RhoE regulates actin cytoskeleton organization and cell migration

Molecular and Cellular Biology

Volumn 18, Issue 8, 1998, Pages 4761-4771

  Guasch, Rosa M ^a,b   Scambler, Peter ^c   Jones, Gareth E ^b   Ridley, Anne J ^a,d  

^a LUDWIG INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; AMINO ACID; CELL CYCLE PROTEIN; GUANOSINE TRIPHOSPHATASE; GUANOSINE TRIPHOSPHATE; RHO FACTOR; SCATTER FACTOR;

ANIMAL CELL; ARTICLE; CELL ADHESION; CELL MIGRATION; CELL STRAIN; CELLULAR DISTRIBUTION; CYTOSKELETON; ENZYME ACTIVITY; FIBROBLAST; GENE; LAMELLIPODIUM; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PSEUDOPODIUM;

EID: 0031877714     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.18.8.4761     Document Type: Article

References (55)

1. Aepfelbacher, M., M. Essler, E. Huber, A. Czech, and P. C. Weber. 1996. Rho is a negative regulator of human monocyte spreading. J. Immunol. 157:5070-5075.
2. Allen, W. E., G. E. Jones, J. W. Pollard, and A. J. Ridley. 1997. Rho, Rac and Cdc42 regulate actin organization and cell adhesion in macrophages. J. Cell Sci. 110:707-720.
3. Amano, M., M. Ito, K. Kimura, Y. Fukata, K. Chihara, T. Nakano, Y. Matsuura, and K. Kaibuchi. 1996. Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase). J. Biol. Chem. 271:20246-20249.
4. Boguski, M. S., and F. McCormick. 1993. Proteins regulating Ras and its relatives. Nature 366:643-654.
5. Boocock, C. A., G. E. Jones, E. R. Stanley, and J. W. Pollard. 1989. Colony-stimulating factor-1 induces rapid behavioural responses in the mouse macrophage cell line, BAC1.2F5. J. Cell Sci. 93:447-456.
6. Bourne, H. R., D. A. Sanders, and F. McCormick. 1991. The GTPase superfamily: conserved structure and molecular mechanism. Nature 349:117-127.
7. Braga, V. M., L. M. Machesky, A. Hall, and N. A. Hotchin. 1997. The small GTPases Rho and Rac are required for the establishment of cadherin-dependent cell-cell contacts. J. Cell Biol. 137:1421-1431.
8. Bretscher, A. 1991. Microfilament structure and function in the cortical cytoskeleton. Annu. Rev. Cell Biol. 7:337-374.
9. Burridge, K., and M. Chrzanowska Wodnicka. 1996. Focal adhesions, contractility, and signaling. Annu. Rev. Cell Dev. Biol. 12:463-518.
10. Burridge, K., K. Fath, T. Kelly, G. Nuckolls, and C. Turner. 1988. Focal adhesions: transmembrane junctions between the extracellular matrix and the cytoskeleton. Annu. Rev. Cell Biol. 4:487-525.
11. Chihara, K., M. Amano, N. Nakamura, T. Yano, M. Shibata, T. Tokui, H. Ichikawa, R. Ikebe, M. Ikebe, and K. Kaibuchi. 1997. Cytoskeletal rearrangements and transcriptional activation of c-fos serum response element by Rho-kinase. J. Biol. Chem. 272:25121-25127.
12. Chrzanowska-Wodnicka, M., and K. Burridge. 1996. Rho-stimulated contractility drives the formation of stress fibers and focal adhesions. J. Cell Biol. 133:1403-1415.
13. Cooper, J. A. 1991. The role of actin polymerization in cell motility. Annu. Rev. Physiol. 53:585-605.
14. Dowrick, P. G., A. R. Prescott, and R. M. Warn. 1991. Scatter factor affects major changes in the cytoskeletal organization of epithelial cells. Cytokine 3:299-310.
15. Entwistle, A., and M. Noble. 1994. Optimizing the performance of confocal point scanning laser microscopes over the full field of view. J. Microsc. 175:238-251.
16. Foster, R., K. Q. Hu, Y. Lu, K. M. Nolan, J. Thissen, and J. Settleman. 1996. Identification of a novel human Rho protein with unusual properties: GT-Pase deficiency and in vivo farnesylation. Mol. Cell. Biol. 16:2689-2699.
