Amyloid precursor proteins inhibit heme oxygenase activity and augment neurotoxicity in Alzheimer's disease

Neuron

Volumn 28, Issue 2, 2000, Pages 461-473

  Takahashi, Masaaki ^a   Doré, Sylvain ^a   Ferris, Christopher D ^a   Tomita, Taisuke ^b   Sawa, Akira ^a   Wolosker, Herman ^a   Borchelt, David R ^a   Iwatsubo, Takeshi ^b   Kim, Seong Hun ^c   Thinakaran, Gopal ^c   Sisodia, Sangram S ^c   Snyder, Solomon H ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TOKYO   (Japan)

^c UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; ANTIOXIDANT; BILIRUBIN; HEME OXYGENASE;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; BILIRUBIN BLOOD LEVEL; BRAIN CORTEX; CELL DEATH; CONTROLLED STUDY; ENZYME ACTIVITY; MOUSE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; TRANSGENIC MOUSE;

EID: 0033638815     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0896-6273(00)00125-2     Document Type: Article

References (68)

1. Transfection of the human heme oxygenase gene into rabbit coronary microvessel endothelial cells: Protective effect against heme and hemoglobin toxicity
2. Transfection of DNA into eukaryotic cells
3. Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo
4. Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro
5. Neuron loss in APP transgenic mice
6. Protein interaction cloning in yeast: Identification of mammalian proteins that react with the leucine zipper of Jun
7. Expression and distribution of amyloid precursor protein-like protein-2 in Alzheimer's disease and in normal brain
8. Heme oxygenase-mediated resistance to oxygen toxicity in hamster fibroblasts
9. Oxygen toxicity and iron accumulation in the lungs of mice lacking heme oxygenase-2
10. Protein topology of presenilin 1
11. Insulin-like growth factor I protects and rescues hippocampal neurons against beta-amyloid- and human amylin-induced toxicity
12. Bilirubin, formed by activation of heme oxygenase-2, protects neurons against oxidative stress injury
13. Heme oxygenase-2 is neuroprotective in cerebral ischemia
14. Prevention of neonatal hyperbilirubinemia by tin protoporphyrin IX, a potent competitive inhibitor of heme oxidation
15. Haem oxygenase-1 prevents cell death by regulating cellular iron
16. Increased nuclear DNA oxidation in the brain in Alzheimer's disease
17. Alzheimer-type neuropathology in transgenic mice overexpressing V717F beth-amyloid precursor protein
18. Selective accumulation of aluminum and iron in the neurofibrillary tangles of Alzheimer's disease: A laser microprobe (LAMMA) study
19. Oxidation of bilirubin in the brain-further characterization of a potentially protective mechanism
20. The Alzheimer family of diseases: Many etiologies, one pathogenesis?
21. Amyloid, the presenilins and Alzheimer's disease
22. Preparing protein A bead-antibody affinity columns-direct coupling
23. Topological arrangement in microsomal membranes of hepatic haem oxygenase induced by cobalt chloride
24. Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice
25. Seeding 'one-dimensional crystallization' of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie?
26. Subcellular localization of presenilins: Association with a unique membrane pool in cultured cells
27. Overexpression of heme oxygenase-1 in human pulmonary epithelial cells results in cell growth arrest and increased resistance to hyperoxia
28. Transferrin and iron in normal, Alzheimer's disease, and Parkinson's disease brain regions
29. Copper, iron and zinc in Alzheimer's disease senile plaques
30. The heme oxygenase system: A regulator of second messenger gases
31. Oxidative stress hypothesis in Alzheimer's disease
32. Immunohistochemical and in situ analysis of amyloid precursor-like protein-1 and amyloid precursor-like protein-2 expression in Alzheimer disease and aged control brains
33. Neurotrophic and neuroprotective effects of hAPP in transgenic mice
34. The orientation of prostaglandin endoperoxide synthases-1 and -2 in the endoplasmic reticulum
35. Association of folding intermediates of glycoproteins with calnexin during protein maturation
36. Evidence of oxidative stress and in vivo neurotoxicity of beta-amyloid in a transgenic mouse model of Alzheimer's disease: A chronic oxidative paradigm for testing antioxidant therapies in vivo
37. Heme oxygenase 1 is required for mammalian iron reutilization
38. Reduced stress defense in heme oxygenase 1-deficient cells
39. Mutant genes in familial Alzheimer's disease and transgenic models
40. Isolation, characterization, and expression in Escherichia coil of a cDNA encoding rat heme oxygenase-2
41. Aberrant expression of bcl-2 gene family in Down's syndrome brains
42. Molecular cloning and expression of a receptor for human tumor necrosis factor
43. Expression of heme oxygenase-1 in the senescent and Alzheimer-diseased brain
44. Amyloid beta-protein and the genetics of Alzheimer's disease
45. Cloning and expression of cDNA for rat heme oxygenase
46. Expression of a ubiquitous, cross-reactive homologue of the mouse beta-amyloid precursor protein (APP)
47. Heme oxygenase-1 is associated with the neurofibrillary pathology of Alzheimer's disease
48. Oxidative damage in Alzheimer's
49. Amyloid-beta deposition in Alzheimer transgenic mice is associated with oxidative stress
50. Molecular cloning of the cDNA for a human amyloid precursor protein homolog: Evidence for a multigene family
51. Bilirubin is an antioxidant of possible physiological importance
52. Distribution of an APP homolog, APLP2, in the mouse olfactory system: A potential role for APLP2 in axogenesis
53. The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue
54. Lipid-induced changes in intracellular iron homeostasis in vitro and in vivo
55. Carbon monoxide: A putative neural messenger
56. Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO mice
57. The 13-kD FK506 binding protein, FKBP13, interacts with a novel homologue of the erythrocyte membrane cytoskeletal protein 4.1
58. Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid beta protein precursor
59. Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid beta protein precursor
60. Survival of cultured neurons from amyloid precursor protein knock-out mice against Alzheimer's amyloid-beta toxicity and oxidative stress
61. Mechanisms of neuronal degeneration in Alzheimer's disease
62. Posttranslational and direct integration of heme oxygenase into microsomes
63. Purification and properties of bovine spleen heme oxygenase. Amino acid composition and sites of action of inhibitors of heme oxidation
64. Evidence that A beta 42 is the real culprit in Alzheimer's disease
65. Heme oxygenase 2: Endothelial and neuronal localization and role in endothelium-dependent relaxation
66. Targeted gene deletion of heme oxygenase 2 reveals neural role for carbon monoxide
67. Increased susceptibility to ischemic brain damage in transgenic mice overexpressing the amyloid precursor protein
68. beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity