Effect of long-term ethanol pretreatment on the metabolism of dichloromethane to carbon monoxide in rats

Toxicology and Applied Pharmacology

Volumn 143, Issue 1, 1997, Pages 83-88

  Wirkner, K ^a   Damme, B ^b   Poelchen, W ^a   Pankow, D ^b  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON MONOXIDE; CARBOXYHEMOGLOBIN; CYTOCHROME P450; DICHLOROMETHANE;

ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ADMINISTRATION; DRUG METABOLISM; ENZYME INDUCTION; INHALATION; LIVER METABOLISM; LIVER MICROSOME; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT;

ANIMALIA;

EID: 0031104795     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1996.8077     Document Type: Article

References (46)

1. Ahmed, A. E., Kubic, V. L., Stevens, J. L., and Anders, M. W. (1980). Halogenated methanes: Metabolism and toxicity. Fed. Proc. 39, 3150-3155.
2. Andersen, M. E., Clewell, H. J., Gargas, M. L., MacNaughton, M. G., Reitz, R. H., Nolan, R. J., and McKenna, M. J. (1991). Physiologically based pharmacokinetic modeling with dichloromethane, its metabolite, carbon monoxide, and blood carboxyhemoglobin in rats and humans. Toxicol. Appl. Pharmacol. 108, 14-27.
3. Astrand, I., Övrum, P., and Carlsson, A. (1975). Exposure to methylene chloride. I. Its concentration in alveolar air and blood during rest and exercise and its metabolism. Scand. J. Work Environ. Health 1, 78-94.
4. Brandt, K. R. (1988). Final report on the safety assessment of methylene chloride. J. Am. Coll. Toxicol. 6, 741-835.
5. DePina, Z. M., Vellalobos-Molina, R., Saavedreá-Molina, A., Riveros-Rosas, H., and Pina, E. (1989). Effects of moderate chronic ethanol consumption on rat liver mitochondrial functions. Alcohol 6, 3-7.
6. DiVincenzo, G. D., and Kaplan, C. J. (1981). Uptake metabolism, and elimination of methylene chloride vapor by humans. Toxicol. Appl. Pharmacol. 59, 130-140.
7. ECETOC (1984). Methylene chloride. Technical Report No. 4, ECETOC, Brussels.
8. ECETOC (1989). Methylene chloride (dichloromethane): An overview of experimental work investigating species, differences in carcinogenicity and their relevance to man. Technical Report No. 34, ECETOC, Brussels.
9. Elves, R. G., Ueng, T.-H., and Alvares, A. P. (1984). Comparative effects of ethanol administration on hepatic monooxygenases in rats and mice. Arch. Toxicol. 55, 258-264.
10. Fagin, J., Bradley, J., and Williams, D. (1980). Carbon monoxide poisoning secondary to inhaling methylene chloride. Brit. Med. J. 281, 1461.
11. Fodor, G. G., and Roscovanu, A. (1976). Erhöhter Blut-CO-Gehalt bei Mensch und Tier durch inkorporierte halogenierte Kohlenwasserstoffe. Zbl. Bakt. Hyg. 1 Abt. Orig. B 162, 34-40.
12. Foster, J. R., Green, T., Smith, L. L., Lewis, R. W., Hext, P. M., and Wyatt, I. (1992). Methylene chloride - An inhalative study to investigate pathological and biochemical events occuring in the lungs of mice over an exposure period of 90 days. Fundam. Appl. Toxicol. 18, 376-388.
13. Gargas, M. L., Clewell, H. J., and Andersen, M. E. (1986). Metabolism of inhaled dihalomethanes in vivo: Differentiation of kinetic constants for two independent pathways. Toxicol. Appl. Pharmacol. 82, 211-223.
14. Glatzel, W., Tietze, K., Gutewort, R., and Pankow, D. (1987). Interaction of dichloromethane and ethanol in rats: Toxicokinetics and nerve conduction velocity. Alcoholism Clin. Exp. Res. 11, 450-452.
15. Guengerich, F. P., Kim, D.-H., and Iwasaki, M. (1991). Role of human cytochrome P-450IIE1 in the oxidation of many low molecular weight cancer suspects. Chem. Res. Toxicol. 4, 168-179.
16. Hughes, N. J., and Tracey, J. A. (1993). A case of methylene chloride (Nitromors) poisoning, effects on carboxyhaemoglobin levels. Human Exp. Toxicol. 12, 159-160.
17. Ishidate, K., Yoshida, M., and Nakazawa, Y. (1988). Effect of typical inducers of microsomal drug metabolizing enzymes on phospholipid metabolism in rat liver. Biochem. Pharmacol. 27, 1925-1934.
18. Ko, I. Y., Park, S. S., Song, B. J., Patten, C., Tan, Y., Hah, Y. C., Yang, C. S., and Gelboin, H. V. (1987). Monoclonal antibodies to ethanol-induced rat liver cytochrome P450 that metabolizes aniline and nitrosamines. Cancer Res. 47, 3101-3109.
19. Koop, D. R., Crump, B. L., Nordblom, G. D., and Coon, M. J. (1985). Immunochemical evidence for induction of alcohol-oxidizing cytochrome P-450 of rabbit liver microsomes by diverse agents: Ethanol, imidazole, trichloroethylene, acetone, pyrazole, and isoniazid. Proc. Natl. Acad. Sci. USA 82, 4065-4069.