17. Freeman, J. L., A. Abo, and J. D. Lambeth. 1996. Rac "insert region" is a novel effector region that is implicated in the activation of NADPH oxidase, but not PAK65. J. Biol. Chem. 271:19794-19801.
18. Hart, P. A., and C. J. Marshall. 1990. Amino acid 61 is a determinant of sensitivity of rap proteins to the ras GTPase activating protein. Oncogene 5:1099-1101.
19. Hirshberg, M., R. W. Stockley, G. Dodson, and M. R. Webb. 1997. The crystal structure of human rac1, a member of the rho-family complexed with a GTP analogue. Nat. Struct. Biol. 4:147-152.
20. Ishizaki, T., M. Naito, K. Fujisawa, M. Maekawa, N. Watanabe, Y. Saito, and S. Narumiya. 1997. p160ROCK, a Rho-associated coiled-coil forming protein kinase, works downstream of Rho and induces focal adhesions. FEBS Lett. 404:118-124.
21. Jalink, K., E. J. van Corven, T. Hengeveld, N. Morii, S. Narumiya, and W. H. Moolenaar. 1994. Inhibition of lysophosphatidate-and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho. J. Cell Biol. 126:801-810.
22. Kimura, K., M. Ito, M. Amano, K. Chihara, Y. Fukata, M. Nakafuku, B. Yamamori, J. Feng, T. Nakano, K. Okawa, A. Iwamatsu, and K. Kaibucbi. 1996. Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase). Science 273:245-248.
23. Kozma, R., S. Ahmed, A. Best, and L. Lim. 1995. The Ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 fibroblasts. Mol. Cell. Biol. 15:1942-1952.
24. Lamarche, N., N. Tapon, L. Stowers, P. D. Burbelo, P. Aspenstrom, T. Bridges, J. Chant, and A. Hall. 1996. Rac and Cdc42 induce actin polymerization and G1 cell cycle progression independently of p65PAK and the JNK/SAPK MAP kinase cascade. Cell 87:519-529.
25. Lauffenburger, D. A., and A. F. Horwitz. 1996. Cell migration: a physically integrated molecular process. Cell 84:359-369.
26. Leung, T., X. Q. Chen, E. Manser, and L. Lim. 1996. The p160 RhoA-binding kinase ROK α is a member of a kinase family and is involved in the reorganization of the cytoskeleton. Mol. Cell. Biol. 16:5313-5327.
27. Leung, T., E. Manser, L. Tan, and L. Lim. 1995. A novel serine/threonine kinase binding the Ras-related RhoA GTPase which translocates the kinase to peripheral membranes. J. Biol. Chem. 270:29051-29054.
28. Lloyd, A. C., H. F. Paterson, J. D. Morris, A. Hall, and C. J. Marshall. 1989. p21H-ras-induced morphological transformation and increases in c-myc expression are independent of functional protein kinase C. EMBO J. 8:1099-1104.
29. Machesky, L. M., and A. Hall. 1996. Rho: a connection between membrane receptor signalling and the cytoskeleton. Trends Cell Biol. 6:304-310.
30. Mackay, D. J., F. Esch, H. Furthmayr, and A. Hall. 1997. Rho-and rac-dependent assembly of focal adhesion complexes and actin filaments in permeabilized fibroblasts: an essential role for ezrin/radixin/moesin proteins. J. Cell Biol. 138:927-938.
31. Mitchison, T. J., and L. P. Cramer. 1996. Actin-based cell motility and cell locomotion. Cell 84:371-379.
32. Morgan, C., J. W. Pollard, and E. R. Stanley. 1987. Isolation and characterization of a cloned growth factor dependent macrophage cell line, BAC1.2F5. J. Cell. Physiol. 130:420-427.
33. Narumiya, S., T. Ishizaki, and N. Watanabe. 1997. Rho effectors and reorganization of actin cytoskeleton. FEBS Lett. 410:68-72.
34. Nishiyama, T., T. Sasaki, K. Takaishi, M. Kato, H. Yaku, K. Araki, Y. Matsuura, and Y. Takai. 1994. rac p21 is involved in insulin-induced membrane ruffling and rho p21 is involved in hepatocyte growth factor-and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced membrane ruffling in KB cells. Mol. Cell. Biol. 14:2447-2456.
35. Nobes, C. D., and A. Hall. 1995. Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 81:53-62.
