Iron regulates hyperoxia-dependent human heme oxygenase 1 gene expression in pulmonary endothelial cells

American Journal of Respiratory Cell and Molecular Biology

Volumn 20, Issue 4, 1999, Pages 797-804

  Fogg, Sandra ^a   Agarwal, Anupam ^a   Nick, Harry S ^a   Visner, Gary A ^a,b  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN; HEME OXYGENASE; HEME OXYGENASE 1; HMOX1 PROTEIN, HUMAN; IRON; MEMBRANE PROTEIN; MESSENGER RNA; OXYGEN; RECOMBINANT PROTEIN;

ARTICLE; BIOSYNTHESIS; CELL CULTURE; CELL NUCLEUS; CYTOLOGY; DRUG EFFECT; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; GENETICS; HUMAN; HYPEROXIA; KINETICS; METABOLISM; PHYSIOLOGY; PULMONARY ARTERY; REPORTER GENE; VASCULAR ENDOTHELIUM;

CATHEPSINS; CELL NUCLEUS; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENES, REPORTER; HEME OXYGENASE (DECYCLIZING); HEME OXYGENASE-1; HUMANS; HYPEROXIA; IRON; KINETICS; MEMBRANE PROTEINS; OXYGEN; PULMONARY ARTERY; RECOMBINANT PROTEINS; RNA, MESSENGER; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 0033113291     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/ajrcmb.20.4.3477     Document Type: Article

References (49)

