrosis in mice
    • Hoyt, D.G., and Lazo, J.S. (1988). Alterations in pulmonary mRNA encoding procollagens, fibronectin and transforming growth factor-β precede bleomycin-induced pulmonary fibrosis in mice. J. Pharmacol. Exp. Ther. 246, 765-771.
    • (1988) J. Pharmacol. Exp. Ther , vol.246 , pp. 765-771
    • Hoyt, D.G.1    Lazo, J.S.2
  • 21
    • 0035176477 scopus 로고    scopus 로고
    • Cellular overexpression of heme oxygenase-1 up-regulates p21 and confers resistance to apoptosis
    • Inguaggiato, P., Gonzalez-Michaca, L., Croatt, A.J., Haggard, J.J., Alam, J., and Nath, K.A. (2001). Cellular overexpression of heme oxygenase-1 up-regulates p21 and confers resistance to apoptosis. Kidney Int. 60, 2181-2191.
    • (2001) Kidney Int , vol.60 , pp. 2181-2191
    • Inguaggiato, P.1    Gonzalez-Michaca, L.2    Croatt, A.J.3    Haggard, J.J.4    Alam, J.5    Nath, K.A.6
  • 22
    • 0034913968 scopus 로고    scopus 로고
    • Transfer of heme oxygenase 1 cDNA by a replication-deficient adenovirus enhances interleukin 10 production from alveolar macrophages that attenuates lipopolysaccharide-induced acute lung injury in mice
    • Inoue, S., Suzuki, M., Nagashima, Y., Suzuki, S., Hashiba, T., Tsuburai, T., Ikehara, K., Matsuse, T., and Ishigatsubo, Y. (2001). Transfer of heme oxygenase 1 cDNA by a replication-deficient adenovirus enhances interleukin 10 production from alveolar macrophages that attenuates lipopolysaccharide-induced acute lung injury in mice. Hum. Gene Ther. 12, 967-979.
    • (2001) Hum. Gene Ther , vol.12 , pp. 967-979
    • Inoue, S.1    Suzuki, M.2    Nagashima, Y.3    Suzuki, S.4    Hashiba, T.5    Tsuburai, T.6    Ikehara, K.7    Matsuse, T.8    Ishigatsubo, Y.9
  • 27
    • 0033118982 scopus 로고    scopus 로고
    • Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice
    • Lu, H.T., Yang D.D., Wysk, M., Gatii, E., Mellman, I., Davis, R.J., and Flavell, R.A. (1999). Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice. EMBO J. 18, 1845-1857.
    • (1999) EMBO J , vol.18 , pp. 1845-1857
    • Lu, H.T.1    Yang, D.D.2    Wysk, M.3    Gatii, E.4    Mellman, I.5    Davis, R.J.6    Flavell, R.A.7
  • 29
    • 0030923630 scopus 로고    scopus 로고
    • The heme oxygenase system: A regulator of second messenger gases
    • Maines, M.D. (1997). The heme oxygenase system: A regulator of second messenger gases. Annu. Rev. Pharmacol. Toxicol. 37, 517-554.
    • (1997) Annu. Rev. Pharmacol. Toxicol , vol.37 , pp. 517-554
    • Maines, M.D.1
  • 30
    • 0027409793 scopus 로고
    • Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Thl)-specific immune responses and inhibits the development of lL-4-producing Th cells
    • Manetti, R., Parronchi, P., Giudizi, M.G., Piccinni, M.P., Maggi, E., Trinchieri, G., and Romagnani, S. (1993). Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Thl)-specific immune responses and inhibits the development of lL-4-producing Th cells. J. Exp. Med. 177, 1199-1204.
    • (1993) J. Exp. Med , vol.177 , pp. 1199-1204
    • Manetti, R.1    Parronchi, P.2    Giudizi, M.G.3    Piccinni, M.P.4    Maggi, E.5    Trinchieri, G.6    Romagnani, S.7
  • 32
    • 0030009860 scopus 로고    scopus 로고
    • Induction of the haem oxygenase gene expression during the reperfusion of ischemic rat myocardium
    • Maulik, N., Sharma, H.S., and Das, D.K. (1996b). Induction of the haem oxygenase gene expression during the reperfusion of ischemic rat myocardium. J. Mol. Cell. Cardiol. 28, 1261-1270.
    • (1996) J. Mol. Cell. Cardiol , vol.28 , pp. 1261-1270
    • Maulik, N.1    Sharma, H.S.2    Das, D.K.3
  • 33
    • 0028329177 scopus 로고
    • Effects of IL-12 on helper T cell-dependent immune responses in vivo
    • McKnight, A.J., Zimmer, G.J., Fogelman, I., Wolf, S.F., and Abbas, A.K. (1994). Effects of IL-12 on helper T cell-dependent immune responses in vivo. J. Immunol. 152, 2172-2179.
