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Current Molecular Medicine

Volumn 2, Issue 6, 2002, Pages 571-577

Bisphosphonate mechanism of action

(2) Rodan, Gideon A a Reszka, Alfred A a

a MERCK RESEARCH LABORATORIES (United States)

Author keywords

Alendronate; Bisphosphonates; Bone remodeling; Cholesterol pathway; Osteoclasts; Osteoporosis; Prenylation

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALENDRONIC ACID; BISPHOSPHONIC ACID DERIVATIVE; CASPASE; CASPASE INHIBITOR; CHOLESTEROL; CLODRONIC ACID; DESMOSTEROL; ETIDRONIC ACID; FARNESOL; GERANYLGERANIOL; GERANYLTRANSFERASE; GGTI 298; GUANOSINE TRIPHOSPHATASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LANOSTEROL; LIPID; MEVALONIC ACID; MINERAL; NITROGEN; PAMIDRONIC ACID; PYROPHOSPHORIC ACID DERIVATIVE; RISEDRONIC ACID; SIMVASTATIN; SQUALENE; SQUALENE SYNTHASE; TILUDRONIC ACID; ZYMOSTEROL;

BONE DEFECT; BONE DENSITY; BONE MASS; BONE MATRIX; BONE MINERAL; BONE MINERALIZATION; BONE REMODELING; BONE STRENGTH; BONE TURNOVER; CELL ACTIVATION; CELL ACTIVITY; CELL TRANSPORT; CELL VACUOLE; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; CYTOSKELETON; DRUG ABSORPTION; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG HALF LIFE; DRUG INACTIVATION; DRUG INHIBITION; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; ENZYME INHIBITION; FRACTURE; HUMAN; NONHUMAN; OSSIFICATION; OSTEOCLAST; OSTEOLYSIS; OSTEOPOROSIS; REVIEW; RISK ASSESSMENT;

ALENDRONATE; ANIMALS; BONE RESORPTION; CHOLESTEROL; CYTOSKELETON; DIPHOSPHONATES; DITERPENES; HUMANS; LIPID METABOLISM; MODELS, BIOLOGICAL; NITROGEN; OSTEOCLASTS; POLYISOPRENYL PHOSPHATES; PROTEIN ISOPRENYLATION;

EID: 0036727151 PISSN: 15665240 EISSN: None Source Type: Journal
DOI: 10.2174/1566524023362104 Document Type: Review

Times cited : (120)

References (66)

1
- 0029827330
- (1996) Calcif. Tissue Int , vol.59 , Issue.SUPPL. 1 , pp. 16-19
- Adachi, J.D.¹

3
- 0004851872
- (1996) Lancet , vol.348 , pp. 1535-1541
- Black, D.M.¹ Cummings, S.R.² Karpf, D.B.³ Cauley, J.A.⁴ Thompson, D.E.⁵ Nevitt, M.C.⁶ Bauer, D.C.⁷ Genant, H.K.⁸ Haskell, W.L.⁹ Marcus, R.¹⁰ Ott, S.M.¹¹ Torner, J.C.¹² Quandt, S.A.¹³ Reiss, T.F.¹⁴ Ensrud K.E¹⁵

4
- 0034530951
- (2000) J. Clin. Endocrinol Metab , vol.85 , pp. 4118-4124
- Black, D.M.¹ Thompson, D.E.² Bauer, D.C.³ Ensrud, K.⁴ Musliner, T.⁵ Hochberg, M.C.⁶ Nevitt, M.C.⁷ Suryawanshi, S.⁸ Cummings, S.R.⁹

5
- 0033498501
- (1999) Arthritis Rheum , vol.42 , pp. 2309-2318
- Cohen, S.¹ Levy, R.M.² Keller, M.³ Boling, E.⁴ Emkey, R.D.⁵ Greenwald, M.⁶ Zizic, T.M.⁷ Wallach, S.⁸ Sewell, K.L.⁹ Lukert, B.P.¹⁰ Axelrod, D.W.¹¹ Chines, A.A.¹²

7
- 0030716177
- (1997) Arch. Intem. Med , vol.157 , pp. 2617-2624
- Ensrud, K.E.¹ Black, D.M.² Palermo, L.³ Bauer, D.C.⁴ Barrett, C.E.⁵ Quandt, S.A.⁶ Thompson, D.E.⁷ Karpf, D.B.⁸

