Assessing the intake of phytoestrogens: isoflavones

Phytochemical Functional Foods

Volumn , Issue , 2003, Pages 189-221

  Lorenzetti, S ^a   Branca, F ^a  

^a Istituto Nazionale di Ricerca per gli Alimenti e la Nutrizione   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 21144447556     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-1-85573-672-6.50014-9     Document Type: Chapter

References (203)

1. H ADLERCREUTZ, H HONJO, A HIGASHI, T FOTSIS, E HAMALAINEN, T HASEGAWA and H OKADA (1991) ‘Urinary excretion of lignans and isoflavonoid phyto-oestrogens in Japanese men and women consuming traditional Japanese diet.’. Am J Clin Nutr 54(6), 1093-1100.
2. H ADLERCREUTZ, H MARKKANEN and S WATANABE (1993) ‘Plasma concentrations of phytooestrogens in Japanese men.’. Lancet 342(8881), 1209-1210.
3. H ADLERCREUTZ (1998) ‘Epidemiology of phytoestrogens.’. Baillieres Clin Endocrinol Metab 12(4), 605-623.
4. J J AMARAL MENDES (2002) ‘The endocrine disrupters: a major medical challenge.’. Food Chem Toxicol 40(6), 781-788.
5. J V ANASTASIA, B L BRAUN and K T SMITH (1990) ‘General and histopathological results of a two-year study of rats fed semi-purified diets containing casein and soya protein.’. Food Chem Toxicol 28(3), 147-156.
6. J J B ANDERSON, H ADLERCREUTZ, S BARNES, M R BENNINK, T B CLARKSON, E JEFFREY, M S KURZER, P MURPHY, K SETCHELL, C M WEAVER and C M HASLER (2000) ‘Appropriate isoflavone food fortification levels: results of a consensus conference.’. Faseb J 14 36.
7. J W ANDERSON, B M JOHNSTONE and M E COOK-NEWELL (1995) ‘Meta-analysis of the effects of soy protein intake on serum lipids.’. N Engl J Med 333(5), 276-282.
8. J W ANDERSON, B M SMITH and C S WASHNOCK (1999) ‘Cardiovascular and renal benefits of dry bean and soybean intake.’. Am J Clin Nutr 70(3 Suppl), 464S-474S.
9. W ANDLAUER, J KOLB and P FURST (2000) ‘Absorption and metabolism of genistein in the isolated rat small intestine.’. FEBS Lett 475(2), 127-130.
10. W ANDLAUER, J KOLB, P STEHLE and P FURST (2000) ‘Absorption and metabolism of genistin in isolated rat small intestine.’. J Nutr 130(4), 843-846.
11. T AKIYAMA, J ISHIDA, S NAKAGAWA, H OGAWARA, S WATANABE, N ITOH, M SHIBUYA and Y FUKAMI (1987) ‘Genistein, a specific inhibitor of tyrosine-specific protein kinases.’. J Biol Chem 262(12), 5592-5595.
12. C AUSSENAC, S LACOMBE and J DAYDE (1998) ‘Quantification of isoflavones by capillary zone electrophoresis in soybean seeds: effects of variety and environment.’. Am J Clin Nutr 68(6 Suppl), 1480S-1485S.
13. M AXELSON, J SJOVALL, B E GUSTAFSSON and K D SETCHELL (1984) ‘Soy - a dietary source of the non-steroidal oestrogen equol in man and animals.’. J Endocrinol 102(1), 49-56.
14. D D BAIRD, D M UMBACH, L LANSDELL, C L HUGHES, K D SETCHELL, C R WEINBERG, A F HANEY, A J WILCOX and J A MCLACHLAN (1995) ‘Dietary intervention study to assess estrogenicity of dietary soy among postmenopausal women.’. J Clin Endocrinol Metab 80(5), 1685-1690.
15. F BALMIR, R STAACK, E JEFFREY, M D JIMENEZ, L WANG and S M POTTER (1996) ‘An extract of soy flour influences serum cholesterol and thyroid hormones in hamsters.’. J Nutr 126(12), 3046-3053.
16. S BARNES (2003) ‘Phytoestrogens and osteoporosis - What is a safe dose?’. Br J Nutr in press
17. R M BARTHOLOMEW and D S RYAN (1980) ‘Lack of mutagenicity of some phytoestrogens in the salmonella/mammalian microsome assay.’. Mutat Res 78(4), 317-321.
18. J A BAUM, H TENG, J W ERDMAN Jr, R M WEIGEL, B P KLEIN, V W PERSKY, S FREELS, P SURYA, R M BAKHIT, E RAMOS, N F SHAY and S M POTTER (1998) ‘Long-term intake of soy protein improves blood lipid profiles and increases mononuclear cell low-density-lipoprotein receptor messenger RNA in hypercolesterolemic postmenopausal women.’. Am J Clin Nutr 68(3), 545-551.
19. H W BENNETTS, E J UNDERWOOD and F L SHIER (1946) ‘A specific breeding problem of sheep on subterranean clover pasture in Western Australia.’. Austral Vet J 22 2-12.
20. S M BELCHER and A ZSARNOVSZKY (2001) ‘Estrogenic actions in the brain: estrogen, phytoestrogens and rapid intracellular signalling mechanisms.’. J Pharmacol Exp Ther 299(2), 408-414.
21. M R BENNINK and A S OM (1998) ‘Inhibition of colon cancer (CC) by soy phytochemicals but not by soy protein.’. Faseb J 12 A655.
22. D F BIRT, S HENDRICH and W WANG (2001) ‘Dietary agents in cancer prevention: flavonoids and isoflavonoids.’. Pharmacol Ther 90(2-3), 157-177.
23. L K BOKER, Y T VAN DER SCHOUW, M J DE KLEIJN, P F JACQUES, D E GROBBEE and P H PEETERS (2002) ‘Intake of dietary phytoestrogens by Dutch women.’. J Nutr 132(6), 1319-1328.
24. L BONTOUX (2001) ‘The European strategy on endocrine disrupters: progress to date and EU/US cooperation.’. Folia Histochem Cytobiol 39(Suppl 2), 9-11.
25. R B BRADBURY and D E WHITE (1951) ‘The chemistry of subterranean clover. Part I. Isolation of formononetin and genistein.’. J Chem Soc 12 3447-3449.
