Absorption and metabolism of genistein in isolated rat small intestine

Journal of Nutrition

Volumn 130, Issue 4, 2000, Pages 843-846

  Andlauer, Wilfried ^a   Kolb, Jochen ^a   Stehle, Peter ^b   Fürst, Peter ^a  

^a UNIVERSITY OF HOHENHEIM   (Germany)

^b UNIVERSITY OF BONN   (Germany)

Author keywords

Genistein; Intestinal absorption; Intestinal metabolism; Isoflavone; Rats

Indexed keywords

FLUOROCARBON; GENISTEIN; ISOFLAVONE DERIVATIVE; SODIUM CHLORIDE;

ACID BASE BALANCE; ANIMAL TISSUE; ARTICLE; BLOOD COMPONENT; BLOOD VESSEL PERMEABILITY; CONTROLLED STUDY; INTESTINE ABSORPTION; MALE; NONHUMAN; OXYGEN CONSUMPTION; PERFUSION PRESSURE; RAT; SMALL INTESTINE;

ANIMALIA;

EID: 0034019760     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/130.4.843     Document Type: Article

References (25)

1. Adlercreutz, H. (1990) Western diet and western diseases: some hormonal and biochemical mechanism and associations. Scand. J. Clin. Lab. Invest. 50: 3-23.
2. Axelson, M., Sjövall, J., Gustafsson, B. E. & Setchell, K. D. R. (1984) Soya - a dietary source of the non-steroidal oestrogen equol in man and animals. J. Endocr. 102: 49-56.
3. Barnes, S., Kirk, M. & Coward, L. (1994a) Isoflavones and their conjugates in soy foods: Extraction conditions and analysis by HPLC-mass spectrometry. J. Agric. Food Chem. 42: 2466-2474.
4. Barnes, S., Peterson, G., Grubbs, C. & Setchell, K. (1994b) Potential role of dietary isoflavones in the prevention of cancer. Adv. Exp. Med. Biol. 354: 135-147.
5. Coward, L., Barnes, N. C., Setchell, K. D. R. & Barnes, S. (1993) Genistein, daidzein, and their β-glycoside conjugates: Antitumor isoflavones in soybean foods from American and Asian diets. J. Agric. Food Chem. 41: 1961-1967.
6. De Vries, M. H., Hofman, A., Koster, A. S. J. & Noordhoek, J. (1989) Systematic intestinal metabolism of 1-Naphthol. A study in the isolated vascularly perfused rat small intestine. Drug Metab. Dispos. 17: 573-578.
7. Dutton, G. J. (1980) Glucuronidation of drugs and other compounds. CRC Press Inc., Boca Raton, FL.
8. Griffiths, L. A. & Smith, G. E. (1972) Metabolism of apigenin and related compounds in the rat. Biochem. J. 128: 901-911.
9. Hartmann, F., Vieillard-Baron, D. & Heinrich, R. (1984) Isolated perfusion of the small intestine using perfluorotributylamine as artificial oxygen carrier. Adv. Exp. Med. Biol. 180: 711-720.
10. Herman, C., Adlercreutz, T., Goldin, B. R., Gorbach, S. L., Höckerstedt, K. A. V., Watanabe, S., Hämäläinen, E. K., Markkanen, M. H., Mäkelä, T. H., Wähälä, K. T., Hase, T. A. & Fotsis, T. (1995) Soybean phytoestrogen intake and cancer risk. J. Nutr. 125: 757S-770S.
11. Hummel, M. (1998) Thesis: Perfusionsstudien zur Verwertung von Taurinkon-jugaten am Dünndarm der Ratte. ISBN 3-89574-251-1: Köster, Berlin.
12. Hummel, M., Pogan, K., Stehle, P. & Fürst, P. (1997) Intestinal taurine availability from synthetic amino acid-taurine conjugates: an in vitro perfusion study in rats. Clin. Nutr. 16: 137-139.
13. Kelly, G. E., Joannou, G. E., Reeder, A. Y., Nelson, C. & Waring, M. A. (1995) The variable metabolic response to dietary isoflavones in humans. Proc. Soc. Exp. Biol. Med. 208: 40-43.
14. King, R. A., Broadbent, J. L. & Head, R. J. (1996) Absorption and excretion of the soy isoflavone genistein in rats. J. Nutr. 126: 176-182.
15. Koster, A. S. J. & Noordhoek, J. (1983) Glucuronidation in isolated perfused rat intestinal segments after mucosal and serosal administration of 1-naphthol. J. Pharm. Exp. Ther. 226: 533-538.
16. Lundh, T. (1990) Conjugation of the plant estrogens formononetin and daidzein and their metabolite equol by gastrointestinal epithelium from cattle and sheep. J. Agric. Food Chem. 38: 1012-1016.
17. Plauth, M., Kremer, I., Raible, A., Stehle, P., Fürst, P. & Hartmann, F. (1992) Nitrogen absorption from isonitrogenous solutions of L-leucyl-L-leucine and L-leucine: a study in the isolated perfused rat small intestine. Clin. Sci. 82: 283-290.
18. Plauth, M., Raible, A., Bauder-Gross, D., Vieillard-Baron, D., Fürst, P. & Hartmann, F. (1991) Effects of dexamethasone on glutamine metabolism in the isolated vascularly perfused rat small intestine. Res. Exp. Med. 191: 349-357.
19. Record, I. R., Dreosti, I. E. & McInerney, J. K. (1995) The antioxidant activity of genistein in vitro. J. Nutr. Biochem. 6: 481-485.
20. Sfakianos, J., Coward, L., Kirk, M. & Barnes, S. (1997) Intestinal uptake and biliary excretion of the isoflavone genistein in rats. J. Nutr. 127: 1260-1268.
21. Wang, H. J. & Murphy, P. A. (1994) Isoflavone content in commercial soybean foods. J. Agric. Food Chem. 42: 1666-1673.
22. Wei, H., Bowen, R., Cai, Q., Barnes, S. & Wang, Y. (1995) Antioxidant and antipromotional effects of the soybean isoflavone genistein. Proc. Soc. Exp. Biol. Med. 208: 124-130.
23. Xu, X., Harris, K. S., Wang, H. J., Murphy, P. A. & Hendrich, S. (1995) Bioavailability of soybean isoflavones depends upon gut microflora in women. J. Nutr. 125: 2307-2315.
24. Yasuda, T., Mizunuma, S., Kano, Y., Saito, K. & Oshawa, K. (1996) Urinary and biliary metabolites of genistein in rats. Biol. Pharm. Bull. 19: 413-417.
25. Zhang, Y., Song, T. T., Cunnick, J. E., Murphy, P. A. & Hendrich, S. (1999) Daidzein and genistein glucuronides in vitro are weakly estrogenic and activate human natural killer cells at nutritionally relevant concentrations. J. Nutr. 129: 399-405.