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Volumn 19, Issue 56, 2000, Pages 6584-6593

Farnesyltransferase and geranylgeranyltransferase I inhibitors and cancer therapy: Lessons from mechanism and bench-to-bedside translational studies

(2) Sebti, Saïd M a Hamilton, Andrew D b

a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE (United States)

b YALE UNIVERSITY (United States)

Author keywords

Cancer therapy; Farnesyltransferase; FTI; Geranylgeranyltransferase I; GGTI; Hypothesis driven clinical trials; Ras

Indexed keywords

1,2,3,4,9,9A HEXAHYDRO 2 [2 (2 METHOXYPHENYL) 1 OXO 2 PROPENYL] 9 (4 METHYLPHENYL) 4,9 ETHANO 3AH BENZ[F]ISOINDOLE 3A CARBOXYLIC ACID; ANTINEOPLASTIC AGENT; B 966; BENZODIAZEPINE; BMS 184878; BMS 193269; BZA 2B; GERANYLGERANYLTRANSFERASE INHIBITOR; L 745631; LONAFARNIB; N (8 AMINO 2 BENZYL 5 ISOPROPYL 9 MERCAPTO 3,6 NONADIENOYL)METHIONINE; N (8 AMINO 2 BENZYL 5 ISOPROPYL 9 MERCAPTO 3,6 NONADIENOYL)METHIONINE METHYL ESTER; N [2 [2 (2 AMINO 3 MERCAPTOPROPYLAMINO) 3 METHYLPENTYLOXY] 3 PHENYLPROPIONYL]METHIONINE SULFONE; N [2 [2 (2 AMINO 3 MERCAPTOPROPYLAMINO) 3 METHYLPENTYLOXY] 3 PHENYLPROPIONYL]METHIONINE SULFONE METHYL ESTER; N [[5 [(2 AMINO 3 MERCAPTOPROPYL)AMINO][1,1' BIPHENYL] 2 YL]CARBONYL]METHIONINE; N [[5 [(2 AMINO 3 MERCAPTOPROPYL)AMINO][1,1' BIPHENYL] 2 YL]CARBONYL]METHIONINE METHYL ESTER; PROTEIN FARNESYLTRANSFERASE INHIBITOR; TIPIFARNIB; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; CANCER; CLINICAL TRIAL; DRUG DESIGN; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; DRUG TOLERABILITY; ENZYME INHIBITION; HUMAN; PRIORITY JOURNAL; REVIEW;

ALKYL AND ARYL TRANSFERASES; ANIMALS; ANTICARCINOGENIC AGENTS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL DIVISION; CLINICAL TRIALS; COMBINED MODALITY THERAPY; DRUG DELIVERY SYSTEMS; DRUG DESIGN; ENZYME INHIBITORS; FARNESYLTRANSTRANSFERASE; HUMANS; MICE; PROTO-ONCOGENE PROTEINS P21(RAS); RHOB GTP-BINDING PROTEIN; SUBSTRATE SPECIFICITY;

STAPHYLOCOCCUS PHAGE 3A;

EID: 0034722890 PISSN: 09509232 EISSN: None Source Type: Journal
DOI: 10.1038/sj.onc.1204146 Document Type: Review

Times cited : (277)

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