26. F BRANCA, A B HANLEY, B POOL-ZOBEL and H VERHAGEN (2001) ‘Biomarkers in disease and health.’. Br J Nutr 86 S55-S92. (Suppl)
27. C BRENCKMANN and A PAPAIOANNOU (2001) ‘Bisphosphonates for osteoporosis in people with cystic fibrosis.’. Cochrane Database Syst Rev 4 CD002010.
28. G BRUNO, O MILITA, M FERRARA, R NISINI, A CANTANI and L BUSINCO (1993) ‘Prevention of atopic diseases in high-risk babies (long-term follow-up).’. Allergy Proc 14(3), 181-186.
29. A BRZEZINSKI and A DEBI (1999) ‘Phytoestrogens: the ‘ natural’ selective estrogen receptor modulators?’. Eur J Obstet Gynecol Reprod Biol 85(1), 47-51.
30. M G BUSBY, A R JEFFCIAT, L T BLOEDON, M A KOCH, T BLACK, K J DIX, W D HEIZER, B F THOMAS, J M HILL, J A CROWELL and S H ZEISEL (2002) ‘Clinical characteristics and pharmacokinetics of purified soy isoflavones: single-dose administration to healthy men.’. Am J Clin Nutr 75(1), 126-136.
31. D CAMPER-KIRBY, S WELCH, A WALKER, I SHIRAISHI, K D SETCHELL, E SCHAEFER, J KAJSTURA, P ANVERSA and M A SUSSMAN (2001) ‘Myocardial Akt activation and gender: increased nuclear activity in females versus males.’. Circ Res 88(10), 1020-1027.
32. A CANTANI (1999) ‘Nutrition of allergic babies and children.’. Eur Rev Med Pharmacol Sci 3(5), 233-234.
33. M CARCEA and E SCHIAVONI (2001) ‘Phytoestrogens in mediterranean vegetables and grains.’. Ann Nutr Metab 45(5), 233.
34. A CASSIDY, S BINGHAM and K D R SETCHELL (1994) ‘Biological effects of a diet of soy protein rich in isoflavones on the menstrual cycle of premenopausal women.’. Am J Clin Nutr 60(3), 333-340.
35. Y C CHANG and M G NAIR (1995) ‘Metabolism of daidzein and genistein by intestinal bacteria.’. J Nat Prod 58(12), 1892-1896.
36. Z CHEN, W ZHENG, L J CUSTER, Q DAI, X O SHU, F JIN and A A FRANKE (1999) ‘Usual dietary consumption of soy foods and its correlation with the excretion rate of isoflavonoids in overnight urine samples among Chinese women in Shanghai.’. Nutr Cancer 33(1), 82-87.
37. L CONTOR (2001) ‘Functional Food Science in Europe.’. Nutr Metab Cardiovasc Dis 11(Suppl 4), 20-23.
38. L COWARD, M KIRK, N ALBIN and S BARNES (1996) ‘Analysis of plasma isoflavones by reversedphase HPLC-multiple reaction ion monitoring-mass spectrometry.’. Clin Chim Acta 247(1-2), 121-142.
39. J R CROUSE 3rd, T MORGAN, J G TERRY, J ELLIS, M VITOLINS and G L BURKE (1999) ‘A randomised trial comparing the effect of casein with that of soy protein containing varying amounts of isoflavones on plasma concentrations of lipids and lipoproteins.’. Arch Intern Med 159(17), 2070-2076.
40. C DABROSIN, J CHEN, L WANG and L U THOMPSON (2002) ‘Flaxseed inhibits metastasis and decreases extracellular vascular endothelial growth factor in human breast cancer xenografts.’. Cancer Lett 185(1), 31-37.
41. A J DAY, M S DUPONT, S RIDLEY, M RHODES, M J RHODES, M R MORGAN and G WILLIAMSON (1998) ‘Deglycosylation of flavonoid and isoflavonoid glycosides by human small intestine and liver and beta-glucosidase activity.’. FEBS Lett 436(1), 71-75.
42. A J DAY, F J CANADA, J C DIAZ, P A KROON, R MCLAUCHLAN, C B FAULDS, G W PLUMB, M R MORGAN and G WILLIAMSON (2000) ‘Dietary flavonoid and isoflavone glycosides are hydrolysed by the lactase site of lactase phlorizin hydrolase.’. FEBS Lett 468(2-3), 166-170.
43. J K DAY, A M BAUER, C DESBORDES, Y ZHUANG, B E KIM, L G NEWTON, V NEHRA, K M FORSEE, R S MACDONALD, C BESCH-WILLIFORD, T H HUANG and D B LUBAHN (2002) ‘Genistein alters methylation patterns in mice.’. J Nutr 132(8 Suppl), 2419S-2423S.
44. M J DE KLEIJN, Y T VAN DER SCHOUW, P W WILSON, H ADLERCREUTZ, W MAZUR, D E GROBBEE and P F JACQUES (2001) ‘Intake of dietary phytoestrogens is low in postmenopausal women in the United States: the Framingham Study (1-4).’. J Nutr 131(6), 1826-1832.
45. A T DIPLOCK, P J AGGERTT, M ASHWELL, F BORNET, E B FERN and M D ROBERFROID (1998) Scientific concepts of functional foods in Europe: consensus document Brussels: ILSI-Europe (FF-27-de98) 1998
46. R L DIVI, H C CHANG and D R DOERGE (1997) ‘Anti-thyroid isoflavones from soybean: isolation, characterization and mechanism of action.’. Biochem Pharmacol 54(10), 1087-1096.
47. D R DOERGE and D M SHEEHAN (2002) ‘Goitrogenic and estrogenic activity of soy isoflavones.’. Environ Health Perspect 110(Suppl 3), 349-353.
48. E DOPP, G VOLLMER, C HAHNEL, Y GREVESMUHL and D SCHIFFMANN (1999) ‘Modulation of the intracellular calcium level in mammalian cells caused by 17β-estradiol, different phytoestrogens and the anti-estrogen ICI 182780.’. J Steroid Biochem Mol Biol 68(1-2), 57-64.
49. A DREWNOWSKI and C GOMEZ-CARNEROS (2000) ‘Bitter taste, phytonutrients and the consumer: a review.’. Am J Clin Nutr 72(6), 1424-1435.
50. A M DUNCAN, B E MERZ, X XU, T C NAGEL, W R PHIPPS and M S KURZER (1999) ‘Soy isoflavones exert modest hormonal effects in premenopausal women.’. J Clin Endocrinol Metab 84(1), 192-197.
