Direct action of genistein on CFTR

Pflugers Archiv European Journal of Physiology

Volumn 434, Issue 4, 1997, Pages 484-491

  Weinreich, Frank ^a,b   Wood, Phillip G ^a   Riordan, John R ^c   Nagel, Georg ^a,b  

^a MAX PLANCK INSTITUTE OF BIOPHYSICS   (Germany)

^b GOETHE UNIVERSITY   (Germany)

^c MAYO CLINIC   (United States)

Author keywords

CFTR; Chloride channel; Genistein; Protein kinase; Xenopus laevis

Indexed keywords

ADENOSINE TRIPHOSPHATE; CHLORIDE CHANNEL; FORSKOLIN; GENISTEIN; ISOBUTYLMETHYLXANTHINE; TRANSMEMBRANE CONDUCTANCE REGULATOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYSTIC FIBROSIS; GENE EXPRESSION; HUMAN; NONHUMAN; OOCYTE; PATCH CLAMP; PRIORITY JOURNAL; XENOPUS LAEVIS;

ADENOSINE TRIPHOSPHATE; ANIMALS; CHLORIDE CHANNELS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; ELECTRIC CONDUCTIVITY; ENZYME INHIBITORS; FEMALE; GENISTEIN; HOMEOSTASIS; ISOFLAVONES; OOCYTES; PHOSPHORIC MONOESTER HYDROLASES; PHOSPHORYLATION; STIMULATION, CHEMICAL; TYROSINE; XENOPUS LAEVIS;

EID: 0030818110     PISSN: 00316768     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004240050424     Document Type: Article

References (29)

1. Akiyama T, Ogawara H (1991) Use and specificity of genistein as inhibitor of protein-tyrosine kinases. Methods Enzymol 201:362-370
2. Anderson MP, Berger HA, Rich DP, Gregory RJ, Smith AE, Welsh MJ (1991) Nucleoside triphosphates are required to open the CFTR chloride channel. Cell 67:775-784
3. - channel gating to an ATP hydrolysis cycle. Neuron 12:473-482
4. - channel activity in Xenopus oocytes expressing the cystic fibrosis gene. J Biol Chem 266:19142-19145
5. Becq F, Jensen TJ, Chang X-B, Savoia A, Rommens JM, Tsui L-C, Buchwald M, Riordan JR, Hanrahan JW (1994) Phosphatase inhibitors activate normal and defective CFTR chloride channels. Proc Natl Acad Sci USA 91:9160-9164
6. Berger HA, Travis SM, Welsh MJ (1993) Regulation of the cystic fibrosis transmembrane conductance regulator Cl channel by specific protein kinases and protein phosphatases. J Biol Chem 268:2037-2047
7. Cantley LC, Josephson L, Warner R, Yanagisawa M, Lechene C, Guidotti G (1977) Vanadate is a potent (Na, K)-ATPase inhibitor found in ATP derived from muscle. J Biol Chem 252:7421-7423
8. Carson MR, Travis SM, Winter MC, Sheppard DN, Welsh MJ (1994) Phosphate stimulates CFTR channels. Biophys J 67:1867-1875
9. Cheng SH, Rich DP, Marshall J, Gregory RJ, Welsh MJ, Smith AE (1991) Phosphorylation of the R domain by cAMP-dependent protein kinase regulates the CFTR chloride channel. Cell 66:1027-1036
10. Cunningham SA, Worrell RT, Benos DJ, Frizzell RA (1992) cAMP-stimulated ion currents in Xenopus oocytes expressing CFTR cRNA. Am J Physiol 262:C783-C788
11. Drumm ML, Wilkinson DJ, Smit LS, Worrell RT, Strong TV, Frizzell RA, Dawson DC, Collins FS (1991) Chloride conductance expressed by AF508 and other mutant CFTRs in Xenopus oocytes. Science 254:1797-1799
12. c-src regulates the fast gate of the cystic fibrosis transmembrane conductance regulator chloride channel. Biophys J 71:3073-3082
13. +-ATPase pump currents in giant excised patches activated by an ATP concentration jump. Biophys J 71:2486-2500
14. Gadsby DC, Nagel G, Hwang T-C (1995) The CFTR chloride channel of mammalian heart. Annu Rev Physiol 57:387-416
15. Hilgemann DW (1989) Giant excised cardiac sarcolemmal membrane patches: sodium and sodium-calcium exchange currents. Pflügers Arch 415:247-249
16. Hilgemann DW (1995) The giant membrane patch. In: Sakmann B, Neher E (eds) Single-channel recording. Plenum, New York, pp 307-327
17. - conductance in mammalian heart. J Gen Physiol 101:629-650
18. Illek B, Fischer H, Santos GF, Widdicombe JH, Machen TE, Reenstra WW (1995) cAMP-independent activation of CFTR Cl channels by the tyrosine kinase inhibitor genistein. Am J Physiol 268:C886-C893
19. Illek B, Fischer H, Machen TE (1996) Alternate stimulation of apical CFTR by genistein in epithelia. Am J Physiol 270: C265-C275
20. Lau KH, Farley JR, Baylink DJ (1989) Phosphotyrosyl protein phosphatases. Biochem J 257:23-36
21. Levitzki A (1992) Tyrphostins: tyrosine kinase blockers as novel antiproliferative agents and dissectors of signal transduction. FASEB J 6:3275-3282
22. Nagel G, Hwang T-C, Nastiuk KL, Nairn AC, Gadsby DC (1992) The protein kinase A-regulated cardiac chloride channel resembles the cystic fibrosis transmembrane conductance regulator. Nature 360:81-84
23. Nagel G, Wellan-Ely A, Bamberg E, Jensen T, Riordan JR (1997) Fast activation of CFTR chloride channels, incorporated into a BLM, by an ATP concentration jump (abstract) Biophys J 72:A113
24. Reenstra WW, Yurko-Mauro K, Dam A, Raman S, Shorten S (1996) CFTR chloride channel activation by genistein: the role of serine/threonine protein phosphatases. Am J Physiol 271:C650-C657
25. Riordan JR (1993) The cystic fibrosis transmembrane conductance regulator. Annu Rev Physiol 55:609-630
26. Riordan JR, Rommens JM, Kerem B-S, Alon N, Rozmahel R, Grzelczak Z, Zielenski J, Lok S, Plavsic N, Chou J-L, Drumm ML, Iannuzzi MC, Collins FS, Tsui L-C (1989) Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA. Science 245:1066-1073
27. - secretion in T84 cell monolayers. Am J Physiol 269:G874-G882
28. - channel in CHO cells stably expressing the cystic fibrosis gene. Nature 352:628-631
29. Yang IC-H, Cheng T-H, Wang F, Price EM, Hwang T-C (1997) Modulation of CFTR chloride channels by calyculin A and genistein. Am J Physiol 272:C142-C155