    • (1994) J. Immunol , vol.152 , pp. 2172-2179
    • McKnight, A.J.1    Zimmer, G.J.2    Fogelman, I.3    Wolf, S.F.4    Abbas, A.K.5
  • 35
    • 0034114527 scopus 로고    scopus 로고
    • Bleomycin-mediated pulmonary toxicity: Evidence for a p53-mediated response
    • Mishra, A., Doyle, N.A., and Martin, W.J.C. (2000). Bleomycin-mediated pulmonary toxicity: Evidence for a p53-mediated response. Am. J. Respir. Cell Mol. Biol. 22, 543-549.
    • (2000) Am. J. Respir. Cell Mol. Biol , vol.22 , pp. 543-549
    • Mishra, A.1    Doyle, N.A.2    Martin, W.J.C.3
  • 36
    • 0032719815 scopus 로고    scopus 로고
    • Transient gene transfer and expression of Smad7 prevents bleomycin-induced lung fibrosis in mice
    • Nakao, A., Fujii, M., Matsumura, R., Kumano, K., Saito, Y., Miyazono, K., and Iwamoto, I. (1999). Transient gene transfer and expression of Smad7 prevents bleomycin-induced lung fibrosis in mice. J. Clin. Invest. 104, 5-11.
    • (1999) J. Clin. Invest , vol.104 , pp. 5-11
    • Nakao, A.1    Fujii, M.2    Matsumura, R.3    Kumano, K.4    Saito, Y.5    Miyazono, K.6    Iwamoto, I.7
  • 37
    • 0033452295 scopus 로고    scopus 로고
    • Heme oxygenase-l: A redoubtable response that limits reperfusion injury in the transplanted adipose liver
    • Nath, K.A. (1999). Heme oxygenase-l: A redoubtable response that limits reperfusion injury in the transplanted adipose liver. J. Clin. Invest. 104, 1485-1486.
    • (1999) J. Clin. Invest , vol.104 , pp. 1485-1486
    • Nath, K.A.1
  • 39
    • 0034529932 scopus 로고    scopus 로고
    • Heme oxygenase: Colors of defense against cellular stress
    • Otterbein, L.E., and Choi, A.M. (2000). Heme oxygenase: Colors of defense against cellular stress. Am. J. Physiol. Lung Cell. Mol. Physiol. 279, L1029-L1037.
    • (2000) Am. J. Physiol. Lung Cell. Mol. Physiol , vol.279 , pp. L1029-L1037
    • Otterbein, L.E.1    Choi, A.M.2
  • 40
    • 0032900940 scopus 로고    scopus 로고
    • Exogenous administration of heme oxygenase-1 by gene transfer provides protection against hyperoxia-induced lung injury
    • Otterbein, L.E., Kolls, J.K., Mantell, L.L., Cook, J.L., Alam, J., and Choi, A.M. (1999a). Exogenous administration of heme oxygenase-1 by gene transfer provides protection against hyperoxia-induced lung injury. J. Clin. Invest. 103, 1047-1054.
    • (1999) J. Clin. Invest , vol.103 , pp. 1047-1054
    • Otterbein, L.E.1    Kolls, J.K.2    Mantell, L.L.3    Cook, J.L.4    Alam, J.5    Choi, A.M.6
  • 41
    • 0032901266 scopus 로고    scopus 로고
    • Carbon monoxide provides protection against hyperoxic lung injury
    • Otterbein, L.E., Mantell, L.L., and Choi, A.M. (1999b). Carbon monoxide provides protection against hyperoxic lung injury. Am. J. Physiol. 276, L688-L694.
    • (1999) Am. J. Physiol , vol.276 , pp. L688-L694
    • Otterbein, L.E.1    Mantell, L.L.2    Choi, A.M.3
  • 44
    • 0028286946 scopus 로고
    • Treatment by human recombinant soluble TNF receptor of pulmonary fibrosis induced by bleomycin or silica in mice
    • Piguet, P.F., and Vesin, C. (1994). Treatment by human recombinant soluble TNF receptor of pulmonary fibrosis induced by bleomycin or silica in mice. Eur. Respir. J. 7, 515-518.
    • (1994) Eur. Respir. J , vol.7 , pp. 515-518
    • Piguet, P.F.1    Vesin, C.2
  • 45
    • 0024414604 scopus 로고
    • Tumor necrosis factor/cachectin plays a key role in bleomycin-induced pneumopathy and fibrosis
    • Piguet, P.F., Collart, M.A., Grau, G.E., Kapanci, Y., and Vassalli, P. (1989). Tumor necrosis factor/cachectin plays a key role in bleomycin-induced pneumopathy and fibrosis. J. Exp. Med. 170, 655-663.
    • (1989) J. Exp. Med , vol.170 , pp. 655-663
    • Piguet, P.F.1    Collart, M.A.2    Grau, G.E.3    Kapanci, Y.4    Vassalli, P.5
  • 47
    • 0026550854 scopus 로고
    • In vivo levels and in vitro production of interferon-γ in fibrosing interstitial lung diseases
    • Prior, C., and Haslam, P.L. (1992). In vivo levels and in vitro production of interferon-γ in fibrosing interstitial lung diseases. Clin. Exp. Immunol. 88, 280-287.
