Carbon monoxide generated by heme oxygenase 1 suppresses endothelial cell apoptosis

Journal of Experimental Medicine

Volumn 192, Issue 7, 2000, Pages 1015-1025

  Brouard, Sophie ^a   Otterbein, Leo E ^b   Anrather, Josef ^c   Tobiasch, Edda ^a   Bach, Fritz H ^a   Choi, Augustine M K ^b   Soares, Miguel P ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Apoptosis; Carbon monoxide; Endothelial cells; Heme oxygenase 1; p38 mitogen activated protein kinase

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CARBON MONOXIDE; HEME OXYGENASE; IRON; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BCL 2; PROTOPORPHYRIN TIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; APOPTOSIS; ARTICLE; ENDOTHELIUM CELL; ENZYME ACTIVATION; INFLAMMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; CARBON MONOXIDE; CATTLE; CELL LINE; CELLS, CULTURED; CYCLIC GMP; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; GENE EXPRESSION; GUANYLATE CYCLASE; HEME OXYGENASE (DECYCLIZING); HEME OXYGENASE-1; HUMANS; IRON; MEMBRANE PROTEINS; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0034596874     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.192.7.1015     Document Type: Article

References (56)

1. Endothelial cells in physiology and in the pathophysiology of vascular disorders
2. The endothelial cell as a regulator of T-cell function
3. Cytokine regulation of endothelial cell function: From molecular level to the bedside
4. Adhesion receptors of the immune system
5. Protective responses of endothelial cells
6. Protective genes expressed in endothelial cells: A regulatory response to injury
7. Overexpression of A1, an NF-κB-inducible anti-apoptotic bcl gene, inhibits endothelial cell activation
8. A20 inhibits NF-κB activation in endothelial cells without sensitizing to tumor necrosis factor-mediated apoptosis
9. A20 blocks endothelial cell activation through a NF-κB-dependent mechanism
10. Bcl-2 and Bcl-XL serve an anti-inflammatory function in endothelial cells through inhibition of NF-κB
11. The heme oxygenase system: A regulator of second messenger gases
12. Heme oxygenase-1: Function, regulation, and implication of a novel stress-inducible protein in oxidant-induced lung injury
13. Overview of HO-1 in inflammatory pathologies
14. Ferritin: A cytoprotective antioxidant strategem of endothelium
15. Retrovirus-mediated HO gene transfer into endothelial cells protects against oxidant-induced injury
16. Transfection of the human heme oxygenase gene into rabbit coronary microvessel endothelial cells: Protective effect against heme and hemoglobin toxicity
17. Reduced stress defense in heme oxygenase 1-deficient cells
18. Hemoglobin provides protection against lethal endotoxemia in rats: The role of heme oxygenase-1
19. Mechanism of hemoglobin-induced protection against endotoxemia in rats: A ferritin-independent pathway
20. Exogenous administration of heme oxygenase-1 by gene transfer provides protection against hyperoxia-induced lung injury
21. Heme oxygenase: A novel target for the modulation of the inflammatory response
22. Up-regulation of heme oxygenase-1 protects genetically fat Zucker rat livers from ischemia/reperfusion injury
23. Expression of heme oxygenase-1 (HO-1) can determine cardiac xenograft survival
24. Antibody-induced transplant arteriosclerosis is prevented by graft expression of anti-oxidant and anti-apoptotic genes
25. Lipopolysaccharide induces disseminated endothelial cell apoptosis requiting ceramide
26. Apoptosis of endothelial cells. Contribution to the pathophysiology of atherosclerosis?
27. Inhibition of bovine endothelial cell activation in vitro by regulated expression of a transdominant inhibitor of NF-κB
28. Adenovirus mediated expression of a dominant negative mutant of p65/RelA inhibits proinflammatory gene expression in endothelial cells without sensitizing to apoptosis
29. Overexpression of heme oxygenase-1 in human pulmonary epithelial cells results in cell growth arrest and increased resistance to hyperoxia
30. Functional analysis of cDNAs for two types of human heme oxygenase and evidence for their separate regulation
31. Protective effects of heme oxygenase-1 in acute lung injury
32. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
33. Carbon monoxide mediates anti-inflammatory effects via the mitogen activated protein kinase pathway
34. Haem oxygenase-1 prevents cell death by regulating cellular iron
35. Endothelial-cell heme uptake from heme proteins: Induction of sensitization and desensitization to oxidant damage
36. Smooth muscle cell-derived carbon monoxide is a regulator of vascular cGMP
37. Carbon monoxide: A putative neural messenger
38. Nitric oxide inhibits apoptosis by preventing increases in caspase-3-like activity via two distinct mechanisms
39. Adenovirus-mediated gene transfer of cGMP-dependent protein kinase increases the sensitivity of cultured vascular smooth muscle cells to the antiproliferative and pro-apoptotic effects of nitric oxide/cGMP
40. Reversal of HO-1 related cytoprotection with increased expression is due to reactive iron
41. Early activation of c-Jun N-terminal kinase and p38 kinase regulate cell survival in response to tumor necrosis factor alpha
42. Sounding the alarm: Protein kinase cascades activated by stress and inflammation
43. Cardiac muscle cell hypertrophy and apoptosis induced by distinct members of the p38 mitogen-activated protein kinase family
44. Carbon monoxide provides protection against hyperoxic lung injury
45. A caspase inhibitor fully protects rats against lethal normothermic liver ischemia by inhibition of liver apoptosis
46. Attenuation of ischemia/reperfusion injury in rats by a caspase inhibitor
47. Modification of vascular responses in xenotransplantation: Inflammation and apoptosis
48. Prolongation of heart xenograft survival in a hamster-to-rat model after therapy with a rationally designed immunosuppressive peptide
49. Endothelial cells undergoing apoptosis become proadhesive for nonactivated platelets
50. C1q binds directly and specifically to surface blebs of apoptotic human keratinocytes: Complement deficiency and systemic lupus erythematosus revisited
51. The biochemistry of programmed cell death
52. Heme oxygenase-1 inhibits TNF-α-induced apoptosis in cultured fibroblast
53. Adaptive responses and apoptosis in endothelial cells exposed to carbon monoxide
54. Induction of apoptosis by SB202190 through inhibition of p38beta mitogen-activated protein kinase
55. 2-terminal kinase in ventricular muscle cells
56. Apoptosis signaling pathway in T cells is composed of ICE/Ced-3 family proteases and MAP kinase kinase 6b