36. O'Hare, M. J., M. G. Omerod, P. Monaghan, E. B. Lane, and B. A. Gusterson. 1991. Characterisation in vitro of luminal and myoepithelial cells isolated from the human mammary gland by cell sorting. Differentiation 46: 209-221.
37. Pizon, V., P. Chardin, I. Lerosey, B. Olofsson, and A. Tavilian. 1988. Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3 encode proteins closely related to ras in the 'effector' region. Oncogene 3:201-204.
38. Postma, F. R., K. Jalink, T. Hengeveld, and W. H. Moolenaar. 1996. Sphingosine-1-phosphate rapidly induces Rho-dependent neurite retraction: action through a specific cell surface receptor. EMBO J. 15:2388-2392.
39. Reynet, C., and C. R. Kahn. 1993. Rad: a member of the Ras family overexpressed in muscle of type II diabetic humans. Science 262:1441-1444.
40. Ridley, A. J. 1996. Rho: theme and variations. Curr. Biol. 6:1256-1264.
41. Ridley, A. J., P. M. Comoglio, and A. Hall. 1995. Regulation of scatter factor/hepatocyte growth factor responses by Ras, Rac, and Rho in MDCK cells. Mol. Cell. Biol. 15:1110-1122.
42. Ridley, A. J., and A. Hall. 1992. The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 70:389-399.
43. Ridley, A. J., H. F. Paterson, C. L. Johnston, D. Diekman, and A. Hall. 1992. The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell 70:401-410.
44. Rosen, E. M., L. Meromsky, I. Goldberg, M. Bhargava, and E. Setter. 1990. Studies on the mechanism of scatter factor. Effects of agents that modulate intracellular signal transduction, macromolecule synthesis and cytoskeleton assembly. J. Cell Sci. 96:639-649.
45. Rubinfeld, B., W. J. Crosier, I. Albert, L. Conroy, R. Clark, F. McCormick, and P. Polakis. 1992. Localization of the rap1GAP catalytic domain and sites of phosphorylation by mutational analysis. Mol. Cell. Biol. 12:4634-4642.
46. Self, A. J., and A. Hall. 1995. Measurement of intrinsic nucleotide exchange and GTP hydrolysis rates. Methods Enzymol. 256:67-76.
47. Smith, D. S., and K. S. Johnson. 1988. Single-step purification of polypeptides expressed in E. coli as fusions with glutathione S-transferase. Gene 67:31-40.
48. Stoker, M., and M. Perryman. 1985. An epithelial scatter factor released by embryo fibroblasts. J. Cell Sci. 77:209-223.
49. Takaishi, K., T. Sasaki, T. Kameyama, S. Tsukita, S. Tsukita, and Y. Takai. 1995. Translocation of activated Rho from the cytoplasm to membrane ruffling area, cell-cell adhesion sites and cleavage furrows. Oncogene 11:39-48.
50. Takaishi, K., T. Sasaki, H. Kotani, H. Nishioka, and Y. Takai. 1997. Regulation of cell-cell adhesion by Rac and Rho small G proteins in MDCK cells. J. Cell Biol. 139:1047-1059.
51. Tsukita, S., S. Yonemura, and S. Tsukita. 1997. ERM proteins: head-to-tail regulation of actin-plasma membrane interaction. Trends Biochem. Sci. 22:53-58.
52. Van Aelst, L., and C. D'Souza-Schorey. 1997. Rho GTPases and signaling networks. Genes Dev. 11:2295-2322.
53. Wei, Y., Y. Zhang, U. Derewenda, X. Liu, W. Minor, R. K. Nakamoto, A. V. Somlyo, A. P. Somlyo, and Z. S. Derewenda. 1997. Crystal structure of RhoA-GDP and its functional implications. Nat. Struct. Biol. 4:699-703.
54. Zhong, C., M. S. Kinch, and K. Burridge. 1997. Rho-stimulated contractility contributes to the fibroblastic phenotype of Ras-transformed epithelial cells. Mol. Biol. Cell. 8:2329-2344.
55. Zhu, J., C. Reynet, J. S. Caldwell, and C. R. Kahn. 1995. Characterization of Rad, a new member of Ras/GTPase superfamily, and its regulation by a unique GTPase-activating protein (GAP)-like activity. J. Biol. Chem. 270:4805-4812.