8
- 0033552255
- (1999) JAMA , vol.282 , pp. 1344-1352
- Harris, S.T.¹ Watts, N.B.² Genant, H.K.³ McKeever, C.D.⁴ Hangartner, T.⁵ Keller, M.⁶ Chesnut C.H. III⁷ Brown, J.⁸ Eriksen, E.F.⁹ Hoseyni, M.S.¹⁰ Axelrod, D.W.¹¹ Miller, P.D.¹²

9
- 0034066105
- (2000) Osteoporos Int , vol.11 , pp. 98-101
- Ho, Y.V.¹ Frauman, A.G.² Thomson, W.³ Seeman, E.⁴

10
- 0035253489
- (2001) N. Engl. J. Med , vol.344 , pp. 333-340
- McClung, M.R.¹ Geusens, P.² Miller, P.D.³ Zippel, H.⁴ Bensen, W.G.⁵ Roux, C.⁶ Adami, S.⁷ Fogelman, I.⁸ Diamond, T.⁹ Eastell, R.¹⁰ Meunier, P.J.¹¹ Reginster, J.Y.¹²

11
- 12944291524
- (2000) Osteoporos Int , vol.11 , pp. 83-91
- Reginster, J.¹ Minne, H.W.² Sorensen, O.H.³ Hooper, M.⁴ Roux, C.⁵ Brandi, M.L.⁶ Lund, B.⁷ Ethgen, D.⁸ Pack, S.⁹ Rournagnac, I.¹⁰ Eastell, R.¹¹

13
- 0033801341
- (2000) Calcif. Tissue Int , vol.67 , pp. 277-285
- Wallach, S.¹ Cohen, S.² Reid, D.M.³ Hughes, R.A.⁴ Hosking, D.J.⁵ Laan, R.F.⁶ Doherty, S.M.⁷ Maricic, M.⁸ Rosen, C.⁹ Brown, J.¹⁰ Barton, I.¹¹ Chines, A.A.¹²

14
- 0033039349
- (1999) Arthritis Rheum , vol.42 , pp. 1246-1254
- Hochberg, M.C.¹ Ross, P.D.² Black, D.³ Cummings, S.R.⁴ Genant, H.K.⁵ Nevitt, M.C.⁶ Barrett Connor, E.⁷ Musliner, T.⁸ Thompson, D.⁹

15
- 0032872263
- (1999) Bone , vol.25 , pp. 613-619
- Nevitt, M.C.¹ Ross, P.D.² Palermo, L.³ Musliner, T.⁴ Genant, H.K.⁵ Thompson, D.E.⁶

16
- 0031043696
- (1997) Calcif. Tissue Int , vol.60 , pp. 255-260
- Ravn, P.¹ Rix, M.² Andreassen, H.³ Clermmesen, B.⁴ Bidstrup, M.⁵ Gunnes, M.⁶

17
- 0032896590
- (1999) Osteoporos Int , vol.9 , pp. 461-468
- Pols, H.A.¹ Felsenberg, D.² Hanley, D.A.³ Stepan, J.⁴ Munoz Torres, M.⁵ Wilkin, T.J.⁶ Gin sheng, G.⁷ Galich, A.M.⁸ Vandormael, K.⁹ Yates, A.J.¹⁰ Stych, B.¹¹

18
- 0028851590
- (1995) N. Engl. J. Med , vol.333 , pp. 1437-1443
- Liberman, U.A.¹ Weiss, S.R.² Broll, J.³ Minne, H.W.⁴ Quan, H.⁵ Bell, N.H.⁶ Rodriguez Portales, J.⁷ Downs R.W., Jr.⁸ Dequeker, J.⁹ Favus, M.¹⁰

19
- 0032902283
- (1999) J. Clin. Pharmacol , vol.39 , pp. 385-393
- Cocquyt, V.¹ Kline, W.F.² Gertz, B.J.³ Van Belle, S.J.⁴ Holland, S.D.⁵ DeSmet, M.⁶ Quan, H.⁷ Vyas, K.P.⁸ Zhang, K.E.⁹ De Greve, J.¹⁰ Porras, A.G.¹¹

20
- 0033051107
- (1999) Clin. Pharmacokinet , vol.36 , pp. 315-328
- Porras, A.G.¹ Holland, S.D.² Gertz, B.J.³

