Neuroendocrine mechanisms regulating food intake and body weight

Obesity Reviews

Volumn 1, Issue 1, 2000, Pages 37-46

  McMinn, J E ^a   Baskin, D G ^c   Schwartz, M W ^b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c Puget Sound VA Health Care System   (United States)

Author keywords

Brain; Leptin; Neuropeptides; Satiety

Indexed keywords

INSULIN; LEPTIN;

BODY WEIGHT; BRAIN; BRAIN STEM; EATING; ENERGY METABOLISM; HOMEOSTASIS; HUMAN; HYPOTHALAMUS; NEUROSECRETION; PHYSIOLOGY; REVIEW; SATIETY; SIGNAL TRANSDUCTION;

BODY WEIGHT; BRAIN; BRAIN STEM; EATING; ENERGY METABOLISM; HOMEOSTASIS; HUMANS; HYPOTHALAMUS; INSULIN; LEPTIN; NEUROSECRETORY SYSTEMS; SATIATION; SIGNAL TRANSDUCTION;

EID: 0034179734     PISSN: 14677881     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1467-789x.2000.00007.x     Document Type: Article

References (94)

1. Keesey RE, Powley TL. The regulation of body weight. Ann Rev Psychol 1986; 37: 109-133.
2. Faust IM, Johnson PR, Hirsch J. Adipose tissue regeneration following lipectomy. Science 1977; 197: 391-393.
3. Larson KA, Anderson DB. The effects of lipectomy on remaining adipose tissue depots in the sprague dawley rat. Growth 1978; 42: 469-477.
4. Seeley RJ, Chavez M, Dallman MF, Matson CA, Woods SC, Schwartz MW. Behavioral, endocrine and hypothalamic responses to involuntary overfeeding. Am J Physiol 1996; 40: R819-R823.
5. Bernstein IL, Lotter EC, Kulkosky PJ. Effect of force-feeding upon basal insulin levels in rats. Proc Soc Exp Biol Med 1975; 150: 546-548.
6. Safer DJ. Diet, behavior modification, and exercise: a review of obesity treatments from a long-term perspective. South Med J 1991; 84: 1470-1474.
7. Kennedy GC. The role of depot fat in the hypothalamic control of food intake in the rat. Proc R Soc Lond B Biol Sci 1953; 140: 579-592.
8. Mayer J, Bates MW. Mechanisms of regulation of food intake. Federation Proc 1951; 10: 389.
9. Bagdade JD, Bierman EL, Porte D Jr. The significance of basal insulin levels in the evaluation of the insulin response to glucose in diabetic and nondiabetic subjects. J Clin Invest 1967; 46: 1549-1557.
10. Baskin DG, Brewitt DA, Corp E, Pacquette T, Figlewicz DP, Lewellen TK, Graham MK, Woods SC and Dorsa DM. Quantitative autoradiographic evidence for insulin receptors in the choroid plexus of the rat brain. Diabetes 1986; 35: 246-249.
11. Pardridge WM. Receptor-mediated peptide transport through the blood-brain barrier. Endocr Rev 1986; 7: 314-330.
12. Schwartz MW, Bergman RN, Kahn SE, Taborsky GJ Jr, Fisher LD, Sipols AJ, Woods SC, Steil GM, Porte D Jr. Evidence for uptake of plasma insulin into cerebrospinal fluid through an intermediate compartment in dogs. J Clin Invest 1991; 88: 1272-1281.
13. Chavez M, Seeley RJ, Woods SC, A comparison between the effects of intraventricular insulin and intraperitoneal LiCl on three measures sensitive to emetic agents. Behav Neurosci 1995; 109: 547-550.
14. Sipols AJ, Baskin DG, Schwartz MW. Effect of intracerebroventricular insulin infusion on diabetic hyperphagia, hypothalamic neuropeptide gene expression. Diabetes 1995; 44: 147-151.
15. Coleman DL. Effects of parabiosis of obese with diabetes and normal mice. Diabetologia 1973; 9: 294-298.
16. Coleman DL, Hummel KP. Effects of parabiosis of normal with genetically diabetic mice. Am J Physiol 1969; 217: 1298-1304.
17. Zhang Y, Proenca R, Maffie M, Barone M, Leopold L, Friedman J. Positional cloning of the mouse obese gene and its human homologue. Nature 1994; 372: 425-432.
18. Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Winters D, Boone T, Collins F. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 1995; 269: 540-543.
19. Halaas JL, Gajiwala KS, Maffel M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK, Friedman JM. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 1995; 269: 543-546.
20. Campfield L, Smith F, Gulsez Y, Devos R, Burn P. Recombinant mouse OB. Protein: Evidence for a peripheral signal linking adiposity and central neural networks. Science 1995; 269: 546-549.
21. Considine RV, Sinha MK, Heiman ML et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. New Engl J Med 1996; 334: 292-295.
22. Golden PL, Maccagnan TJ, Pardridge WM. Human blood-brain barrier leptin receptor: binding and endocytosis in isolated human brain microvessels. J Clin Invest 1997; 99: 14-18.
23. Bjorbaek C, Elmquist JK, Michl P, Ahima RS, Van Bueren A, McCall AL, Flier JS. Expression of leptin receptor isoforms in rat brain microvessels. Endocrinology 1998; 139: 3485-3491.
24. Banks WA, Kastin AJ, Huang W, Jaspan JB, Maness LM. Leptin enters the brain by a saturable system independent of insulin. Peptides 1996; 17: 305-311.
25. Leibowitz SF, Hammer NJ, Chang K. Hypothalamic paraventricular nucleus lesions produce overeating and obesity in the rat. Pharmacol Biochem Bebav 1981; 27: 1031-1040.
26. Aravich PF, Sclafani A. Paraventricular hypothalamic lesions and medial hypothalamic knife cuts produce similar hyperphagic syndromes. Behav Neurosci 1983; 97: 970-983.
27. Bernardis LL, Bellinger LL. The lateral hypothalamic area revisited: neuroanatomy, body weight regulation, neuroendocrinology and metabolism. Neurosci Biobehav Rev 1993; 17: 141-193.
28. Marks JL, Mu L, Schwartz MW, Porte D Jr, Baskin DG. Effect of fasting on regional levels of neuropeptide Y mRNA and insulin receptors in the rat hypothalamus: An autoradiographic study. Mol Cell Neurosci 1992; 3: 199-205.
29. Brady LS, Smith MA, Gold PW, Herkenham M. Altered expression of hypothalamic neuropeptide mRNAs in food restricted and food-deprived rats. Neuroendocrinology 1990; 52: 441-447.
30. Hahn TM, Breininger JF, Baskin DG, Schwartz MW. Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons. Nature Neurosci 1998; 1: 271-272.
31. Qu D, Ludwig DS, Gammeltoft S, Piper M, Pelleymounter MA, Cullen MJ, Mathes WF, Przypek J, Kanarek R, Maratos-Flier E. A role for melanin-concentrating hormone in the central regulation of feeding behaviour. Nature 1996; 380: 243-247.
32. Sakurai T, Amemiya A, Ishii M et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 1998; 92: 573-85.
33. Bergendahl M, Wiemann JN, Clifton DK, Huhtaniemi I, Steiner RA. Short-term starvation decreases POMC mRNA, but does not alter GnRH mRNA, in the brain of adult male rats. Neuroendocrinology 1992; 56: 913-920.
34. Morley JE, Levine AS, Gosnell BA, Kneip J, Grace M. Effect of neuropeptide Y on ingestive behaviors in the rat. Am J Physiol 1987; 252: R599-R609.
35. Rossi M, Kim MS, Morgan DGA et al. A c-terminal fragment of agouti-related protein increases feeding and antagonizes the effect of alpha-melanocyte stimulating hormone in vivo. Endocrinology 1998; 139: 4428-4431.
36. Britton DR, Koob GF, Rivier J, Vale W. Intraventricular corticotropin-releasing factor enhances behavioral effects of novelty. Life Sci 1982; 31: 363-367.
37. Tsujii S, Bray GA. Acetylation alters the feeding response to MSH and beta-endorphin. Brain Res Bull 1989; 23: 165-169.
38. Schwartz MW, Seeley RJ, Campfield LA, Burn P, Baskin DG. Identification of targets of leptin action in rat hypothalamus. J Clin Invest 1996; 98: 1101-1106.
