Haem can bind to and inhibit mammalian calcium-dependent Slo1 BK channels

Nature

Volumn 425, Issue 6957, 2003, Pages 531-535

  Tang, Xiang Dong ^a   Xu, Rong ^a   Reynolds, Mark F ^b   Garcia, Maria L ^c   Heinemann, Stefan H ^d   Hoshi, Toshinori ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b SAINT JOSEPH S UNIVERSITY   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

^d FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; MEMBRANES; MOLECULAR STRUCTURE;

REDOX-SENSITIVE REACTION CENTERS;

PROTEINS;

CALCIUM ION; HEME; HEMOPROTEIN; ION CHANNEL; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL;

BIOLOGY; PROTEIN;

ANIMAL TISSUE; ARTICLE; CHANNEL GATING; ELECTROPHYSIOLOGY; EMBRYO; MAMMAL; NONHUMAN; POTASSIUM CONDUCTANCE; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; RAT; SIGNAL TRANSDUCTION; SLO1 CHANNEL;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; BRAIN; ELECTROPHYSIOLOGY; HEME; HEMIN; HUMANS; ION CHANNEL GATING; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA SUBUNITS; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MOLECULAR SEQUENCE DATA; MUTATION; OXIDATION-REDUCTION; POTASSIUM CHANNELS, CALCIUM-ACTIVATED; PROTEIN BINDING; RATS;

ANIMALIA; MAMMALIA;

EID: 0141963861     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature02003     Document Type: Article

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