1. Fisher, A. B. 1980. Oxygen therapy: side effects and toxicity. Am. Rev. Respir. Dis. 122:61-69.
2. Deneke, S. M., and B. L. Fanburg. 1980. Normobaric oxygen toxicity of the lung. New Engl. J. Med. 303:76-86.
3. Block, E. R., J. M. Patel, and N. P. Sheridan. 1985. Effect of oxygen and endotoxin on lactate dehydrogenase release. 5-Hydroxytryptamine uptake and antioxidant enzyme activities in endothelial cells. J. Cell Physiol. 122: 240-248.
4. Martin, W. J., II, and D. L. Kachel. 1989. Oxygen-mediated impairment of human pulmonary endothelial cell growth: evidence fur a specific threshold of toxicity. J. Lab. Clin. Med. 113:413-421.
5. Freeman, B. A., and J. D. Crapo. 1992. Free radicals and tissue injury. Lab. Invest. 47:412-426.
6. Meneghini, R. 1997. Iron homeostasis, oxidative stress, and DNA damage. Free Radic. Biol. Med. 23:783-792.
7. Frank, L. 1991. Hyperoxic inhibition of newborn rat lung development: protection by deferoxamine. Free Radic. Biol. Med. 11:341-348.
8. Fukada, Y., E. H. Herman, and V. J. Ferrans. 1992. Effect of ICRF-187 on the pulmonary damage induced by hyperoxia in the rat. Toxicology 74: 185-202.
9. Frank, L. 1991. Developmental aspects of experimental pulmonary oxygen toxicity. Free Radic. Biol. Med. 11:463-494.
10. Vile, G. F., and R. M. Tyrell. 1993. Oxidative stress resulting from ultraviolet a irradiation of human skin fibroblasts leads to a heme oxygenase-dependent increase in ferritin. J. Biol. Chem. 268:14678-14681.
11. Vogt, B. A., J. Alam, A. J. Croatt, G. M. Vercellotti, and K. A. Nath. 1995. Acquired resistance to acute oxidative stress: possible role of heme oxygenase and ferritin. Lab. Invest. 72:474-483.
12. Keyse, S. M., and R. M. Tyrell. 1987. Both near ultraviolet radiation and oxidizing agent hydrogen peroxide induce a 32-kDa stress protein in normal human skin fibroblasts. J. Biol. Chem. 262:14821-14825.
13. Visner, G. A., S. Fogg, and H. S. Nick. 1996. Hyperoxia-responsive proteins in rat pulmonary microvascular endothelial cells. Am. J. Physiol. 270 (Lung Cell. Mol. Physiol. 14):L517-L525.
14. Lee, P. J., J. Alam, S. L. Sylvester, N. Inamdar, L. Otterbein, and A. M. K. Choi. 1996. Regulation of heme oxygenase-1 expression in vivo and in vitro in hyperoxic lung injury. Am. J. Respir. Cell Mol. Biol. 14:556-568.
15. Jornot, L., and A. F. Junod. 1993. Variable glutathione levels and expression of antioxidant enzymes in human endothelial cells. Am. J. Physiol. 264 (Lung Cell. Mol. Physiol. 8):L482-L489.
16. Maines, M. D. 1988. Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications. FASEB J. 2:2557-2568.
17. McCoubrey, W. K., T. J. Huang, and M. D. Maines. 1997. Isolation and characterization of a cDNA from the rat brain that encodes hemoprotein heme oxygenase 3. Eur. J. Biochem. 247:725-732.
18. Dennery, P. A., D. R. Spitz, G. Yang, A. Tatarov, C. S. Lee, and M. L. Shegog. 1998. Oxygen toxicity and iron accumulation in the lungs of mice lacking heme oxygenase-2. J. Clin. Invest. 101:1001-1011.
19. Poss, K. D., and S. Tonegawa. 1997. Heme oxygenase 1 is required for mammalian iron utilization. Proc. Natl. Acad. Sci. USA 94:10919-10924.
20. Poss, K. D., and S. Tonegawa. 1997. Reduced stress defense in heme oxygenase 1-deficient cells. Proc. Natl. Acad. Sci USA 94:10925-10930.
21. Balla, J., H. S. Jacob, G. Balla, K. Nath, J. W. Eaton, and J. M. Vercellotti. 1993. Endothelial-cell heme uptake from heme proteins: induction of sensitization and desensitization to oxidant damage. Proc. Natl. Acad. Sci. USA 90:9285-9289.
22. Balla, G., G. M. Vercellotti, U. Muller-Eberhard, J. Eaton, and H. S. Jacob. 1991. Exposure of endothelial cells to free heme potentiates damage mediated by granulocytes and toxic oxygen species. Lab. Invest. 64:648-655.
23. Stocker, R., Y. Yamamoto, A. F. McDonagh, A. N. Glazer, and B. A. Ames. 1987. Bilirubin is an antioxidant of possible physiological importance. Science 235:1043-1046.
24. Neuzil, J., and R. Stocker. 1993. Bilirubin attentuates radical mediated damage to serum albumin. FEBS Lett. 331:281-284.
25. Vile, G. F., S. Basu-Modak, C. Waltner, and R. M. Tyrell. 1994. Heme oxygenase 1 mediates an adaptive response to oxidative stress in human skin fibroblasts. Proc. Natl. Acad. Sci. USA 91:2607-2610.
26. Visner, G. A., E. D. Staples, S. E. Chesrown, E. R. Block, D. S. Zander, and H. S. Nick. 1994. Isolation and maintenance of human pulmonary artery endothelial cells in culture isolated from transplant donor. Am. J. Physiol. 267 (Lung Cell. Mol. Physiol. 11):L406-L413.