51. A M DUNCAN, K E UNDERHILL, X XU, J LAVALLEUR, W R PHIPPS and M S KURZER (1999) ‘Modest hormonal effects of soy isoflavones in postmenopausal women.’. J Clin Endocrinol Metab 84(10), 3479-3484.
52. A M DUNCAN, B E MERZ-DEMLOW, X XU, W R PHIPPS and M S KURZER (2000) ‘Premenopausal equol excretors show plasma hormone profiles associated with lowered risk of breast cancer.’. Cancer Epidemiol Biomarkers Prev 9(6), 581-586.
53. O EIDELMAN, J ZHANG, M SRIVASTAVA and H B POLLARD (2001) ‘Cystic fibrosis and the use of pharmacogenomics to determine surrogate endpoints for drug discovery.’. Am J Pharmacogenomics 1(3), 223-238.
54. G FAGLIA, P BECK-PECCOZ, C FERRARI, B AMBROSI, A SPADA and P TRAVAGLINI (1973) ‘Enhanced plasma thyrotrophin response to thyrotrophin-releasing hormone following oestradiol administration in man.’. Clin Endocrinol 2(3), 207-210.
55. K M FLYNN, S A FERGUSON, K B DELCLOS and R R NEWBOLD (2000) ‘Effects of genistein exposure on sexually dimorphic behaviors in rats.’. Toxicol Sci 55(2), 311-319.
56. K M FLYNN, S A FERGUSON, K B DELCLOS and R R NEWBOLD (2000) ‘Multigenerational exposure to genistein has no severe effects on maternal behavior in rats.’. Neurotoxicology 21(6), 997-1001.
57. T FOTSIS, M S PEPPER, R MONTESANO, E AKTAS, S BREIT, L SCHWEIGERER, S RASKU, K WAHALA and H ADLERCREUTZ (1998) ‘Phytoestrogens and inhibition of angiogenesis.’. Baillieres Clin Endocrinol Metab 12(4), 649-666.
58. T FOUCARD and I MALMHEDEN-YMAN (1999) ‘A study on severe food reactions in Sweden - is soy protein an underestimated cause of food anaphylaxis?’. Allergy 54(3), 261-265.
59. A A FRANKE, L J CUSTER and Y TANAKA (1998) ‘Isoflavones in human breast milk and other biological fluids.’. Am J Clin Nutr 68(6 Suppl), 1466S-1473S.
60. P J FRENCH, J BIJMAN, A G BOT, W E BOOMARS, B J SCHOLTE and H R D E JONGE (1997) ‘Genistein activates CFTR Cl- channels via a tyrosine kinase- and protein phosphatase-independent mechanism.’. Am J Physiol 273(2 Ptl), C747-C753.
61. D GALLO, F CANTELMO, M DISTEFANO, C FERLINI, G F ZANNONI, A RIVA, P MORAZZONI, E BOMBARDELLI, S MANCUSO and G SCAMBIA (1999) ‘Reproductive effects of dietary soy in female Wistar rats.’. Food Chem Toxicol 37(5), 493-502.
62. C D GARDNER, K A NEWELL, R CHERIN and W L HASKELL (2001) ‘The effect of soy protein with or without isoflavones relative to milk protein on plasma lipids in hypercholesterolemic postmenopausal women.’. Am J Clin Nutr 73(4), 728-735.
63. M C GERSHENGORN, B E MARCUS-SAMUELS and E GERAS (1979) ‘Estrogens increase the number of thyrotrophin-releasing hormone receptors on mammotropic cells in culture.’. Endocrinology 105(1), 171-176.
64. M T GOODMAN, L R WILKENS, J H HANKIN, L LYU, A H WU and L N KOLONEL (1997) ‘Association of soy and fiber consumption with the risk of endometrial cancer.’. Am J Epidemiol 146(4), 294-306.
65. T GOTO, H MAEDA and T TANAKA (2002) ‘A selective inhibitor of matrix metalloproteinases inhibits the migration of isolated osteoclasts by increasing the life span of podosomes.’. J Bone Miner Metab 20(2), 98-105.
66. C S HAWORTH, P L SELBY, A K WEBB, M E DODD, H MUSSON, R MCL NIVEN, G ECONOMOU, A W HORROCKS, A J FREEMONT, E B MAWER and J E ADAMS (1999) ‘Low bone mineral density in adults with cystic fibrosis.’. Thorax 54(11), 961-967.
67. C S HAWORTH, A K WEBB, J J EGAN, P L SELBY, P S HASLETON, P W BISHOP and T J FREEMONT (2000) ‘Bone histomorphometry in adult patients with cystic fibrosis.’. Chest 118(2), 434-439.
68. K HERMANSEN, M SONDERGAARD, L HOIE, M CARSTENSEN and B BROCK (2001) ‘Beneficial effects of a soy-based dietary supplement on lipid levels and cardiovascular risk markers in type 2 diabetic subjects.’. Diabetes Care 24(2), 228-233.
69. S C HO, J L WOO, S S LEUNG, A L SHAM, T H LAM and E D JANUS (2000) ‘Intake of soy products is associated with better plasma lipid profiles in the Hong Kong Chinese population.’. J Nutr 130(10), 2590-2593.
70. P C HOLLMAN and M B KATAN (1998) ‘Bioavailability and health effects of dietary flavonols in man.’. Arch Toxicol Suppl 20 237-247.
71. E K HONORE, J K WILLIAMS, M S ANTHONY and T B CLARKSON (1997) ‘Soy isoflavones enhance coronary vascular reactivity in atherosclerotic female macaques.’. Fertil Steril 67(1), 148-154.
72. P L HORN-ROSS, K J HOGGATT and M M LEE (2002) ‘Phytoestrogens and thyroid cancer risk: the San Francisco Bay Area thyroid cancer study.’. Cancer Epidemiol Biomarkers Prev 11(1), 43-49.
73. C Y HSIEH, R C SANTELL, S Z HASLAM and W G HELFERICH (1998) ‘Estrogenic effects of genistein on the growth of estrogen receptor-positive human breast cancer (MCF-7) cells in vitro and in vivo.’. Cancer Res 58(17), 3833-3838.
