Interferon-α induces apoptosis in human KB cells through a stress-dependent mitogen activated protein kinase pathway that is antagonized by epidermal growth factor

Cell Death and Differentiation

Volumn 6, Issue 8, 1999, Pages 773-780

  Caraglia, M ^d   Abbruzzese, A ^c   Leardi, A ^d   Pepe, S ^d   Budillon, A ^a   Baldassare, G ^a   Selleri, C ^d   De Lorenzo, S ^d   Fabbrocini, A ^d   Giuberti, G ^d   Vitale, G ^d   Lupoli, G ^d   Bianco, A R ^d   Tagliaferri, P ^b  

^a NATIONAL CANCER INSTITUTE   (Italy)

^b UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^d NONE

Author keywords

Apoptosis; Epidermal growth factor; Heat shock proteins; Interferon ; JNK 1; Tumour cells

Indexed keywords

ALPHA INTERFERON; EPIDERMAL GROWTH FACTOR; HEAT SHOCK PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; RECOMBINANT ALPHA2 INTERFERON;

AMINO TERMINAL SEQUENCE; APOPTOSIS; ARTICLE; CELL DEATH; CELL STRAIN KB; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STRESS;

EID: 0032836086     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4400550     Document Type: Article

References (40)

1. Cohen MC and Cohen S (1996) Cytokine function: a study in biologic diversity. Am. J. Clin. Pathol. 105: 589-598
2. Budillon A, Tagliaferri P, Caraglia M, Torrisi MR, Normanno N, Iacobelli S, Palmieri G, Stoppelli MP, Frati L and Bianco AR (1991) Upregulation of epidermal growth factor receptor induced by alpha-interferon in human epidermoid cancer cells. Cancer Res. 51: 1294-1299
3. Caraglia M, Libroia AM, Corradino S, Coppola V, Guarrasi R, Barile C, Genua G, Bianco AR and Tagliaferri P (1994) α-Interferon induces depletion of intracellular iron content and upregulation of functional transferrin receptors on human epidermoid cancer KB cells. Biochem. Biophys. Res. Commun. 203: 281-288
4. Caraglia M, Passeggio A, Beninati S, Leardi A, Nicolini L, Improta S, Pinto A, Bianco AR, Tagliaferri P and Abbruzzese A (1997) Interferon α2 recombinant and epidermal growth factor modulate proliferation and hypusine synthesis in human epidermoid cancer KB cells. Biochem. J. 324: 737-741
5. Caraglia M, Leardi A, Corradino S, Ciardiello F, Budillon A, Guarrasi R, Bianco AR and Tagliaferri P (1995) α-Interferon potentiates epidermal growth factor receptor-mediated effects on human epidermoid carcinoma KB cells. Int. J. Cancer 61: 342-347
6. Tagliaferri P, Caraglia M, Muraro R, Budillon A, Pinto A and Bianco AR (1994) Pharmacological modulation of peptide growth factor receptor expression on tumor cells as a basis for cancer therapy. Anti-Cancer Drugs 5: 379-393
7. Rodriguez-Villanueva J and McDonnell TJ (1995) Induction of apoptotic cell death in non-melanoma skin cancer by interferon-α. Int. J. Cancer 61: 110-114
8. Roth W, Wagenknecht B, Dichgans J and Weller MJ (1998) Interferon-alpha enhances CD95L-induced apoptosis of human malignant glioma cells. J. Neuroimmunol. 87: 121-129
9. Tanaka N, Sato M, Lamphier MS, Nozawa H, Oda E, Noguchi S, Schreiber RD, Tsujimoto Y and Taniguchi T (1998) Type I interferons are essential mediators of apoptotic death in virally infected cells. Genes Cells 3: 29-37
10. Tilly JL, Billig H, Kowalski KI and Hsueh AJ (1992) Epidermal growth factor and basic fibroblast growth factor suppress the spontaneous onset of apoptosis in cultured rat ovarian granulosa cells and follicles by a tyrosine kinase-dependent mechanism. Mol. Endocrinol. 6: 1942-1950.
11. Peng H, Wen TC, Tanaka J, Maeda N, Matsuda S, Desaki J, Sudo S, Zhang B and Sakanaka M (1998) Epidermal growth factor protects neuronal cells in vivo and in vitro against transient forebrain ischemia- and free radical-induced injuries. J. Cereb. Blood Flow Metab. 18: 349-360
12. Stoll SW, Benedict M, Mitra R, Hiniker A, Elder JT and Nunez G (1998) EGF receptor signaling inhibits keratinocyte apoptosis: evidence for mediation by Bcl-XL. Oncogene 16: 1493-1499
13. Welsh MJ and Gaestel M (1998) Small heat-shock protein family: function in health and disease. Ann. N.Y. Acad. Sci. 851: 28-35
14. Mestril R, Chi SH, Sayen MR, O'Reilly K and Dillmann WH (1994) Expression of inducible stress protein 70 in rat heart myogenic cells confers protection against simulated ischemia-induced injury. J. Clin. Invest. 93: 759-767
15. Xu Q, Hu Y, Kleindienst R and Wick G (1997) Nitric oxide induces heat-shock protein 70 expression in vascular smooth muscle cells via activation of heat shock factor 1. J. Clin. Invest. 100: 1089-1097
16. Laderoute KR, Grant TD, Murphy BJ and Sutherland RM (1992) Enhanced epidermal growth factor receptor synthesis in human squamous carcinoma cells exposed to low levels of oxygen. Int. J. Cancer 52: 428-432