27. Ryan, U. S. 1984. Isolation and culture of pulmonary endothelial cells. Environ. Health Perspect. 56:103-114.
28. VanLenten, B. J., J. Prieve, M. Navab, S. Hama, A. J. Lusis, and A. M. Fogelman. 1995. Lipid-induced changes in intracellular iron homeostasis in vitro and in vivo. J. Clin. Invest. 95:2104-2110.
29. Shibahara, S., R. Muller, H. Taguchi, and T. Yoshida. 1985. Cloning and expression of cDNA for rat heme oxygenase. Proc. Natl. Acad. Sci. USA 82:7865-7869.
30. Visner, G. A., W. C. Dougall, J. M. Wilson, I. A. Burr, and H. S. Nick. 1990. Regulation of manganese superoxide dismutase by lipopolysaccharide, interleukin-1, and tumor necrosis factor: role in the acute inflammatory response. J. Biol. Chem. 265:2856-2864.
31. Laine, R. O., N. F. Shay, and M. S. Kilberg. 1994. Nuclear retention of the induced mRNA following amino-acid dependent transcriptional regulation of mammalian rihosomal proteins L17 and S25. J. Biol. Chem. 269: 9693-9697.
32. Shibahara, S., M. Sato, R. M. Muller, and T. Yoshida. 1989. Structural organization of the human heme oxygenase gene and the function of its promoter. Eur. J. Biochem. 179:557-563.
33. Takeda, K., S. Ishizawa, M. Sato, T. Yoshida, and S. Shibahara. 1994. Identification of a cis-acting element that is responsible for cadmium-mediated induction of the human heme oxygenase gene. J. Biol. Chem. 269:22858-22867.
34. Abraham, N. G., Y. Lavrovsky, M. L. Schwartzman, R. A. Stoltz, R. D. Levere, M. E. Gerritsen, S. Shibahara, and A. Kappas. 1995. Transfection of the human heme oxygenase gene into rabbit coronary microvessel endothelial cells: protective effect against heme and hemoglobin toxicity. Proc. Natl. Acad. Sci. USA 92:6798-6802.
35. Pantopoulos, K., and M. W. Hentae. 1995. Rapid responses to oxidative stress mediated by iron regulatory protein. EMBO J. 14:2917-2924.
36. Shibahara, S., R. M. Muller, and H. Taguchi. 1987. Transcriptional control of rat heme oxygenase by heat shock. J. Biol. Chem. 262:12889-12892.
37. Keyes, S. M., L. A. Applegate, Y. Tromvoukis, and R. M. Tyrell. 1990. Oxidant stress leads to transcriptional activation of the human heme oxygenase gene in cultured skin fibroblasts. Mol. Cell. Biol. 9:4967-4969.
38. Lee, P. J., J. Alam, G. W. Wiegand, and A. M. Choi. 1996. Overexpression of heme oxygenase-1 in human pulmonary epithelial cells results in cell growth arrest and increased resistance to hyperoxia. Proc. Natl. Acad. Sci. USA 93:10393-10398.
39. Vile, G. F., S. Basu-Modak, C. Waltner, and R. M. Tyrell. 1994. Heme oxygenase 1 mediates an adaptive response to oxidative stress in human skin fibroblasts. Proc. Natl. Acad. Sci. USA 91:2607-2610.
40. Zhao, G., I. S. Ayene, and A. B. Fisher. 1997. Role of iron in ischemia-reperfusion oxidative injury of rat lungs. Am. J. Respir. Cell Mol. Biol. 16:293-299.
41. Gutteridge, J. M. C. 1986. Iron promoters of the Fenton reaction and lipid peroxidation can be released from haemoglobin by superoxides. FEBS Lett. 201:291-295.
42. Rothman, R. J., A. Serroni, and J. L. Farber. 1992. Cellular pool of transient ferric iron, chelatable by deferoxamine and distinct from ferritin, that is involved in oxidative cell injury. Mol. Pharmacol. 42:703-710.
43. Eisenstein, R. S., D. Garcia-Mayol, W. Pettingell, and H. N. Munro. 1991. Regulation of ferritin and heme oxygenase synthesis in rat fibroblasts by different forms of iron. Proc. Natl. Acad. Sci. USA 88:688-692.
44. Weiss, B., G. Werner-Felmayer, E. R. Werner, K. Grunewald, H. Wachter, and M. W. Hentze. 1994. Iron regulates nitric oxide synthase activity by controlling nuclear transcription. J. Exp. Med. 180:969-976.
45. Gardner, P. R., I. Raineri, L. B. Epstein, and C. W. White. 1995. Superoxide radical and iron modulate aconitase activity in mammalian cells. J. Biol. Chem. 270:13399-13405.
46. Agarwal, A., J. Balla, G. Balla, A. J. Croatt, G. M. Vercellotti, and K. A. Nath. 1996. Renal tubular epithelial cells mimic endothelial cells upon exposure to oxidized LDL. Am. J. Physiol. 271:F814-F823.
47. Tyrell, R. M., L. A. Applegate, and Y. Tromvoukis. 1993. The proximal promoter region of the human heme oxygenase gene contains elements involved in stimulation of transcriptional activity by a variety of agents including oxidants. Carcinogenesis 14:761-765.
48. Alam, J., J. Cai, and A. Smith. 1994. Isolation and characterization of the mouse heme oxygenase-1 gene. J. Biol. Chem. 269:1001-1009.
49. Choi, A. M. K., and J. Alam. 1996. Heme oxygenase-1: function, regulation, and implication of a novel stress-inducible protein in oxidant-induced lung injury. Am. J. Respir. Cell Mol. Biol. 15:9-19.