74. M H HUANG, G G HARRISON, M M MOHAMED, J A GORNBEIN, S M HENNING, V L GO and G A GREENDALE (2000) ‘Assessing the accuracy of a food frequency questionnaire for estimating usual intake of phytoestrogens.’. Nutr Cancer 37(2), 145-154.
75. A C HUGGETT, S PRIDMORE, A MALNOE, F HASCHKE and E A OFFORD (1997) ‘Phyto-oestrogens in soy based infant formula.’. Lancet 350(9080), 815-816.
76. H G HUR, J O LAY Jr, R D BEGER, J P FREEMAN and F RAFII (2000) ‘Isolation of human intestinal bacteria metabolizing the natural isoflavone glycosides daidzin and genistin.’. Arch Microbiol 174(6), 422-428.
77. B ILLEK, H FISCHER, G F SANTOS, J H WIDDICOMBE, T E MACHEN and W W REENSTRA (1995) ‘cAMP-independent activation of CFTR Cl channels by the tyrosine kinase inhibitor genistein.’. Am J Physiol 268(4 Ptl), C886-C893.
78. B ILLEK and H FISCHER (1998) ‘Flavonoids stimulate Cl conductance of human airway epithelium in vitro and in vivo.’. Am J Physiol 275(5 Ptl), L902-L910.
79. C H IRVINE, M G FITZPATRICK and S L ALEXANDER (1998) ‘Phytoestrogens in soy-based infant foods: concentrations, daily intake and possible biological effects.’. Proc. Soc. Exper Biol Med 217(3), 247-253.
80. D S IRVINE (1999) ‘Changes in human male reproductive health.’. T D Glover, C L R Barratt,(Eds) Male Fertility and Infertility’ Cambridge: Cambridge University Press 128-146.
81. D J JENKINS, C W KENDALL, P W CONNELLY, C J JACKSON, T PARKER, D FAULKNER and E VIDGEN (2002) ‘Effects of high- and low-isoflavone (phytoestrogen) soy foods on inflammatory biomarkers and proinflammatory cytokines in middle-aged men and women.’. Metabolism 51(7), 919-924.
82. T O JOHNSON, J ERMOLIEFF and M R JIROUSEK (2002) ‘Protein tyrosine phosphatase 1B inhibitors for diabetes.’. Nat Rev Drug Discov 1(9), 696-709.
83. A M JOUSSEN, K ROHRSCHNEIDER, J REICHLING, B KIRCHHOF and F E KRUSE (2000) ‘Treatment of corneal neovascularization with dietary isoflavonoids and flavonoids.’. Exp Eye Res 71(5), 483-487.
84. R KAMEI, Y KITAGAWA, M KADOKURA, F HATTORI, O HAZEKI, Y EBINA, T NISHIHARA and S OIKAWA (2002) ‘Shikonin stimulates glucose uptake in 3T3-L1 adipocytes via an insulinindependent tyrosine kinase pathway.’. Biochem. Biophys Res Commun 292(3), 642-651.
85. S KAPIOTIS, M HERMAN, I HELD, C SEELOS, H EHRINGER and B M GMEINER (1997) ‘Genistein, the dietary-derived angiogenesis inhibitor, prevents LDL oxidation and protects endothelial cells from damage by atherogenic LDL.’. Arterioscler Thromb Vasc Biol 17(11), 2868-2874.
86. N KERRY and M ABBEY (1998) ‘The isoflavone genistein inhibits copper and peroxyl radical mediated low density lipoprotein oxidation in vitro.’. Atherosclerosis 140(2), 341-347.
87. M KIELY, M FAUGHNAN, K WAHALA, H BRANTS and A MULLIGAN (2003) ‘Phytoestrogen levels in foods - the design and construction of the VENUS database.’. Br J Nutr in press
88. H KIM, T G PETERSON and S BARNES (1998) ‘Mechanism of action of the soy isoflavone genistein: emerging role for its effects via transforming growth factor β signalling pathways.’. Am J Clin Nutr 68(6 Suppl), 1418S-1425S.
89. H KIM, H XIA, L LI and J GEWIN (2000) ‘Attenuation of neurodegeneration-relevant modifications of brain proteins by dietary soy.’. Biofactors 12(1-4), 243-250.
90. M KIMIRA, Y ARAI, K SHIMOI and S WATANABE (1998) ‘Japanese intake of flavonoids and isoflavonoids from foods.’. J Epidemiol 8(3), 168-175.
91. R A KING and D B BURSILL (1998) ‘Plasma and urinary kinetics of the isoflavones daidzein and genistein after a single soy meal in humans.’. Am J Clin Nutr 67(5), 867-872.
92. P KIRK, R E PATTERSON and J LAMPE (1999) ‘Development of a soy food frequency questionnaire to estimate isoflavone consumption in US adults.’. J Am Diet Assoc 99(5), 558-563.
93. T KLEMOLA, T VANTO, K JUNTUNEN-BACKMAN, K KALIMO, R KORPELA and E VARJONEN (2002) ‘Allergy to soy formula and to extensively hydrolyzed whey formula in infants with cows milk allergy: a prospective, randomized study with a follow-up to the age of 2 years.’. J Pediatr 140(2), 219-224.
94. J I KOENIG (2001) ‘Estrogen and brain function.’. Trends Endocrinol Metab 12(1), 4-6.
95. P KONTESSIS, S JONES, R DODDS, R TREVISAN, R NOSADINI, P FIORETTO, M BORSATO, D SACERDOTI and G VIBERTI (1990) ‘Renal, metabolic and hormonal responses to ingestion of animal and vegetable proteins.’. Kidney Int 38(1), 136-144.
96. G G KUIPER, B CARLSSON, K GRANDIEN, E ENMARK, J HAGGBLAD, S NILSSON and J A GUSTAFSSON (1997) ‘Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors α and β.’. Endocrinol 138(3), 863-870.
97. M S KURZER (2002) ‘Hormonal effects of soy in premenopausal women and men.’. J Nutr 132(3), 570S-573S.
98. M S KURZER and X XU (1997) ‘Dietary phytoestrogens.’. Ann Rev Nutr 17 353-381.
99. G LACK (2002) ‘Clinical risk assessment of GM foods.’. Toxicol Lett 127(1-3), 337-340.
100. E D LEPHART, T W WEST, K S WEBER, R W RHEES, K D SETCHELL, H ADLERCREUTZ and T D LUND (2002) ‘Neurobehavioral effects of dietary soy phytoestrogens.’. Neurotoxicol Teratol 24(1), 5-16.