21
- 0029164610
- (1995) Bone , vol.16 , pp. 235-245
- Azuma, Y.¹ Sato, H.² Oue, Y.³ Okabe, K.⁴ Ohta, T.⁵ Tsuchimoto, M.⁶ Kiyoki, M.⁷

22
- 0030227986
- (1996) Bone , vol.19 , pp. 281-290
- Masarachia, P.¹ Weinreb, M.² Balena, R.³ Rodan, G.A.⁴

23
- 0002043349
- (Recker, R. R. ed), CRC Press, Boca Raton
- (1983) Bone Histomorphometry: Techniques and Interpretation , pp. 143-224
- Parfittt, A.M.¹

24
- 0033678399
- (2000) J. Clin. Endocrinol. Metab , vol.85 , pp. 3109-3115
- Tonino, R.P.¹ Meunier, P.J.² Emkey, R.³ Rodriguez Portales, J.A.⁴ Menkes, C.J.⁵ Wasnich, R.D.⁶ Bone, H.G.⁷ Santora, A.C.⁸ Wu, M.⁹ Desai, R.¹⁰ Ross, P.D.¹¹

25
- 0034814098
- (2001) J. Bone Miner. Res , vol.16 , pp. 1871-1878
- Riis, B.J.¹ Ise, J.² von Stein, T.³ Bagger, Y.⁴ Christiansen, C.⁵

26
- 0033755981
- (2000) Bone , vol.27 , pp. 687-694
- Boivin, G.Y.¹ Chavassieux, P.M.² Santora, A.C.³ Yates, J.⁴ Meunier, P.J.⁵

27
- 0034906270
- (2001) Bone , vol.29 , pp. 185-191
- Roschger, P.¹ Rinnerthaler, S.² Yates, J.³ Rodan, G.A.⁴ Fratzl, P.⁵ Klaushofer, K.⁶

28
- 0027279616
- (1993) Calcif. Tissue Int , vol.53 , pp. 283-288
- Guy, J.A.¹ Shea, M.² Peter, C.P.³ Morrissey, R.⁴ Hayes, W.C.⁵

29
- 0028915931
- (1995) J. Clin. Invest , vol.95 , pp. 2127-2133
- Lafage, M.H.¹ Balena, R.² Battle, M.A.³ Shea, M.⁴ Seedor, J.G.⁵ Klein, H.⁶ Hayes, W.C.⁷ Rodan, G.A.⁸

30
- 0033755583
- (2000) Bone , vol.27 , pp. 639-645
- Mosekilde, L.¹ Thomsen, J.S.² Mackey, M.S.³ Phipps, R.J.⁴

31
- 0027071851
- (1992) J. Bone Miner. Res , vol.7 , pp. 1399-1406
- Toolan, B.C.¹ Shea, M.² Myers, E.R.³ Borchers, R.E.⁴ Seedor, J.G.⁵ Quartuccio, H.⁶ Rodan, G.⁷ Hayes, W.C.⁸

32
- 0031002026
- (1997) Science , vol.276 , pp. 270-273
- Salo, J.¹ Lehenkari, P.² Mulari, M.³ Metsikko, K.⁴ Vaananen, H.K.⁵

33
- 0026320852
- (1991) J. Clin. Invest , vol.88 , pp. 2095-2105
- Sato, M.¹ Grasser, W.² Endo, N.³ Akins, R.⁴ Simmons, H.⁵ Thompson, D.D.⁶ Golub, E.⁷ Rodan, G.A.⁸

34
- 0029097506
- (1995) Bone , vol.17 , pp. 137-144
- Murakami, H.¹ Takahashi, N.² Sasaki, T.³ Udagawa, N.⁴ Tanaka, S.⁵ Nakamura, I.⁶ Zhang, D.⁷ Barbier, A.⁸ Suda, T.⁹

35
- 0034967671
- (2001) Bone , vol.28 , pp. 609-616
- Ito, M.¹ Amizuka, N.² Nakajima, T.³ Ozawa, H.⁴

36
- 0030947272
- (1997) Pharm. Res , vol.14 , pp. 625-630
- Rogers, M.J.¹ Xiong, X.² Ji, X.³ Monkkonen, J.⁴ Russell, R.G.⁵ Williamson, M.P.⁶ Ebetino, F.H.⁷ Watts, D.J.⁸

