Isoprenylation of intracellular proteins as a new target for the therapy of human neoplasms: Preclinical and clinical implications

Current Drug Targets

Volumn 6, Issue 3, 2005, Pages 301-323

  Caraglia, Michele ^a   Budillon, A ^a   Tagliaferri, P ^b   Marra, M ^c   Abbruzzese, A ^c   Caponigro, F ^a  

^a NATIONAL CANCER INSTITUTE   (Italy)

^b UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^c SECOND UNIVERSITY OF NAPLES   (Italy)

Author keywords

Aminobisphosphonates; Farnesyltransferase inhibitors; Farnesyltransferases; Geranylgeranyltransferases; Isoprenylation; Ras; Small G proteins; Statins

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 (2 CHLORO 4 IODOANILINO) N CYCLOPROPYLMETHOXY 3,4 DIFLUOROBENZAMIDE; 3 BENZYL 7 CYANO 2,3,4,5 TETRAHYDRO 1 (1H IMIDAZOL 4 YLMETHYL) 4 (2 THIENYLSULFONYL) 1H 1,4 BENZODIAZEPINE; ALPHA INTERFERON; ANTICONVULSIVE AGENT; ANTINEOPLASTIC AGENT; APOPTOSIS INHIBITOR; ATORVASTATIN; BISPHOSPHONIC ACID DERIVATIVE; BMS 186511; CAPECITABINE; CARBOPLATIN; CELL PROTEIN; CYCLOPHOSPHAMIDE; CYTOKINE; DAUNORUBICIN; DOCETAXEL; DOXORUBICIN; FLUINDOSTATIN; FLUOROURACIL; GEMCITABINE; GERANYLTRANSFERASE; GGTI 298; GLYCOPROTEIN P; GLYCOPROTEIN P INHIBITOR; GRANULOCYTE COLONY STIMULATING FACTOR; GROWTH FACTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; HORMONE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IMATINIB; IRINOTECAN; ISIS 2503; L 774; L 778123; LONAFARNIB; MEVALONIC ACID; MEVINOLIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; N [[5 [(2 AMINO 3 MERCAPTOPROPYL)AMINO][1,1' BIPHENYL] 2 YL]CARBONYL]METHIONINE METHYL ESTER; PACLITAXEL; PAMIDRONIC ACID; PEPTIDE DERIVATIVE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHONIC ACID DERIVATIVE; PRAVASTATIN; PROTEIN DNAJ; PROTEIN FARNESYLTRANSFERASE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; PROTEIN SERINE THREONINE KINASE; RAC PROTEIN; RAS PROTEIN; RHO FACTOR; SIMVASTATIN; SORAFENIB; TIPIFARNIB; TOPOTECAN; TRASTUZUMAB; UBIQUINONE; UNCLASSIFIED DRUG; ZOLEDRONIC ACID;

ACUTE KIDNEY FAILURE; ANOREXIA; ANTINEOPLASTIC ACTIVITY; BLADDER CANCER; BLOOD TOXICITY; BONE MARROW SUPPRESSION; BONE METASTASIS; CANCER CHEMOTHERAPY; CLINICAL TRIAL; DIARRHEA; DOSE RESPONSE; DRUG MECHANISM; DRUG METABOLISM; DRUG POTENTIATION; DRUG STRUCTURE; DRUG TARGETING; FATIGUE; GASTROINTESTINAL HEMORRHAGE; GASTROINTESTINAL TOXICITY; HAND FOOT SYNDROME; HEAD AND NECK CANCER; HUMAN; ISOPRENYLATION; LEUKEMIA; LIVER TOXICITY; LUNG NON SMALL CELL CANCER; MUSCLE DISEASE; MYOGLOBINURIA; NAUSEA; NEUROTOXICITY; NEUTROPENIA; NONHUMAN; ONCOGENE RAS; PERIPHERAL NEUROPATHY; PROTEIN PROCESSING; QT PROLONGATION; RASH; REVIEW; RHABDOMYOLYSIS; SIGNAL TRANSDUCTION; SKIN TOXICITY; SOLID TUMOR; SQUAMOUS CELL CARCINOMA; STOMATITIS; THROMBOCYTOPENIA; VOMITING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ALKYL AND ARYL TRANSFERASES; ANIMALS; ANTINEOPLASTIC AGENTS; BENZODIAZEPINES; FARNESYLTRANSTRANSFERASE; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; IMIDAZOLES; MEVALONIC ACID; NEOPLASMS; PIPERIDINES; PROTEIN ISOPRENYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PYRIDINES; QUINOLONES; RAS PROTEINS;

EID: 18744363084     PISSN: 13894501     EISSN: None     Source Type: Journal    
DOI: 10.2174/1389450053765833     Document Type: Review

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