101. A H LICHTENSTEIN (1998) ‘Soy protein, isoflavones and cardiovascular disease risk.’. J Nutr 128(10), 1589-1592.
102. J LIGGINS, L J BLUCK, S RUNSWICK, C ATKINSON, W A COWARD and S A BINGHAM (2000) ‘Daidzein and genistein contents of vegetables.’. Br J Nutr 84(5), 717-725.
103. J LIGGINS, A MULLIGAN, S RUNSWICK and S A BINGHAM (2002) ‘Daidzein and genistein content of cereals.’. Eur J Clin Nutr 56(10), 961-966.
104. C LINASSIER, M PIERRE, J B LE PECQ and J PIERRE (1990) ‘Mechanism of action in NIH-3T3 cells of genistein, an inhibitor of EGF receptor tyrosine kinase activity.’. Biochem Pharmacol 39(1), 187-193.
105. Y LIU and M HU (2002) ‘Absorption and metabolism of flavonoids in the caco-2 cell culture model and a perfused rat intestinal model.’. Drug Metab Dispos 30(4), 370-377.
106. S LORENZETTI, A PATERNÒ, D GERMANI, S CIANFARANI and F BRANCA (2001) ‘Phytoestrogens and IGF-I in vitro regulation of bone resorption by osteoclasts.’. Ann Nutr Metab 45(5), 229.
107. E A LUCAS, R D WILD, L J HAMMOND, D A KHALIL, S JUMA, B P DAGGY, B J STOECKER and B H ARJMANDI (2002) ‘Flaxseed improves lipid profile without altering biomarkers of bone metabolism in postmenopausal women.’. J Clin Endocrinol Metab 87(4), 1527-1532.
108. E W LUSAS and M N RIAZ (1995) ‘Soy protein products: processing and use.’. J Nutr 125(3 Suppl), 573S-580S.
109. G LUTTY, J GRUNWALD, A B MAJJI, M UYAMA and S YONEYA (1999) ‘Changes in choriocapillaris and retinal pigment epithelium (RPE) in age-related macular degeneration.’. Mol Vis 5 35-38.
110. A P MAJUMDAR (1990) ‘Role of tyrosine kinases in gastrin induction of ornithine decarboxylase in colonic mucosa.’. Am J Physiol 259(4 Ptl), G626-G630.
111. S C MANOLAGAS (2000) ‘Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis.’. Endocr Rev 21(2), 115-137.
112. J A MARSHALL, R F HAMMAN and J BAXTER (1991) ‘High-fat, low-carbohydrate diet and the etiology of non-insulin-dependent diabetes mellitus: the San Luis Valley diabetes study.’. Am J Epidemiol 134(6), 590-603.
113. D R MATTISON, D R PLOWCHALK, M J MEADOWS, A Z AL-JUBURI, J GANDY and A MALEK (1990) ‘Reproductive toxicity: male and female reproductive systems as targets for chemical injury.’. Med Clin North Am 74(2), 391-411.
114. W MAZUR and H ADLERCREUTZ (1998) ‘Natural and anthropogenic environmental oestrogens: the scientific basis for risk assessment. Naturally occurring oestrogens in food.’. Pure Appl Chem 70(2), 1759-1776.
115. W MAZUR, T FOTSIS, K WAHALA, S OJALA, A SALAKKA and H ADLERCREUTZ (1996) ‘Isotope dilution gas chromatographic-mass spectrometric method for the determination of isoflavonoids, coumestrol and lignans in food samples.’. Anal Biochem 233(2), 169-180.
116. J E MCMINN, D G BASKIN and M W SCHWARTZ (2000) ‘Neuroendocrine mechanisms regulating food intake and body weight.’. Obes Rev 1(1), 37-46.
117. J MEI, S S YEUNG and A W KUNG (2001) ‘High dietary phytoestrogen intake is associated with higher bone mineral density in postmenopausal but not premenopausal women.’. J Clin Endocrinol Metab 86(11), 5217-5221.
118. B E MERZ-DEMLOW, A M DUNCAN, K E WANGEN, X XU, T P CARR, W R PHIPPS and M S KURZER (2000) ‘Soy isoflavones improve plasma lipids in normocholesterolemic, premenopausal women.’. Am J Clin Nutr 71(6), 1462-1469.
119. M J MESSINA, V PERSKY, K D SETCHELL and S BARNES (1994) ‘Soy intake and cancer risk: a review of the in vitro and in vivo data.’. Nutr Cancer 21(2), 113-131.
120. M MESSINA (1995) ‘Isoflavone intakes by Japanese were overestimated.’. Am J Clin Nutr 62(3), 645.
121. M MESSINA and M BENNINK (1998) ‘Soyfoods, isoflavones and risk of colonic cancer: a review of the in vitro and in vivo data.’. Baillieres Clin Endocrinol Metab 12(4), 707-728.
122. M J MESSINA (1999) ‘Legumes and soybeans: overview of their nutritional profiles and health effects.’. Am J Clin Nutr 70(3 Suppl), 439S-450S.
123. M J MESSINA and C L LOPRINZI (2001) ‘Soy for breast cancer survivors: a critical review of the literature.’. J Nutr 131(11 Suppl), 3095S-3108S.
124. J H MITCHELL, E CAWOOD, D KINNIBURGH, A PROVAN, A R COLLINS and D S IRVINE (2001) ‘Effect of a phytoestrogen food supplement on reproductive health in normal males.’. Clin Sci 100(6), 613-618.
125. J MOLINE, I F BUKHAROVICH, M S WOLFF and R PHILLIPS (2000) ‘Dietary flavonoids and hypertension: is there a link?’. Med Hypotheses 55(4), 306-309.
126. M S MORTON, A MATOS-FERREIRA, L ABRANCHES-MONTEIRO, R CORREIA, N BLACKLOCK, P S CHAN, C CHENG, S LLOYD, W CHIEH-PING and K GRIFFITHS (1997) ‘Measurement and metabolism of isoflavonoids and lignans in the human male.’. Cancer Lett 114(1-2), 145-151.
127. C NAGATA, M KABUTO, Y KURISU and H SHIMIZU (1997) ‘Decreased serum estradiol concentration associated with high dietary intake of soy products in premenopausal Japanese women.’. Nutr Cancer 29(3), 228-233.
