Drug therapy: Neonatal hyperbilirubinemia

New England Journal of Medicine

Volumn 344, Issue 8, 2001, Pages 581-590

  Dennery, Phyllis A ^a,c   Seidman, Daniel S ^b   Stevenson, David K ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^c STANFORD UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE; ALBUMIN; BENZYL ALCOHOL; BICARBONATE; BILIRUBIN; BILIVERDIN; CARBON DIOXIDE; CHLORAMPHENICOL; COLESTYRAMINE; DNA; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; GLUCURONOSYLTRANSFERASE; GLYCOPROTEIN P; HEME; HEME OXYGENASE; HEXOKINASE; IRON; MESOPORPHYRIN TIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; OXIDOREDUCTASE; PHENOBARBITAL; PYRUVATE KINASE; STREPTOMYCIN; SULFAFURAZOLE; THYMINE;

ALLERGIC REACTION; CLINICAL FEATURE; CLINICAL TRIAL; ENTEROHEPATIC CIRCULATION; EXCHANGE BLOOD TRANSFUSION; HUMAN; KERNICTERUS; NEUROTOXICITY; NEWBORN JAUNDICE; NONHUMAN; PATHOPHYSIOLOGY; PHOTOTHERAPY; PORTAL VEIN THROMBOSIS; PREDICTION; PRIORITY JOURNAL; REVIEW; RISK; THROMBOCYTOPENIA; BLOOD; BRAIN; DRUG EFFECT; FEMALE; MALE; METABOLISM; NEWBORN; NEWBORN SCREENING;

BILIRUBIN; BRAIN; EXCHANGE TRANSFUSION, WHOLE BLOOD; FEMALE; HEME; HUMANS; INFANT, NEWBORN; JAUNDICE, NEONATAL; KERNICTERUS; MALE; NEONATAL SCREENING; PHOTOTHERAPY;

EID: 0035932059     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM200102223440807     Document Type: Review

References (114)