    • (1992) Clin. Exp. Immunol , vol.88 , pp. 280-287
    • Prior, C.1    Haslam, P.L.2
  • 48
    • 0033648666 scopus 로고    scopus 로고
    • Heme oxygenase activity: Current methods and applications
    • Ryter, S.W., Kvam, E., and Tyrrell, R.M. (2000). Heme oxygenase activity: Current methods and applications. Methods Mol. Biol. 99, 369-391.
    • (2000) Methods Mol. Biol , vol.99 , pp. 369-391
    • Ryter, S.W.1    Kvam, E.2    Tyrrell, R.M.3
  • 52
    • 0033588866 scopus 로고    scopus 로고
    • Treatment of bleomycin-induced pulmonary fibrosis by transfer of urokinase-type plasminogen activator genes
    • Sisson, T.H., Hattori, N., Xu, Y., and Simon, R.H. (1999). Treatment of bleomycin-induced pulmonary fibrosis by transfer of urokinase-type plasminogen activator genes. Hum. Gene Ther. 10, 2315-2323.
    • (1999) Hum. Gene Ther , vol.10 , pp. 2315-2323
    • Sisson, T.H.1    Hattori, N.2    Xu, Y.3    Simon, R.H.4
  • 54
    • 0014348401 scopus 로고
    • The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase
    • Tenhunen, R., Marver, H.S., and Schmid, R. (1968). The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase. Proc. Natl. Acad. Sci. U.S.A. 61, 748-755.
    • (1968) Proc. Natl. Acad. Sci. U.S.A , vol.61 , pp. 748-755
    • Tenhunen, R.1    Marver, H.S.2    Schmid, R.3
  • 57
    • 0033862955 scopus 로고    scopus 로고
    • Abrogation of bleomycin-induced epithelial apoptosis and lung fibrosis by captopril or by a caspase inhibitor
    • Wang, R., Ibarra-Sunga, O., Verlinski, L., Pick, R., and Uhal, B.D. (2000). Abrogation of bleomycin-induced epithelial apoptosis and lung fibrosis by captopril or by a caspase inhibitor. Am. J. Physiol. Lung Cell. Mol. Physiol. 279, L143-L151.
    • (2000) Am. J. Physiol. Lung Cell. Mol. Physiol , vol.279 , pp. L143-L151
    • Wang, R.1    Ibarra-Sunga, O.2    Verlinski, L.3    Pick, R.4    Uhal, B.D.5
  • 58
    • 0027291380 scopus 로고
    • Altered expression of small proteoglycans, collagen, and transforming growth factor-β1 in developing bleomycin-induced pulmonary fibrosis in rats
    • Westergren-Thorsson, G., Hernnas, J., Sarnstrand, B., Oldberg, A., Heinegard, D., and Malmstrom, A. (1993). Altered expression of small proteoglycans, collagen, and transforming growth factor-β1 in developing bleomycin-induced pulmonary fibrosis in rats. J. Clin. Invest. 92, 632-637.
    • (1993) J. Clin. Invest , vol.92 , pp. 632-637
    • Westergren-Thorsson, G.1    Hernnas, J.2    Sarnstrand, B.3    Oldberg, A.4    Heinegard, D.5    Malmstrom, A.6
  • 59
    • 0030045835 scopus 로고    scopus 로고
    • Heme oxygenase: A novel target for the modulation of the inflammatory response
    • Willis, D., Moore, A.R., Frederick, R., and Willoughby, D.A. (1996). Heme oxygenase: A novel target for the modulation of the inflammatory response. Nat. Med. 2, 87-90.
    • (1996) Nat. Med , vol.2 , pp. 87-90
    • Willis, D.1    Moore, A.R.2    Frederick, R.3    Willoughby, D.A.4
  • 60
    • 33745996622 scopus 로고
    • The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid
    • Woessner, J.F. (1961). The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid. Arch. Biochem. Biophys. 93, 440-447.
    • (1961) Arch. Biochem. Biophys , vol.93 , pp. 440-447
    • Woessner, J.F.1
  • 61
    • 0033592753 scopus 로고    scopus 로고
    • A preliminary study of long-term treatment with interferon γ-1b and low-dose prednisolone in patients with idiopathic pulmonary fibrosis
    • Ziesche, R., Hofbauer, E., Wittmann, K., Petkov, V., and Block, L.H. (1999). A preliminary study of long-term treatment with interferon γ-1b and low-dose prednisolone in patients with idiopathic pulmonary fibrosis. N. Engl. J. Med. 341, 1264-1269.
    • (1999) N. Engl. J. Med , vol.341 , pp. 1264-1269
    • Ziesche, R.1    Hofbauer, E.2    Wittmann, K.3    Petkov, V.4    Block, L.H.5


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