128. M NAKAJIMA, M J COONEY, A H TU, K Y CHANG, J CAO, A ANDO, G J AN, M MELIA and E DE JUAN Jr (2001) ‘Normalization of retinal vascular permeability in experimental diabetes with genistein.’. Invest Ophthalmol Vis Sci 42(9), 2110-2114.
129. Y NAKAMURA, S TSUJI and Y TONOGAI (2000) ‘Determination of the levels of isoflavonoids in soybeans and soy-derived foods and estimation of isoflavonoids in the Japanese daily intake.’. J AOAC Int 83(3), 635-650.
130. NCI (1996) ‘Clinical Development Plan: Genistein. National Cancer Institute (NCI) Chemoprevention Branch and Agent Development Committee.’ J Cell Biochem. 26S: 114-26.
131. NCI (1998) National Cancer Institute's Common Toxicity Criteria. Version 2.0. http://ctep.info.nih.gov/CTC3/ctc.htm
132. P D NESBITT, Y LAM and L U THOMPSON (1999) ‘Human metabolism of mammalian lignan precursors in raw and processed flaxseed.’. Am J Clin Nutr 69(3), 549-555.
133. P J NESTEL, T YAMASHITA, T SASAHARA, S POMEROY, A DART, P KOMESAROFF, A OWEN and M ABBEY (1997) ‘Soy isoflavones improve systemic arterial compliance but not plasma lipids in menopausal and perimenopausal women.’. Arterioscler Thromb Vasc Biol 17(12), 3392-3398.
134. T OSAWA (1998) ‘Recent progress on functional food research in Japan.’. T Shibamoto, J Tereao, T. Osawa,(Eds) Functional Foods for Disease Prevention II. Medical Plants and Other Foods Washington, D C: American Chemical Society 2-9. (ACS Symposium Series 702)
135. V W PERSKY, M E TURYK, L WANG, S FREELS, R CHATTERTON Jr, S BARNES, J ERDMAN Jr, D W SEPKOVIC, H L BRADLOW and S POTTER (2002) ‘Effect of soy protein on endogenous hormones in postmenopausal women.’. Am J Clin Nutr 75(1), 145-153.
136. G PETERSON and S BARNES (1991) ‘Genistein inhibition of the growth of human breast cancer cells: independence from estrogen receptors and the multi-drug resistance gene.’. Biochem Biophys Res Commun 179(1), 661-667.
137. G PETERSON and S BARNES (1993) ‘Genistein and biochanin A inhibit the growth of human prostate cancer cells but not epidermal growth factor receptor tyrosine autophosphorylation.’. Prostate 22(4), 335-345.
138. W R PHIPPS, K E WANGEN, A M DUNCAN, B E MERZ-DEMLOW, X XU and M S KURZER (2001) ‘Lack of effect of isoflavonic phytoestrogen intake on leptin concentrations in premenopausal and postmenopausal women.’. Fertil Steril 75(6), 1059-1064.
139. K POLKOWSKI and A P MAZUREK (2000) ‘Biological properties of genistein. A review of in vitro and in vivo data.’. Acta Pol Pharm 57(2), 135-155.
140. S M POTTER (1995) ‘Overview of proposed mechanisms for the hypocholesterolemic effect of soy.’. J Nutr 125(3 Suppl), 606S-611S.
141. S M POTTER, J PERTILE and M D BERBER-JIMENEZ (1996) ‘Soy protein concentrate and isolated soy protein similarly lower blood serum cholesterol but differently affect thyroid hormones in hamsters.’. J Nutr 126(8), 2007-2011.
142. S M POTTER, J A BAUM, H TENG, R J STILLMAN, N F SHAY and J W ERDMAN Jr (1998) ‘Soy protein and isoflavones: their effects on blood lipids and bone density in postmenopausal women.’. Am J Clin Nutr 68(6 Suppl), 1375S-1379S.
143. J J RACKIS, J E MCGEE, M R GUMBMANN and A N BOOTH (1979) ‘Effects of soy proteins containing trypsin inhibitors in long term feeding studies in rats.’. J Am Oil Chem Soc 56(3), 162-168.
144. T RANICH, S J BHATHENA and M T VELASQUEZ (2001) ‘Protective effects of dietary phytoestrogens in chronic renal disease.’. J Ren Nutr 11(4), 183-193.
145. C V RAO, C X WANG, B SIMI, R LUBET, G KELLOFF, V STEELE and B S REDDY (1997) ‘Enhancement of experimental colon cancer by genistein.’. Cancer Res 57(17), 3717-3722.
146. M REHMAN, J HOYLAND, J DENTON and A J FREEMONT (1995) ‘Histomorphometric classification of postmenopausal osteoporosis: implications for the management of osteoporosis.’. J Clin Pathol 48(3), 229-235.
147. B L RIGGS, S KHOSLA and L J MELTON 3rd (1998) ‘A unitary model for involutional osteoporosis: estrogen deficiency causes both type I and type II osteoporosis in postmenopausal women and contributes to bone loss in aging men.’. J Bone Miner Res 13(5), 763-773.
148. B L RIGGS (2000) ‘The mechanism of estrogen regulation of bone resorption.’. J Clin Invest 106(10), 1203-1204.
149. G A RODAN and T J MARTIN (2000) ‘Therapeutic approaches to bone diseases.’. Science 289(5484), 1508-1514.
150. G A RODAN and A A RESZKA (2002) ‘Bisphosphonate mechanism of action.’. Curr Mol Med 2(6), 571-577.
151. B J ROLLS (1995) ‘Carbohydrates, fats and satiety.’. Am J Clin Nutr 61(4), 960S-967S.
152. G M ROOMANS (2001) ‘Pharmacological treatment of the ion transport defect in cystic fibrosis.’. Expert Opin Investig Drugs 10(1), 1-19.
153. A ROTH, W SCHAFFNER and C HERTEL (1999) ‘Phytoestrogen kaempferol (3,4’,5,7-tetrahydroxyflavone) protects PC12 and T47D cells from beta-amyloid-induced toxicity.’. J Neurosci Res 57(3), 399-404.
154. I ROWLAND, H WISEMAN, T SANDERS, H ADLERCREUTZ and E BOWEY (1999) ‘Metabolism of oestrogens and phytoestrogens: role of the gut microflora.’. Biochem Soc Trans 27(2), 304-308.
155. I ROWLAND, H WISEMAN, T SANDERS, H ADLERCREUTZ and E BOWEY (2000) ‘Interindividual variation in metabolism of soy isoflavones and lignans: influence of habitual diet on equol production by the gut microflora.’. Nutr Cancer 36(1), 27-32.