1. Zur Kenntniss des Ikterus neonatorum, insbesondere der dabei auftretenden Gehirnveränderungen
2. Bilirubin metabolism with special reference to neonatal jaundice
3. Bilirubin 20 mg/dl=vigintiphobia
4. Neonatal hyperbilirubinemia and long-term outcome: Another look at the collaborative perinatal project
5. Does hyperbilirubinemia damage the brain of healthy full-term infants?
6. Evaluation and treatment of jaundice in the term newborn: A kinder, gentler approach
7. Problems associated with early discharge of newborn infants: Early discharge of newborns and mothers: A critical review of the literature
8. Early discharge of the term newborn: A continued dilemma
9. Bilirubin and ascorbate antioxidant activity in neonatal plasma
10. Kernicterus in a full term infant
11. Kernicterus in otherwise healthy, breast-fed term newborns
12. Measurement of red blood cell life-span
13. Neonatal jaundice and liver disease
14. Carbon monoxide in breath, blood, and other tissues
15. Hidden risks: Early discharge and bilirubin toxicity due to glucose 6-phosphate dehydrogenase deficiency
16. Glucose-6-phosphate dehydrogenase deficiency and carboxyhemoglobin concentrations associated with bilirubin-related morbidity and death in Nigerian infants
17. Exaggerated jaundice in Navajo neonates: The role of bilirubin production
18. Comparison of bilirubin production in Japanese and Caucasian infants
19. Gilbert syndrome accelerates development of neonatal jaundice
20. Crigler-Najjar disease type I: Therapeutic approaches to genetic liver diseases into the next century
21. Conjugated bilirubin in neonates with glucose-6-phosphate dehydrogenase deficiency
22. The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome
23. Racial variability in the UDP-glucuronosyltransferase 1 (UGT1A1) promoter: A balanced polymorphism for regulation of bilirubin metabolism?
24. Neonatal hyperbilirubinemia and mutation of the bilirubin uridine diphosphate-glucuronosyltransferase gene: A common missense mutation among Japanese, Koreans and Chinese
25. Gilbert syndrome and glucose-6-phosphate dehydrogenase deficiency: A dose-dependent genetic interaction crucial to neonatal hyperbilirubinemia
26. Effect of fasting on the uptake of bilirubin and sulfobromophthalein by the isolated perfused rat liver
27. Fasting-related hyperbilirubinemia in rats: The effect of decreased intestinal motility
28. Cytotoxicity of bilirubin for human fibroblasts and rat astrocytes in culture: Effect of the ratio of bilirubin to serum albumin
29. Dose-effect relationship of bilirubin on striatal synaptosomes in rats
30. The in vivo effect of bilirubin on the N-methyl-D-aspartate receptor/ion channel complex in the brains of newborn piglets
31. How bilirubin gets into the brain
32. Sulfated bile acids inhibit Na(+)-H+ antiport in human kidney brush-border membrane vesicles
33. Regional cerebral metabolic consequences of bilirubin in rat depend upon post-gestational age at the time of hyperbilirubinemia
34. Erythroblastosis fetalis. VIII. Studies of serum bilirubin in relation to kernicterus
35. Erythroblastosis fetalis and hyperbilirubinemia: A five-year follow-up with neurological, psychological, and audiological evaluation
36. Bilirubin and brain injury
37. A difference in mortality rate and incidence of kernicterus among premature infants allotted to two prophylactic antibacterial regimens
38. Relationship of benzyl alcohol to kernicterus, intraventricular hemorrhage, and mortality in preterm infants
39. Brain bilirubin content is increased in P-glycoprotein-deficient transgenic null mutant mice
40. Clinical features of bilirubin encephalopathy
41. Criteria for exchange transfusion in jaundiced newborns
42. Clearance of bilirubin from rat brain after reversible osmotic opening of the blood-brain barrier
43. Deposition of bilirubin acid in the central nervous system - A hypothesis for the development of kernicterus
44. Brainstem bilirubin toxicity in the newborn primate may be promoted and reversed by modulating PCO2
45. Development of cerebellar hypoplasia in jaundiced Gunn rats: A quantitative light microscopic analysis
46. A pilot registry for acute and chronic kernicterus in term and near-term infants
47. MR findings in kernicterus
48. Toxicity to bilirubin in neonates: Infant development during first year in relation to maximum neonatal serum bilirubin concentration
49. Hyperbilirubinemia in preterm infants and neurodevelopmental outcome at 2 years of age: Results of a national collaborative survey
50. Hyperbilirubinemia in low birth weight infants and outcome at 5 years of age
51. Behavioral changes correlated with brain-stem auditory evoked responses in term infants with moderate hyperbilirubinemia
52. Is auditory brainstem response a bilirubin toxicity marker?
53. Brainstem auditory evoked response in newborns with hyperbilirubinemia
54. Neonatal hyperbilirubinemia and physical and cognitive performance at 17 years of age
55. Neurologic outcome of singleton ≥2500g CORE Project babies not treated for hyperbilirubinemia