39. Schwartz MW, Seeley RJ, Weigle DS, Campfield LA, Burn P, Baskin DG. Leptin increases hypothalamic proopiomelanocortin (POMC) mRNA expression in the rostral arcuate nucleus. Diabetes 1997; 46: 2119-2123.
40. Gibbs J, Young RC, Smith GP. Cholecystokinin decreases food intake in rats. J Comp Physiol Psychol 1973; 84: 488-495.
41. West DB, Fey D, Woods SC. Cholecystokinin persistently suppresses meal size but not food intake in free-feeding rats. Am J Physiol 1984; 246: R776-R787.
42. Woods SC, Seeley RJ, Porte D Jr. Schwartz MW Signals that regulate food intake and energy homeostasis. Science 1998; 280: 1378-1382.
43. Flynn MC, Scott TR, Pritchard TC, Plata-Salaman CR. Mode of action of OB protein (leptin) on feeding. Am J Physiol 1998; 275: R174-R179.
44. Chua SC, Chung WK, Wu-Peng XS, Zhang Y, Liu S, Tartaglia L, Leibel RL. Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (Leptin) receptor. Science 1996; 271: 994-996.
45. Schwartz MW, Peskind E, Raskind M, Nicolson M, Moore J, Morawiecki A, Boyko EJ, Porte D Jr. Cerebrospinal fluid leptin levels: Relationship to plasma levels and to adiposity in humans. Nature Med 1996; 2: 589-593.
46. Jang M, Romsos DR. Neuropeptide Y, corticotropin-releasing hormone concentrations within specific hypothalamic regions of lean but not ob/ob mice respond to food-deprivation, refeeding. J Nutr 1998; 128: 2520-2525.
47. Montague CT, Farooqi IS, Whitehead JP et al. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 1997; 387: 903-908.
48. Roth H, Korn T, Rosenkranz K, Hinney A, Ziegler A, Kunz J, Siegfried W, Mayer H, Hebebrand J, Grzeschik KH. Transmission disequilibrium and sequence variants at the leptin receptor gene in extremely obese German children and adolescents. Hum Genet 1998; 103: 540-546.
49. Baskin DG, Schwartz MW, Seeley RJ et al. Leptin receptor long-form splice-variant protein expression in neuron cell bodies of the brain and co-localization with neuropeptide Y mRNA in the arcuate nucleus. J Histochem Cytochem 1999; 47: 353-362.
50. Schwartz MW, Baskin DG, Bukowski TR et al. Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice. Diabetes 1996; 45: 531-535.
51. Mizuno TM, Mobbs CV. Hypothalamic agouti-related protein messenger ribonucleic acid is inhibited by leptin, stimulated by fasting. Endocrinology 1999; 140: 814-817.
52. Cheung CC, Clifton DK, Steiner RA. Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus. Endocrinology 1997; 138: 4489-4492.
53. Vrang N, Larsen PJ, Clausen JT, Kristensen P. Neurochemical characterization of hypothalamic cocaine-amphetamine-regulated transcript neurons. J Neurosci 1999; 19: 1-8.
54. Mizuno TM, Kleopolulos SP, Bergen HT, Roberts JL, Priest CA, Mobbs CV. Hypothalamic pro-opiomelanocortin mRNA is reduced by fasting in ob/ob and db/db mice, but is stimulated by leptin. Diabetes 1997; 47: 294-297.
55. Kristensen P, Judge ME, Thim L et al. Hypothalamic CART is a new anorectic peptide regulated by leptin. Nature 1998; 393: 72-76.
56. Tokunaga K, Fukushima M, Kemnitz JW, Bray GA. Comparison of ventromedial and paraventricular lesions in rats that become obese. Am J Physiol 1986; 251: R1221-R1227.
57. Swanson LW, Kuypers HGJM. The paraventricular nucleus of the hypothalamus: cytoarchitectonic subdivisions and organization of projections to the pituitary, dorsal vagal complex, and spinal cord as demonstrated by retrograde fluorescence double-labeling methods. J Comp Neurol 1980; 194: 555-570.
58. Cechetto DF, Saper CB. Neurochemical organization of the hypothalamic projection to the spinal cord in the rat. J Comp Neurol 1988; 272: 579-604.