156. I ROWLAND, M FAUGHNAN, L HOEY, K WÄHÄLÄ, G WILLIAMSON and A CASSIDY (2003) ‘Bioavailability of phytoestrogens.’. Br J Nutr in press
157. J SALMERON, A ASCHERIO, E B RIMM, G A COLDITZ, D SPIEGELMAN, D J JENKINS, M J STAMPFER, A L WING and W C WILLETT (1997) ‘Dietary fiber, glycemic load and risk of NIDDM in men.’. Diabetes Care 20(4), 545-550.
158. J SALMERON, J E MANSON, M J STAMPFER, G COLDITZ, A L WING and W C WILLET (1997) ‘Dietary fiber, glycemic load and risk of non-insulin-dependent diabetes mellitus in women.’. JAMA 277(6), 472-477.
159. R C SANTELL, Y C CHANG, M G NAIR and W G HELFERICH (1997) ‘Dietary genistein exerts estrogenic effects upon the uterus, mammary gland and the hypothalamic/pituitary axis in rats.’. J Nutr 127(2), 263-269.
160. A SEOW, C Y SHI, A A FRANKE, J H HANKIN, H P LEE and M C YU (1998) ‘Isoflavonoid levels in spot urine are associated with frequency of dietary soy intake in a population-based sample of middle-aged and older Chinese in Singapore.’. Cancer Epidem Biomarkers Prev 7(2), 135-140.
161. K D SETCHELL (1998) ‘Phytoestrogens: the biochemistry, physiology and implications for human health of soy isoflavones.’. Am J Clin Nutr 68(6 Suppl), 1333S-1346S.
162. K D SETCHELL (2001) ‘Soy isoflavones-benefits and risks from nature's selective estrogen receptor modulators (SERMs).’. J Am Coll Nutr 20(5 Suppl), 354S-362S.
163. K D SETCHELL, N M BROWN, P DESAI, L ZIMMER-NECHEMIAS, B E WOLFE, W T BRASHEAR, A S KIRSCHNER, A CASSIDY and J E HEUBI (2001) ‘Bioavailability of pure isoflavones in healthy humans and analysis of commercial soy isoflavones supplements.’. J Nutr 131(4 Suppl), 1362S-1375S.
164. K D SETCHELL, N M BROWN, L ZIMMER-NECHEMIAS, W T BRASHEAR, B E WOLFE, A S KIRSCHNER and J E HEUBI (2002) ‘Evidence for lack of absorption of soy glycosides in humans, supporting the crucial role of intestinal metabolism for availability.’. Am J Clin Nutr 76(2), 447-453.
165. K D R SETCHELL, L ZIMMER-NECHEMIAS, J CAI and J E HEUBI (1997) ‘Exposure of infants to phyto-oestrogens from soy-based infant formula.’. Lancet 350(9070), 23-27.
166. K D SETCHELL, L ZIMMER-NECHEMIAS, J CAI and J E HEUBI (1998) ‘Isoflavone content of infant formulas and the metabolic fate of these phytoestrogens in early life.’. Am J Clin Nutr 68(6 Suppl), 1453S-1461S.
167. R M SHARPE and N E SKAKKEBAEK (1993) ‘Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract?’. Lancet 341(8857), 1392-1395.
168. D M SHEEHAN (1998) ‘Herbal medicines, phytoestrogens and toxicity risk: benefit considerations.’. Proc Soc Exp Biol Med 217(3), 379-385.
169. D A SHUTT and A W H BRADEN (1968) ‘The significance of equol in relation to the oestrogenic responses in sheep ingesting clover with a high formononetin content.’. Austr J Agric Res 19 545-553.
170. C R SIRTORI, E GIANAZZA, C MANZONI, M R LOVATI and P A MURPHY (1997) ‘Role of isoflavones in the cholesterol reduction by soy proteins in the clinic.’. Am J Clin Nutr 65(1), 166-167.
171. C R SIRTORI, R BOSISIO, F PAZZUCCONI, A BONDIOLI, E GATTI, M R LOVATI and P MURPHY (2002) ‘Soy Milk with a High Glycitein Content Does Not Reduce Low-Density Lipoprotein Cholesterolemia in Type II Hypercholesterolemic Patients.’. Ann Nutr Metab 46(2), 88-92.
172. D STRANEY, R KHAN, R TAN and S BAGGA (2002) ‘Host recognition by pathogenic fungi through plant flavonoids.’. Adv Exp Med Biol 505 9-22.
173. L SUAUD, J LI, Q JIANG, R C RUBENSTEIN and T R KLEYMAN (2002) ‘Genistein restores functional interactions between Delta F508-CFTR and EnaC in Xenopus oocytes.’. J Biol Chem 277(11), 8928-8933.
174. S L TEITELBAUM (2000) ‘Bone resorption by osteoclasts.’. Science 289 1504-1508.
175. O TERONEN, P HEIKKILA, Y T KONTTINEN, M LAITINEN, T SALO, R HANEMAAIJER, A TERONEN, P MAISI and T SORSA (1999) ‘MMP inhibition and downregulation by bisphosphonates.’. Ann N Y Acad Sci 878 453-465.
176. O TSCHOPP, A BOEHLER, R SPEICH, W WEDER, B SEIFERT, E W RUSSI and C SCHMID (2002) ‘Osteoporosis before lung transplantation: association with low body mass index, but not with underlying disease.’. Am J Transplant 2(2), 167-172.
177. M UEHARA, Y ARAI, S WATANABE and H ADLERCREUTZ (2000) ‘Comparison of plasma and urinary phytoestrogens in Japanese and Finnish women by time-resolved fluoroimmunoassay.’. Biofactors 12(1-4), 217-225.
178. D URBAN, W IRWIN, M KIRK, M A MARKIEWICZ, R MYERS, M SMITH, H WEISS, W E GRIZZLE and S BARNES (2001) ‘The effect of isolated soy protein on plasma biomarkers in elderly men with elevated serum prostate specific antigen.’. J Urol 165(1), 294-300.