56. Hospital readmission due to neonatal hyperbilirubinemia
57. Length of stay, jaundice, and hospital readmission
58. Kernicterus in a full-term infant: The need for increased vigilance
59. A case of kernicterus in New Zealand: A predictable tragedy?
60. Bilirubin production in healthy term infants as measured by carbon monoxide in breath
61. Pulmonary excretion of carbon monoxide in the human infant as an index of bilirubin production. II. Infants of diabetic mothers
62. Oxytocin and neonatal hyperbilirubinemia: Studies of bilirubin production
63. Predictive ability of a predischarge hour-specific serum bilirubin for subsequent significant hyperbilirubinemia in healthy term and near-term newborns
64. Predicting hyperbilirubinemia in newborns: The importance of timing
65. Transcutaneous bilirubinometry: Its role in the assessment of neonatal jaundice
66. Transcutaneous bilirubinometry in neonatal intensive care units
67. Transcutaneous bilirubinometry decreases the need for serum bilirubin measurements and saves money
68. Semiportable electrochemical instrument for determining carbon monoxide in breath
69. Evaluation of a fully automated end-tidal carbon monoxide instrument for breath analysis
70. Decreased response to phototherapy for neonatal jaundice in breast-fed infants
71. The effect of feeding glucose water to breastfeeding newborns on weight, body temperature, blood glucose, and breastfeeding duration
72. Activated charcoal as an adjunct to phototherapy for neonatal jaundice
73. Enteral administration of agar as an effective adjunct to phototherapy of neonatal hyperbilirubinemia
74. Cholestyramine and phototherapy for neonatal jaundice
75. The use of metalloporphyrins for the chemoprevention of neonatal jaundice
76. Control of jaundice in preterm newborns by an inhibitor of bilirubin production: Studies with tin-mesoporphyrin
77. Direct comparison of Sn-mesoporphyrin, an inhibitor of bilirubin production, and phototherapy in controlling hyperbilirubinemia in term and near-term newborns
78. Control of severe hyperbilirubinemia in full-term newborns with the inhibitor of bilirubin production Sn-mesoporphyrin
79. Control of heme metabolism with synthetic metalloporphyrins
80. Metalloporphyrin phototoxicity
81. In vitro heme oxygenase isozyme activity inhibition by metalloporphyrins
82. Influence of light on the hyperbilirubinaemia of infants
83. Rapid clearance of a structural isomer of bilirubin during phototherapy
84. Blue light, green light, white light, more light: Treatment of neonatal jaundice
85. Green light in phototherapy
86. Efficacy of fluorescent daylight, blue, and green lamps in the management of nonhemolytic hyperbilirubinemia
87. Phototherapy for neonatal jaundice
88. Early changes in cutaneous bilirubin and serum bilirubin isomers during intensive phototherapy of jaundiced neonates with blue and green light
89. Prevention of hyperbilirubinemia of prematurity by phototherapy
90. A randomized, controlled application of the Wallaby phototherapy system compared with standard phototherapy
91. A clinical trial of fiberoptic phototherapy vs conventional therapy
92. Double phototherapy with high irradiance compared with single phototherapy in neonates with hyperbilirubinemia
93. Light-emitting diodes: A novel Light source for phototherapy
94. Why use homeopathic doses of phototherapy?
95. Acute management of extreme neonatal jaundice - The potential benefits of intensified phototherapy and interruption of enterohepatic bilirubin circulation
96. Practice parameter: Management of hyperbilirubinemia in the healthy term newborn
97. Rebound bilirubin levels in infants receiving phototherapy
98. Erythroblastosis fetalis. VII. Treatment with exchange transfusion
99. Administration of albumin in the management of hyperbilirubinemia by exchange transfusions
100. Necrotizing enterocolitis after catheterization of the umbilical vessels
101. Probable graft-vs-graft reaction in an infant after exchange transfusion and marrow transplantation
102. Adverse events associated with exchange transfusion in healthy and ill newborns
103. The impact of phototherapy in the management of neonatal hyperbilirubinemia: Comparison of historical cohorts
104. Effect of phenobarbital on hyperbilirubinemia and glucuronide formation in newborns
105. Effectiveness and safety of prenatal phenobarbital for the prevention of neonatal jaundice
106. Effect of phenobarbital on bilirubin metabolism in rat brain
107. Enzymatic removal of bilirubin from blood: A potential treatment for neonatal jaundice
108. Simulation of bilirubin detoxification in the newborn using an extracorporeal bilirubin oxidase reactor
109. Frequency of neonatal bilirubin testing and hyperbilirubinemia in a large health maintenance organization
110. Hyperbilirubinemia
111. Neonatal jaundice in 'healthy' very low birthweight infants
112. Jaundice in full-term and near-term babies who leave the hospital within 36 hours: The pediatrician's nemesis