17. Ichijo H, Nishida E, Irie K, ten Dijke P, Saitoh M, Moriguchi T, Takagi M, Matsumoto K, Miyazono K and Gotoh Y (1997) Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways. Science 275: 90-94
18. Wang W, Zhou G, Hu MCT, Yao Z and Tan TH (1997) Activation of the hematopoietic progenitor kinase-1 (HPK1)-dependent, stress-activated c-Jun N-terminal kinase (JNK) pathway by transforming growth factor beta (TGF-beta)-activated kinase (TAK1), a kinase mediator of TGF beta signal transduction. J. Biol. Chem. 272: 22771-22775
19. Frey RS and Mulder KM (1997) Involvement of extracellular signal-regulated kinase 2 and stress-activated protein kinase/Jun N-terminal kinase activation by transforming growth factor beta in the negative growth control of breast cancer cells. Cancer Res. 57: 628-633
20. Xia Z, Dickens M, Raingeaud J, Davis RJ and Greenberg ME (1995) Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270: 1326-1331
21. Yan CYI and Greene LA (1998) Prevention of PC12 cell death by N-acetylcysteine requires activation of the Ras pathway. J. Neurosci. 18: 4042-4049
22. Aikawa R, Komuro I, Yamazaki T, Zou Y, Kudoh S, Tanaka M, Shiojima I, Hiroi Y and Yazaki Y (1997) Oxidative stress activates extracellular signal-regulated kinases through Src and Ras in cultured cardiac myocytes of neonatal rats. J. Clin. Invest. 100: 1813-1821
23. Stadheim TA and Kucera GL (1998) Extracellular signal-regulated kinase (ERK) activity is required for TPA-mediated inhibition of drug-induced apoptosis. Biochem. Biophys. Res. Commun. 245: 266-271
24. Derijard B, Raingeaud J, Barrett T, Wu I-H, Han J, Ulevitch RJ and Davis RJ (1995) Independent human MAP kinase signal transduction pathways defined by MEK and MKK isoforms. Science 267: 682-685
25. Goillot E, Raingeaud J, RangerA, Tepper RI, Davis RJ, Harlow E and Sanchez I (1997) Mitogen-activated protein kinase-mediated Fas apoptotic signaling pathway. Proc. Natl. Acad. Sci. USA 94: 3302-3307
26. Zanke BW, Lee C, Arab S and Tannock IF (1998) Death of tumor cells after intracellular acidification is dependent on stress-activated protein kinases (SAPK/JNK) pathway activation and cannot be inhibited by Bcl-2 expression or interleukin 1 beta-converting enzyme inhibition. Cancer Res. 58: 2801-2808
27. Mosser DD and Martin LH (1992) Induced thermotolerance to apoptosis in a human T lymphocyte cell line. J. Cell Physiol. 151: 561-570
28. Wei YQ, Zhao X, Kariya Y, Fukata H, Teshigawara K and Uchida A (1994) Induction of apoptosis by quercetin: involvement of heat shock protein. Cancer Res. 54: 4952-4957
29. Burel C, Mezger V, Pinto M, Rallu M, Trigon S and Morange M(1992) Mammalian heat shock protein families. Expression and functions. Experientia 48: 629-633
30. Karin M (1998) Mitogen-activated protein kinase cascades as regulators of stress responses. Ann. N.Y. Acad. Sci. 851: 139-146
31. Treisman R (1996) Regulation of transcription by MAP kinase cascades. Curr. Opin. Cell. Biol. 8: 205-215
32. Sanchez-Perez I, Murguia JR and Perona R (1998) Cisplatin induces a persistent activation of JNK that is related to cell death. Oncogene 16: 533-540
33. Ahlers A, Engel K, Sott C, Gaestel M, Herrmann F and Brach MA (1994) Interleukin-3 and granulocyte-macrophage colony-stimulating factor induce activation of the MAPKAP kinase 2 resulting in in vitro serine phosphorylation of the small heat shock protein (Hsp27). Blood 83: 1791-1798
34. Armstrong D, Kaufmann SH, Ottaviano YL, Furuya Y, Buckley JA, Isaacs JT and Davidson NE (1994) Epidermal growth factor-mediated apoptosis of MDA-MB-468 human breast cancer cells. Cancer Res. 54: 5280-5283
35. Bokoch GM (1998) Caspase-mediated activation of PAK2 during apoptosis: proteolytic kinase activation as a general mechanism of apoptotic signal transduction? Cell Death Differ. 5: 637-645
36. Harrington EA, Fanidi A and Evan GI (1994) Oncogenes and cell death. Curr. Opin. Gen. Dev. 4: 120-129
37. Evan GI, Wyllie AH, Gilbert CS, Littlewood TD, Land H, Brooks M, Waters CM, Penn LZ and Hancock DC (1992) Induction of apoptosis in fibroblast by c-myc protein. Cell 69: 119-128
38. Smeyne R, Vendrell M, Hayward M, Baker S, Miao G, Schilling K, Robertson L, Curran T and Morgan J (1993) Continuous c-fos expression precedes programmed cell-death in vivo. Nature (London) 363: 166-169
39. Krontiris TG (1995) Oncogenes. New Engl. J. Med. 333: 303-306
40. Dedera DA, Walker EK, LeBrun DP, Sen-Majumdar A, Stevens ME, Barsh GS and Cleary ML (1993) Chimeric homeobox gene E2A-PBX1 induces proliferation, apoptosis, and malignant lymphomas in transgenic mice. Cell 74: 833-843