179. S VALTUEÑA, K D CASHMAN, S P ROBINS, A CASSIDY, A KARDINAAL and F BRANCA (2003) ‘Investigating the role of natural phytoestrogens on bone health in postmenopausal women.’. Br J Nutr in press
180. A M J VAN ERP-BAART, H A M BRANTS, M KIELY, A MULLIGAN, A TURRINI, C SERMONETA, A KILKINNEN and L M VALSTA (2003) ‘Isoflavone intake in different European countries: the VENUS approach.’. Br J Nutr in press
181. P K VERKASALO, P N APPLEBY, N E ALLEN, G DAVEY, H ADLERCREUTZ and T J KEY (2001) ‘Soya intake and plasma concentrations of daidzein and genistein: validity of dietary assessment among eighty British women (Oxford arm of the European Prospective Investigation into Cancer and Nutrition).’. Br J Nutr 86(3), 415-421.
182. J D WAGNER, W T CEFALU, M S ANTHONY, K N LITWAK, L ZHANG and T B CLARKSON (1997) ‘Dietary soy protein and estrogen replacement therapy improve cardiovascular risk factors and decrease aortic cholesteryl ester content in ovariectomized cynomolgus monkeys.’. Metabolism 46(6), 698-705.
183. K E WANGEN, A M DUNCAN, X XU and M S KURZER (2001) ‘Soy isoflavones improve plasma lipids in normocholesterolemic and mildly hypercholesterolemic postmenopausal women.’. Am J Clin Nutr 73(2), 225-231.
184. S WASHBURN, G L BURKE, T MORGAN and M ANTHONY (1999) ‘Effect of soy protein supplementation on serum lipoproteins, blood pressure and menopausal symptoms in perimenopausal women.’. Menopause 6(1), 7-13.
185. K WAKAI, I EGAMI, K KATO, T KAWAMURA, A TAMAKOSHI, Y LIN, T NAKAYAMA, M WADA and Y OHNO (1999) ‘Dietary intake and sources of isoflavones among Japanese.’. Nutr Cancer 33(2), 139-145.
186. C M WEAVER, W R PROULX and R HEANEY (1999) ‘Choices for achieving adequate dietary calcium with a vegetarian diet.’. Am J Clin Nutr 70(3 Suppl), 543S-548S.
187. P WEBER (2001) ‘Role of biomarkers in nutritional science and industry - a comment.’. Br J Nutr 86 S93-S95. (Suppl)
188. H WEI, Q CAO and R O RAHN (1996) ‘Inhibition of UV light- and Fenton reaction-induced oxidative DNA damage by the soybean isoflavone genistein.’. Carcinogenesis 17(1), 73-77.
189. F WEINREICH, P G WOOD, J R RIORDAN and G NAGEL (1997) ‘Direct action of genistein on CFTR.’. Pfluegers Arch 434(4), 484-491.
190. P L WHITTEN, H B PATISAUL and L J YOUNG (2002) ‘Neurobehavioral actions of coumestrol and related isoflavonoids in rodents.’. Neurotoxicol Teratol 24(1), 47-54.
191. C P WILD, C ANDERSSON, N M O'BRIEN, L WILSON and J A WOODS (2001) ‘A critical evaluation of the application of biomarkers in epidemiological studies on diet and health.’. Br J Nutr 86(Suppl 1), S37-S53.
192. H WISEMAN (1999) ‘The bioavailability of non-nutrient plant factors: dietary flavonoids and phyto-oestrogens.’. Proc Nutr Soc 58(1), 139-146.
193. J WOOD, K BONJEAN, S RUETZ, A BELLAHCENE, L DEVY, J M FOIDART, V CASTRONOVO and J R GREEN (2002) ‘Novel antiangiogenic effects of the bisphosphonate compound zoledronic acid.’. J Pharmacol Exp Ther 302(3), 1055-1061.
194. B WUTHRICH (1999) ‘Food additives and genetically modified food - a risk for allergic patients?’. Schweiz Rundsch Med Prax 88(14), 609-614. 616-18
195. S YAMAMOTO, T SOBUE, S SASAKI, M KOBAYASHI, Y ARAI, M UEHARA, H ADLERCREUTZ, S WATANABE, T TAKAHASHI, Y IITOI, Y IWASE, M AKABANE and S TSUGANE (2001) ‘Validity and reproducibility of a self-administered food-frequency questionnaire to assess isoflavone intake in a Japanese population in comparison with dietary records and blood and urine isoflavones.’. J Nutr 131(10), 2741-2747.
196. Y YAMASHITA, S KAWADA and H NAKANO (1990) ‘Induction of mammalian topoisomerase II dependent DNA cleavage by nonintercalative flavonoids, genistein and orobol.’. Biochem Pharmacol 39(4), 737-744.
197. O YU, W JUNG, J SHI, R A CROES, G M FADER, B MCGONIGLE and J T ODELL (2000) ‘Production of the isoflavones genistein and daidzein in non-legume dicot and monocot tissues.’. Plant Physiol 124(2), 781-794.
198. X XU, K S HARRIS, H J WANG, P A MURPHY and S HENDRICH (1995) ‘Bioavailability of soybean isoflavones depends upon gut microflora in women.’. J Nutr 125(9), 2307-2315.
199. R S ZEIGER, H A SAMPSON, S A BOCK, A W BURKS Jr, K HARDEN, S NOONE, D MARTIN, S LEUNG and G WILSON (1999) ‘Soy allergy in infants and children with IgE-associated cow's milk allergy.’. J Pediatr 134(5), 614-622.
200. Y ZHANG, T T SONG, J E CUNNICK, P A MURPHY and S HENDRICH (1999) ‘Daidzein and genistein glucuronides in vitro are weakly estrogenic and activate human natural killer cells in nutritionally relevant concentrations.’. J Nutr 129(2), 399-405.
201. Y ZHANG, G J WANG, T T SONG, P A MURPHY and S HENDRICH (1999) ‘Urinary disposition of the soybean isoflavones daidzein, genistein and glycitein differs among humans with moderate fecal isoflavone degradation activity.’. J Nutr 129(5), 957-962.
202. J R ZHOU, E T GUGGER, T TANAKA, Y GUO, G L BLACKBURN and S K CLINTON (1999) ‘Soybean phytochemicals inhibit the growth of transplantable human prostate carcinoma and tumor angiogenesis in mice.’. J Nutr 129(9), 1628-1635.
203. Y S ZHU, P M YEN, W W CHIN and D W PFAFF (1996) ‘Estrogen and thyroid interaction on regulation of gene expression.’. Proc Natl Acad Sci USA 93(22), 12587-12592.