59. Toni R, Jackson IM, Lechan RM. Neuropeptide Y-immunoreactive innervation of thyrotropin-releasing hormone-sythesizing neurons in the rat hypothalamic paraventricular nucleus. Endocrinology 1990; 126: 2444-2453.
60. Broberger C, Visser TJ, Kuhar MJ, Hokfelt T. Neuropeptide Y innervation and neuropeptide Y-Y-1-receptor-expressing neurons in the paraventricular hypothalamic nucleus of the mouse. Neuroendocrinology 1999; 70: 295-305.
61. Legradi G, Lechan RM. Agouti-related protein containing nerve terminals innervate thyrotropin-releasing hormone neurons in the hypothalamic paraventricular nucleus. Endocrinology 1999; 140: 3643-3652.
62. Fekete C, Legradi G, Mihaly E, Huang Q-H, Tatro JB, Rand WM, Emerson CH, Lechan RM. Alpha-melanocyte-stimulating hormone is contained in nerve terminals innervating thyrotropin-releasing hormone-synthesizing neurons in the hypothalamic paraventricular nucleus and prevents fasting-induced suppression of prothyrotropin-releasing hormone gene expression. J. Neurosci 2000; 20: 1550-1558.
63. Vrang N, Larsen PJ, Kristensen P, Tang-Christensen M. Central administration of cocaine-amphetamine-regulated transcript activates hypothalamic neuroendocrine neurons in the rat. Endocrinology 2000; 141: 794-801.
64. Mountjoy K, Mortrud M, Low M, Simerly R, Cone R. Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain. Mol Endocrinol 1994; 8: 1298-1308.
65. Huszar D, Lynch C, Fairchild-Huntress V et al. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 1997; 88: 131-141.
66. Vaisse C, Clement K, Guy-Grand B, Froguel P. A frameshift mutation in human MC4R is associated with a dominant form of obesity. Nat Genet 1998; 20: 113-114.
67. Legradi G, Emerson CH, Ahima RS, Flier JS, Lechan RM. Leptin prevents fasting-induced suppression of prothyrotropin-releasing hormone messenger ribonucleic acid in neurons of the hypothalamic paraventricular nucleus. Endocrinology 1997; 138: 2569-2576.
68. Teitelbaum P, Epstein AN. The lateral hypothalamic syndrome: recovery of feeding and drinking after lateral hypothalamic lesions. Psychol Rev 1962; 69: 74-90.
69. Saper CB. Organization of cerebral cortical afferent systems in the rat: hypothalamocortical projections. J Comp Neurol 1985; 237: 21-16.
70. Saper CB, Akil H, Watson SJ. Lateral hypothalamic innervation of the cerebral cortex: immunoreactive staining for a peptide resembling but immunochemically distinct from pituitary/arcuate alpha-melanocyte stimulating hormone. Brain Res Bull 1986; 16: 107-120.
71. Bittencourt JC, Presse F, Arias C, Peto C, Vaughan J, Nahon JL, Vale W, Sawchenko PE. The melanin-concentrating hormone system of the rat brain: an immuno- and hybridization histochemical characterization. J Comp Neurol 1992; 319: 218-245.
72. Elias CF, Saper CB, Maratos-Flier E et al. Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area. J Comp Neurol 1998; 402: 442-459.
73. Shimada M, Tritos NA, Lowell BB, Flier JS, Maratos-Flier E. Mice lacking melanin-concentrating hormone are hypophagic and lean. Nature 1996; 396: 670-673.
74. Van Den Pol AN, Gao X-B, Obrietan K, Kilduff TS, Belousov AB. Presynaptic and postsynaptic actions and modulation of neuroendocrine neurons by a new hypothalamic peptide hypocretin/orexin. J Neurosci 1998; 18: 7962-7971.
75. Horvath TL, Diano S, Van Den Pol AN. Synaptic interaction between hypocretin (orexin) and neuropeptide Y cells in the rodent and primate hypothalamus: a novel circuit implicated in metabolic and endocrine regulations. J Neurosci 1999; 19: 1072-1087.
