Flaxseed inhibits metastasis and decreases extracellular vascular endothelial growth factor in human breast cancer xenografts

Cancer Letters

Volumn 185, Issue 1, 2002, Pages 31-37

  Dabrosin, Charlotta ^a   Chen, Jianmin ^a   Wang, Linda ^a   Thompson, Lilian U ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

Angiogenesis; Flaxseed; MDA MB 435; Metastasis; Microdialysis; Vascular endothelial growth factor

Indexed keywords

ENDOTHELIAL CELL GROWTH FACTOR; ESTROGEN; ISOFLAVONE DERIVATIVE; LYMPHOKINE; PHYTOESTROGEN; PLANT MEDICINAL PRODUCT; SIGNAL PEPTIDE; VASCULOTROPIN; VASCULOTROPIN A; LIGNAN;

ANIMAL; ARTICLE; BODY WEIGHT; CANCER TRANSPLANTATION; CELL CULTURE; DOWN REGULATION; EXPERIMENTAL NEOPLASM; EXTRACELLULAR SPACE; FEMALE; FLAX; HUMAN; LUNG TUMOR; LYMPH NODE METASTASIS; METABOLISM; MOUSE; NUDE MOUSE; PLANT SEED; XENOGRAFT; ANIMAL EXPERIMENT; ANIMAL MODEL; BREAST CARCINOMA; CONTROLLED STUDY; HUMAN CELL; LINSEED; METASTASIS; NONHUMAN; PRIORITY JOURNAL; SUPPLEMENTATION; TUMOR GROWTH; TUMOR XENOGRAFT;

ANIMALS; BODY WEIGHT; DOWN-REGULATION; ENDOTHELIAL GROWTH FACTORS; ESTROGENS, NON-STEROIDAL; EXTRACELLULAR SPACE; FEMALE; FLAX; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; ISOFLAVONES; LUNG NEOPLASMS; LYMPHATIC METASTASIS; LYMPHOKINES; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; PHYTOESTROGENS; PLANT PREPARATIONS; SEEDS; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS; ANIMAL; HUMAN; SUPPORT, NON-U.S. GOV'T;

MAMMALIA; MUS MUSCULUS;

EID: 0037044563     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(02)00239-2     Document Type: Article

References (41)

1. Dietary factors and risk of breast cancer: Combined analysis of 12 case-control studies
2. International comparisons of mortality rates for cancer of the breast, ovary, prostate, and colon, and per capita food consumption
3. Soy intake and cancer risk: A review of the in vitro and in vivo data
4. Experimental studies on lignans and cancer
5. Flaxseed and its lignan and oil components reduce mammary tumor growth at a late stage of carcinogenesis
6. Exposure to flaxseed or its lignan component during different developmental stages influences rat mammary gland structures
7. Exposure to flaxseed or purified lignan during lactation influences rat mammary gland structures
8. Production and metabolism of lignans by the human faecal flora
9. Mammalian lignan production from various foods
10. Vascular endothelial growth factor (VEGF) and its receptors
11. Angiogenesis in cancer, vascular, rheumatoid and other disease
12. Expression of vascular endothelial growth factor, its receptor, and other angiogenic factors in human breast cancer
13. Correlation of vascular endothelial growth factor content with recurrences, survival, and first relapse site in primary node-positive breast carcinoma after adjuvant treatment
14. Vascular endothelial growth factor is of high prognostic value in node-negative breast carcinoma
15. The 121 amino acid isoform of vascular endothelial growth factor is more strongly tumorigenic than other splice variants in vivo
16. Studies of human breast cancer metastasis using nude mice
17. Effects of linoleic acid on the growth and metastasis of two human breast cancer cell lines in nude mice and the invasive capacity of these cell lines in vitro
18. Influence of regional location of the inoculation site and dietary fat on the pathology of MDA-MB-435 human breast cancer cell-derived tumors grown in nude mice
19. Tumorigenicity and metastasis of human breast carcinoma cell lines in nude mice
20. AIN-93 purified diets for laboratory rodents: Final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet
21. Microdialysis - Principles and applications for studies in animals and man
22. Variability of glutathione levels in normal breast tissue and subcutaneous fat during the menstrual cycle: An in vivo study with microdialysis technique
23. The biology of vascular endothelial growth factor
24. The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing
25. Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms
26. Quantitative analysis of vascular endothelial growth factor in primary breast cancer
27. Invasive lobular and invasive ductal carcinoma of the breast show distinct patterns of vascular endothelial growth factor expression and angiogenesis
28. Expression of the angiogenic factors vascular endothelial cell growth factor, acidic and basic fibroblast growth factor, tumor growth factor beta-1, platelet-derived endothelial cell growth factor, placenta growth factor, and pleiotrophin in human primary breast cancer and its relation to angiogenesis
29. Growth factor control of extracellular proteolysis
30. Identification of hypoxia-inducible factor 1 ancillary sequence and its function in vascular endothelial growth factor gene induction by hypoxia and nitric oxide
31. Central role of p53 on regulation of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) expression in mammary carcinoma
32. Levels of hypoxia-inducible factor-1 alpha during breast carcinogenesis
33. Estrogen and angiogenesis: A review
34. Identification of functional estrogen response elements in the gene coding for the potent angiogenic factor vascular endothelial growth factor
35. Regulation of angiogenic growth factors in the female reproductive tract by estrogens and progestins
36. Regulation of sex hormone-binding globulin production by isoflavonoids and patterns of isoflavonoid conjugation in HepG2 cell cultures
37. Inhibition of human aromatase by mammalian lignans and isoflavonoid phytoestrogens
38. Flaxseed and its mammalian lignan precursor cause a lengthening or cessation of estrous cycling in rats
39. Genistein, a dietary ingested isoflavonoid, inhibits cell proliferation and in vitro angiogenesis
40. Genistein exerts multiple suppressive effects on human breast carcinoma cells
41. Dietary flaxseed inhibits human breast cancer growth and metastasis and downregulates expression of insulin-like growth factor and epithelial cell growth factor receptor