20. Koop, D. R., Leatham, C. L., and Tierney, D. J. (1989). The utility of p-nitrophenol hydroxylation in P450IIE1 analysis. Drug Metab. Rev. 20, 541-551.
21. Kubic, V. L., and Anders, M. W. (1978). Metabolism of dihalomethanes to carbon monoxide. III. Studies on the mechanism of the reaction. Biochem. Pharmacol. 27, 2349-2355.
22. Kubic, V. L., Anders, M. W., Engel, R. R., Barlow, C. H., and Caughey, W. S. (1974). Metabolism of dihalomethanes to carbon monoxide. I. In vivo studies. Drug Metab. Dispos. 2, 53-57.
23. Langehennig, P. L., Seeler, R. A., and Berman, E. (1976). Paint removers and carboxyhemoglobin. N. Engl. J. Med. 295, 1137.
24. Lieber, C. S. (1991). Alcohol, liver, and nutrition. J. Am. Coll. Nutr. 10, 602-632.
25. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randell, R. J. (1951). Protein measurement with Folin phenol reagent. J. Biol. Chem. 193, 265-275.
26. Luoma, P., and Vorne, M. (1976). Changes in hepatic microsomal enzyme activity during long-term ethanol feeding in rat. Acta Pharmacol. Toxicol. 38, 260-266.
27. Manno, M., Rugge, M., and Cocheo, V. (1992). Double fatal inhalation of dichloromethane. Human Exp. Toxicol. 11, 540-545.
28. McKenna, M. J., Zempel, J. A., and Braun, W. H. (1982). The pharmacokinetics of inhaled methylene chloride in rats. Toxicol. Appl. Pharmacol. 65, 1-10.
29. Morgan, E. T., Koop, D. R., and Coon, M. J. (1982). Catalytic activity of cytochrome P-450 isozyme 3a isolated from liver microsomes of ethanol-treated rabbits. J. Biol. Chem. 257, 13951-13957.
30. Omura, T., and Sato, R. (1964). The carbon monoxide-binding pigment of liver microsomes I. Evidence for its hemoprotein nature. J. Biol. Chem. 239, 2370-2378.
31. Pankow, D., and Hoffmann, P. (1989). Dichloromethane metabolism to carbon monoxide can be induced by isoniazid, acetone and fasting. Arch. Toxicol. Suppl. 13, 302-303.
32. Pankow, D., Kretschmer, S., and Hoffmann, P. (1990). Inhibition and stimulation of dichloromethane metabolism to carbon monoxide in the rat following administration of ethanol. Eur. J. Pharmacol. 183, 566.
33. Prasad, J. S., Crankshaw, D. L., Erickson, R. R., Elliott, C. E., Husby, A. D., and Holtzman, J. L. (1985). Studies on the effect of chronic consumption of moderate amounts of ethanol on male rat hepatic microsomal drug-metabolizing activity. Biochem. Pharmacol. 34, 3427-3431.
34. Rao, G. A., Larkin, E. C., Sankaran, H., and Derr, R. F. (1988). Lack of relationship between effects of chronic alcohol consumption and the amount of alcohol intake. Biochem. Arch. 4, 255-261.
35. Raucy, J. L., and Lasker, J. M. (1991). Isolation of P450 enzymes from human liver. In Methods in Enzymology, Vol. 206, Cytochrome P450 (Waterman, M. R., and Johnson, E. F., Eds.), p. 602. Academic Press, New York.
36. Reinke, L. A., and Moyer, M. L. (1985). p-Nitrophenolhydroxylation. A microsomal oxidation which is highly inducible by ethanol. Drug Metab. Dispos. 13, 548-552.
37. Rudge, F. W. (1990). Treatment of methylene chloride induced carbon monoxide poisoning with hyperbaric oxygenation. Mil. Med. 11, 570.
38. Schmidt, P. (Ed.) (1988). Biologische Kontrollmethoden in der Arbeitsmedizin, pp. 345-346. Verlag Volk & Gesundheit, Berlin.
39. Stewart, R. D., and Hake, C. L. (1976). Paint-remover hazard. J. Am. Med. Assoc. 235, 398-401.
40. Takano, T., and Miyazaki, Y. (1988). Metabolism of dichloromethane and the subsequent binding of its product, carbon monoxide, to cytochrome P-450 in perfused rat liver. Toxicol. Lett. 40, 93-96.
41. Trela, B. A., Carlson, G. P., and Mayer, P. R. (1989). Effect of carbon monoxide on the cytochrome P-450-mediated metabolism of aniline and p-nitroanisole in the isolated perfused rabbit lung. J. Toxicol. Environ. Health 27, 331-340.
42. Van de Wiel, J. A. G., Fijneman, P. H. S., Teeuw, K. B., Van Ommen, B., Nordhoek, J., and Bos, R. P. (1993). Influence of long-term ethanol treatment on rat liver biotransformation enzymes. Alcohol 10, 397-402.
43. Wells, G. G., and Waldron, H. A. (1984). Methylene chloride burns. Brit. Med. J. 41, 420.
44. Wirkner, K., and Poelchen, W. (1996). Influence of long-term ethanol treatment on rat liver aniline and p-nitrophenolhydroxylation. Alcohol 13, 69-74.
45. Wolna, P., Wünscher, U., and Damme, B. (1994). Toxicokinetics of accidental scenarios with dichloromethane. Arch. Pharmacol. 349(Suppl.), R107.
46. Younes, M., and Strubelt, O. (1987). Alcohol-induced hepatotoxicity: A role for oxygen free radicals. Free Radical Res. Commun. 3, 19-23.