76. Hanada R, Nakazato M, Matsukura S, Murakami N, Yoshimatsu H, Sakata T. Differential regulation of melanin-concentrating hormone and orexin genes in the agouti-related protein/melanocortin-4 receptor system. Biochem Biophys Res Commun 2000; 268: 88-91.
77. Smith GP (ed). Satiation: from Gut to Brain. Oxford University Press: New York, 1998, pp 97-125.
78. Zhang X, Fogel R, Renehan WE. Stimulation of the paraventricular nucleus modulates the activity of gut-sensitive neurons in the vagal complex. Am J Physiol 1999; 277: G79-G90.
79. Luiten PGM, Ter Horst GJ, Steffens AB. The hypothalamus and intrinsic connections and outflow pathways to the endocrine system in relation to the control of feeding and metabolism. Prog Neurobiol 1987; 28: 1-54.
80. Nishimura H, Oomura Y. Effects of hypothalamic stimulation on activity of dorsomedial medulla neurons that respond to subdiaphragmatic vagal stimulation. J Neurophysiol 1987; 58: 655-675.
81. Touzani K, Tramu G, Nahon JL, Velley L. Hypothalamic melanin-concentrating hormone and alpha-neoendorphin-immunoreactive neurons project to the medial part of the rat parabrachial area. Neuroscience 1993; 53: 865-876.
82. Figlewicz DP, Stein LJ, West D, Porte D Jr, Woods SC. Intracisternal insulin alters sensitivity to CCK-induced meal suppression in baboons. Am J Physiol 1986; 250: R856-R860.
83. Riedy CA, Chavez M, Figlewicz DP, Woods SC. Intraventricular insulin increases sensitivity to CCK in rats (Abstract). Soc Neurosci Abstr 1991; 17: 543.
84. Figlewicz DP, Sipols AJ, Seeley RJ, Chavez M, Woods SC, Porte D Jr. IVT insulin enhances the meal-suppressive efficacy of IVT CCK-8 in the baboon. Behav Neuroscience 1994; 109: 567-569.
85. Wang L, Martinez V, Barrachina M, Tache Y. Fos expression in the brain induced by peripheral injection of CCK or leptin plus CCK in fasted lean mice. Brain Res 1998; 791: 157-166.
86. Matson CA, Wiater MF, Kuijper JL, Weigle DS. Synergy between leptin and cholecystokinin (CCK) to control daily caloric intake. Peptides 1997; 18: 1275-1278.
87. Barrachina MD, Martinez V, Wang L, Wei JY, Tache Y. Synergistic interaction between leptin and cholecystokinin to reduce short-term food intake in lean mice. Proc Natl Acad Sci USA 1997; 94: 10455-10460.
88. van Dijk G, Thiele TE, Donahey JCK, Campfield LA, Smith FJ, Burn P, Bernstein IL, Woods SC, Seeley RJ. Central infusion of leptin and GLP-1 (7-36) amide differentially stimulate c-Fos-like immunoreactivity in the rat brain. Am J Physiol 1996; 271: R1096-R1100.
89. Elmquist JK, Ahima RS, Maratos-Flier E, Flier JS, Saper CB. Leptin activates neurons in ventrobasal hypothalamus and brainstem. Endocrinology 1997; 138: 839-842.
90. Li BH, Rowland NE. Effects of vagotomy on cholecystokinin-and dexfenfluramine-induced Fos-like immunoreactivity in the rat brain. Brain Res Bull 1995; 37: 589-593.
91. Emond M, Schwartz GJ, Ladenheim EE, Moran TH. Central , leptin modulates behavioral and neural responsitivity to CCK. Am J Physiol 1999; 276: R1545-R1549.
92. Corp ES, Melville LD, Greenberg D, Gibbs J, Smith GP. Effect of fourth ventricular neuropeptide Y and peptide YY on ingestive and other behaviors. Am J Physiol 1990; 259: R317-R323.
93. Grill HJ, Ginsberg AB, Seeley RJ, Kaplan JM. Brainstem application of melanocortin receptor ligands produces long-lasting effects on feeding and body weight. J Neurosci 1998; 18: 10128-10135.
94. Heymsfield SB, Greenberg AS, Fujioka K et al. Recombinant leptin for weight loss in obese and lean adults. J Am Med Assoc 1999; 282: 1568-1575.