Geranylgeranylated RhoB is sufficient to mediate tissue-specific suppression of Akt kinase activity by farnesyltransferase inhibitors

FEBS Letters

Volumn 481, Issue 3, 2000, Pages 205-208

  Liu, Ai Xue ^a   Prendergast, George C ^a,b  

^a WISTAR INSTITUTE   (United States)

^b DuPont Pharmaceuticals Company   (United States)

Author keywords

Akt; Apoptosis; Farnesyltransferase inhibitor; Prk; Ras; Rho; Signal transduction

Indexed keywords

PROTEIN FARNESYLTRANSFERASE INHIBITOR; PROTEIN KINASE; PROTEIN KINASE AKT; PROTEIN RHOB; RHO FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL STRAIN COS1; CELL STRAIN MCF 7; CELL SURVIVAL; ENZYME INHIBITION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ALKYL AND ARYL TRANSFERASES; ANIMAL; ANTINEOPLASTIC AGENTS; APOPTOSIS; COS CELLS; ENZYME ACTIVATION; ENZYME INHIBITORS; ENZYME REPRESSION; EPIDERMAL GROWTH FACTOR; GENES, RAS; HUMAN; ORGAN SPECIFICITY; PROTEIN ISOPRENYLATION; PROTEIN-TYROSINE KINASE; PROTO-ONCOGENE PROTEIN P21(RAS); RETROVIRIDAE PROTEINS, ONCOGENIC; RHOB GTP-BINDING PROTEIN; SUPPORT, U.S. GOV'T, P.H.S.; TUMOR CELLS, CULTURED;

EID: 0034703471     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(00)02003-2     Document Type: Article

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