37
- 0033145872
- (1999) Am. J. Orthod. Dentofacial Orthop , vol.115 , pp. 645-653
- Kim, T.W.¹ Yoshida, Y.² Yokoya, K.³ Sasaki, T.⁴

38
- 0028859369
- (1995) J. Clin. Invest , vol.96 , pp. 2277-2283
- Zimolo, Z.¹ Wesolowski, G.² Rodan, G.A.³

39
- 0029133135
- (1995) J. Bone Miner. Res , vol.10 , pp. 1478-1487
- Hughes, D.E.¹ Wright, K.R.² Uy, H.L.³ Sasaki, A.⁴ Yoneda, T.⁵ Roodman, G.D.⁶ Mundy, G.R.⁷ Boyce, B.F.⁸

40
- 0031785895
- (1998) Mol. Pharmacol , vol.54 , pp. 631-638
- Coxon, F.P.¹ Benford, H.L.² Russell, R.G.³ Rogers, M.J.⁴

41
- 0032404144
- (1998) Cancer Res , vol.58 , pp. 5294-5297
- Shipman, C.M.¹ Croucher, P.I.² Russell, R.G.³ Helfrich, M.H.⁴ Rogers, M.J.⁵

42
- 0031932783
- (1998) Leukemia , vol.12 , pp. 220-229
- Aparicio, A.¹ Gardner, A.² Tu, Y.³ Savage, A.⁴ Berenson, J.⁵ Lichtenstein, A.⁶

43
- 0033520927
- (1999) J. Biol. Chem , vol.274 , pp. 34967-34973
- Reszka, A.A.¹ Halasy Nagy, J.M.² Masarachia, P.J.³ Rodan, G.A.⁴

44
- 0035209393
- (2001) Bone , vol.29 , pp. 553-559
- Halasy Nagy, J.M.¹ Rodan, G.A.² Reszka, A.A.³

45
- 0029782880
- (1996) J. Bone Miner. Res , vol.11 , pp. 1498-1507
- David, R.¹ Nguyen, H.² Barbier, A.³ Baron, R.⁴

46
- 0009390724
- (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 3068-3073
- Schmidt, A.¹ Rutledge, S.J.² Endo, N.³ Opas, E.E.⁴ Tanaka, H.⁵ Wesolowski, G.⁶ Leu, C.T.⁷ Huang, Z.⁸ Ramachandaran, C.⁹ Rodan, S.B.¹⁰ Rodan, G.A.¹¹

47
- 0029873660
- (1996) J. Bone Miner. Res , vol.11 , pp. 535-543
- Endo, N.¹ Rutledge, S.J.² Opas, E.E.³ Vogel, R.⁴ Rodan, G.A.⁵ Schmidt, A.⁶

48
- 0030776772
- (1997) Biochem. Pharmacol , vol.54 , pp. 721-727
- Opas, E.E.¹ Rutledge, S.J.² Golub, E.³ Stern, A.⁴ Zimolo, Z.⁵ Rodan, G.A.⁶ Schmidt, A.⁷

49
- 0030918039
- (1997) Bone , vol.20 , pp. 399-404
- Murakami, H.¹ Takahashi, N.² Tanaka, S.³ Nakamura, I.⁴ Udagawa, N.⁵ Nakajo, S.⁶ Nakaya, K.⁷ Abe, M.⁸ Yuda, Y.⁹ Konno, F.¹⁰ Barbier, A.¹¹ Suda, T.¹²

50
- 0030931795
- (1997) J. Biol. Chem , vol.272 , pp. 22472-22480
- Skorey, K.¹ Ly, H.D.² Kelly, J.³ Hammond, M.⁴ Ramachandran, C.⁵ Huang, Z.⁶ Gresser, M.J.⁷ Wang, Q.⁸

51
- 1842405434
- (1997) J. Bone Miner. Res , vol.12 , pp. 1358-1367
- Frith, J.C.¹ Monkkonen, J.² Blackburn, G.M.³ Russell, R.G.⁴ Rogers, M.J.⁵

52
- 0035460134
- (2001) Arthritis Rheum , vol.44 , pp. 2201-2210
- Frith, J.C.¹ Monkkonen, J.² Auriola, S.³ Monkkonen, H.⁴ Rogers, M.J.⁵

