The Farnesyltransferase Inhibitor, FTI-2153, Blocks Bipolar Spindle Formation and Chromosome Alignment and Causes Prometaphase Accumulation during Mitosis of Human Lung Cancer Cells

Journal of Biological Chemistry

Volumn 276, Issue 19, 2001, Pages 16161-16167

  Crespo, Nichole C ^a   Ohkanda, Junko ^b   Yen, Tim J ^c   Hamilton, Andrew D ^b   Sebti, Saïd M ^a  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^b YALE UNIVERSITY   (United States)

^c FOX CHASE CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; DRUG PRODUCTS; ENZYMES; RESPIRATORY SYSTEM; TOXICITY; TUMORS;

THERAPEUTIC AGENTS;

CHROMOSOMES;

4,6 DIAMIDINO 2 PHENYLINDOLE; CENTROMERE PROTEIN E; DNA; FTI 2153; INDOLE DERIVATIVE; PROETIN CENP F; PROTEIN; PROTEIN FARNESYLTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG; ENZYME INHIBITOR; FARNESYL TRANS TRANSFERASE; TRANSFERASE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL DIVISION; CENTROMERE; CHROMOSOME; CONTROLLED STUDY; DRUG MECHANISM; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LUNG CANCER; METAPHASE; MITOSIS; MITOSIS SPINDLE; PRIORITY JOURNAL; PROPHASE; PROTEIN LOCALIZATION; RING CHROMOSOME; VIDEORECORDING; CELL CULTURE; CELL CYCLE; DRUG ANTAGONISM; DRUG EFFECT; HUMAN CHROMOSOME; LUNG TUMOR; PHYSIOLOGY; ULTRASTRUCTURE;

ALKYL AND ARYL TRANSFERASES; CELL CYCLE; CELL DIVISION; CHROMOSOMES, HUMAN; ENZYME INHIBITORS; FARNESYLTRANSTRANSFERASE; HUMANS; LUNG NEOPLASMS; METAPHASE; MITOSIS; MITOTIC SPINDLE APPARATUS; TUMOR CELLS, CULTURED;

EID: 0035844247     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M006213200     Document Type: Article

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