Soy protein concentrate and isolated soy protein similarly lower blood serum cholesterol but differently affect thyroid hormones in hamsters

Journal of Nutrition

Volumn 126, Issue 8, 1996, Pages 2007-2011

  Potter, Susan M ^a,b   Pertile, Joy ^a   Berber Jimenez, M D ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b 463 Bevier Hall ^*  (United States)

Author keywords

cholesterol; hamsters; soybean protein; thyroid hormones

Indexed keywords

CASEIN; CHOLESTEROL; HYPOCHOLESTEROLEMIC AGENT; LIOTHYRONINE; LIPOPROTEIN; PROMAX 70; SOYBEAN PROTEIN; THYROID HORMONE; THYROXINE; UNCLASSIFIED DRUG;

AMINO ACID COMPOSITION; ANIMAL EXPERIMENT; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DOSE RESPONSE; FOOD COMPOSITION; HYPERCHOLESTEROLEMIA; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PROTEIN INTAKE; PROTEIN ISOLATION; THYROID HORMONE BLOOD LEVEL;

ANIMALS; ANTICHOLESTEREMIC AGENTS; CASEINS; CHOLESTEROL; CRICETINAE; DIETARY PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; MESOCRICETUS; SOYBEAN PROTEINS; SOYBEANS; THYROID HORMONES; THYROXINE; TRIIODOTHYRONINE; VEGETABLE PROTEINS;

EID: 0029740335     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Allain, C. A., Poon, L. S., Chang, C. H. G., Richmond, W. & Wu, P.C. (1974) Enzymatic determination of total serum cholesterol. Clin. Chem. 20: 470-475.
2. Anderson, R. L. &. Wolf, W. J. (1994) Compositional changes in trypsin inhibitors, phytic acid, saporins and isoflavones related to soybean processing. J. Nutr. 25: 3815-5885.
3. Anderson, J. W., Johnston, B. M. & Cook-Newell, M. E. (1995) Meta-analysis of the effects of soy protein intake on serum lipids. N. Engl. J. Med. 333: 276-282.
4. Bakhit, R. M., Klein, B. P., Essex-Sorlie, D., Ham, J. O., Erdman, J. W., Jr. & Potter, S. M. (1994) Intake of 25 g soybean protein with or without soybean fiber alters plasma lipids in men with elevated cholesterol concentrations. J. Nutr. 124: 213-222.
5. Balmir, F., Bakhit, R. M., Erdman, J. W., Jr. & Potter, S. M. (1993) Intake of 25 g soy protein does not alter plasma hormone concentrations in mildly hypercholesterolemic men. FASEB J. 7: A802 (abs.).
6. Beynen, A. C. & Schouten, J. A. (1983) Influence of dietary soy-bean protein and casein on the level of plasma cholesterol in hamsters. Nutr. Rep. Int. 28: 835-841.
7. Britton, K. E., Quinn, V., Brown, B. L. &. Ekins, R. P. (1975) A strategy for thyroid function tests. Br. Med. J. 3: 350-352.
8. Carroll, K. K. (1991) Review of clinical studies on cholesterol-lowering response to soy protein. J. Am. Diet. Assoc. 91: 820-827.
9. Forsythe, W. A. III. (1986) Comparison of dietary casein or soy protein effects on plasma lipids and hormone concentrations in the gerbil. J. Nutr. 116: 1165-1171.
10. Ham, J. O., Chapman, K. M., Essex-Sorlie, D., Bakhit, R. M., Prabhudesai, M., Winter, L., Erdman, J. W. & Potter, S. M. (1993) Endocrinological response to soy protein and fiber in mildly hypercholesterolemic men. Nutr. Res. 13: 873-884.
11. Hydowitz, J. D. (1960) Occurrence of goiter in an infant on soy diet. N. Engl. J. Med. 262: 351-360.
12. Konijn, A. M., Gershon, B. & Guggenheim, K. (1973) Further purification and mode of action of a goitrogenic material from soybean flour. J. Nutr. 103: 378-383.
13. Liener, I. E. (1964) Implications of antinutritional components in soybean foods. Crit Rev. Food Sci, Nutr. 34: 31-67.
14. 4, and decreases serum thyrotropin in the rat. Endocrinology 126: 2890-2895.
15. Mardell, R. & Gerson, M. (1978) A method of assessing serum triiodothyronine concentrations that is independent of subject's age and variations in concentrations of binding proteins in serum. Clin. Chem. 24: 1792-1796.
16. Potter, S. M., Bakhit, R. M., Essex-Sorlie, D., Weingartner, K. E., Chapman, K. M., Nelson, R. A., Prabhudesai, M., Savage, W. D., Nelson, A. I, Winter, L. W. & Erdman, J. W., Jr. (1993) Depression of plasma cholesterol in men by consumption of baked products containing soy protein. Am. J. Clin. Nutr. 58: 501-506.
17. Prince, H. P. &. Ramsden, D. B. (1977) A new theoretical description of the binding of thyroid hormones by serum proteins. Clin. Endocrinol. 7: 307-324.
18. SAS Institute, Inc. (1985) SAS Users Guide: Statistics, 5th ed. SAS Institute, Gary, NC.
19. Scholz-Ahrens, K. E., Hagemeister, H., Unshelm, J., Agergaard, N. & Barth, C. A. (1990) Response of hormones modulating plasma cholesterol to dietary casein or soy protein in minipigs. J. Nutr. 120: 1387-1392.
20. Sharpless, G. R., Pearsons, J. & Proto, G. S. (1939) Production of goiter in rats with raw and heated soybean flour. J. Nutr. 17: 545-555.
21. Steel, R. G. D. & Torrie, J. H. (1980) Principles and Procedures of Statistics-A Biometrical Approach. 2nd ed. McGraw-Hill, New York, NY.
22. Suwa, J. & Kimura, S. (1981) Isolation and the goitrogenic activity of soybean elements which affect thyroid function. Annu. Rep. Fac. Educ. Gumna Univ. Art Technol. Ser. 17: 71-80.
23. Terpstra, A. H. M., Holmes, J. C. & Nicolosi, R. J. (1991) The hypocholesterolemic effect of dietary soybean protein vs casein in hamsters fed cholesterol-enriched or cholesterol-free semipurifled diets. J. Nutr. 121: 944-947.
24. Terpstra, A. H. M., Laitinen, L., Stucchi, A. F. & Nicolosi, R. J. (1994) The effect of semipurified diets containing two levels (20% and 40%) of either casein or soybean protein isolate and concentrate on plasma lipids in hamsters. Nutr. Res. 14: 885-895.
25. 2+ precipitation procedure for quantitation of high density lipoprotein cholesterol. Clin. Chem. 28: 1379-1388.
26. Wilgus, H. S., Gassner, F. X., Patton, A. R. & Gustavsen, R. G. (1941) The goitrogenicity of soybeans. J. Nutr. 22: 43-52.