53
- 0026486931
- (1992) J. Lipid Res , vol.33 , pp. 1657-1663
- Amin, D.¹ Cornell, S.A.² Gustafson, S.K.³ Needle, S.J.⁴ Ullrich, J.W.⁵ Bilder, G.E.⁶ Perrone, M.H.⁷

54
- 0029791778
- (1996) Arzneimittelforschung , vol.46 , pp. 759-762
- Amin, D.¹ Cornell, S.A.² Perrone, M.H.³ Bilder, G.E.⁴

55
- 0027436434
- (1993) J. Biol. Chem , vol.268 , pp. 24832-24837
- Ciosek C.P., Jr.¹ Magnin, D.R.² Harrity, T.W.³ Logan, J.V.⁴ Dickson J.K., Jr.⁵ Gordon, E.M.⁶ Hamilton, K.A.⁷ Jolibois, K.G.⁸ Kunselman, L.K.⁹ Lawrence, R.M.¹⁰

56
- 0029011739
- (1995) J. Med. Chem , vol.38 , pp. 2596-2605
- Magnin, D.R.¹ Biller, S.A.² Dickson J.K., Jr.³ Logan, J.V.⁴ Lawrence, R.M.⁵ Chen, Y.⁶ Sulsky, R.B.⁷ Ciosek C.P., Jr.⁸ Harrity, T.W.⁹ Jolibois, K.G.¹⁰ Kunselman, L.K.¹¹ Rich, L.C.¹² Slusarchyk, D.A.¹³

57
- 0030859911
- (1997) J. Pharm. Biomed Anal , vol.15 , pp. 1877-1880
- Risser, F.¹ Pfister, C.U.² Degen, P.H.³

58
- 0031977199
- (1998) J. Bone Miner. Res , vol.13 , pp. 581-589
- Luckman, S.P.¹ Hughes, D.E.² Coxon, F.P.³ Graham, R.⁴ Russell, G.⁵ Rogers, M.J.⁶

59
- 13044283050
- (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 133-138
- Fisher, J.E.¹ Rogers, M.J.² Halasy, J.M.³ Luckman, S.P.⁴ Hughes, D.E.⁵ Masarachia, P.J.⁶ Wesolowski, G.⁷ Russell, R.G.⁸ Rodan, G.A.⁹ Reszka, A.A.¹⁰

60
- 0033958778
- (2000) Arch. Biochem. Biophys , vol.373 , pp. 231-241
- Bergstrom, J.D.¹ Bostedor, R.G.² Masarachia, P.J.³ Reszka, A.A.⁴ Rodan, G.⁵

61
- 0033573882
- (1999) Biochem. Biophys. Res. Commun , vol.255 , pp. 491-494
- van Beek, E.¹ Pieterman, E.² Cohen, L.³ Lowik, C.⁴ Papapoulos, S.⁵

62
- 0033554651
- (1999) Biochem. Biophys. Res. Commun , vol.264 , pp. 108-111
- van Beek, E.¹ Pieterman, E.² Cohen, L.³ Lowik, C.⁴ Papapoulos, S.⁵

63
- 0035146537
- (2001) J. Pharmacol. Exp. Ther , vol.296 , pp. 235-242
- Dunford, J.E.¹ Thompson, K.² Coxon, F.P.³ Luckman, S.P.⁴ Hahn, F.M.⁵ Poulter, C.D.⁶ Ebetino, F.H.⁷ Rogers, M.J.⁸

64
- 0035823604
- (2001) J. Biol. Chem , vol.276 , pp. 33930-33937
- Montalvetti, A.¹ Bailey, B.N.² Martin, M.B.³ Severin, G.W.⁴ Oldfield, E.⁵ Docampo, R.⁶

65
- 0033930168
- (2000) J. Bone Miner. Res , vol.15 , pp. 1467-1476
- Coxon, F.P.¹ Helfrich, M.H.² van't³ Hof, R.⁴ Sebti, S.⁵ Ralston, S.H.⁶ Hamilton, A.⁷ Rogers, M.J.⁸

66
- 0034520352
- (2000) Endocrinology , vol.141 , pp. 4793-4796
- Fisher, J.E.¹ Rodan, G.A.² Reszka, A.A.³

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