Soy protein and isoflavones: Their effects on blood lipids and bone density in postmenopausal women

American Journal of Clinical Nutrition

Volumn 68, Issue 6 SUPPL., 1998, Pages

  Potter, Susan M ^a,b   Baum, Jo Ann ^a   Teng, Hongyu ^a   Stillman, Rachel J ^a   Shay, Neil F ^a   Erdman Jr , John W ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b Protein Technologies International   (United States)

Author keywords

Bone density; Bone mineral content; Cholesterol; Genistein; HDL cholesterol; Isoflavones; LDL receptor mRNA; Postmenopausal women; Soy

Indexed keywords

CASEIN; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; ISOFLAVONE; LIPID; LOW DENSITY LIPOPROTEIN RECEPTOR; MESSENGER RNA; SOYBEAN PROTEIN;

ADULT; BONE DENSITY; BONE MINERAL; CLINICAL TRIAL; CONFERENCE PAPER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; FEMUR; HUMAN; HUMAN CELL; HYPERCHOLESTEROLEMIA; LIPID BLOOD LEVEL; LOW FAT DIET; LUMBAR SPINE; MAJOR CLINICAL STUDY; MONONUCLEAR CELL; POSTMENOPAUSE; PROTEIN INTAKE; RANDOMIZED CONTROLLED TRIAL;

GLYCINE MAX;

EID: 0031772172     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/68.6.1375S     Document Type: Conference Paper

References (17)

1. Potter SM. Soy protein and serum lipids. Curr Opin Lipidol 1996;7:260-4.
2. Anderson JW, Johnstone BM, Cook-Newell ME. Meta-analysis of the effects of soy protein intake on serum lipids. N Engl J Med 1995;333:276-82.
3. Carroll KK. Review of clinical studies on cholesterol-lowering response to soy protein. J Am Diet Assoc 1991;91:820-7.
4. Potter SM. Overview of proposed mechanisms for the hypocholesterolemic effect of soy. J Nutr 1995;125:606S-11S.
5. Klein KO. Isoflavones, soy-based infant formulas, and relevance to endocrine function. Nutr Rev 1998;56:193-204.
6. Baum J, Teng H, Erdman JW Jr, et al. Long-term intake of soy protein improves blood lipid profiles and increases mononuclear cell low-density-lipoprotein receptor messenger RNA in hypercholesterolemic, postmenopausal women. Am J Clin Nutr 1998;68:545-51.
7. NIH Consensus Development Panel on Triglyceride, High-Density Lipoprotein, and Coronary Heart Disease. Triglyceride, high-density lipoprotein, and coronary heart disease. JAMA 1993;269: 505-10.
8. Gidez LI, Miller GJ, Burstein M, Slagle S, Eder HA. Separation and quantitation of subclasses of human plasma high density lipoproteins by a simple precipitation procedure. J Lipid Res 1982;23: 1206-23.
9. Lovati MR, Manzoni C, Canavesi A, et al. Soybean protein diet increases low-density lipoprotein receptor activity in mononuclear cells from hypercholesterolemic patients. J Clin Invest 1987;80: 1498-502.
10. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987;162:156-9.
11. Wang AM, Doyle MV, Mark DF. Quantitation of mRNA by the polymerase chain reaction. Proc Natl Acad Sci U S A 1989;86: 9717-21.
12. Weigel RM, Narvaez M. Multiple regression analysis of differential response to treatment in randomized controlled clinical trials. Control Clin Trials 1991;12:378-94.
13. Potter SM, Bakhit RM, Essex-Sorlie D, et al. Depression of plasma cholesterol in men by consumption of baked products containing soy protein. Am J Clin Nutr 1993;58:501-6.
14. Bakhit RM, Klein BP, Essex-Sorlie D, Ham JO, Erdman JW Jr, Potter SM. Intake of 25 g soybean protein with or without soybean fiber alters plasma lipids in men with elevated cholesterol concentrations. J Nutr 1994;124:213-22.
15. Stampfer MJ, Colditz GA. Estrogen replacement therapy and coronary heart disease: a quantitative assessment of the epdemiologic evidence. Prev Med 1991;20:47-63.
16. Ettinger B, Genant HK, Steiger P, Madvig P. Low-dosage micronized 17-estradiol prevents bone loss in postmenopausal women. Am J Obstet Gynecol 1992;166:479-88.
17. Odell WE, Heath H. Osteoporosis: pathophysiology, prevention, diagnosis, and treatment. Dis Mon 1993;19:789-98.